Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

The Gulf War, stress and a leaky blood—brain barrier

Nature Medicine volume 2, pages 1307–1308 (1996)Cite this article

Extreme stress renders the blood—brain barrier permeable to drugs that normally act peripherally (pages 1382–1385).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Rowland, L.P., Fink, M.E. & Rubin, L. Cerebrospinal fluid: Blood-brain barrier, brain edema and hydrocephalus. in Principles of Neural Science (eds. Kandel, E.R., Schwartz, J.H., & Jessell, T.M.) 1050–1060 (Elsevier, New York, 1991).

    Google Scholar 

  2. Deyi, X., Limxiu, W. & Shuqui, P. The inhibition and protection of cholinesterase by physostigmine and pyridostigmine against soman poisoning in vivo. Fundam. Appl. Toxicol. 1, 217–221 (1981).

    Article  Google Scholar 

  3. Diruhumber, P., French, M.C., Green, D.M., Lead-beater, L. & Stratton, J.A. The protection of primates against soman poisoning by pretreatment with pyridostigmine. J. Pharmacol. 31, 295–299 (1979).

    Article  Google Scholar 

  4. Sharabi, Y. et al. Survey of symptoms following intake of pyridostigmine during the Persian Gulf War. Isr. J. Med. Sci. 27, 656–658 (1991).

    CAS  Google Scholar 

  5. Friedman, A. et al. Pyridostigmine brain penetration under stress enhances neuronal excitability and induces early immediate transcriptional response. Nature Med. 2, 1382–1385 (1996).

    Article  CAS  Google Scholar 

  6. Belova, I. & Jonsson, G. Blood-brain barrier permeability and immobilization stress. Acta Physiol. Scand. 116, 21–29 (1982).

    Article  CAS  Google Scholar 

  7. Dvorska, I. et al. On the blood-brain barrier to peptides: Effects of immobilization stress on regional blood supply and accumulation of labelled peptides in the rat brain. Endocr. Res. 26, 77–82 (1992).

    CAS  Google Scholar 

  8. Ben-Nathan, D., Lustig, S. & Danenberg, H.D. Stress-induced neuroinvasiveness of a neurovirulent noninvasive Sindbis virus in cold or isolation subjected mice. Life Sci. 48, 1493–1500 (1991).

    Article  CAS  Google Scholar 

  9. Sharma, H.S., Nyberg, F., Cervos-Navarro, J. & Dey, P.K. Histamine modulates heat stress-induced changes in blood-brain barrier permeability, cerebral blood flow, brain oedema and serotonin levels: an experimental study in the young rat. Neuroscience 50, 445–454 (1992).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology and Experimental Therapeutics, Loyola University Chicago Stritch School of Medicine Maywood, Illinois, 60153, USA

    Israel Hanin

Authors
  1. Israel Hanin
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hanin, I. The Gulf War, stress and a leaky blood—brain barrier. Nat Med 2, 1307–1308 (1996). https://doi.org/10.1038/nm1296-1307

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1296-1307

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing