Articles

  • Article |

    Malaria cases are predominant during the rainy seasons in many endemic regions owing to the life cycle of the mosquito vector. How Plasmodium falciparum adapts in humans during the intervening dry season, without causing malaria symptoms or killing the host, offers new insights into its persistence in humans.

    • Carolina M. Andrade
    • , Hannah Fleckenstein
    • , Richard Thomson-Luque
    • , Safiatou Doumbo
    • , Nathalia F. Lima
    • , Carrie Anderson
    • , Julia Hibbert
    • , Christine S. Hopp
    • , Tuan M. Tran
    • , Shanping Li
    • , Moussa Niangaly
    • , Hamidou Cisse
    • , Didier Doumtabe
    • , Jeff Skinner
    • , Dan Sturdevant
    • , Stacy Ricklefs
    • , Kimmo Virtaneva
    • , Muhammad Asghar
    • , Manijeh Vafa Homann
    • , Louise Turner
    • , Joana Martins
    • , Erik L. Allman
    • , Marie-Esther N’Dri
    • , Volker Winkler
    • , Manuel Llinás
    • , Catherine Lavazec
    • , Craig Martens
    • , Anna Färnert
    • , Kassoum Kayentao
    • , Aissata Ongoiba
    • , Thomas Lavstsen
    • , Nuno S. Osório
    • , Thomas D. Otto
    • , Mario Recker
    • , Boubacar Traore
    • , Peter D. Crompton
    •  & Silvia Portugal
  • Article |

    A single-cell map of transcriptomic changes during acute liver failure unveils new insights into pathogenesis and potential therapeutic targets.

    • Aleksandra A. Kolodziejczyk
    • , Sara Federici
    • , Niv Zmora
    • , Gayatree Mohapatra
    • , Mally Dori-Bachash
    • , Shanni Hornstein
    • , Avner Leshem
    • , Debby Reuveni
    • , Ehud Zigmond
    • , Ana Tobar
    • , Tomer Meir Salame
    • , Alon Harmelin
    • , Amir Shlomai
    • , Hagit Shapiro
    • , Ido Amit
    •  & Eran Elinav
  • Article
    | Open Access

    A modeling study using case and mortality data from the first 8 months of the COVID-19 pandemic in the United States explores five potential future scenarios of social distancing mandates and mask use at the state level, with projections of the course of the epidemic through winter 2021.

    • Robert C. Reiner Jr
    • , Ryan M. Barber
    • , James K. Collins
    • , Peng Zheng
    • , Christopher Adolph
    • , James Albright
    • , Catherine M. Antony
    • , Aleksandr Y. Aravkin
    • , Steven D. Bachmeier
    • , Bree Bang-Jensen
    • , Marlena S. Bannick
    • , Sabina Bloom
    • , Austin Carter
    • , Emma Castro
    • , Kate Causey
    • , Suman Chakrabarti
    • , Fiona J. Charlson
    • , Rebecca M. Cogen
    • , Emily Combs
    • , Xiaochen Dai
    • , William James Dangel
    • , Lucas Earl
    • , Samuel B. Ewald
    • , Maha Ezalarab
    • , Alize J. Ferrari
    • , Abraham Flaxman
    • , Joseph Jon Frostad
    • , Nancy Fullman
    • , Emmanuela Gakidou
    • , John Gallagher
    • , Scott D. Glenn
    • , Erik A. Goosmann
    • , Jiawei He
    • , Nathaniel J. Henry
    • , Erin N. Hulland
    • , Benjamin Hurst
    • , Casey Johanns
    • , Parkes J. Kendrick
    • , Apurva Khemani
    • , Samantha Leigh Larson
    • , Alice Lazzar-Atwood
    • , Kate E. LeGrand
    • , Haley Lescinsky
    • , Akiaja Lindstrom
    • , Emily Linebarger
    • , Rafael Lozano
    • , Rui Ma
    • , Johan Månsson
    • , Beatrice Magistro
    • , Ana M. Mantilla Herrera
    • , Laurie B. Marczak
    • , Molly K. Miller-Petrie
    • , Ali H. Mokdad
    • , Julia Deryn Morgan
    • , Paulami Naik
    • , Christopher M. Odell
    • , James K. O’Halloran
    • , Aaron E. Osgood-Zimmerman
    • , Samuel M. Ostroff
    • , Maja Pasovic
    • , Louise Penberthy
    • , Geoffrey Phipps
    • , David M. Pigott
    • , Ian Pollock
    • , Rebecca E. Ramshaw
    • , Sofia Boston Redford
    • , Grace Reinke
    • , Sam Rolfe
    • , Damian Francesco Santomauro
    • , John R. Shackleton
    • , David H. Shaw
    • , Brittney S. Sheena
    • , Aleksei Sholokhov
    • , Reed J. D. Sorensen
    • , Gianna Sparks
    • , Emma Elizabeth Spurlock
    • , Michelle L. Subart
    • , Ruri Syailendrawati
    • , Anna E. Torre
    • , Christopher E. Troeger
    • , Theo Vos
    • , Alexandrea Watson
    • , Stefanie Watson
    • , Kirsten E. Wiens
    • , Lauren Woyczynski
    • , Liming Xu
    • , Jize Zhang
    • , Simon I. Hay
    • , Stephen S. Lim
    •  & Christopher J. L. Murray
  • Article |

    The largest whole-exome sequencing study of sporadic congenital hydrocephalus identities mutations associated with disrupted fetal neuro-gliogenesis as the primary pathophysiological event in a significant number of cases.

