Latest Research

  • Letter |

    Cases linked to superspreading events are estimated to account for 80% of all local transmission of SARS-CoV-2 in Hong Kong in a study with implications for public health policies.

    • Dillon C. Adam
    • , Peng Wu
    • , Jessica Y. Wong
    • , Eric H. Y. Lau
    • , Tim K. Tsang
    • , Simon Cauchemez
    • , Gabriel M. Leung
    •  & Benjamin J. Cowling
  • Letter |

    Convalescent plasma for treatment of hospitalized patients with COVID-19 is associated with improved survival in a retrospective comparison with matched controls, supporting further study in randomized controlled trials.

    • Sean T. H. Liu
    • , Hung-Mo Lin
    • , Ian Baine
    • , Ania Wajnberg
    • , Jeffrey P. Gumprecht
    • , Farah Rahman
    • , Denise Rodriguez
    • , Pranai Tandon
    • , Adel Bassily-Marcus
    • , Jeffrey Bander
    • , Charles Sanky
    • , Amy Dupper
    • , Allen Zheng
    • , Freddy T. Nguyen
    • , Fatima Amanat
    • , Daniel Stadlbauer
    • , Deena R. Altman
    • , Benjamin K. Chen
    • , Florian Krammer
    • , Damodara Rao Mendu
    • , Adolfo Firpo-Betancourt
    • , Matthew A. Levin
    • , Emilia Bagiella
    • , Arturo Casadevall
    • , Carlos Cordon-Cardo
    • , Jeffrey S. Jhang
    • , Suzanne A. Arinsburg
    • , David L. Reich
    • , Judith A. Aberg
    •  & Nicole M. Bouvier
  • Article |

    Single-cell transcriptomics analysis of endometrium samples from healthy women collected across the menstrual cycle provides insights into the cellular and molecular changes surrounding and during the implantation window in the absence of pregnancy.

    • Wanxin Wang
    • , Felipe Vilella
    • , Pilar Alama
    • , Inmaculada Moreno
    • , Marco Mignardi
    • , Alina Isakova
    • , Wenying Pan
    • , Carlos Simon
    •  & Stephen R. Quake
  • Brief Communication |

    The durability of immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unknown. Lessons from seasonal coronavirus infections in humans show that reinfections can occur within 12 months of initial infection, coupled with changes in levels of virus-specific antibodies.

    • Arthur W. D. Edridge
    • , Joanna Kaczorowska
    • , Alexis C. R. Hoste
    • , Margreet Bakker
    • , Michelle Klein
    • , Katherine Loens
    • , Maarten F. Jebbink
    • , Amy Matser
    • , Cormac M. Kinsella
    • , Paloma Rueda
    • , Margareta Ieven
    • , Herman Goossens
    • , Maria Prins
    • , Patricia Sastre
    • , Martin Deijs
    •  & Lia van der Hoek
  • Letter |

    A GMP-compliant process for generating human iPSC-derived mesenchymal stromal cells tested in a phase 1 trial is safe and well tolerated in subjects with acute steroid-resistant graft versus host disease.

    • Adrian J. C. Bloor
    • , Amit Patel
    • , James E. Griffin
    • , Maria H. Gilleece
    • , Rohini Radia
    • , David T. Yeung
    • , Diana Drier
    • , Laurie S. Larson
    • , Gene I. Uenishi
    • , Derek Hei
    • , Kilian Kelly
    • , Igor Slukvin
    •  & John E. J. Rasko
  • Author Correction |

    • Adam G. Laing
    • , Anna Lorenc
    • , Irene del Molino del Barrio
    • , Abhishek Das
    • , Matthew Fish
    • , Leticia Monin
    • , Miguel Muñoz-Ruiz
    • , Duncan R. McKenzie
    • , Thomas S. Hayday
    • , Isaac Francos-Quijorna
    • , Shraddha Kamdar
    • , Magdalene Joseph
    • , Daniel Davies
    • , Richard Davis
    • , Aislinn Jennings
    • , Iva Zlatareva
    • , Pierre Vantourout
    • , Yin Wu
    • , Vasiliki Sofra
    • , Florencia Cano
    • , Maria Greco
    • , Efstathios Theodoridis
    • , Joshua Freedman
    • , Sarah Gee
    • , Julie Nuo En Chan
    • , Sarah Ryan
    • , Eva Bugallo-Blanco
    • , Pärt Peterson
    • , Kai Kisand
    • , Liis Haljasmägi
    • , Loubna Chadli
    • , Philippe Moingeon
    • , Lauren Martinez
    • , Blair Merrick
    • , Karen Bisnauthsing
    • , Kate Brooks
    • , Mohammad A. A. Ibrahim
    • , Jeremy Mason
    • , Federico Lopez Gomez
    • , Kola Babalola
    • , Sultan Abdul-Jawad
    • , John Cason
    • , Christine Mant
    • , Jeffrey Seow
    • , Carl Graham
    • , Katie J. Doores
    • , Francesca Di Rosa
    • , Jonathan Edgeworth
    • , Manu Shankar-Hari
    •  & Adrian C. Hayday
  • Consensus Statement
    | Open Access

    The CONSORT-AI and SPIRIT-AI extensions improve the transparency of clinical trial design and trial protocol reporting for artificial intelligence interventions.

    • Samantha Cruz Rivera
    • , Xiaoxuan Liu
    • , An-Wen Chan
    • , Alastair K. Denniston
    • , Melanie J. Calvert
    • , Ara Darzi
    • , Christopher Holmes
    • , Christopher Yau
    • , David Moher
    • , Hutan Ashrafian
    • , Jonathan J. Deeks
    • , Lavinia Ferrante di Ruffano
    • , Livia Faes
    • , Pearse A. Keane
    • , Sebastian J. Vollmer
    • , Aaron Y. Lee
    • , Adrian Jonas
    • , Andre Esteva
    • , Andrew L. Beam
    • , Maria Beatrice Panico
    • , Cecilia S. Lee
    • , Charlotte Haug
    • , Christophe J. Kelly
    • , Christopher Yau
    • , Cynthia Mulrow
    • , Cyrus Espinoza
    • , John Fletcher
    • , David Moher
    • , Dina Paltoo
    • , Elaine Manna
    • , Gary Price
    • , Gary S. Collins
    • , Hugh Harvey
    • , James Matcham
    • , Joao Monteiro
    • , M. Khair ElZarrad
    • , Lavinia Ferrante di Ruffano
    • , Luke Oakden-Rayner
    • , Melissa McCradden
    • , Pearse A. Keane
    • , Richard Savage
    • , Robert Golub
    • , Rupa Sarkar
    •  & Samuel Rowley
  • Consensus Statement
    | Open Access

    The CONSORT-AI and SPIRIT-AI extensions improve the transparency of clinical trial design and trial protocol reporting for artificial intelligence interventions.

    • Xiaoxuan Liu
    • , Samantha Cruz Rivera
    • , David Moher
    • , Melanie J. Calvert
    • , Alastair K. Denniston
    • , An-Wen Chan
    • , Ara Darzi
    • , Christopher Holmes
    • , Christopher Yau
    • , Hutan Ashrafian
    • , Jonathan J. Deeks
    • , Lavinia Ferrante di Ruffano
    • , Livia Faes
    • , Pearse A. Keane
    • , Sebastian J. Vollmer
    • , Aaron Y. Lee
    • , Adrian Jonas
    • , Andre Esteva
    • , Andrew L. Beam
    • , An-Wen Chan
    • , Maria Beatrice Panico
    • , Cecilia S. Lee
    • , Charlotte Haug
    • , Christopher J. Kelly
    • , Christopher Yau
    • , Cynthia Mulrow
    • , Cyrus Espinoza
    • , John Fletcher
    • , Dina Paltoo
    • , Elaine Manna
    • , Gary Price
    • , Gary S. Collins
    • , Hugh Harvey
    • , James Matcham
    • , Joao Monteiro
    • , M. Khair ElZarrad
    • , Lavinia Ferrante di Ruffano
    • , Luke Oakden-Rayner
    • , Melissa McCradden
    • , Pearse A. Keane
    • , Richard Savage
    • , Robert Golub
    • , Rupa Sarkar
    •  & Samuel Rowley
  • Letter |

    The randomized-controlled trial ADVICE4U demonstrates non-inferiority of an automated AI-based decision support system compared with advice from expert physicians for optimal insulin dosing in youths with type 1 diabetes.

    • Revital Nimri
    • , Tadej Battelino
    • , Lori M. Laffel
    • , Robert H. Slover
    • , Desmond Schatz
    • , Stuart A. Weinzimer
    • , Klemen Dovc
    • , Thomas Danne
    • , Moshe Phillip
    • , Moshe Phillip
    • , Revital Nimri
    • , Shlomit Shalitin
    • , Rachel Bello
    • , Michal Nevo-Shenker
    • , Naama Fisch-Shvalb
    • , Galit Shiovitch-Mantzuri
    • , Orit Choresh
    • , Irit Drutz
    • , Yehiel Nava
    • , Alona Hemo
    • , Orna Hermon
    • , Rachel Nave
    • , Tadej Battelino
    • , Klemen Dovc
    • , Natasa Bratina
    • , Darja Smigoe-Schweiger
    • , Brigita Mali
    • , Ana Gianini
    • , Urska Sever
    • , Barbara Murn Berkopec
    • , Lori M. Laffel
    • , Michelle Katz
    • , Elvira Isganaitis
    • , Sanjeev Mehta
    • , Heidi Quinn
    • , Nisha Naik
    • , Zijing Guo
    • , Lisa Volkening
    • , Robert H. Slover
    • , Gregory Forlenza
    • , R. Paul Wadwa
    • , G. Todd Alonso
    • , Laurel Messer
    • , Lindsey Towers
    • , Katie Thivener
    • , Cari Berget
    • , Samantha Lange
    • , Emily Jost
    • , Maria Rossick-Solis
    • , Desmond Schatz
    • , Michael Haller
    • , Paul Hiers
    • , Laura Jacobsen
    • , Madison Smith
    • , Anastasia O’Neill
    • , Jennifer Hosford
    • , Alexis Perry
    • , Stuart A. Weinzimer
    • , Eda Cengiz
    • , Jennifer Sherr
    • , Kathryn Gibbons
    • , Lori Carria
    • , Melinda Zgorski
    • , Thomas Danne
    • , Torben Biester
    • , Olga Kordonouri
    • , Thekla von dem Berge
    • , Sarah Biester
    •  & Kerstin Remus
  • Author Correction |

    • Pier Vitale Nuzzo
    • , Jacob E. Berchuck
    • , Keegan Korthauer
    • , Sandor Spisak
    • , Amin H. Nassar
    • , Sarah Abou Alaiwi
    • , Ankur Chakravarthy
    • , Shu Yi Shen
    • , Ziad Bakouny
    • , Francesco Boccardo
    • , John Steinharter
    • , Gabrielle Bouchard
    • , Catherine R. Curran
    • , Wenting Pan
    • , Sylvan C. Baca
    • , Ji-Heui Seo
    • , Gwo-Shu Mary Lee
    • , M. Dror Michaelson
    • , Steven L. Chang
    • , Sushrut S. Waikar
    • , Guru Sonpavde
    • , Rafael A. Irizarry
    • , Mark Pomerantz
    • , Daniel D. De Carvalho
    • , Toni K. Choueiri
    •  & Matthew L. Freedman
  • Letter |

    In a first step toward developing autologous tissue grafts for the treatment of children with intestinal failure, patient-derived jejunal organoids seeded on scaffolds of decellularized human intestinal matrix formed grafts that had jejunal properties and formed luminal structures when transplanted into mice.

    • Laween Meran
    • , Isobel Massie
    • , Sara Campinoti
    • , Anne E. Weston
    • , Riana Gaifulina
    • , Lucinda Tullie
    • , Peter Faull
    • , Michael Orford
    • , Anna Kucharska
    • , Anna Baulies
    • , Laura Novellasdemunt
    • , Nikolaos Angelis
    • , Elizabeth Hirst
    • , Julia König
    • , Alfonso Maria Tedeschi
    • , Alessandro Filippo Pellegata
    • , Susanna Eli
    • , Ambrosius P. Snijders
    • , Lucy Collinson
    • , Nikhil Thapar
    • , Geraint M. H. Thomas
    • , Simon Eaton
    • , Paola Bonfanti
    • , Paolo De Coppi
    •  & Vivian S. W. Li
  • Perspective |

    A strategy for assessing the effectiveness of different strategies for HIV cure is presented.

    • Mohamed Abdel-Mohsen
    • , Douglas Richman
    • , Robert F. Siliciano
    • , Michel C. Nussenzweig
    • , Bonnie J. Howell
    • , Javier Martinez-Picado
    • , Nicolas Chomont
    • , Katharine J. Bar
    • , Xu G. Yu
    • , Mathias Lichterfeld
    • , Jose Alcami
    • , Daria Hazuda
    • , Frederic Bushman
    • , Janet D. Siliciano
    • , Michael R. Betts
    • , Adam M. Spivak
    • , Vicente Planelles
    • , Beatrice H. Hahn
    • , Davey M. Smith
    • , Ya-Chi Ho
    • , Maria J. Buzon
    • , Christian Gaebler
    • , Mirko Paiardini
    • , Qingsheng Li
    • , Jacob D. Estes
    • , Thomas J. Hope
    • , Jay Kostman
    • , Karam Mounzer
    • , Marina Caskey
    • , Lawrence Fox
    • , Ian Frank
    • , James L. Riley
    • , Pablo Tebas
    • , Luis J. Montaner
    • , Mohamed Abdel-Mohsen
    • , Douglas Richman
    • , Robert F. Siliciano
    • , Michel C. Nussenzweig
    • , Bonnie J. Howell
    • , Javier Martinez-Picado
    • , Nicolas Chomont
    • , Katharine J. Bar
    • , Xu G. Yu
    • , Mathias Lichterfeld
    • , Jose Alcami
    • , Daria Hazuda
    • , Frederic Bushman
    • , Janet D. Siliciano
    • , Michael R. Betts
    • , Adam M. Spivak
    • , Vicente Planelles
    • , Beatrice H. Hahn
    • , Davey M. Smith
    • , Ya-Chi Ho
    • , Maria J. Buzon
    • , Christian Gaebler
    • , Mirko Paiardini
    • , Qingsheng Li
    • , Jacob D. Estes
    • , Thomas J. Hope
    • , Jay Kostman
    • , Karam Mounzer
    • , Marina Caskey
    • , Lawrence Fox
    • , Ian Frank
    • , James L. Riley
    • , Pablo Tebas
    •  & Luis J. Montaner
  • Letter |

    Polygenic risk scores can predict susceptibility to drug-induced liver injury in patients and can stratify cellular viability of iPSC-derived liver organoids and primary hepatocytes from multiple donors.

