In a recent study, researchers generated a mouse model expressing variant APOL1 that recapitulates human kidney disease. Variant APOL1 leads to caspase-1-dependent pyroptosis, which opens the door for the development of new druggable targets to treat APOL1-mediated kidney disease.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Kim Caesar/Springer Nature
References
Genovese, G. et al. Science 329, 841–845 (2010).
Kruzel-Davila, E. et al. J. Am. Soc. Nephrol. http://dx.doi.org/10.1681/ASN.2016050546 (2016).
Ma, L. et al. J. Am. Soc. Nephrol. http://dx.doi.org/10.1681/ASN.2016050567 (2016).
Thomson, R. et al. Proc. Natl. Acad. Sci. USA 111, E2130–E2139 (2014).
Vanwalleghem, G. et al. Nat. Commun. 6, 8078 (2015).
Beckerman, P. et al. Nat. Med. 23, 429–438 (2017).
Bruggeman, L.A. et al. J. Am. Soc. Nephrol. 27, 3600–3610 (2016).
Larsen, C.P. et al. Mod. Pathol. 28, 95–102 (2015).
Vezzani, A. et al. Curr. Opin. Investig. Drugs 11, 43–50 (2010).
Dummer, P.D. et al. Semin. Nephrol. 35, 222–236 (2015).
Nichols, B. et al. Kidney Int. 87, 332–342 (2015).
Limou, S., Dummer, P.D., Nelson, G.W., Kopp, J.B. & Winkler, C.A. Kidney Int. 88, 28–34 (2015).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Winkler, C., Nelson, G. A mouse recapitulating APOL1-associated kidney disease. Nat Med 23, 411–412 (2017). https://doi.org/10.1038/nm.4318
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.4318
