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Intracellular chloride accumulation: a possible mechanism for cognitive deficits in Down syndrome

Nature Medicine volume 21, pages 312–313 (2015)Cite this article

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A study involving a mouse model of Down syndrome and analysis of human postmortem brain samples indicates that hippocampal GABAA receptor signaling in Down syndrome may be excitatory. This advance promises new clinical applications in Down syndrome.

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Figure 1: Schematic model of GABAA receptor–mediated neurotransmission in a mouse model of DS.

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Authors and Affiliations

  1. Alberto C. Costa is in the Department of Pediatrics, Division of Pediatric Neurology, Case Western Reserve University, Cleveland, Ohio, USA.,

    Alberto C Costa

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  1. Alberto C Costa
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Correspondence to Alberto C Costa.

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Costa, A. Intracellular chloride accumulation: a possible mechanism for cognitive deficits in Down syndrome. Nat Med 21, 312–313 (2015). https://doi.org/10.1038/nm.3836

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