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Volume 13 Issue 7, July 2007

In this issue, Lois Smith and colleagues find that mice fed a diet high in ω–3 polyunsaturated fatty acids have reduced pathological retinal angiogenesis, and the authors propose that such a diet could be used to prevent retinopathy. The cover image shows the retinal vasculature (isolectin B4 labeling, red) interacting with microglia (Csf1r–positive, green) in a 1–day–old mouse.

Volume 13 Issue 7

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Editorial

  • The FDA needs more power to monitor the safety of drugs in the market, but it also needs to show that it can handle the additional responsibilities.

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Correspondence

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Book Review

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News & Views

  • The factors that regulate airway goblet cell metaplasia and mucus secretion are essential to understanding how airway obstruction occurs in asthma. In this issue, Xiang et al. demonstrate the existence of an airway epithelial, extraneuronal GABAergic signaling system that promotes mucus overproduction during allergic airway inflammation (pages 862–867).

    • David B Corry
    • Farrah Kheradmand
    News & Views

  • Necrosis induces inflammation, but how necrotic cells signal to immune cells was poorly understood. New work by Chen et al. shows that IL-1α acts as a mediator, translating a signal from the necrotic cells to induce the recruitment of immune cells to the site of injury (pages 851–856).

    • Keith B Elkon
    News & Views

  • In a new role for an ion transporter, Na+-K+-Cl− cotransporter-1 may regulate the lung endothelial and epithelial barriers and consequently modulate the host response to pneumonia and sepsis.

    • Michael A Matthay
    • Xiao Su
    News & Views

  • In response to intense stress, neuropeptide Y facilitates all of the processes that result in adipose tissue growth, but only when mice are fed a palatable high-fat diet (pages 803–811).

    • James P Warne
    • Mary F Dallman
    News & Views

  • Introducing four genes into mouse skin fibroblasts reprograms these cells into embryonic stem cells. If similar techniques work in human cells, patient-specific stem cells for tissue engineering and cell-based therapies may be closer to reality.

    • Howard Y Chang
    • George Cotsarelis
    News & Views

  • Mutations in the phosphoinositide metabolism gene FIG4 disrupt the endosomal pathway, leading to neurodegeneration and a newly identified variant of Charcot-Marie-Tooth disorder.

    • Laura Volpicelli-Daley
    • Pietro De Camilli
    News & Views

  • In psoriasis, expression of the α1β1 integrin is necessary for T cells to enter the epidermis to cause inflammation and psoriatic lesions (pages 836–842).

    • Johann E Gudjonsson
    • James T Elder
    News & Views
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