    • Sheng Chih Jin
    • , Weilai Dong
    • , Adam J. Kundishora
    • , Shreyas Panchagnula
    • , Andres Moreno-De-Luca
    • , Charuta G. Furey
    • , August A. Allocco
    • , Rebecca L. Walker
    • , Carol Nelson-Williams
    • , Hannah Smith
    • , Ashley Dunbar
    • , Sierra Conine
    • , Qiongshi Lu
    • , Xue Zeng
    • , Michael C. Sierant
    • , James R. Knight
    • , William Sullivan
    • , Phan Q. Duy
    • , Tyrone DeSpenza
    • , Benjamin C. Reeves
    • , Jason K. Karimy
    • , Arnaud Marlier
    • , Christopher Castaldi
    • , Irina R. Tikhonova
    • , Boyang Li
    • , Helena Perez Peña
    • , James R. Broach
    • , Edith M. Kabachelor
    • , Peter Ssenyonga
    • , Christine Hehnly
    • , Li Ge
    • , Boris Keren
    • , Andrew T. Timberlake
    • , June Goto
    • , Francesco T. Mangano
    • , James M. Johnston
    • , William E. Butler
    • , Benjamin C. Warf
    • , Edward R. Smith
    • , Steven J. Schiff
    • , David D. Limbrick Jr
    • , Gregory Heuer
    • , Eric M. Jackson
    • , Bermans J. Iskandar
    • , Shrikant Mane
    • , Shozeb Haider
    • , Bulent Guclu
    • , Yasar Bayri
    • , Yener Sahin
    • , Charles C. Duncan
    • , Michael L. J. Apuzzo
    • , Michael L. DiLuna
    • , Ellen J. Hoffman
    • , Nenad Sestan
    • , Laura R. Ment
    • , Seth L. Alper
    • , Kaya Bilguvar
    • , Daniel H. Geschwind
    • , Murat Günel
    • , Richard P. Lifton
    •  & Kristopher T. Kahle
  • Article |

    Tumor-secreted midkine modulates immune tolerance in the melanoma tumor microenvironment and determines resistance to immune checkpoint blockade.

    • Daniela Cerezo-Wallis
    • , Marta Contreras-Alcalde
    • , Kevin Troulé
    • , Xavier Catena
    • , Cynthia Mucientes
    • , Tonantzin G. Calvo
    • , Estela Cañón
    • , Cristina Tejedo
    • , Paula C. Pennacchi
    • , Sabrina Hogan
    • , Peter Kölblinger
    • , Héctor Tejero
    • , Andrew X. Chen
    • , Nuria Ibarz
    • , Osvaldo Graña-Castro
    • , Lola Martinez
    • , Javier Muñoz
    • , Pablo Ortiz-Romero
    • , José L. Rodriguez-Peralto
    • , Gonzalo Gómez-López
    • , Fátima Al-Shahrour
    • , Raúl Rabadán
    • , Mitchell P. Levesque
    • , David Olmeda
    •  & María S. Soengas
  • Article |

    The risk of developing active tuberculosis (TB) in individuals with latent TB infection is highly variable within and among different risk groups. A personalized risk predictor was developed to better target preventative treatment to individuals at greatest risk, supporting evidence-based clinical decision-making for latent TB.

    • Rishi K. Gupta
    • , Claire J. Calderwood
    • , Alexei Yavlinsky
    • , Maria Krutikov
    • , Matteo Quartagno
    • , Maximilian C. Aichelburg
    • , Neus Altet
    • , Roland Diel
    • , Claudia C. Dobler
    • , Jose Dominguez
    • , Joseph S. Doyle
    • , Connie Erkens
    • , Steffen Geis
    • , Pranabashis Haldar
    • , Anja M. Hauri
    • , Thomas Hermansen
    • , James C. Johnston
    • , Christoph Lange
    • , Berit Lange
    • , Frank van Leth
    • , Laura Muñoz
    • , Christine Roder
    • , Kamila Romanowski
    • , David Roth
    • , Martina Sester
    • , Rosa Sloot
    • , Giovanni Sotgiu
    • , Gerrit Woltmann
    • , Takashi Yoshiyama
    • , Jean-Pierre Zellweger
    • , Dominik Zenner
    • , Robert W. Aldridge
    • , Andrew Copas
    • , Molebogeng X. Rangaka
    • , Marc Lipman
    • , Mahdad Noursadeghi
    •  & Ibrahim Abubakar
  • Article |

    Application of Bayesian models to vital statistics data from 21 industrialized countries shows that approximately 206,000 additional people died than if the COVID-19 pandemic had not occured. The heterogeneous distribution of excess deaths across the countries reflects differences in how the pandemic has been managed as well as the resilience of healthcare systems in these nations.

