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Volume 10 Issue 1, January 2004

In 2004, Nature Medicine enters its tenth year of publication, continuing our mission to serve the biomedical research community as the venue for top-flight primary research articles, news and perspectives. The cover image commemorates our anniversary year with a collage of covers spanning our publication history. (Graphic by Lewis Long)

Volume 10 Issue 1

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Editorial

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News

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Correspondence

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Book Review

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News & Views

  • Endogenous marijuana-like compounds regulate implantation during pregnancy by activating cannabinoid receptors on the embryo's surface. A new study explores the dynamics of this process and renews concerns about marijuana use in pregnant women.

    • Daniele Piomelli
    News & Views

  • HTLV-1 infection poses a risk for leukemia and other ailments. Now the elusive cellular receptor for this pathogen has finally been identified, and it is the same receptor that allows glucose to enter cells.

    • Julie Overbaugh
    News & Views

  • T-cell depletion is commonly used in strategies that attempt to coax the immune system into tolerating foreign tissue after transplantation. Studies in mice now indicate that this depletion may be at odds with the goal of inducing tolerance (pages 87–92).

    • Hugh Auchincloss
    News & Views

  • A new drug that activates the Wnt pathway maintains the undifferentiated state of pluripotent human and mouse embryonic stem cells. This finding opens the door to defining the precise molecular mechanism of embryonic stem cell self-renewal, which is crucial for providing a steady supply of embryonic stem cells for regenerative medicine (pages 55–63).

    • Kinichi Nakashima
    • Sophia Colamarino
    • Fred H Gage
    News & Views

  • Short bursts of hypoxia induce a form of learning in the neuronal network that controls breathing. This process now is shown to share mechanisms with synaptic plasticity in the hippocampus.

    • George B Richerson
    • John M Bekkers
    News & Views

  • Almost all prostate cancer patients become resistant to therapy that blocks androgen-mediated cell proliferation. The key to this resistance may lie in expression of the androgen receptor itself (pages 33–39).

    • John T Isaacs
    • William B Isaacs
    News & Views
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Brief Communication

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Article

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Letter

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Technical Report

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Corrigendum

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On the Market

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