News & Views

  • News & Views |

    Interleukin-8, produced by intratumoral and circulating myeloid cells, correlates with an immunosuppressive myeloid-enriched tumor microenvironment and adverse cancer prognosis.

    • Ziad Bakouny
    •  & Toni K. Choueiri
  • News & Views |

    Modeling an approach in which people who have recovered from COVID-19 are returned to society to reduce interactions between infected people and vulnerable people indicates the effectiveness of such an approach in reducing deaths.

    • Ole F. Norheim
  • News & Views |

    Deaths from opioid overdose in the USA have followed three distinct waves that have all affected baby boomers, generation X and millennials.

    • Wayne Hall
    • , Louisa Degenhardt
    •  & Matthew Hickman
  • News & Views |

    Novel RNA-targeting antisense therapy is shown to reduce lipoprotein(a) levels in 286 patients with existing atherosclerotic disease by upwards of 80% in a phase 2 clinical trial.

    • Archna Bajaj
    •  & Daniel J. Rader
  • News & Views |

    A trial of a therapeutic vaccine against HIV induces cellular immunity and, although it provides hope, it highlights the hurdles for the development of such strategies.

    • Beatriz Mothe
    •  & Christian Brander
  • News & Views |

    Analysis of the intestinal content of fetuses suggests very limited bacterial colonization with potential immunological roles, which opens new research questions.

    • Maria Carmen Collado
    •  & Nicola Segata
  • News & Views |

    Wireless monitoring of vital signs in the neonatal intensive care unit enables the detection of vital signs, body movement, and vocalization.

    • Prakesh S. Shah
  • News & Views |

    A study in Peru of community-wide implementation of the use of salt substitution strengthens the evidence for its use as a public-health strategy to reduce blood pressure and, thus, chronic disease risk.

    • Feng J. He
    • , Monique Tan
    • , Jing Song
    •  & Graham A. MacGregor
  • News & Views |

    In late December 2019, a cluster of patients with ‘atypical pneumonia’ of unknown etiology was reported in Wuhan, China. A novel human coronavirus, now provisionally called ‘SARS-CoV-2’, was identified as the cause of this disease, now named ‘COVID-19’.

    • Leo L. M. Poon
    •  & Malik Peiris
  • News & Views |

    Cells develop a heterogeneous response to KRAS inhibitors, bypassing their anti-growth effects by producing more of the protein that does not bind the inhibitor.

    • Aaron N. Hata
    •  & Alice T. Shaw
  • News & Views |

    A new positron emission tomography radiotracer enables imaging of the human glutamate receptor AMPA-R, a fundamental component of neurotransmission involved in neuropsychiatric disorders.

    • John H. Krystal
  • News & Views |

    A statistical model based on an analysis of routinely collected data from 1980 to 2017 predicts 1,601 excess injury deaths per year in the contiguous USA if average temperatures rise by 1.5 °C.

    • Shanthi Ameratunga
    •  & Alistair Woodward
  • News & Views |

    A recent analysis highlighting the potential for algorithms to perpetuate existing racial biases in healthcare underscores the importance of thinking carefully about the labels used during algorithm development.

    • Jenna Wiens
    • , W. Nicholson Price II
    •  & Michael W. Sjoding
  • News & Views |

    Enteroviral infection persistence as determined by host genetic susceptibility, rather than independent, short-lived infections, may contribute to islet autoimmunity and be a precursor to the development of type 1 diabetes.

    • Bart O. Roep
  • News & Views |

    There is a transgenerational increase in the susceptibility of female offspring to developing PCOS that occurs via the female germline and is linked to fetal exposure to excess androgen.

    • H. M. Picton
    •  & A. H. Balen
  • News & Views |

    Ultra-deep sequencing of paired plasma-circulating free DNA and white blood cells allows the identification of tumor-derived somatic mutations with high accuracy by filtering out variants consistent with clonal hematopoiesis.

    • Beatriz Bellosillo
    •  & Clara Montagut
  • News & Views |

    New findings regarding the risks of over-the-counter probiotics in critically ill patients underscore the need for microbiota-targeted therapies that are based on efficacy in a disease- and host-specific context.