    • Vasilis Kontis
    • , James E. Bennett
    • , Theo Rashid
    • , Robbie M. Parks
    • , Jonathan Pearson-Stuttard
    • , Michel Guillot
    • , Perviz Asaria
    • , Bin Zhou
    • , Marco Battaglini
    • , Gianni Corsetti
    • , Martin McKee
    • , Mariachiara Di Cesare
    • , Colin D. Mathers
    •  & Majid Ezzati
  • Article |

    The Zero Childhood Cancer pediatric precision medicine program informs treatment recommendations for children with high-risk cancers through comprehensive molecular profiling

    • Marie Wong
    • , Chelsea Mayoh
    • , Loretta M. S. Lau
    • , Dong-Anh Khuong-Quang
    • , Mark Pinese
    • , Amit Kumar
    • , Paulette Barahona
    • , Emilie E. Wilkie
    • , Patricia Sullivan
    • , Rachel Bowen-James
    • , Mustafa Syed
    • , Iñigo Martincorena
    • , Federico Abascal
    • , Alexandra Sherstyuk
    • , Noemi A. Bolanos
    • , Jonathan Baber
    • , Peter Priestley
    • , M. Emmy M. Dolman
    • , Emmy D. G. Fleuren
    • , Marie-Emilie Gauthier
    • , Emily V. A. Mould
    • , Velimir Gayevskiy
    • , Andrew J. Gifford
    • , Dylan Grebert-Wade
    • , Patrick A. Strong
    • , Elodie Manouvrier
    • , Meera Warby
    • , David M. Thomas
    • , Judy Kirk
    • , Katherine Tucker
    • , Tracey O’Brien
    • , Frank Alvaro
    • , Geoffry B. McCowage
    • , Luciano Dalla-Pozza
    • , Nicholas G. Gottardo
    • , Heather Tapp
    • , Paul Wood
    • , Seong-Lin Khaw
    • , Jordan R. Hansford
    • , Andrew S. Moore
    • , Murray D. Norris
    • , Toby N. Trahair
    • , Richard B. Lock
    • , Vanessa Tyrrell
    • , Michelle Haber
    • , Glenn M. Marshall
    • , David S. Ziegler
    • , Paul G. Ekert
    •  & Mark J. Cowley
  • Article |

    Single-cell transcriptomics reveals that the heterogeneity of anti-CD19 CAR T cell infusion products contributes to variability in clinical response, early molecular response and development of immune effector cell-associated neurotoxicity syndrome in patients with large B cell lymphomas.

    • Qing Deng
    • , Guangchun Han
    • , Nahum Puebla-Osorio
    • , Man Chun John Ma
    • , Paolo Strati
    • , Beth Chasen
    • , Enyu Dai
    • , Minghao Dang
    • , Neeraj Jain
    • , Haopeng Yang
    • , Yuanxin Wang
    • , Shaojun Zhang
    • , Ruiping Wang
    • , Runzhe Chen
    • , Jordan Showell
    • , Sreejoyee Ghosh
    • , Sridevi Patchva
    • , Qi Zhang
    • , Ryan Sun
    • , Frederick Hagemeister
    • , Luis Fayad
    • , Felipe Samaniego
    • , Hans C. Lee
    • , Loretta J. Nastoupil
    • , Nathan Fowler
    • , R. Eric Davis
    • , Jason Westin
    • , Sattva S. Neelapu
    • , Linghua Wang
    •  & Michael R. Green
  • Article |

    A human stem cell–derived model helps to uncover neuronal phenotypes associated with genetic forms of neuropsychiatric disease.

    • Themasap A. Khan
    • , Omer Revah
    • , Aaron Gordon
    • , Se-Jin Yoon
    • , Anna K. Krawisz
    • , Carleton Goold
    • , Yishan Sun
    • , Chul Hoon Kim
    • , Yuan Tian
    • , Min-Yin Li
    • , Julia M. Schaepe
    • , Kazuya Ikeda
    • , Neal D. Amin
    • , Noriaki Sakai
    • , Masayuki Yazawa
    • , Leila Kushan
    • , Seiji Nishino
    • , Matthew H. Porteus
    • , Judith L. Rapoport
    • , Jonathan A. Bernstein
    • , Ruth O’Hara
    • , Carrie E. Bearden
    • , Joachim F. Hallmayer
    • , John R. Huguenard
    • , Daniel H. Geschwind
    • , Ricardo E. Dolmetsch
    •  & Sergiu P. Paşca
  • Article |

    Single-cell transcriptomics analysis of endometrium samples from healthy women collected across the menstrual cycle provides insights into the cellular and molecular changes surrounding and during the implantation window in the absence of pregnancy.

