Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 12 Issue 12, December 2006

The epiphyseal region of long bone, featuring numerous bone-degrading osteoclasts (red cells). In this issue, Takayanagi and colleagues show that CaMKIV phosphorylation of CREB is essential for osteoclast maturation and function. Photo courtesy of Hiroshi Takayanagi.

Volume 12 Issue 12

Subscribe

Editorial

Top of page ⤴

News

Top of page ⤴

Correspondence

Top of page ⤴

Book Review

Top of page ⤴

News & Views

  • HIV-1 infection results in chronic activation of the immune system—a process that is thought to contribute to T-cell depletion and progression to AIDS. Chronic activation is now suggested to occur through a breakdown of the mucosal barrier and stimulation of immune cells by microbial products (pages 1365–1371).

    • Barton F Haynes
    News & Views

  • Activation of certain G protein–coupled receptors stimulates production of the neurotoxic amyloid-β peptide through internalization of a membrane-embedded protease (pages 1390–1396).

    • Michael S Wolfe
    News & Views

  • Certain oncogenes seem to be able to trigger cellular senescence and growth arrest, thereby holding cancer at bay. Two new studies suggest that oncogenes trigger senescence through activation of a pathway initially described as sensing DNA damage.

    • Liu Cao
    • Toren Finkel
    News & Views

  • A protein has been identified that promotes the formation of osteoclasts, bone-degrading cells—while also inhibiting osteoblasts, bone-forming cells. The findings could lead to new avenues of drug development to strengthen bone (pages 1403–1409).

    • Brendan F Boyce
    • Lianping Xing
    News & Views

  • An explanation has come to light for the long-observed phenomenon that ultraviolet light suppresses the immune response in the skin. Light and other stimuli prompt the proliferation of regulatory T cells through the upregulation of receptor activator of NF-κB ligand (RANKL) on skin cells (pages 1372–1379).

    • Tomoyuki Yamaguchi
    • Shimon Sakaguchi
    News & Views

  • Dietary lipids seem to activate a Toll-like receptor, which is better known for its defense against infectious pathogens. The findings suggest that the resulting inflammatory response may link obesity with type 2 diabetes.

    • Matthias Tschöp
    • George Thomas
    News & Views
Top of page ⤴

Research Highlights

Top of page ⤴

Article

Top of page ⤴

Letter

Top of page ⤴

Technical Report

Top of page ⤴

Corrigendum

Top of page ⤴

Search

Advanced search

Quick links