Volume 11 Issue 4, 1 April 2005



Technical Report




Book Review

News & Views

  • News & Views |

    The accumulation of fibroblasts in epithelial organs such as the kidney can produce dangerous scars. Such tissue fibrosis begins when epithelial cells morph into fibroblasts by epithelial-mesenchymal transition. A key regulator of this process in the kidney now emerges ( pages 387–393 ).

    • Eric G Neilson
  • News & Views |

    The force exerted by blood as it flows through the vessels influences the development of atherosclerosis. An understanding of how disturbed flow leads to disease is now emerging.

    • David G Harrison
  • News & Views |

    A new mouse model begins to unravel a longstanding mystery: why are cancers often associated with blood coagulation disorders?

    • Olga I Stenina
    •  & Edward F Plow
  • News & Views |

    THC acts as a pain reliever in part by engaging a receptor in peripheral tissues, CB2. But exactly where CB2 is and how it operates has been unclear. A new study shows that cannabinoids, acting through CB2 on skin cells, stimulate the local release of endogenous opioids.

    • Krisztina Monory
    •  & Beat Lutz
  • News & Views |

    Blocking β-adrenergic receptors is a standard treatment for heart failure, but it limits the normal ability to modulate cardiac function. Targeting therapy further downstream by blocking activation of calcium-calmodulin–dependent protein kinase could provide an alternative ( pages 409–407 ).

    • Donald M Bers
  • News & Views |

    Immunotherapy for allergies can be an imperfect and unpredictable exercise; immunization with allergens can even lead to an acute allergic response. A new approach, involving fusing the allergen to a protein that modulates the immune response, could provide a more effective and safer alternative ( pages 446–449 ).

    • Janet Kalesnikoff
    •  & Stephen J Galli
  • News & Views |

    Mutations in NOD2, encoding an intracellular bacteria-sensing protein, have been associated recently with Crohn disease. Two studies in mice investigate how these mutations may affect innate immunity to microbes in the intestine and progression of disease.

    • Brian Kelsall



  • Supplement |


    Vaccines are our best protection against infectious disease and offer hope as immunotherapeutic approaches for the treatment of allergy, autoimmunity, cancer and other diseases.