    • Wanxin Wang
    • , Felipe Vilella
    • , Pilar Alama
    • , Inmaculada Moreno
    • , Marco Mignardi
    • , Alina Isakova
    • , Wenying Pan
    • , Carlos Simon
    •  & Stephen R. Quake
  • Article |

    Biomarker analysis of the phase 3 JAVELIN Renal 101 trial uncovers molecular determinants of therapy-specific outcomes, which may inform personalized treatment strategies for patients with advanced renal cell carcinoma.

    • Robert J. Motzer
    • , Paul B. Robbins
    • , Thomas Powles
    • , Laurence Albiges
    • , John B. Haanen
    • , James Larkin
    • , Xinmeng Jasmine Mu
    • , Keith A. Ching
    • , Motohide Uemura
    • , Sumanta K. Pal
    • , Boris Alekseev
    • , Gwenaelle Gravis
    • , Matthew T. Campbell
    • , Konstantin Penkov
    • , Jae Lyun Lee
    • , Subramanian Hariharan
    • , Xiao Wang
    • , Weidong Zhang
    • , Jing Wang
    • , Aleksander Chudnovsky
    • , Alessandra di Pietro
    • , Amber C. Donahue
    •  & Toni K. Choueiri
  • Article |

    Chimeric antigen receptor T cells targeting HIV-infected cells prevent T cell loss and reduce virus in blood and tissues of HIV-infected humanized mice, highlighting a path toward a cell-based therapy for HIV infection.

    • Colby R. Maldini
    • , Daniel T. Claiborne
    • , Ken Okawa
    • , Tao Chen
    • , Derrick L. Dopkin
    • , Xiaochuan Shan
    • , Karen A. Power
    • , Radiana T. Trifonova
    • , Katharine Krupp
    • , Meredith Phelps
    • , Vladimir D. Vrbanac
    • , Serah Tanno
    • , Timothy Bateson
    • , George J. Leslie
    • , James A. Hoxie
    • , Christian L. Boutwell
    • , James L. Riley
    •  & Todd M. Allen
  • Article |

    Using magnetic resonance images of the heart and aorta from 26,893 individuals in the UK Biobank, a phenome-wide association study associates cardiovascular imaging phenotypes with a wide range of demographic, lifestyle and clinical features.

    • Wenjia Bai
    • , Hideaki Suzuki
    • , Jian Huang
    • , Catherine Francis
    • , Shuo Wang
    • , Giacomo Tarroni
    • , Florian Guitton
    • , Nay Aung
    • , Kenneth Fung
    • , Steffen E. Petersen
    • , Stefan K. Piechnik
    • , Stefan Neubauer
    • , Evangelos Evangelou
    • , Abbas Dehghan
    • , Declan P. O’Regan
    • , Martin R. Wilkins
    • , Yike Guo
    • , Paul M. Matthews
    •  & Daniel Rueckert
  • Article |

    Elevated levels of serum IL-6 and TNF-α at the time of hospitalization are independent and significant predictors of clinical outcome in two cohorts of patients with COVID-19.

    • Diane Marie Del Valle
    • , Seunghee Kim-Schulze
    • , Hsin-Hui Huang
    • , Noam D. Beckmann
    • , Sharon Nirenberg
    • , Bo Wang
    • , Yonit Lavin
    • , Talia H. Swartz
    • , Deepu Madduri
    • , Aryeh Stock
    • , Thomas U. Marron
    • , Hui Xie
    • , Manishkumar Patel
    • , Kevin Tuballes
    • , Oliver Van Oekelen
    • , Adeeb Rahman
    • , Patricia Kovatch
    • , Judith A. Aberg
    • , Eric Schadt
    • , Sundar Jagannath
    • , Madhu Mazumdar
    • , Alexander W. Charney
    • , Adolfo Firpo-Betancourt
    • , Damodara Rao Mendu
    • , Jeffrey Jhang
    • , David Reich
    • , Keith Sigel
    • , Carlos Cordon-Cardo
    • , Marc Feldmann
    • , Samir Parekh
    • , Miriam Merad
    •  & Sacha Gnjatic
  • Article |

    A common immune signature in the blood of patients with COVID-19, who are otherwise clinically heterogeneous, sheds light into the pathogenesis and clinical progression of the disease.