    • Bastiaan W. Haak
    •  & W. Joost Wiersinga
  • News & Views |

    Dapagliflozin, a sodium-glucose co-transporter-2 inhibitor, reduced the risk of cardiovascular death or heart failure events in 4,744 patients with chronic heart failure with reduced ejection fraction.

    • Muthiah Vaduganathan
    •  & Javed Butler
  • News & Views |

    Homozygous APOE3-Christchurch (R136S) mutation protects a presenilin 1 (PSEN1) mutation carrier from developing Alzheimer’s disease until her seventies.

    • Kelly A. Zalocusky
    • , Maxine R. Nelson
    •  & Yadong Huang
  • News & Views |

    An engineered truncated gene derived from the dystrophin-related protein (utrophin), prevents pathology without an immune response in an animal model of Duchenne muscular dystrophy (DMD) gene therapy.

    • Kay E. Davies
    •  & Jeffrey S. Chamberlain
  • News & Views |

    Antibodies elicited by the widely deployed rVSV-EBOV Ebola virus vaccine mirror those of disease survivors, animal models and other vaccine platforms. Notably, neutralizing antibodies are consistently elicited from a recurring pair of germline genes.

    • Erica Ollmann Saphire
  • News & Views |

    A novel oral capsule can deploy microneedle patches that release drugs into the intestinal wall for uptake into the bloodstream as shown in animal studies, thereby avoiding injections.

    • Mark R. Prausnitz
    • , Yasmine Gomaa
    •  & Wei Li
  • News & Views |

    Single-cell RNA sequencing characterizes clonal dynamics and distinct cellular states contributing to intratumoral heterogeneity in glioblastoma and medulloblastoma.

    • Maleeha A. Qazi
    • , David Bakhshinyan
    •  & Sheila K. Singh
  • News & Views |

    A microscope equipped with augmented display and accurate deep-learning models for real-time detection and highlighting of cancerous cells enables detection of breast cancer lymph node metastasis and prostate cancer.

    • Narges Razavian
  • News & Views |

    Infants with congenital Zika virus infection are at risk for multiple abnormalities related to impairment in neurodevelopment. Although some findings apparent at birth may resolve with time, infants with no abnormalities apparent at birth may develop problems in early childhood.

    • William J. Muller
    •  & Sarah B. Mulkey
  • News & Views |

    TCF21, a gene associated with coronary heart disease, promotes plaque stability and reduces clinical events by enhancing smooth muscle cell phenotype modulation into “fibromyocytes” in atherosclerosis.

    • Huize Pan
    •  & Muredach P. Reilly
  • News & Views |

    Large-scale analysis of 49 countries in Africa shows improvements in the prevalence of babies under 6 months of age being fed only breast milk, but there are large disparities in progress across and within countries.

    • Penelope Reimers
    • , Chantell Witten
    •  & Anna Coutsoudis
  • News & Views |

    Machine learning can use patients’ demographic information and previous clinical history to help physicians select the antibiotics most likely to successfully treat urinary tract infections, despite growing levels of resistance.

    • Xavier Didelot
    •  & Koen B. Pouwels
  • News & Views |

    Quorum-sensing bacteria can deliver a nanobody targeting the ‘don’t eat me’ ligand CD47 to tumors that results in systemic anti-tumor immunity-induced regression in mice.

    • Michael Dougan
    •  & Stephanie K. Dougan
  • News & Views |

    The prevalence of excess weight gain is increasing more rapidly in rural than in urban environments. Increased intake of ultra-processed foods has been associated with obesity, and the rise of supermarkets and marketing strategies may have contributed to the greater weight increases in rural areas.

    • William H. Dietz
  • News & Views |

    Heat-inactivated Akkermansia muciniphila helps alleviate features of metabolic syndrome in overweight and obese subjects.

    • Fernando F. Anhê
    • , Jonathan D. Schertzer
    •  & André Marette
  • News & Views |

    Assessment of more than 400,000 people over the age of 40 demonstrates that homozygosity for a CCR5 variant that prevents HIV-1 infection comes at the cost of increased rates of mortality.

    • Jeremy Luban