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The sleep–wake switch: A neuronal alarm clock

Nature Medicine volume 6, pages 510–511 (2000)Cite this article

A 70-year-old hypothesis that a rostral hypothalamic area is essential for maintaining sleep is re-awakened by the demonstration that the sleep-active ventrolateral preoptic neurons interact with wake-promoting systems in the upper brainstem.

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Figure 1: Emerging concept of the neural control of NREM sleep.

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Authors and Affiliations

  1. Greater Los Angeles Healthcare System and Departments of Psychology and Medicine, Neurophysiology and Sleep Physiology Research Sepulveda Center, Veterans Administration, University of California at Los Angeles, 16111 Plummer St., Sepulveda, 91343, California, USA

    Dennis McGinty & Ron Szymusiak

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  1. Dennis McGinty
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  2. Ron Szymusiak
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McGinty, D., Szymusiak, R. The sleep–wake switch: A neuronal alarm clock. Nat Med 6, 510–511 (2000). https://doi.org/10.1038/74988

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