    • Adam G. Laing
    • , Anna Lorenc
    • , Irene del Molino del Barrio
    • , Abhishek Das
    • , Matthew Fish
    • , Leticia Monin
    • , Miguel Muñoz-Ruiz
    • , Duncan R. McKenzie
    • , Thomas S. Hayday
    • , Isaac Francos-Quijorna
    • , Shraddha Kamdar
    • , Magdalene Joseph
    • , Daniel Davies
    • , Richard Davis
    • , Aislinn Jennings
    • , Iva Zlatareva
    • , Pierre Vantourout
    • , Yin Wu
    • , Vasiliki Sofra
    • , Florencia Cano
    • , Maria Greco
    • , Efstathios Theodoridis
    • , Joshua Freedman
    • , Sarah Gee
    • , Julie Nuo En Chan
    • , Sarah Ryan
    • , Eva Bugallo-Blanco
    • , Pärt Peterson
    • , Kai Kisand
    • , Liis Haljasmägi
    • , Loubna Chadli
    • , Philippe Moingeon
    • , Lauren Martinez
    • , Blair Merrick
    • , Karen Bisnauthsing
    • , Kate Brooks
    • , Mohammad A. A. Ibrahim
    • , Jeremy Mason
    • , Federico Lopez Gomez
    • , Kola Babalola
    • , Sultan Abdul-Jawad
    • , John Cason
    • , Christine Mant
    • , Jeffrey Seow
    • , Carl Graham
    • , Katie J. Doores
    • , Francesca Di Rosa
    • , Jonathan Edgeworth
    • , Manu Shankar-Hari
    •  & Adrian C. Hayday
  • Article |

    In a phase II clinical trial of patients with classical Hodgkin lymphoma, peripheral CD4+ T cell receptor diversity and the abundance of mature natural killer cells and CD3CD68+CD4+GrB+ innate cells were associated with favorable responses to anti-PD-1 monotherapy.

    • Fathima Zumla Cader
    • , Xihao Hu
    • , Walter L. Goh
    • , Kirsty Wienand
    • , Jing Ouyang
    • , Elisa Mandato
    • , Robert Redd
    • , Lee N. Lawton
    • , Pei-Hsuan Chen
    • , Jason L. Weirather
    • , Ron C. J. Schackmann
    • , Bo Li
    • , Wenjiang Ma
    • , Philippe Armand
    • , Scott J. Rodig
    • , Donna Neuberg
    • , X. Shirley Liu
    •  & Margaret A. Shipp
  • Article |

    Multimodal single-cell profiling reveals heterogeneity of colonic CD8+ T cells in patients with ulcerative colitis, including expansion of a chronically activated IL-26-expressing subpopulation with innate-like features.

    • Daniele Corridoni
    • , Agne Antanaviciute
    • , Tarun Gupta
    • , David Fawkner-Corbett
    • , Anna Aulicino
    • , Marta Jagielowicz
    • , Kaushal Parikh
    • , Emmanouela Repapi
    • , Steve Taylor
    • , Dai Ishikawa
    • , Ryo Hatano
    • , Taketo Yamada
    • , Wei Xin
    • , Hubert Slawinski
    • , Rory Bowden
    • , Giorgio Napolitani
    • , Oliver Brain
    • , Chikao Morimoto
    • , Hashem Koohy
    •  & Alison Simmons
  • Article |

    A pilot clinical trial evaluating metformin in patients with pediatric brain tumors shows that it is a safe approach resulting in improved cognitive function that is consistent with the recovery of adult hippocampal neurogenesis observed in mouse models.

    • Ramy Ayoub
    • , Rebecca M. Ruddy
    • , Elizabeth Cox
    • , Adeoye Oyefiade
    • , Daniel Derkach
    • , Suzanne Laughlin
    • , Benjamin Ades-aron
    • , Zahra Shirzadi
    • , Els Fieremans
    • , Bradley J. MacIntosh
    • , Cynthia B. de Medeiros
    • , Jovanka Skocic
    • , Eric Bouffet
    • , Freda D. Miller
    • , Cindi M. Morshead
    •  & Donald J. Mabbott
  • Article |

    In a new strategy for increasing the availability of lungs for transplantation, human lungs declined for transplantation because of their poor quality can be recuperated by connecting them to the circulation of a pig.

    • Ahmed E. Hozain
    • , John D. O’Neill
    • , Meghan R. Pinezich
    • , Yuliya Tipograf
    • , Rachel Donocoff
    • , Katherine M. Cunningham
    • , Andrew Tumen
    • , Kenmond Fung
    • , Rei Ukita
    • , Michael T. Simpson
    • , Jonathan A. Reimer
    • , Edward C. Ruiz
    • , Dawn Queen
    • , John W. Stokes
    • , Nancy L. Cardwell
    • , Jennifer Talackine
    • , Jinho Kim
    • , Hans-Willem Snoeck
    • , Ya-Wen Chen
    • , Alexander Romanov
    • , Charles C. Marboe
    • , Adam D. Griesemer
    • , Brandon A. Guenthart
    • , Matthew Bacchetta
    •  & Gordana Vunjak-Novakovic
  • Article |

    Multiple subpopulations of synovial tissue macrophages with varied transcriptional, phenotypic and functional features may contribute to disease flare and tissue repair in patients with active rheumatoid arthritis and patients in clinical remission.

    • Stefano Alivernini
    • , Lucy MacDonald
    • , Aziza Elmesmari
    • , Samuel Finlay
    • , Barbara Tolusso
    • , Maria Rita Gigante
    • , Luca Petricca
    • , Clara Di Mario
    • , Laura Bui
    • , Simone Perniola
    • , Moustafa Attar
    • , Marco Gessi
    • , Anna Laura Fedele
    • , Sabarinadh Chilaka
    • , Domenico Somma
    • , Stephen N. Sansom
    • , Andrew Filer
    • , Charles McSharry
    • , Neal L. Millar
    • , Kristina Kirschner
    • , Alessandra Nerviani
    • , Myles J. Lewis
    • , Costantino Pitzalis
    • , Andrew R. Clark
    • , Gianfranco Ferraccioli
    • , Irina Udalova
    • , Christopher D. Buckley
    • , Elisa Gremese
    • , Iain B. McInnes
    • , Thomas D. Otto
    •  & Mariola Kurowska-Stolarska
  • Article |

    The PREDICT 1 trial shows large inter-individual variations in postprandial metabolic responses to standardized meals in over 1,000 participants, demonstrating potential for development of personalized nutrition strategies.

    • Sarah E. Berry
    • , Ana M. Valdes
    • , David A. Drew
    • , Francesco Asnicar
    • , Mohsen Mazidi
    • , Jonathan Wolf
    • , Joan Capdevila
    • , George Hadjigeorgiou
    • , Richard Davies
    • , Haya Al Khatib
    • , Christopher Bonnett
    • , Sajaysurya Ganesh
    • , Elco Bakker
    • , Deborah Hart
    • , Massimo Mangino
    • , Jordi Merino
    • , Inbar Linenberg
    • , Patrick Wyatt
    • , Jose M. Ordovas
    • , Christopher D. Gardner
    • , Linda M. Delahanty
    • , Andrew T. Chan
    • , Nicola Segata
    • , Paul W. Franks
    •  & Tim D. Spector
  • Article
    | Open Access

    Spatiotemporal characterization of microbial diversity and antibiotic resistance in a tertiary-care hospital reveals broad distribution and persistence of antibiotic-resistant organisms that could cause opportunistic infections in a healthcare setting.

    • Kern Rei Chng
    • , Chenhao Li
    • , Denis Bertrand
    • , Amanda Hui Qi Ng
    • , Junmei Samantha Kwah
    • , Hwee Meng Low
    • , Chengxuan Tong
    • , Maanasa Natrajan
    • , Michael Hongjie Zhang
    • , Licheng Xu
    • , Karrie Kwan Ki Ko
    • , Eliza Xin Pei Ho
    • , Tamar V. Av-Shalom
    • , Jeanette Woon Pei Teo
    • , Chiea Chuen Khor
    • , David Danko
    • , Daniela Bezdan
    • , Ebrahim Afshinnekoo
    • , Sofia Ahsanuddin
    • , Chandrima Bhattacharya
    • , Daniel J. Butler
    • , Kern Rei Chng
    • , Francesca De Filippis
    • , Jochen Hecht
    • , Andre Kahles
    • , Mikhail Karasikov
    • , Nikos C. Kyrpides
    • , Marcus H. Y. Leung
    • , Dmitry Meleshko
    • , Harun Mustafa
    • , Beth Mutai
    • , Russell Y. Neches
    • , Amanda Ng
    • , Marina Nieto-Caballero
    • , Olga Nikolayeva
    • , Tatyana Nikolayeva
    • , Eileen Png
    • , Jorge L. Sanchez
    • , Heba Shaaban
    • , Maria A. Sierra
    • , Xinzhao Tong
    • , Ben Young
    • , Josue Alicea
    • , Malay Bhattacharyya
    • , Ran Blekhman
    • , Eduardo Castro-Nallar
    • , Ana M. Cañas
    • , Aspassia D. Chatziefthimiou
    • , Robert W. Crawford
    • , Youping Deng
    • , Christelle Desnues
    • , Emmanuel Dias-Neto
    • , Daisy Donnellan
    • , Marius Dybwad
    • , Eran Elhaik
    • , Danilo Ercolini
    • , Alina Frolova
    • , Alexandra B. Graf
    • , David C. Green
    • , Iman Hajirasouliha
    • , Mark Hernandez
    • , Gregorio Iraola
    • , Soojin Jang
    • , Angela Jones
    • , Frank J. Kelly
    • , Kaymisha Knights
    • , Paweł P. Łabaj
    • , Patrick K. H. Lee
    • , Levy Shawn
    • , Per Ljungdahl
    • , Abigail Lyons
    • , Gabriella Mason-Buck
    • , Ken McGrath
    • , Emmanuel F. Mongodin
    • , Milton Ozorio Moraes
    • , Niranjan Nagarajan
    • , Houtan Noushmehr
    • , Manuela Oliveira
    • , Stephan Ossowski
    • , Olayinka O. Osuolale
    • , Orhan Özcan
    • , David Paez-Espino
    • , Nicolas Rascovan
    • , Hugues Richard
    • , Gunnar Rätsch
    • , Lynn M. Schriml
    • , Torsten Semmler
    • , Osman U. Sezerman
    • , Leming Shi
    • , Le Huu Song
    • , Haruo Suzuki
    • , Denise Syndercombe Court
    • , Dominique Thomas
    • , Scott W. Tighe
    • , Klas I. Udekwu
    • , Juan A. Ugalde
    • , Brandon Valentine
    • , Dimitar I. Vassilev
    • , Elena Vayndorf
    • , Thirumalaisamy P. Velavan
    • , María M. Zambrano
    • , Jifeng Zhu
    • , Sibo Zhu
    • , Christopher E. Mason
    • , Swaine L. Chen
    • , Christopher E. Mason
    • , Oon Tek Ng
    • , Kalisvar Marimuthu
    • , Brenda Ang
    •  & Niranjan Nagarajan
  • Article |

    An iPSC-based three-dimensional model of the human blood–brain barrier reveals that NFAT and APOE dysregulation in pericyte-like mural cells contributes to cerebral amyloid angiopathy and can potentially be targeted to treat Alzheimer’s disease.

    • Joel W. Blanchard
    • , Michael Bula
    • , Jose Davila-Velderrain
    • , Leyla Anne Akay
    • , Lena Zhu
    • , Alexander Frank
    • , Matheus B. Victor
    • , Julia Maeve Bonner
    • , Hansruedi Mathys
    • , Yuan-Ta Lin
    • , Tak Ko
    • , David A. Bennett
    • , Hugh P. Cam
    • , Manolis Kellis
    •  & Li-Huei Tsai
  • Article |

    A new approach for whole-genome sequencing of plasma circulating tumor DNA allows for dynamic monitoring of disease burden and ultra-sensitive detection of minimal residual disease.

    • Asaf Zviran
    • , Rafael C. Schulman
    • , Minita Shah
    • , Steven T. K. Hill
    • , Sunil Deochand
    • , Cole C. Khamnei
    • , Dillon Maloney
    • , Kristofer Patel
    • , Will Liao
    • , Adam J. Widman
    • , Phillip Wong
    • , Margaret K. Callahan
    • , Gavin Ha
    • , Sarah Reed
    • , Denisse Rotem
    • , Dennie Frederick
    • , Tatyana Sharova
    • , Benchun Miao
    • , Tommy Kim
    • , Greg Gydush
    • , Justin Rhoades
    • , Kevin Y. Huang
    • , Nathaniel D. Omans
    • , Patrick O. Bolan
    • , Andrew H. Lipsky
    • , Chelston Ang
    • , Murtaza Malbari
    • , Catherine F. Spinelli
    • , Selena Kazancioglu
    • , Alexi M. Runnels
    • , Samantha Fennessey
    • , Christian Stolte
    • , Federico Gaiti
    • , Giorgio G. Inghirami
    • , Viktor Adalsteinsson
    • , Brian Houck-Loomis
    • , Jennifer Ishii
    • , Jedd D. Wolchok
    • , Genevieve Boland
    • , Nicolas Robine
    • , Nasser K. Altorki
    •  & Dan A. Landau
  • Article |

    A pooled genetic, transcriptomic and immunopathologic analysis of over 500 tumors from patients with advanced renal cell cancer suggests that response to PD-1 blockade depends on both CD8+ T cell infiltration and enrichment of tumor-intrinsic somatic alterations.

    • David A. Braun
    • , Yue Hou
    • , Ziad Bakouny
    • , Miriam Ficial
    • , Miriam Sant’ Angelo
    • , Juliet Forman
    • , Petra Ross-Macdonald
    • , Ashton C. Berger
    • , Opeyemi A. Jegede
    • , Liudmilla Elagina
    • , John Steinharter
    • , Maxine Sun
    • , Megan Wind-Rotolo
    • , Jean-Christophe Pignon
    • , Andrew D. Cherniack
    • , Lee Lichtenstein
    • , Donna Neuberg
    • , Paul Catalano
    • , Gordon J. Freeman
    • , Arlene H. Sharpe
    • , David F. McDermott
    • , Eliezer M. Van Allen
    • , Sabina Signoretti
    • , Catherine J. Wu
    • , Sachet A. Shukla
    •  & Toni K. Choueiri
  • Article |

    Local microbiome composition influences treatment efficacy of chemotherapy in colon cancer via modulation of tolerogenic versus immunogenic ileal intestinal epithelial cell death, which in turn influences follicular helper T cell priming.

    • Maria Paula Roberti
    • , Satoru Yonekura
    • , Connie P. M. Duong
    • , Marion Picard
    • , Gladys Ferrere
    • , Maryam Tidjani Alou
    • , Conrad Rauber
    • , Valerio Iebba
    • , Christian H. K. Lehmann
    • , Lukas Amon
    • , Diana Dudziak
    • , Lisa Derosa
    • , Bertrand Routy
    • , Caroline Flament
    • , Corentin Richard
    • , Romain Daillère
    • , Aurélie Fluckiger
    • , Isabelle Van Seuningen
    • , Mathias Chamaillard
    • , Audrey Vincent
    • , Stephanie Kourula
    • , Paule Opolon
    • , Pierre Ly
    • , Eugénie Pizzato
    • , Sonia Becharef
    • , Juliette Paillet
    • , Christophe Klein
    • , Florence Marliot
    • , Filippo Pietrantonio
    • , Stéphane Benoist
    • , Jean-Yves Scoazec
    • , Peggy Dartigues
    • , Antoine Hollebecque
    • , David Malka
    • , Franck Pagès
    • , Jérôme Galon
    • , Ivo Gomperts Boneca
    • , Patricia Lepage
    • , Bernard Ryffel
    • , Didier Raoult
    • , Alexander Eggermont
    • , Tom Vanden Berghe
    • , François Ghiringhelli
    • , Peter Vandenabeele
    • , Guido Kroemer
    •  & Laurence Zitvogel
  • Article |

    Primary tumor presence and progression shape the systemic immune landscape and immune responses to pathogens in multiple murine tumor models.

    • Breanna M. Allen
    • , Kamir J. Hiam
    • , Cassandra E. Burnett
    • , Anthony Venida
    • , Rachel DeBarge
    • , Iliana Tenvooren
    • , Diana M. Marquez
    • , Nam Woo Cho
    • , Yaron Carmi
    •  & Matthew H. Spitzer
  • Article |

    A deep learning system able to identify the most common skin conditions may help clinicians in making more accurate diagnoses in routine clinical practice

    • Yuan Liu
    • , Ayush Jain
    • , Clara Eng
    • , David H. Way
    • , Kang Lee
    • , Peggy Bui
    • , Kimberly Kanada
    • , Guilherme de Oliveira Marinho
    • , Jessica Gallegos
    • , Sara Gabriele
    • , Vishakha Gupta
    • , Nalini Singh
    • , Vivek Natarajan
    • , Rainer Hofmann-Wellenhof
    • , Greg S. Corrado
    • , Lily H. Peng
    • , Dale R. Webster
    • , Dennis Ai
    • , Susan J. Huang
    • , Yun Liu
    • , R. Carter Dunn
    •  & David Coz
  • Article |

    In individuals diagnosed with age-related macular degeneration in one eye, a deep learning model can predict progression to the ‘wet’, sight-threatening form of the disease in the second eye within a 6-month time frame.

    • Jason Yim
    • , Reena Chopra
    • , Terry Spitz
    • , Jim Winkens
    • , Annette Obika
    • , Christopher Kelly
    • , Harry Askham
    • , Marko Lukic
    • , Josef Huemer
    • , Katrin Fasler
    • , Gabriella Moraes
    • , Clemens Meyer
    • , Marc Wilson
    • , Jonathan Dixon
    • , Cian Hughes
    • , Geraint Rees
    • , Peng T. Khaw
    • , Alan Karthikesalingam
    • , Dominic King
    • , Demis Hassabis
    • , Mustafa Suleyman
    • , Trevor Back
    • , Joseph R. Ledsam
    • , Pearse A. Keane
    •  & Jeffrey De Fauw
  • Article |

    Plasmodium vivax can cause a clinically silent liver-stage infection that can reactivate, triggering blood-stage disease. A new test measuring antibody responses can identify P. vivax carriers for targeted treatment intervention.

    • Rhea J. Longley
    • , Michael T. White
    • , Eizo Takashima
    • , Jessica Brewster
    • , Masayuki Morita
    • , Matthias Harbers
    • , Thomas Obadia
    • , Leanne J. Robinson
    • , Fumie Matsuura
    • , Zoe S. J. Liu
    • , Connie S. N. Li-Wai-Suen
    • , Wai-Hong Tham
    • , Julie Healer
    • , Christele Huon
    • , Chetan E. Chitnis
    • , Wang Nguitragool
    • , Wuelton Monteiro
    • , Carla Proietti
    • , Denise L. Doolan
    • , Andre M. Siqueira
    • , Xavier C. Ding
    • , Iveth J. Gonzalez
    • , James Kazura
    • , Marcus Lacerda
    • , Jetsumon Sattabongkot
    • , Takafumi Tsuboi
    •  & Ivo Mueller
  • Article
    | Open Access

    An HIV vaccine that elicits both antibodies and cellular immune responses confers long-lasting protection against viral challenge in nonhuman primates.

    • Prabhu S. Arunachalam
    • , Tysheena P. Charles
    • , Vineet Joag
    • , Venkata S. Bollimpelli
    • , Madeleine K. D. Scott
    • , Florian Wimmers
    • , Samantha L. Burton
    • , Celia C. Labranche
    • , Caroline Petitdemange
    • , Sailaja Gangadhara
    • , Tiffany M. