News & Views

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  • New strategies based on nucleic acid technologies are being exploited to treat chronic hepatitis B—a pilot clinical study of antisense oligonucleotide treatment shows the potential promise of this approach.

    • T. Jake Liang
    News & Views
  • A phase 1 trial shows the feasibility of a novel approach combining a powered hip exoskeleton with a passive leg prosthesis to improve the energy efficiency of walking.

    • Varun Nalam
    • He (Helen) Huang
    News & Views
  • Machine learning applied to electronic medical records can be used to create personalized lab-test reference ranges and to quantify disease risk, which will pave the way for precision medicine in clinical care.

    • Alice Tang
    • Tomiko Oskotsky
    • Marina Sirota
    News & Views
  • Cytokine blockade can improve the survival rate of patients with COVID-19 who are at risk of respiratory failure, but timing and patient selection are key.

    • Randy Q. Cron
    • Roberto Caricchio
    • W. Winn Chatham
    News & Views
  • The first preliminary evidence that in vivo gene editing in a clinical setting is feasible with no early signs of severe adverse events comes from an ongoing clinical trial to treat transthyretin amyloidosis, a fatal monogenetic disease.

    • Hildegard Büning
    • Axel Schambach
    News & Views
  • A new trial suggests that pirfenidone, an approved treatment for idiopathic pulmonary fibrosis, may also reduce myocardial fibrosis in patients with heart failure who have a preserved left ventricular ejection fraction.

    • John G. F. Cleland
    • Pierpaolo Pellicori
    • Arantxa González
    News & Views
  • Heterologous dosing with the adenovirus-based ChAdOx1 (AstraZeneca) vaccine followed by an mRNA vaccine induced stronger immune responses than did the homologous ChAdOx1 vaccine series, according to recent immunogenicity studies.

    • Meagan E. Deming
    • Kirsten E. Lyke
    News & Views
  • A new study unpacks the complexities of COVID-19 vaccine hesitancy and acceptance across low-, middle- and high-income countries.

    • Shingai Machingaidze
    • Charles Shey Wiysonge
    News & Views
  • A yeast strain engineered to regulate levels of pathogenic metabolites in the gut provides protection against colitis in mouse models.

    • Mark Mimee
    • Cathryn R. Nagler
    News & Views
  • A prospective cohort analysis finds a link between the ChAdOx1 vaccine and an autoimmune disorder known as immune thrombocytopenia—but questions remain and causality is yet to be established.

    • Allyson M. Pishko
    • James B. Bussel
    • Douglas B. Cines
    News & Views
  • A phase 3 study shows that MDMA may be a promising treatment for PTSD, which will require a shift in how this drug is perceived.

    • David J. Nutt
    • Harriet de Wit
    News & Views