Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Reducing glutamate signaling pays off in fragile X

A recent theory about the basis for fragile X syndrome is now validated in a mouse model. The findings point the way to treatment options targeting group 1 metabotropic glutamate receptors.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Genetic reduction of metabotropic glutamate receptor 5 (mGluR5) signaling rescues fragile X syndrome (FXS) in mice.

Katie Ris-Vicari

References

  1. Dolen, G. et al. Neuron 56, 955–962 (2007).

    Article  CAS  Google Scholar 

  2. Penagarikano, O., Mulle, J.G. & Warren, S.T. Annu. Rev. Genomics Hum. Genet. 8, 109–129 (2007).

    Article  CAS  Google Scholar 

  3. Bear, M.F., Huber, K.M. & Warren, S.T. Trends Neurosci. 27, 370–377 (2004).

    Article  CAS  Google Scholar 

  4. Nosyreva, E.D. & Huber, K.M. J. Neurophysiol. 95, 3291–3295 (2006).

    Article  CAS  Google Scholar 

  5. Muddashetty, R.S., Kelic, S., Gross, C., Xu, M. & Bassell, G.J. J. Neurosci. 27, 5338–5348 (2007).

    Article  CAS  Google Scholar 

  6. McBride, S.M. et al. Neuron 45, 753–764 (2005).

    Article  CAS  Google Scholar 

  7. Chuang, S.C. et al. J. Neurosci. 25, 8048–8055 (2005).

    Article  CAS  Google Scholar 

  8. Yan, Q.J., Rammal, M., Tranfaglia, M. & Bauchwitz, R.P. Neuropharmacology 49, 1053–1066 (2005).

    Article  CAS  Google Scholar 

  9. Lea, P.M. & Faden, A.I. CNS Drug Rev. 12, 149–166 (2006).

    Article  CAS  Google Scholar 

  10. Lu, Y.M. et al. J. Neurosci. 17, 5196–5205 (1997).

    Article  CAS  Google Scholar 

  11. Volk, L.J., Pfeiffer, B.E., Gibson, J.R. & Huber, K.M. J. Neurosci. 27, 11624–11634 (2007).

    Article  CAS  Google Scholar 

  12. Narayanan, U. et al. J. Neurosci. 27, 14349–14357 (2007).

    Article  CAS  Google Scholar 

  13. Nakamoto, M. et al. Proc. Natl. Acad. Sci. USA 104, 15537–15542 (2007).

    Article  CAS  Google Scholar 

  14. Shepherd, J.D. & Huganir, R.L. Annu. Rev. Cell Dev. Biol. 23, 613–643 (2007).

    Article  CAS  Google Scholar 

  15. Davidkova, G. & Carroll, R.C. J. Neurosci. 27, 13273–13278 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bassell, G., Gross, C. Reducing glutamate signaling pays off in fragile X. Nat Med 14, 249–250 (2008). https://doi.org/10.1038/nm0308-249

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0308-249

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing