An indigestion drug blamed for a debilitating illness that affected thousands of people in the 1950s has been resurrected as a potential treatment for Alzheimer's disease. But not everyone is cheering for the drug, clioquinol, to make a comeback. Lauren Cahoon reports.
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Change history
07 May 2009
In the version of this article initially published, Ashley Bush of the Mental Health Research Institute in Melbourne, Australia is cited as the sole originator of the metals theory for Alzheimer’s disease, and Prana Biotechnology is described as being founded in Melbourne. The theory and Prana Biotechnology were jointly developed by Bush and Rudolph Tanzi of Massachusetts General Hospital, with the help of Rob Moir, and in collaboration with Colin Masters of the University of Melbourne. Additionally, it was Michel Xilinas who recognized the chelating properties of clioquinol. The errors have been corrected in the HTML and PDF versions of the article.
References
Schaumburg, H. Experimental and Clinical Neurotoxicology (ed. Spencer, P.) Ch. 27, 395–406 (Oxford University Press, New York, 2000).
Cherny, R.A. et al. Neuron 30, 665–676 (2001).
Ritchie, C.W. Arch. Neurol. 60, 1685–1691 (2003).
Nakae, K., Yamamoto, S., Shigematsu, I. & Kono R. Lancet 301, 171–173 (1973).
Shigematsu, I., Yanagawa, H., Yamamoto, S. & Nakae, K. Jpn. J. Med. Sci. Biol. 28, 23–33 (1975).
Lannfelt, L. et al. Lancet Neurol. 7, 779–786 (2008).
Nguyen, T., Hamby, A. & Massa, S.M. Proc. Natl. Acad. Sci. 102, 11840–11845 (2005).
Kaur, D. et al. Neuron 37, 899–909 (2003).
Wang, Y. et al. J. Biol. Chem. 284, 314–323 (2009).
Ding, W.Q. et al. Cancer Res. 65, 3389–3395 (2005).
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Cahoon, L. The curious case of clioquinol. Nat Med 15, 356–359 (2009). https://doi.org/10.1038/nm0409-356
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DOI: https://doi.org/10.1038/nm0409-356
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