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  • The liver can create a uniquely favorable milieu for early colonization by metastatic pancreatic cancer cells. A study now highlights mechanisms — such as neutrophil extracellular traps, or NETs — that drive this process; this could inform strategies for intercepting metastasis and improving survival.

    • Le Li
    • Florencia McAllister
    • Anirban Maitra
    News & Views
  • Circuitry-based neuroimaging analyses can enhance our understanding of abnormal brain functioning in patients with major depressive disorder and other psychiatric conditions — but their utility for guiding treatment selection is less certain.

    • Boadie W. Dunlop
    • Helen S. Mayberg
    News & Views
  • As diabetes technology evolves, implementation of equitable, sustainable, remote patient monitoring will ensure that this technology is accessible to everyone with type 1 diabetes — but strategies to address the burden of data collection and review are crucial.

    • Laura M. Nally
    • Jennifer L. Sherr
    News & Views
  • Bilateral administration of human OTOF gene therapy appears safe, and preliminary data suggest that it could effectively treat a rare form of hereditary hearing loss by enhancing speech perception, sound source localization and overall auditory experience.

    • Carson Smith
    • Mohammad Faraz Zafeer
    • Mustafa Tekin
    News & Views
  • Accumulating data support the systemic benefits of semaglutide (and potentially other GLP-1RA-based therapies) in people with obesity, meaning that cardiologists and other clinicians must become familiar with prescribing them — particularly once market competition makes these drugs more accessible.

    • Naveed Sattar
    • Matthew M. Y. Lee
    • Darren K. McGuire
    News & Views
  • Data from a large randomized trial show that a personalized diet can improve cardiometabolic health, providing support for a ‘food as medicine’ concept that, although centuries old, still lacks robust evidence.

    • Josef Neu
    News & Views
  • In an era of expanding perioperative approaches for resectable non–small-cell lung cancer, new data demonstrate that dual neoadjuvant immunotherapy targeting PD-1 and LAG-3 is feasible; future analyses may enhance patient selection by identifying immune signatures predictive of response.

    • Misty D. Shields
    • Christine M. Lovly
    News & Views
  • Large language models can translate the archaic language of pharmacy prescriptions into plain English, but reducing medication errors for patients will require interventions that go further.

    • Johanna I. Westbrook
    • Nasir Wabe
    • Magdalena Z. Raban
    News & Views
  • A pilot study suggests that the bispecific T cell engager blinatumomab may provide a new therapy for patients with refractory rheumatoid arthritis; larger studies and deep phenotyping will be crucial to thoroughly evaluate and optimize this approach.

    • Frances Humby
    • Bruce Kirkham
    • Leonie Taams
    News & Views
  • Vision–language models can be trained to read cardiac ultrasound images with implications for improving clinical workflows, but additional development and validation will be required before such models can replace humans.

    • Rima Arnaout
    News & Views
  • A strategy that controls confounders in quantitative microbiome data challenges the validity of previously reported microbial markers in colorectal cancer and serves as a wake-up call for the microbiome research field.

    • Na Jiao
    • Lixin Zhu
    • Ruixin Zhu
    News & Views
  • Food allergy treatment is undergoing a paradigm shift with new therapies emerging, including the recent FDA approval of omalizumab — but without evidence of disease modification and with uncertain quality-of-life improvement, it may not be a panacea for all.

    • Kirsten P. Perrett
    News & Views
  • AI models for tasks such as pathology and dermatology struggle to generalize to new patient groups or hospitals that they were not trained on; learning more robust features from unlabeled data could prevent overfitting to the training distribution and thereby increase fairness.

    • Rajiv Movva
    • Pang Wei Koh
    • Emma Pierson
    News & Views
  • A small, prospective clinical study shows that ex vivo drug screening of pediatric cancer samples can identify effective therapeutic options. If validated, these findings could herald a new approach to precision medicine in this setting.

    • M. Emmy M. Dolman
    • Paul G. Ekert
    News & Views
  • A large study of older adults in China points to physical and cognitive function — not age — as key predictors of heat-related mortality, highlighting the need for climate adaptation policies to prioritize accessibility across all age groups.

    • Josiah L. Kephart
    • Safiyyah M. Okoye
    News & Views
  • After many lean years, important progress has been made in updating the anti-tuberculosis drug armamentarium; a new drug that targets bacterial protein synthesis is one of several that could help transform the treatment of this neglected and deadly disease.

    • Eric L. Nuermberger
    • Richard E. Chaisson
    News & Views
  • A new study shows the benefits of treating anxiety to prevent postnatal depression — and highlights the need for more pragmatic research to simplify treatment packages, address other comorbid symptoms, and deliver effective perinatal mental health care at scale.

    • Daisy R. Singla
    News & Views