News & Comment

  • News Feature |

    Researchers studying insect-borne disease hope to bring down the exorbitant cost of mosquitoes.

    • Monique Brouillette
  • Editorial |

    Immune interventions capable of preventing or eradicating HIV infection have yet to achieve broad success in humans. Renewed vigor in the clinical trial arena may bring us closer to that goal.

  • Turning Points |

    Max Nieuwdorp is an internist, endocrinologist and vascular medicine specialist at Amsterdam University Medical Centers. He chairs the Diabetes Center there and is chief of the Department and Laboratory of Vascular Medicine.

    • Max Nieuwdorp
  • Research Highlight |

    • Hannah Stower
  • Turning Points |

    Ami Bhatt is a physician-scientist and assistant professor of medicine and genetics at Stanford University. Her research deploys next-generation sequencing to explore host–microbiome interactions, including those in cancer.

    • Ami S. Bhatt
  • News & Views |

    Multi-omics longitudinal profiling of individuals can detect subtle changes in health status at the earliest possible time point, allowing preemptive initiation of mechanism-appropriate disease-prevention strategies.

    • Steven R. Steinhubl
  • News Feature |

    • Hannah Valantine
    • , Elizabeth Travis
    • , Wafa El-Adhami
    • , Isabelle Vernos
    • , Laura Mosqueda
    • , Elizabeth Wayne
    • , Fiona Kearns-Zimmerman
    • , Lauren Bonefont
    • , Sandhya S. Visweswariah
    • , Wuraola Akande-Sholabi
    •  & Jessica Polka
  • News & Views |

    Human survivors of Ebola virus disease are more likely than uninfected controls to develop memory loss, uveitis, and other abnormal conditions, and Ebola virus remains in semen much longer than previously thought.

    • Daniel S. Chertow
  • News & Views |

    Three innovative precision medicine studies show the utility of evidence beyond that from tumor DNA sequencing to guide therapy in patients with cancer.

    • Christophe Le Tourneau
    • , Edith Borcoman
    •  & Maud Kamal
  • Editorial |

    The use of electronic cigarettes is on the rise, but we need more evidence about their risks as well as their value in curbing tobacco use. Ultimately, we need to design better, smarter vaping tools for smoking cessation.

  • Turning Points |

    Lars Zender is professor and chairman of internal medicine at University Hospital Tubingen in Germany. He has received many awards, including the Gottfried Wilhelm Leibniz Prize of the German Research Foundation.

    • Lars Zender
  • Comment |

    It has been only recently that scientists come to realize the existence of a lymphatic system within the central nervous system. However, an Italian anatomist had already found and described the system in fine detail over 200 years ago.

    • Stefano Sandrone
    • , Daniel Moreno-Zambrano
    • , Jonathan Kipnis
    •  & Jan van Gijn
  • News & Views |

    Improved protocols for the visualization of immature neurons in the human brain provide evidence for generation of neurons in the adult hippocampus and uncover reduced neurogenesis in Alzheimer’s disease.

    • Embla Steiner
    • , Mathew Tata
    •  & Jonas Frisén
  • News & Views |

    A large study provides causal evidence of the opposing effects of plasma low-density lipoprotein (LDL) levels on ischemic and hemorrhagic stroke in a Chinese population and suggests there is a a net benefit associated with LDL lowering.

    • Neal S. Parikh
    •  & Mitchell S. V. Elkind
  • Q&A |

    We discussed with five scientists what the sources and roles of real-world evidence are, how we can use such data in clinical trials and how these data can be converted into useful information that can impact patient management and regulatory decisions in oncology.

    • Hannah Stower
  • Editorial |

    Cancer surveillance programs have reported a global downward trend in cancer mortality rates for most common tumor types. However, startling geographic inequalities exist, and some cancers continue to pose a challenge. Ensuring global access to high-quality diagnostic and treatment approaches is needed to make decreasing cancer deaths a more widespread trend.

  • Turning Points |

    Samra Turajlic is a consultant medical oncologist at the Royal Marsden National Health Service Foundation Trust and a clinician–scientist at the Francis Crick Institute.

    • Samra Turajlic
  • News Feature |

    Cancer registries that track tumors as they spread could reveal how these growths metastasize

    • Brianna Abbott
  • Turning Points |

    Georgina V. Long is co-medical director of Melanoma Institute Australia and Chair of Melanoma Medical Oncology and Translational Research. She is the first woman president of the Society for Melanoma Research.

    • Georgina V. Long
  • News & Views |

    Application of immunoprofiling of human peripheral blood samples from an aging cohort identifies changes in the immune system that inform our understanding of age-associated complex diseases.

    • Soumya Raychaudhuri
    •  & Rajat M. Gupta
  • News & Views |

    Transcriptional signatures and immune cell infiltrates associated with immune activation distinguish patients with glioblastoma who initially respond to immune checkpoint blockade from those who do not.

    • Hirotaka Ito
    • , Hiroshi Nakashima
    •  & E. Antonio Chiocca
  • News & Views |

    The analysis of autopsy material from individuals with multiple sclerosis with single-cell transcriptomics and 14C carbon dating calls for a reevaluation of mature oligodendrocytes in myelin repair.

    • Klaus-Armin Nave
    •  & Hannelore Ehrenreich
  • News & Views |

    Non-invasive prenatal diagnostics allow for the successful identification of paternally inherited and de novo mongenic diseases using circulating cell-free DNA.

    • Nancy B. Spinner
    •  & Ian D. Krantz
  • News Feature |

    Careful sorting of probiotics may finally pave the way for an FDA approval.

    • Shraddha Chakradhar
  • Turning Points |

    Eran Elinav is an immunologist at the Weizmann Institute of Science in Rehovot, Israel. He has earned many distinctions, including being named a Howard Hughes Medical Institute and Bill and Melinda Gates Foundation research scholar in 2017.

    • Eran Elinav
  • Editorial |

    As the world reckons with the news of the first use of genome editing in the human germline, researchers, clinicians, ethicists and policy makers must work across international boundaries to outline a transparent path forward for the responsible translation of this technology in the future.