Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Cancer-derived induced pluripotent stem cells provide a new opportunity to model the effects of the cancer genome. In this Perspective, Eirini Papapetrou discusses the future applications of these cells for cancer modeling and therapeutic understanding.
Recent studies have led to the identification of genetic loci that are shared between psychiatric disorders. Here O’Donovan and Owen argue that it is unlikely that risk alleles exist that are singular to any one such disorder.
The developmental trajectories of neuropsychiatric disorders suggest that early life events might contribute substantially to disease. Here the author discusses the potential to treat within these critical time windows of development to alter disease course.
Psychiatric disorders are difficult to model owing to their inherent complexity and heterogeneity. This Perspective focuses on the use of 3D brain organoids in modeling these disorders, considering both their advantages and their limitations.
Recent evidence indicates that one of the underlying mechanisms in the pathogenesis of neuropsychiatric disorders is dysregulated dentate gyrus neurogenesis. Here the authors present evidence supporting this hypothesis and suggest therapeutic avenues.
Abi-Dargham and Horga discuss the challenges of developing and standardizing brain-imaging technologies to aid with the diagnosis and treatment of psychiatric disorders.
Ron Duman and colleagues discuss recent insights into a role for circuit disruption in the mechanisms of stress-induced depression. Furthermore they discuss the potential for rapid-acting antidepressants to alleviate these defects.