Research Highlights

Activating the PD-1 checkpoint might reset the immune system and reduce disease activity in patients with rheumatoid arthritis, according to a phase 2a trial.

Anti-poverty programs can alleviate the negative impact of low family income on brain structure and mental health in adolescents.

In a clinical trial, interrupting adjuvant endocrine therapy to attempt pregnancy did not increase the risk of breast cancer recurrence.

Researchers have developed a non-invasive brain–computer interface that reconstructs narratives from perceived or imagined speech.

A thromboprotective platelet signature, conserved across species, could provide new therapeutic targets for the treatment of venous blood clots in immobilized patients.

Uninterrupted embryo culture and time-lapse monitoring are increasingly offered to people undergoing IVF — but a randomized study fails to show any benefit over routine embryo-selection methods.

The PHYSIC trial reveals substantial variability in how people respond to four different classes of blood-pressure-lowering drugs — highlighting the need to personalize treatments.

A new study provides the strongest support yet for abnormal α-synuclein as a diagnostic biomarker that shows up even in the prodromal phase — with immediate implications for trial design and therapeutic development.

A one-time gene-editing therapy restored motor function and prolonged lifespan in mice, spurring further research to refine and optimize the approach for future clinical use.

Using CAR T cells to treat solid tumors is notoriously challenging, but a new study shows impressive responses rates in children with high-risk neuroblastoma.

Implementation of WHO-recommended policies to tackle noncommunicable diseases has stalled since the beginning of the COVID-19 pandemic.

Decades ago, city living was associated with a height advantage in children and adolescents — but this developmental advantage has now diminished in much of the world.

An in vitro technique to drop a Y chromosome and duplicate an X chromosome could expand the reach of fertility treatments in the future, although translation to humans remains an open question.

According to a randomized trial, home-based monitoring of complicated pregnancies could be a safe alternative to hospital admission.

For patients with advanced, resectable melanoma, treatment with pembrolizumab before as well as after surgery led to improved outcomes — without additional toxicity.

For people taking statins, inflammation contributes more to cardiovascular disease risk than residual cholesterol does — and could be targeted with adjunct therapy.

An MRI-guided, focused ultrasound ablation technique shows promise as a non-invasive treatment.

Existing models for predicting the 10-year risk of stroke are less accurate for Black adults than for white adults, even with the addition of novel machine-learning algorithms.

In patients with advanced melanoma, adherence to a habitual Mediterranean diet was associated with a higher probability of responding to immunotherapy.

Hailey, an AI feedback tool, helps online mental health support workers to respond with more empathy.