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  • Between Bedside and Bench
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A safer stem cell: inducing pluripotency

Nature Medicine volume 15, pages 1001–1002 (2009)Cite this article

Bedside to Bench

The isolation of human embryonic stem cells1 (hESCs) theoretically gave scientists the starting material to produce any cell type in the body for use in regenerative medicine. One major obstacle to this approach has been the inevitable host immunological response to transplanted foreign tissue. The development of protocols for inducing hESC-like pluripotent cells from mature adult cell types has provided a potential solution to this problem. A series of recent studies2,3,4,5 have now focused on how to produce patient-specific cell lines efficiently and safely enough to bring into the clinic.

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References

  1. Thomson, J.A. et al. Science 282, 1145–1147 (1998).

    Article  CAS  Google Scholar 

  2. Kim, D. et al. Cell Stem Cell 4, 472–476 (2009).

    Article  CAS  Google Scholar 

  3. Woltjen, K. et al. Nature 458, 766–770 (2009).

    Article  CAS  Google Scholar 

  4. Kaji, K. et al. Nature 458, 771–775 (2009).

    Article  CAS  Google Scholar 

  5. Yu, J. et al. Science 324, 797–801 (2009).

    Article  CAS  Google Scholar 

  6. Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).

    Article  CAS  Google Scholar 

  7. Takahashi, K. et al. Cell 131, 861–872 (2007).

    Article  CAS  Google Scholar 

  8. Yu, J. et al. Science 318, 1917–1920 (2007).

    Article  CAS  Google Scholar 

  9. Park, I.H. et al. Nature 451, 141–146 (2008).

    Article  CAS  Google Scholar 

  10. Okita, K., Ichisaka, T. & Yamanaka, S. Nature 448, 313–317 (2007).

    Article  CAS  Google Scholar 

  11. Stadtfeld, M., Nagaya, M., Utikal, J., Weir, G. & Hochedlinger, K. Science 322, 945–949 (2008).

    Article  CAS  Google Scholar 

  12. Okita, K., Nakagawa, M., Hyenjong, H., Ichisaka, T. & Yamanaka, S. Science 322, 949–953 (2008).

    Article  CAS  Google Scholar 

  13. Gonzalez, F. et al. Proc. Natl. Acad. Sci. USA 106, 8918–8922 (2009).

    Article  CAS  Google Scholar 

  14. Kang, L., Wang, J., Zhang, Y., Kou, Z., & Gao, S. Cell Stem Cell published online, doi:10.1016/j.stem.2009.07.001 (2009).

  15. Zhao, X et al. Nature advance online publication, doi:10.1038/nature08267 (2009).

  16. Raya, A. et al. Nature 460, 53–59 (2009).

    Article  CAS  Google Scholar 

  17. Amariglio, N. et al. PLoS Med. 6, e1000029 (2009).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Laura Clarke and Derek van der Kooy are at the University of Toronto, Toronto, Canada.,

    Laura Clarke & Derek van der Kooy

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  1. Laura Clarke
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  2. Derek van der Kooy
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Correspondence to Derek van der Kooy.

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Clarke, L., van der Kooy, D. A safer stem cell: inducing pluripotency. Nat Med 15, 1001–1002 (2009). https://doi.org/10.1038/nm0909-1001

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