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Defining the 'survivasome' of Mycobacterium tuberculosis

Identification of drug targets in M. tuberculosis is a challenge for bench science. High-throughput mutagenesis with transposons together with microarray-based genome and transcriptome profiling has begun to meet this challenge.

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Figure 1: Transposon site hybridization (TraSH).

Simon Fenwick

References

  1. Gandhi, N.R. et al. Lancet 368, 1575–1580 (2006).

    Article  Google Scholar 

  2. Sassetti, C.M., Boyd, D.H. & Rubin, E.J. Mol. Microbiol. 48, 77–84 (2003).

    Article  CAS  Google Scholar 

  3. Cole, S.T. et al. Nature 393, 537–544 (1998).

    Article  CAS  Google Scholar 

  4. Sassetti, C.M. & Rubin, E.J. Proc. Natl. Acad. Sci. USA 100, 12989–12994 (2003).

    Article  CAS  Google Scholar 

  5. Rengarajan, J., Bloom, B.R. & Rubin, E.J. Proc. Natl. Acad. Sci. USA 102, 8327–8332 (2005).

    Article  CAS  Google Scholar 

  6. Warner, D.F. & Mizrahi, V. Nat. Med. 13, 282–284 (2007).

    Article  CAS  Google Scholar 

  7. Lamichhane, G., Tyagi, S. & Bishai, W.R. Infect. Immun. 73, 2533–2540 (2005).

    Article  CAS  Google Scholar 

  8. Jain, S.K. et al. J. Infect. Dis. (in the press).

  9. Lamichhane, G. et al. Proc. Natl. Acad. Sci. USA 100, 7213–7218 (2003).

    Article  CAS  Google Scholar 

  10. Graham, J.E. & Clark-Curtiss, J.E. Proc. Natl. Acad. Sci. USA 96, 11554–11559 (1999).

    Article  CAS  Google Scholar 

  11. Faucher, S.P., Porwollik, S., Dozois, C.M., McClelland, M. & Daigle, F. Proc. Natl. Acad. Sci. USA 103, 1906–1911 (2006).

    Article  CAS  Google Scholar 

  12. Boshoff, H.I. et al. J. Biol. Chem. 279, 40174–40184 (2004).

    Article  CAS  Google Scholar 

  13. Andries, K. et al. Science 307, 223–227 (2005).

    Article  CAS  Google Scholar 

  14. Matsumoto, M. et al. PLoS Med. 3, e466 (2006).

    Article  Google Scholar 

Download references

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Lamichhane, G., Bishai, W. Defining the 'survivasome' of Mycobacterium tuberculosis. Nat Med 13, 280–282 (2007). https://doi.org/10.1038/nm0307-280

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