    • Masaru Koido
    • , Eri Kawakami
    • , Junko Fukumura
    • , Yui Noguchi
    • , Momoko Ohori
    • , Yasunori Nio
    • , Paola Nicoletti
    • , Guruprasad P. Aithal
    • , Ann K. Daly
    • , Paul B. Watkins
    • , Hisashi Anayama
    • , Yvonne Dragan
    • , Tadahiro Shinozawa
    •  & Takanori Takebe
  • Letter |

    Longitudinal molecular profiling of copy number alterations in patients with Barrett’s esophagus can identify patients at higher risk of developing esophageal cancer.

    • Sarah Killcoyne
    • , Eleanor Gregson
    • , David C. Wedge
    • , Dan J. Woodcock
    • , Matthew D. Eldridge
    • , Rachel de la Rue
    • , Ahmad Miremadi
    • , Sujath Abbas
    • , Adrienn Blasko
    • , Cassandra Kosmidou
    • , Wladyslaw Januszewicz
    • , Aikaterini Varanou Jenkins
    • , Moritz Gerstung
    •  & Rebecca C. Fitzgerald
  • Article |

    Biomarker analysis of the phase 3 JAVELIN Renal 101 trial uncovers molecular determinants of therapy-specific outcomes, which may inform personalized treatment strategies for patients with advanced renal cell carcinoma.

    • Robert J. Motzer
    • , Paul B. Robbins
    • , Thomas Powles
    • , Laurence Albiges
    • , John B. Haanen
    • , James Larkin
    • , Xinmeng Jasmine Mu
    • , Keith A. Ching
    • , Motohide Uemura
    • , Sumanta K. Pal
    • , Boris Alekseev
    • , Gwenaelle Gravis
    • , Matthew T. Campbell
    • , Konstantin Penkov
    • , Jae Lyun Lee
    • , Subramanian Hariharan
    • , Xiao Wang
    • , Weidong Zhang
    • , Jing Wang
    • , Aleksander Chudnovsky
    • , Alessandra di Pietro
    • , Amber C. Donahue
    •  & Toni K. Choueiri
  • Letter
    | Open Access

    A single immunization with an adenovirus vector-based vaccine expressing a stabilized SARS-CoV-2 spike protein induces protection against SARS-CoV-2-induced weight loss, pneumonia and mortality in hamsters.

    • Lisa H. Tostanoski
    • , Frank Wegmann
    • , Amanda J. Martinot
    • , Carolin Loos
    • , Katherine McMahan
    • , Noe B. Mercado
    • , Jingyou Yu
    • , Chi N. Chan
    • , Stephen Bondoc
    • , Carly E. Starke
    • , Michael Nekorchuk
    • , Kathleen Busman-Sahay
    • , Cesar Piedra-Mora
    • , Linda M. Wrijil
    • , Sarah Ducat
    • , Jerome Custers
    • , Caroline Atyeo
    • , Stephanie Fischinger
    • , John S. Burke
    • , Jared Feldman
    • , Blake M. Hauser
    • , Timothy M. Caradonna
    • , Esther A. Bondzie
    • , Gabriel Dagotto
    • , Makda S. Gebre
    • , Catherine Jacob-Dolan
    • , Zijin Lin
    • , Shant H. Mahrokhian
    • , Felix Nampanya
    • , Ramya Nityanandam
    • , Laurent Pessaint
    • , Maciel Porto
    • , Vaneesha Ali
    • , Dalia Benetiene
    • , Komlan Tevi
    • , Hanne Andersen
    • , Mark G. Lewis
    • , Aaron G. Schmidt
    • , Douglas A. Lauffenburger
    • , Galit Alter
    • , Jacob D. Estes
    • , Hanneke Schuitemaker
    • , Roland Zahn
    •  & Dan H. Barouch
  • Article |

    Chimeric antigen receptor T cells targeting HIV-infected cells prevent T cell loss and reduce virus in blood and tissues of HIV-infected humanized mice, highlighting a path toward a cell-based therapy for HIV infection.

    • Colby R. Maldini
    • , Daniel T. Claiborne
    • , Ken Okawa
    • , Tao Chen
    • , Derrick L. Dopkin
    • , Xiaochuan Shan
    • , Karen A. Power
    • , Radiana T. Trifonova
    • , Katharine Krupp
    • , Meredith Phelps
    • , Vladimir D. Vrbanac
    • , Serah Tanno
    • , Timothy Bateson
    • , George J. Leslie
    • , James A. Hoxie
    • , Christian L. Boutwell
    • , James L. Riley
    •  & Todd M. Allen
  • Article |

    Using magnetic resonance images of the heart and aorta from 26,893 individuals in the UK Biobank, a phenome-wide association study associates cardiovascular imaging phenotypes with a wide range of demographic, lifestyle and clinical features.

    • Wenjia Bai
    • , Hideaki Suzuki
    • , Jian Huang
    • , Catherine Francis
    • , Shuo Wang
    • , Giacomo Tarroni
    • , Florian Guitton
    • , Nay Aung
    • , Kenneth Fung
    • , Steffen E. Petersen
    • , Stefan K. Piechnik
    • , Stefan Neubauer
    • , Evangelos Evangelou
    • , Abbas Dehghan
    • , Declan P. O’Regan
    • , Martin R. Wilkins
    • , Yike Guo
    • , Paul M. Matthews
    •  & Daniel Rueckert
  • Article |

    Elevated levels of serum IL-6 and TNF-α at the time of hospitalization are independent and significant predictors of clinical outcome in two cohorts of patients with COVID-19.

    • Diane Marie Del Valle
    • , Seunghee Kim-Schulze
    • , Hsin-Hui Huang
    • , Noam D. Beckmann
    • , Sharon Nirenberg
    • , Bo Wang
    • , Yonit Lavin
    • , Talia H. Swartz
    • , Deepu Madduri
    • , Aryeh Stock
    • , Thomas U. Marron
    • , Hui Xie
    • , Manishkumar Patel
    • , Kevin Tuballes
    • , Oliver Van Oekelen
    • , Adeeb Rahman
    • , Patricia Kovatch
    • , Judith A. Aberg
    • , Eric Schadt
    • , Sundar Jagannath
    • , Madhu Mazumdar
    • , Alexander W. Charney
    • , Adolfo Firpo-Betancourt
    • , Damodara Rao Mendu
    • , Jeffrey Jhang
    • , David Reich
    • , Keith Sigel
    • , Carlos Cordon-Cardo
    • , Marc Feldmann
    • , Samir Parekh
    • , Miriam Merad
    •  & Sacha Gnjatic
  • Author Correction |

    • Alexander W. Charney
    • , Nicole W. Simons
    • , Konstantinos Mouskas
    • , Lauren Lepow
    • , Esther Cheng
    • , Jessica Le Berichel
    • , Christie Chang
    • , Robert Marvin
    • , Diane Marie Del Valle
    • , Sharlene Calorossi
    • , Alona Lansky
    • , Laura Walker
    • , Manishkumar Patel
    • , Hui Xie
    • , Nancy Yi
    • , Alex Yu
    • , Gurpawan Kang
    • , Lora E. Liharska
    • , Emily Moya
    • , Matthew Hartnett
    • , Sandra Hatem
    • , Lillian Wilkins
    • , Melody Eaton
    • , Hajra Jamal
    • , Kevin Tuballes
    • , Steven T. Chen
    • , Jonathan Chung
    • , Jocelyn Harris
    • , Craig Batchelor
    • , Jose Lacunza
    • , Mahlet Yishak
    • , Kimberly Argueta
    • , Neha Karekar
    • , Brian Lee
    • , Geoffrey Kelly
    • , Daniel Geanon
    • , Diana Handler
    • , John Leech
    • , Hiyab Stefanos
    • , Travis Dawson
    • , Ieisha Scott
    • , Nancy Francoeur
    • , Jessica S. Johnson
    • , Akhil Vaid
    • , Benjamin S. Glicksberg
    • , Girish N. Nadkarni
    • , Eric E. Schadt
    • , Bruce D. Gelb
    • , Adeeb Rahman
    • , Robert Sebra
    • , Glenn Martin
    • , Charuta Agashe
    • , Priyal Agrawal
    • , Kasey Alesso-Carra
    • , Eziwoma Alibo
    • , Kelvin Alvarez
    • , Angelo Amabile
    • , Steven Ascolillo
    • , Rasheed Bailey
    • , Priya Begani
    • , Paloma Bravo Correra
    • , Stacey-Ann Brown
    • , Mark Buckup
    • , Larissa Burka
    • , Lena Cambron
    • , Gina Carrara
    • , Serena Chang
    • , Jonathan Chien
    • , Mashkura Chowdhury
    • , Cansu Cimen Bozkus
    • , Phillip Comella
    • , Dana Cosgrove
    • , Francesca Cossarini
    • , Liam Cotter
    • , Arpit Dave
    • , Bheesham Dayal
    • , Maxime Dhainaut
    • , Rebecca Dornfeld
    • , Katie Dul
    • , Nissan Eber
    • , Cordelia Elaiho
    • , Frank Fabris
    • , Jeremiah Faith
    • , Dominique Falci
    • , Susie Feng
    • , Brian Fennessy
    • , Marie Fernandes
    • , Sandeep Gangadharan
    • , Joanna Grabowska
    • , Gavin Gyimesi
    • , Maha Hamdani
    • , Manon Herbinet
    • , Elva Herrera
    • , Arielle Hochman
    • , Gabriel E. Hoffman
    • , Jaime Hook
    • , Laila Horta
    • , Etienne Humblin
    • , Subha Karim
    • , Jessica Kim
    • , Dannielle Lebovitch
    • , Grace Lee
    • , Gyu Ho Lee
    • , Jacky Lee
    • , Mike Leventhal
    • , Katherine Lindblad
    • , Alexandra Livanos
    • , Rosalie Machado
    • , Zafar Mahmood
    • , Kelcey Mar
    • , Shrisha Maskey
    • , Paul Matthews
    • , Katherine Meckel
    • , Saurabh Mehandru
    • , Cynthia Mercedes
    • , Dara Meyer
    • , Gurkan Mollaoglu
    • , Sarah Morris
    • , Kai Nie
    • , Marjorie Nisenholtz
    • , George Ofori-Amanfo
    • , Kenan Onel
    • , Merouane Ounadjela
    • , Vishwendra Patel
    • , Cassandra Pruitt
    • , Shivani Rathi
    • , Jamie Redes
    • , Ivan Reyes-Torres
    • , Alcina Rodrigues
    • , Alfonso Rodriguez
    • , Vladimir Roudko
    • , Evelyn Ruiz
    • , Pearl Scalzo
    • , Pedro Silva
    • , Alessandra Soares Schanoski
    • , Meghan Straw
    • , Sasha Tabachnikova
    • , Collin Teague
    • , Bhaskar Upadhyaya
    • , Verena Van Der Heide
    • , Natalie Vaninov
    • , Daniel Wacker
    • , Hadley Walsh
    • , C. Matthias Wilk
    • , Jessica Wilson
    • , Karen M. Wilson
    • , Li Xue
    • , Naa-akomaah Yeboah
    • , Sabina Young
    • , Nina Zaks
    • , Renyuan Zha
    • , Thomas Marron
    • , Noam Beckmann
    • , Seunghee Kim-Schulze
    • , Sacha Gnjatic
    •  & Miriam Merad
  • Letter |

    Characterization of a cohort of children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection provides insights into the immunopathogenic features of the disease.

    • Michael J. Carter
    • , Matthew Fish
    • , Aislinn Jennings
    • , Katie J. Doores
    • , Paul Wellman
    • , Jeffrey Seow
    • , Sam Acors
    • , Carl Graham
    • , Emma Timms
    • , Julia Kenny
    • , Stuart Neil
    • , Michael H. Malim
    • , Shane M. Tibby
    •  & Manu Shankar-Hari
  • Article |

    A common immune signature in the blood of patients with COVID-19, who are otherwise clinically heterogeneous, sheds light into the pathogenesis and clinical progression of the disease.

    • Adam G. Laing
    • , Anna Lorenc
    • , Irene del Molino del Barrio
    • , Abhishek Das
    • , Matthew Fish
    • , Leticia Monin
    • , Miguel Muñoz-Ruiz
    • , Duncan R. McKenzie
    • , Thomas S. Hayday
    • , Isaac Francos-Quijorna
    • , Shraddha Kamdar
    • , Magdalene Joseph
    • , Daniel Davies
    • , Richard Davis
    • , Aislinn Jennings
    • , Iva Zlatareva
    • , Pierre Vantourout
    • , Yin Wu
    • , Vasiliki Sofra
    • , Florencia Cano
    • , Maria Greco
    • , Efstathios Theodoridis
    • , Joshua Freedman
    • , Sarah Gee
    • , Julie Nuo En Chan
    • , Sarah Ryan
    • , Eva Bugallo-Blanco
    • , Pärt Peterson
    • , Kai Kisand
    • , Liis Haljasmägi
    • , Loubna Chadli
    • , Philippe Moingeon
    • , Lauren Martinez
    • , Blair Merrick
    • , Karen Bisnauthsing
    • , Kate Brooks
    • , Mohammad A. A. Ibrahim
    • , Jeremy Mason
    • , Federico Lopez Gomez
    • , Kola Babalola
    • , Sultan Abdul-Jawad
    • , John Cason
    • , Christine Mant
    • , Jeffrey Seow
    • , Carl Graham
    • , Katie J. Doores
    • , Francesca Di Rosa
    • , Jonathan Edgeworth
    • , Manu Shankar-Hari
    •  & Adrian C. Hayday
  • Letter |

    Analysis of UK Biobank participants with wearable physical activity monitors demonstrates that high-volume physical activity and high-intensity activity are associated with reduced mortality.

    • Tessa Strain
    • , Katrien Wijndaele
    • , Paddy C. Dempsey
    • , Stephen J. Sharp
    • , Matthew Pearce
    • , Justin Jeon
    • , Tim Lindsay
    • , Nick Wareham
    •  & Søren Brage
  • Letter |

    A deep neural network applied to smartphone-based vascular imaging can detect diabetes, opening new possibilities for non-invasive diagnosis.

    • Robert Avram
    • , Jeffrey E. Olgin
    • , Peter Kuhar
    • , J. Weston Hughes
    • , Gregory M. Marcus
    • , Mark J. Pletcher
    • , Kirstin Aschbacher
    •  & Geoffrey H. Tison
  • Letter |

    Endogenous skeletal stem cells are recruited to form cartilage in mice when stimulated by microfracture surgery together with localized delivery of growth factors, pointing to a new approach for treating cartilage defects.

    • Matthew P. Murphy
    • , Lauren S. Koepke
    • , Michael T. Lopez
    • , Xinming Tong
    • , Thomas H. Ambrosi
    • , Gunsagar S. Gulati
    • , Owen Marecic
    • , Yuting Wang
    • , Ryan C. Ransom
    • , Malachia Y. Hoover
    • , Holly Steininger
    • , Liming Zhao
    • , Marcin P. Walkiewicz
    • , Natalina Quarto
    • , Benjamin Levi
    • , Derrick C. Wan
    • , Irving L. Weissman
    • , Stuart B. Goodman
    • , Fan Yang
    • , Michael T. Longaker
    •  & Charles K. F. Chan
  • Letter |

    In a cohort of nearly half a million births in Ontario, Canada, maternal cannabis use in pregnancy was associated with an increased incidence of autism spectrum disorder diagnosis in the offspring.

    • Daniel J. Corsi
    • , Jessy Donelle
    • , Ewa Sucha
    • , Steven Hawken
    • , Helen Hsu
    • , Darine El-Chaâr
    • , Lise Bisnaire
    • , Deshayne Fell
    • , Shi Wu Wen
    •  & Mark Walker
  • Brief Communication |

    Integration of large datasets of familial whole-exome sequencing, neurodevelopmental gene expression, electronic health records and healthcare claims led to the identification of a subtype of autism spectrum disorder that is associated with lipid dysregulation.

    • Yuan Luo
    • , Alal Eran
    • , Nathan Palmer
    • , Paul Avillach
    • , Ami Levy-Moonshine
    • , Peter Szolovits
    •  & Isaac S. Kohane
  • Letter |

    Whole-exome sequencing is not sensitive or specific enough to replace the gold standard of tandem mass spectrometry screening of rare inborn errors of metabolism, but can help to reduce false positives and facilitate the timely resolution of ambiguous cases.

    • Aashish N. Adhikari
    • , Renata C. Gallagher
    • , Yaqiong Wang
    • , Robert J. Currier
    • , George Amatuni
    • , Laia Bassaganyas
    • , Flavia Chen
    • , Kunal Kundu
    • , Mark Kvale
    • , Sean D. Mooney
    • , Robert L. Nussbaum
    • , Savanna S. Randi
    • , Jeremy Sanford
    • , Joseph T. Shieh
    • , Rajgopal Srinivasan
    • , Uma Sunderam
    • , Hao Tang
    • , Dedeepya Vaka
    • , Yangyun Zou
    • , Barbara A. Koenig
    • , Pui-Yan Kwok
    • , Neil Risch
    • , Jennifer M. Puck
    •  & Steven E. Brenner
  • Article |

    In a phase II clinical trial of patients with classical Hodgkin lymphoma, peripheral CD4+ T cell receptor diversity and the abundance of mature natural killer cells and CD3CD68+CD4+GrB+ innate cells were associated with favorable responses to anti-PD-1 monotherapy.

    • Fathima Zumla Cader
    • , Xihao Hu
    • , Walter L. Goh
    • , Kirsty Wienand
    • , Jing Ouyang
    • , Elisa Mandato
    • , Robert Redd
    • , Lee N. Lawton
    • , Pei-Hsuan Chen
    • , Jason L. Weirather
    • , Ron C. J. Schackmann
    • , Bo Li
    • , Wenjiang Ma
    • , Philippe Armand
    • , Scott J. Rodig
    • , Donna Neuberg
    • , X. Shirley Liu
    •  & Margaret A. Shipp
  • Review Article |

    The COVID-19 pandemic has resulted in an accelerated development of applications for digital health, including symptom monitoring and contact tracing. Their potential is wide ranging and must be integrated into conventional approaches to public health for best effect.

    • Jobie Budd
    • , Benjamin S. Miller
    • , Erin M. Manning
    • , Vasileios Lampos
    • , Mengdie Zhuang
    • , Michael Edelstein
    • , Geraint Rees
    • , Vincent C. Emery
    • , Molly M. Stevens
    • , Neil Keegan
    • , Michael J. Short
    • , Deenan Pillay
    • , Ed Manley
    • , Ingemar J. Cox
    • , David Heymann
    • , Anne M. Johnson
    •  & Rachel A. McKendry
  • Letter |

    Transmission dynamics models of COVID-19 and malaria reveal how different scenarios of COVID-19 spread and varying levels of interruption to antimalarial programs could result in increased deaths in sub-Saharan Africa.

    • Ellie Sherrard-Smith
    • , Alexandra B. Hogan
    • , Arran Hamlet
    • , Oliver J. Watson
    • , Charlie Whittaker
    • , Peter Winskill
    • , Fatima Ali
    • , Audu B. Mohammad
    • , Perpetua Uhomoibhi
    • , Ibrahim Maikore
    • , Nnenna Ogbulafor
    • , Jamilu Nikau
    • , Mara D. Kont
    • , Joseph D. Challenger
    • , Robert Verity
    • , Ben Lambert
    • , Matthew Cairns
    • , Bhargavi Rao
    • , Marc Baguelin
    • , Lilith K. Whittles
    • , John A. Lees
    • , Sangeeta Bhatia
    • , Edward S. Knock
    • , Lucy Okell
    • , Hannah C. Slater
    • , Azra C. Ghani
    • , Patrick G. T. Walker
    • , Okefu Oyale Okoko
    •  & Thomas S. Churcher
  • Letter |

    In a study of children with high genetic risk aged 2 years or older, a risk score integrating pancreatic islet autoantibodies, genetic factors and family history is highly predictive of type 1 diabetes in the subsequent 8 years.

    • Lauric A. Ferrat
    • , Kendra Vehik
    • , Seth A. Sharp
    • , Åke Lernmark
    • , Marian J. Rewers
    • , Jin-Xiong She
    • , Anette-G. Ziegler
    • , Jorma Toppari
    • , Beena Akolkar
    • , Jeffrey P. Krischer
    • , Michael N. Weedon
    • , Richard A. Oram
    • , William A. Hagopian
    • , Aaron Barbour
    • , Kimberly Bautista
    • , Judith Baxter
    • , Daniel Felipe-Morales
    • , Kimberly Driscoll
    • , Brigitte I. Frohnert
    • , Marisa Stahl
    • , Patricia Gesualdo
    • , Michelle Hoffman
    • , Rachel Karban
    • , Edwin Liu
    • , Jill Norris
    • , Stesha Peacock
    • , Hanan Shorrosh
    • , Andrea Steck
    • , Megan Stern
    • , Erica Villegas
    • , Kathleen Waugh
    • , Olli G. Simell
    • , Annika Adamsson
    • , Suvi Ahonen
    • , Mari Åkerlund
    • , Leena Hakola
    • , Anne Hekkala
    • , Henna Holappa
    • , Heikki Hyöty
    • , Anni Ikonen
    • , Jorma Ilonen
    • , Sinikka Jäminki
    • , Sanna Jokipuu
    • , Leena Karlsson
    • , Jukka Kero
    • , Miia Kähönen
    • , Mikael Knip
    • , Minna-Liisa Koivikko
    • , Merja Koskinen
    • , Mirva Koreasalo
    • , Kalle Kurppa
    • , Jarita Kytölä
    • , Tiina Latva-aho
    • , Katri Lindfors
    • , Maria Lönnrot
    • , Elina Mäntymäki
    • , Markus Mattila
    • , Maija Miettinen
    • , Katja Multasuo
    • , Teija Mykkänen
    • , Tiina Niininen
    • , Sari Niinistö
    • , Mia Nyblom
    • , Sami Oikarinen
    • , Paula Ollikainen
    • , Zhian Othmani
    • , Sirpa Pohjola
    • , Petra Rajala
    • , Jenna Rautanen
    • , Anne Riikonen
    • , Eija Riski
    • , Miia Pekkola
    • , Minna Romo
    • , Satu Ruohonen
    • , Satu Simell
    • , Maija Sjöberg
    • , Aino Stenius
    • , Päivi Tossavainen
    • , Mari Vähä-Mäkilä
    • , Sini Vainionpää
    • , Eeva Varjonen
    • , Riitta Veijola
    • , Irene Viinikangas
    • , Suvi M. Virtanen
    • , Desmond Schatz
    • , Diane Hopkins
    • , Leigh Steed
    • , Jennifer Bryant
    • , Katherine Silvis
    • , Michael Haller
    • , Melissa Gardiner
    • , Richard McIndoe
    • , Ashok Sharma
    • , Stephen W. Anderson
    • , Laura Jacobsen
    • , John Marks
    • , P. D. Towe
    • , Ezio Bonifacio
    • , Cigdem Gezginci
    • , Anja Heublein
    • , Eva Hohoff
    • , Sandra Hummel
    • , Annette Knopff
    • , Charlotte Koch
    • , Sibylle Koletzko
    • , Claudia Ramminger
    • , Roswith Roth
    • , Jennifer Schmidt
    • , Marlon Scholz
    • , Joanna Stock
    • , Katharina Warncke
    • , Lorena Wendel
    • , Christiane Winkler
    • , Daniel Agardh
    • , Carin Andrén Aronsson
    • , Maria Ask
    • , Rasmus Bennet
    • , Corrado Cilio
    • , Susanne Dahlberg
    • , Helene Engqvist
    • , Emelie Ericson-Hallström
    • , Annika Björne Fors
    • , Lina Fransson
    • , Thomas Gard
    • , Monika Hansen
    • , Hanna Jisser
    • , Fredrik Johansen
    • , Berglind Jonsdottir
    • , Helena Elding Larsson
    • , Marielle Lindström
    • , Markus Lundgren
    • , Marlena Maziarz
    • , Maria Månsson-Martinez
    • , Jessica Melin
    • , Zeliha Mestan
    • , Caroline Nilsson
    • , Karin Ottosson
    • , Kobra Rahmati
    • , Anita Ramelius
    • , Falastin Salami
    • , Anette Sjöberg
    • , Birgitta Sjöberg
    • , Carina Törn
    • , Åsa Wimar
    • , Michael Killian
    • , Claire Cowen Crouch
    • , Jennifer Skidmore
    • , Masumeh Chavoshi
    • , Arlene Meyer
    • , Jocelyn Meyer
    • , Denise Mulenga
    • , Nole Powell
    • , Jared Radtke
    • , Matei Romancik
    • , Shreya Roy
    • , Davey Schmitt
    • , Sarah Zink
    • , Dorothy Becker
    • , Margaret Franciscus
    • , MaryEllen Dalmagro-Elias Smith
    • , Ashi Daftary
    • , Mary Beth Klein
    • , Chrystal Yates
    • , Sarah Austin-Gonzalez
    • , Maryouri Avendano
    • , Sandra Baethke
    • , Brant Burkhardt
    • , Martha Butterworth
    • , Joanna Clasen
    • , David Cuthbertson
    • , Christopher Eberhard
    • , Steven Fiske
    • , Jennifer Garmeson
    • , Veena Gowda
    • , Kathleen Heyman
    • , Belinda Hsiao
    • , Christina Karges
    • , Francisco Perez Laras
    • , Qian Li
    • , Shu Liu
    • , Xiang Liu
    • , Kristian Lynch
    • , Colleen Maguire
    • , Jamie Malloy
    • , Cristina McCarthy
    • , Hemang Parikh
    • , Cassandra Remedios
    • , Chris Shaffer
    • , Laura Smith
    • , Susan Smith
    • , Noah Sulman
    • , Roy Tamura
    • , Dena Tewey
    • , Michael Toth
    • , Ulla Uusitalo
    • , Ponni Vijayakandipan
    • , Keith Wood
    • , Jimin Yang
    • , Liping Yu
    • , Dongmei Miao
    • , Polly Bingley
    • , Alistair Williams
    • , Kyla Chandler
    • , Ilana Kelland
    • , Yassin Ben Khoud
    • , Huma Zahid
    • , Matthew Randell
    • , Masumeh Chavoshi
    • , Jared Radtke
    • , Sarah Zink
    • , Sandra Ke
    • , Niveen Mulholland
    • , Stephen S. Rich
    • , Wei-Min Chen
    • , Suna Onengut-Gumuscu
    • , Emily Farber
    • , Rebecca Roche Pickin
    • , Jonathan Davis
    • , Jordan Davis
    • , Dan Gallo
    • , Jessica Bonnie
    • , Paul Campolieto
    • , Joseph F. Petrosino
    • , Nadim J. Ajami
    • , Richard E. Lloyd
    • , Matthew C. Ross
    • , Jacqueline L. O’Brien
    • , Diane S. Hutchinson
    • , Daniel P. Smith
    • , Matthew C. Wong
    • , Xianjun Tian
    • , Tulin Ayvaz
    • , Auriole Tamegnon
    • , Nguyen Truong
    • , Hannah Moreno
    • , Lauren Riley
    • , Eduardo Moreno
    • , Tonya Bauch
    • , Lenka Kusic
    • , Ginger Metcalf
    • , Donna Muzny
    • , Harshavardhan Doddapaneni
    • , Richard Gibbs
    • , Kasia Bourcier
    • , Thomas Briese
    • , Suzanne Bennett Johnson
    • , Eric Triplett
    • , Anette G. Ziegler
    • , Roy Tamura
    • , Jill Norris
    • , Suvi M. Virtanen
    • , Brigitte I. Frohnert
    • , Patricia Gesualdo
    • , Mirva Koreasalo
    • , Maija Miettinen
    • , Sari Niinistö
    • , Anne Riikonen
    • , Katherine Silvis
    • , Eva Hohoff
    • , Sandra Hummel
    • , Christiane Winkler
    • , Carin Andrén Aronsson
    • , Jennifer Skidmore
    • , MaryEllen Dalmagro-Elias Smith
    • , Martha Butterworth
    • , Qian Li
    • , Xiang Liu
    • , Roy Tamura
    • , Ulla Uusitalo
    • , Jimin Yang
    • , Stephen S. Rich
    • , Jill Norris
    • , Andrea Steck
    • , Jorma Ilonen
    • , Anette G. Ziegler
    • , Carina Törn
    • , Qian Li
    • , Xiang Liu
    • , Hemang Parikh
    • , Henry Erlich
    • , Wei-Min Chen
    • , Suna Onengut-Gumuscu
    • , Desmond Schatz
    • , Anette G. Ziegler
    • , Corrado Cilio
    • , Ezio Bonifacio
    • , Mikael Knip
    • , Desmond Schatz
    • , Brant Burkhardt
    • , Kristian Lynch
    • , Liping Yu
    • , Polly Bingley
    • , Kasia Bourcier
    • , Heikki Hyöty
    • , Eric Triplett
    • , Richard Lloyd
    • , Patricia Gesualdo
    • , Kathleen Waugh
    • , Maria Lönnrot
    • , Daniel Agardh
    • , Corrado Cilio
    • , Helena Elding Larsson
    • , Michael Killian
    • , Brant Burkhardt
    • , Kristian Lynch
    • , Thomas Briese
    • , Kathleen Waugh
    • , Desmond Schatz
    • , Michael Killian
    • , Suzanne Bennett Johnson
    • , Roswith Roth
    • , Judith Baxter
    • , Kimberly Driscoll
    • , Desmond Schatz
    • , Joanna Stock
    • , Steven Fiske
    • , Xiang Liu
    • , Kristian Lynch
    • , Laura Smith
    • , Judith Baxter
    • , Åke Lernmark
    • , Judith Baxter
    • , Michael Killian
    • , Kimberly Bautista
    • , Patricia Gesualdo
    • , Michelle Hoffman
    • , Rachel Karban
    • , Jill Norris
    • , Kathleen Waugh
    • , Annika Adamsson
    • , Miia Kähönen
    • , Tiina Niininen
    • , Aino Stenius
    • , Eeva Varjonen
    • , Diane Hopkins
    • , Leigh Steed
    • , Jennifer Bryant
    • , Melissa Gardiner
    • , John Marks
    • , Claudia Ramminger
    • , Joanna Stock
    • , Christiane Winkler
    • , Carin Andrén Aronsson
    • , Berglind Jonsdottir
    • , Jessica Melin
    • , Michael Killian
    • , Claire Cowen Crouch
    • , Denise Mulenga
    • , Cristina McCarthy
    • , Laura Smith
    • , Susan Smith
    • , Roy Tamura
    • , Suzanne Bennett Johnson
    • , Daniel Agardh
    • , Edwin Liu
    • , Sibylle Koletzko
    • , Kalle Kurppa
    • , Marisa Stahl
    • , Michelle Hoffman
    • , Kalle Kurppa
    • , Katri Lindfors
    • , Satu Simell
    • , Leigh Steed
    • , Carin Andrén Aronsson
    • , Michael Killian
    • , Roy Tamura
    • , Michael Haller
    • , Helena Elding Larsson
    • , Brigitte I. Frohnert
    • , Patricia Gesualdo
    • , Michelle Hoffman
    • , Andrea Steck
    • , Miia Kähönen
    • , Riitta Veijola
    • , Leigh Steed
    • , Laura Jacobsen
    • , John Marks
    • , Joanna Stock
    • , Katharina Warncke
    • , Markus Lundgren
    • , Åsa Wimar
    • , Claire Cowen Crouch
    • , Xiang Liu
    •  & Roy Tamura
  • Letter |

    Combining fine-scale social contact data with epidemic modeling reveals interactions among contact tracing, quarantine, testing and physical distancing for controlling COVID-19.

    • Josh A. Firth
    • , Joel Hellewell
    • , Petra Klepac
    • , Stephen Kissler
    • , Mark Jit
    • , Katherine E. Atkins
    • , Samuel Clifford
    • , C. Julian Villabona-Arenas
    • , Sophie R. Meakin
    • , Charlie Diamond
    • , Nikos I. Bosse
    • , James D. Munday
    • , Kiesha Prem
    • , Anna M. Foss
    • , Emily S. Nightingale
    • , Kevin van Zandvoort
    • , Nicholas G. Davies
    • , Hamish P. Gibbs
    • , Graham Medley
    • , Amy Gimma
    • , Stefan Flasche
    • , David Simons
    • , Megan Auzenbergs
    • , Timothy W. Russell
    • , Billy J. Quilty
    • , Eleanor M. Rees
    • , Quentin J. Leclerc
    • , W. John Edmunds
    • , Sebastian Funk
    • , Rein M. G. J. Houben
    • , Gwenan M. Knight
    • , Sam Abbott
    • , Fiona Yueqian Sun
    • , Rachel Lowe
    • , Damien C. Tully
    • , Simon R. Procter
    • , Christopher I. Jarvis
    • , Akira Endo
    • , Kathleen O’Reilly
    • , Jon C. Emery
    • , Thibaut Jombart
    • , Alicia Rosello
    • , Arminder K. Deol
    • , Matthew Quaife
    • , Stéphane Hué
    • , Yang Liu
    • , Rosalind M. Eggo
    • , Carl A. B. Pearson
    • , Adam J. Kucharski
    •  & Lewis G. Spurgin
  • Letter |

    A combination of clinical and molecular analyses supports an association between disorders of immune complement or coagulation with poor outcome in patients with SARS-CoV-2 infection.

    • Vijendra Ramlall
    • , Phyllis M. Thangaraj
    • , Cem Meydan
    • , Jonathan Foox
    • , Daniel Butler
    • , Jacob Kim
    • , Ben May
    • , Jessica K. De Freitas
    • , Benjamin S. Glicksberg
    • , Christopher E. Mason
    • , Nicholas P. Tatonetti
    •  & Sagi D. Shapira
  • Letter
    | Open Access

    Identification in Rwanda of mutations in Plasmodium falciparum capable of conferring in vitro resistance to artemisinin, an essential medicine for the treatment of malaria, underscore the crucial need for surveillance in Africa to safeguard efficacy of life-saving therapies.

    • Aline Uwimana
    • , Eric Legrand
    • , Barbara H. Stokes
    • , Jean-Louis Mangala Ndikumana
    • , Marian Warsame
    • , Noella Umulisa
    • , Daniel Ngamije
    • , Tharcisse Munyaneza
    • , Jean-Baptiste Mazarati
    • , Kaendi Munguti
    • , Pascal Campagne
    • , Alexis Criscuolo
    • , Frédéric Ariey
    • , Monique Murindahabi
    • , Pascal Ringwald
    • , David A. Fidock
    • , Aimable Mbituyumuremyi
    •  & Didier Menard
  • Article |

    Multimodal single-cell profiling reveals heterogeneity of colonic CD8+ T cells in patients with ulcerative colitis, including expansion of a chronically activated IL-26-expressing subpopulation with innate-like features.

    • Daniele Corridoni
    • , Agne Antanaviciute
    • , Tarun Gupta
    • , David Fawkner-Corbett
    • , Anna Aulicino
    • , Marta Jagielowicz
    • , Kaushal Parikh
    • , Emmanouela Repapi
    • , Steve Taylor
    • , Dai Ishikawa
    • , Ryo Hatano
    • , Taketo Yamada
    • , Wei Xin
    • , Hubert Slawinski
    • , Rory Bowden
    • , Giorgio Napolitani
    • , Oliver Brain
    • , Chikao Morimoto
    • , Hashem Koohy
    •  & Alison Simmons
  • Letter |

    Clinical sequencing across a large prospective cohort of patients with myelodysplasic syndrome uncovers distinct associations between the mono- and biallelic states of TP53 and clinical presentation

    • Elsa Bernard
    • , Yasuhito Nannya
    • , Robert P. Hasserjian
    • , Sean M. Devlin
    • , Heinz Tuechler
    • , Juan S. Medina-Martinez
    • , Tetsuichi Yoshizato
    • , Yusuke Shiozawa
    • , Ryunosuke Saiki
    • , Luca Malcovati
    • , Max F. Levine
    • , Juan E. Arango
    • , Yangyu Zhou
    • , Francesc Solé
    • , Catherine A. Cargo
    • , Detlef Haase
    • , Maria Creignou
    • , Ulrich Germing
    • , Yanming Zhang
    • , Gunes Gundem
    • , Araxe Sarian
    • , Arjan A. van de Loosdrecht
    • , Martin Jädersten
    • , Magnus Tobiasson
    • , Olivier Kosmider
    • , Matilde Y. Follo
    • , Felicitas Thol
    • , Ronald F. Pinheiro
    • , Valeria Santini
    • , Ioannis Kotsianidis
    • , Jacqueline Boultwood
    • , Fabio P. S. Santos
    • , Julie Schanz
    • , Senji Kasahara
    • , Takayuki Ishikawa
    • , Hisashi Tsurumi
    • , Akifumi Takaori-Kondo
    • , Toru Kiguchi
    • , Chantana Polprasert
    • , John M. Bennett
    • , Virginia M. Klimek
    • , Michael R. Savona
    • , Monika Belickova
    • , Christina Ganster
    • , Laura Palomo
    • , Guillermo Sanz
    • , Lionel Ades
    • , Matteo Giovanni Della Porta
    • , Alexandra G. Smith
    • , Yesenia Werner
    • , Minal Patel
    • , Agnès Viale
    • , Katelynd Vanness
    • , Donna S. Neuberg
    • , Kristen E. Stevenson
    • , Kamal Menghrajani
    • , Kelly L. Bolton
    • , Pierre Fenaux
    • , Andrea Pellagatti
    • , Uwe Platzbecker
    • , Michael Heuser
    • , Peter Valent
    • , Shigeru Chiba
    • , Yasushi Miyazaki
    • , Carlo Finelli
    • , Maria Teresa Voso
    • , Lee-Yung Shih
    • , Michaela Fontenay
    • , Joop H. Jansen
    • , José Cervera
    • , Yoshiko Atsuta
    • , Norbert Gattermann
    • , Benjamin L. Ebert
    • , Rafael Bejar
    • , Peter L. Greenberg
    • , Mario Cazzola
    • , Eva Hellström-Lindberg
    • , Seishi Ogawa
    •  & Elli Papaemmanuil
  • Letter |

    An antisense oligonucleotide induces exon skipping in cell lines derived from patients with CLN3 Batten disease, and reduces lysosomal impairment and ameliorates neurological phenotypes in a mouse model of the disease.

    • Jessica L. Centa
    • , Francine M. Jodelka
    • , Anthony J. Hinrich
    • , Tyler B. Johnson
    • , Joseph Ochaba
    • , Michaela Jackson
    • , Dominik M. Duelli
    • , Jill M. Weimer
    • , Frank Rigo
    •  & Michelle L. Hastings
  • Letter |

    Screening for a set of autosomal-dominant genetic conditions in a large, unselected cohort of individuals uncovers carriers who were missed by routine medical care, demonstrating the utility of broad genetic screening.

    • J. J. Grzymski
    • , G. Elhanan
    • , J. A. Morales Rosado
    • , E. Smith
    • , K. A. Schlauch
    • , R. Read
    • , C. Rowan
    • , N. Slotnick
    • , S. Dabe
    • , W. J. Metcalf
    • , B. Lipp
    • , H. Reed
    • , L. Sharma
    • , E. Levin
    • , J. Kao
    • , M. Rashkin
    • , J. Bowes
    • , K. Dunaway
    • , A. Slonim
    • , N. Washington
    • , M. Ferber
    • , A. Bolze
    •  & J. T. Lu
  • Article |

    A pilot clinical trial evaluating metformin in patients with pediatric brain tumors shows that it is a safe approach resulting in improved cognitive function that is consistent with the recovery of adult hippocampal neurogenesis observed in mouse models.

    • Ramy Ayoub
    • , Rebecca M. Ruddy
    • , Elizabeth Cox
    • , Adeoye Oyefiade
    • , Daniel Derkach
    • , Suzanne Laughlin
    • , Benjamin Ades-aron
    • , Zahra Shirzadi
    • , Els Fieremans
    • , Bradley J. MacIntosh
    • , Cynthia B. de Medeiros
    • , Jovanka Skocic
    • , Eric Bouffet
    • , Freda D. Miller
    • , Cindi M. Morshead
    •  & Donald J. Mabbott
  • Letter |

    The combination of near to real-time whole-genome sequence analysis and epidemiology resulted in reliable assessments of the extent of SARS-CoV-2 transmission in the community, facilitating early decision-making to control local transmission of SARS-CoV-2 in the Netherlands.

    • Bas B. Oude Munnink
    • , David F. Nieuwenhuijse
    • , Mart Stein
    • , Áine O’Toole
    • , Manon Haverkate
    • , Madelief Mollers
    • , Sandra K. Kamga
    • , Claudia Schapendonk
    • , Mark Pronk
    • , Pascal Lexmond
    • , Anne van der Linden
    • , Theo Bestebroer
    • , Irina Chestakova
    • , Ronald J. Overmars
    • , Stefan van Nieuwkoop
    • , Richard Molenkamp
    • , Annemiek A. van der Eijk
    • , Corine GeurtsvanKessel
    • , Harry Vennema
    • , Adam Meijer
    • , Andrew Rambaut
    • , Jaap van Dissel
    • , Reina S. Sikkema
    • , Aura Timen
    • , Marion Koopmans
    • , G. J. A. P. M. Oudehuis
    • , Janke Schinkel
    • , Jan Kluytmans
    • , Marjolein Kluytmans-van den Bergh
    • , Wouter van den Bijllaardt
    • , Robbert G. Berntvelsen
    • , Miranda M. L. van Rijen
    • , Peter Schneeberger
    • , Suzan Pas
    • , Bram M. Diederen
    • , Anneke M. C. Bergmans
    • , P. A. Verspui van der Eijk
    • , Jaco Verweij
    • , Anton G. N. Buiting
    • , Roel Streefkerk
    • , A. P. Aldenkamp
    • , P. de Man
    • , J. G. M. Koelemal
    • , D. Ong
    • , S. Paltansing
    • , N. Veassen
    • , Jacqueline Sleven
    • , Leendert Bakker
    • , Heinrich Brockhoff
    • , Ariene Rietveld
    • , Fred Slijkerman Megelink
    • , James Cohen Stuart
    • , Anne de Vries
    • , Wil van der Reijden
    • , A. Ros
    • , Esther Lodder
    • , Ellen Verspui-van der Eijk
    • , Inge Huijskens
    • , E. M. Kraan
    • , M. P. M. van der Linden
    • , S. B. Debast
    • , N. Al Naiemi
    • , A. C. M. Kroes
    • , Marjolein Damen
    • , Sander Dinant
    • , Sybren Lekkerkerk
    • , Oscar Pontesilli
    • , Pieter Smit
    • , Carla van Tienen
    • , P. C. R. Godschalk
    • , Jorien van Pelt
    • , Alewijn Ott
    • , Charlie van der Weijden
    • , Heiman Wertheim
    • , Janette Rahamat-Langendoen
    • , Johan Reimerink
    • , Rogier Bodewes
    • , Erwin Duizer
    • , Bas van der Veer
    • , Chantal Reusken
    • , Suzanne Lutgens
    • , Peter Schneeberger
    • , Mirjam Hermans
    • , P. Wever
    • , A. Leenders
    • , Henriette ter Waarbeek
    •  & Christian Hoebe
  • Letter |

    A new study that models the COVID-19 epidemic in France suggests that although a second peak is likely unavoidable, maintaining social distancing and wearing masks when lockdown restrictions are lifted, as well as continuing to shelter vulnerable individuals, will reduce mortality and avoid overwhelming ICU facilities.

    • Nicolas Hoertel
    • , Martin Blachier
    • , Carlos Blanco
    • , Mark Olfson
    • , Marc Massetti
    • , Marina Sánchez Rico
    • , Frédéric Limosin
    •  & Henri Leleu
  • Letter |

    Pharmacological inhibition of GFRAL–RET signaling in preclinical tumor models supports the therapeutic potential for reversing GDF15-dependent cachexia in people with cancer.

    • Rowena Suriben
    • , Michael Chen
    • , Jared Higbee
    • , Julie Oeffinger
    • , Richard Ventura
    • , Betty Li
    • , Kalyani Mondal
    • , Zhengyu Gao
    • , Dina Ayupova
    • , Pranali Taskar
    • , Diana Li
    • , Shelley R. Starck
    • , Hung-I Harry Chen
    • , Michele McEntee
    • , Subhash D. Katewa
    • , Van Phung
    • , Marilyn Wang
    • , Avantika Kekatpure
    • , Damodharan Lakshminarasimhan
    • , Andre White
    • , Andrea Olland
    • , Raj Haldankar
    • , Mark J. Solloway
    • , Jer-Yuan Hsu
    • , Yan Wang
    • , Jie Tang
    • , Darrin A. Lindhout
    •  & Bernard B. Allan