Volume 11 Issue 8, 1 August 2005

Technical Report






Book Review

News & Views

  • News & Views |

    Two studies show how the enzyme ACE2 protects against lung injury caused by SARS and other agents. ACE2 seems to counteract the effects of ACE, which are more damaging ( pages 875–879 ).

    • John Nicholls
    •  & Malik Peiris
  • News & Views |

    The use of thiazolidinediones, drugs for type 2 diabetes that may also be useful for other chronic inflammatory disorders, is limited by fluid retention. Research in mice identifies a mechanism for this side effect and introduces a potential remedy ( pages 861–866 ).

    • Clay F Semenkovich
  • News & Views |

    The future of cancer treatment lies in targeted therapies. That oft-repeated phrase of the last few years comes with a warning: watch out for drug resistance. A new mathematical model explores how combinations of drugs could keep resistance at bay.

    • Charles L Sawyers
  • News & Views |

    The buildup of protein aggregates consisting of proteins such as tau, huntingtin and amyloid-β occurs in a range of degenerative disorders. Recent studies have begun to shed light on the relative contribution of aggregates versus other, intermediate forms of the protein to disease. The most recent entry in the field examines the protein tau.

    • Karen Duff
    •  & Emmanuel Planel
  • News & Views |

    A snarl of regulators influence cardiac hypertrophy, but factors that negatively regulate this process are not well understood. A new molecule has now emerged that seems to control pathologic but not physiologic cardiac hypertrophy in mice. It works by repressing the activity of a key transcription factor after both molecules are induced ( pages 837–844 ).

    • Levon M Khachigian
  • News & Views |

    Adult stem cells can self-renew and can give rise to committed progenitors—but definitive evidence of cells with both properties is lacking in most tissues. A cell in skeletal muscle, the satellite cell, now meets these criteria.

    • Thomas A Rando
  • News & Views |

    The bacterium that causes Lyme disease is a manipulative creature. This pathogen exploits a component in the saliva of its vector, a tick, to facilitate invasion of vertebrate hosts.

    • Patricia Rosa
  • News & Views |

    A new immunization approach could result in safer, more effective vaccines for intracellular infectious agents and cancer ( pages 853–860 ).

    • Fred R Frankel