Review Articles

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  • This Review explores how research coproduction with Indigenous peoples is evolving; it discusses the challenges and complexities and makes recommendations for researchers wishing to pursue coproduction with Indigenous peoples in responsive and effective ways.

    • Chris Cunningham
    • Monica Mercury
    Review Article
  • Recent years have seen major advances in heart failure treatment, but gaps in implementation and disparities in care remain; this Review outlines the current state of the field.

    • Carolyn S. P. Lam
    • Kieran F. Docherty
    • Torbjørn Omland
    Review Article
  • This Review summarizes recent advances in biomarkers and therapies for Alzheimer disease—the products of decades of research—and discusses the challenges, gaps and clinical implications.

    • Wade K. Self
    • David M. Holtzman
    Review Article
  • This Review outlines three ‘grand challenges’ to protect and promote health in the face of climate change, and discusses the role of the health community in driving change within and beyond the health sector.

    • Diarmid Campbell-Lendrum
    • Tara Neville
    • Maria Neira
    Review Article
  • Multimorbidity is increasing globally, and addressing it requires a shift in the prevailing clinical, educational and scientific thinking. This Review discusses emerging mechanisms, research challenges and the implications for patients and healthcare systems.

    • Claudia Langenberg
    • Aroon D. Hingorani
    • Christopher J. M. Whitty
    Review Article
  • Adverse childhood experiences can negatively impact lifelong health; this Review discusses the underlying mechanisms and potential solutions, advocating for multisectoral interventions and implementation research.

    • Zulfiqar A. Bhutta
    • Supriya Bhavnani
    • Vikram Patel
    Review Article
  • This review explains how large language models (LLMs), such as ChatGPT, are developed and discusses their strengths and limitations in the context of potential clinical applications.

    • Arun James Thirunavukarasu
    • Darren Shu Jeng Ting
    • Daniel Shu Wei Ting
    Review Article
  • Cardiometabolic health is tightly linked to diet and the gut microbiome. This Review explains how meta-omics technologies are revealing the intricate links between them and discusses the most promising paths to clinical translation.

    • Mireia Valles-Colomer
    • Cristina Menni
    • Nicola Segata
    Review Article
  • This Review surveys the NASH clinical trial landscape and the main challenges to drug approval, and discusses new approaches to overcoming these, including innovative trial designs, non-invasive tests and biomarkers.

    • Stephen A. Harrison
    • Alina M. Allen
    • Naim Alkhouri
    Review Article
  • This Review discusses the effect of comorbidities and multimorbidity on the three mechanistically distinct phases of COVID-19, evaluating the evidence in the context of confounding factors and our evolving understanding of the disease.

    • Clark D. Russell
    • Nazir I. Lone
    • J. Kenneth Baillie
    Review Article
  • This Review provides a timely overview of new technological advances and treatment approaches, with a particular emphasis on brain-circuit-based interventions for precision psychiatry.

    • Katherine W. Scangos
    • Matthew W. State
    • Leanne M. Williams
    Review Article
  • The COVID-19 mRNA vaccines have transformed the field of mRNA nanomedicine, but this new class of therapeutics has the potential to treat many other diseases. This Review profiles the latest advances and challenges.

    • Xiangang Huang
    • Na Kong
    • Wei Tao
    Review Article
  • This Review discusses the impact of COVID-19 on mental health, from pandemic-related societal effects to direct infection-related neuropsychiatric sequelae, highlighting the lessons learned and outstanding knowledge gaps.

    • Brenda W. J. H. Penninx
    • Michael E. Benros
    • Christiaan H. Vinkers
    Review Article
  • Multimodal artificial intelligence models could unlock many exciting applications in health and medicine; this Review outlines the most promising uses and the technical pitfalls to avoid.

    • Julián N. Acosta
    • Guido J. Falcone
    • Eric J. Topol
    Review Article
  • Cellular senescence has emerged as a promising therapeutic target for disorders across the lifespan; this Review highlights the most promising strategies for translating senescence-targeting interventions into clinical use in the near future.

    • Selim Chaib
    • Tamar Tchkonia
    • James L. Kirkland
    Review Article
  • Precision medicine for rheumatic diseases is still in its infancy, but recent advances are enabling comprehensive profiling and mechanistic insights. This Review outlines the progress, promises, and challenges of translating these findings into the clinic.

    • Joel M. Guthridge
    • Catriona A. Wagner
    • Judith A. James
    Review Article
  • Restoration of visual function in degenerative retinal disease may be an attainable goal, thanks to advances in cell-based therapy, gene therapy, and prosthetics. This Review discusses the most promising strategies that will probably reach clinical use in the next decade.

    • Russell N. Van Gelder
    • Michael F. Chiang
    • Clive N. Svendsen
    Review Article
  • Certain acute infections (including SARS-CoV-2) are associated with an unexplained chronic disability in a minority of patients; this Review summarizes what is known about these understudied and complex illnesses.

    • Jan Choutka
    • Viraj Jansari
    • Akiko Iwasaki
    Review Article
  • Oncology is trailblazing the field of engineered cellular therapeutics. This Review discusses the goals of cellular immunotherapy in cancer, key challenges facing the field and strategies to overcome them—paving the way for treatment of other diseases.

    • Amanda V. Finck
    • Tatiana Blanchard
    • Carl H. June
    Review Article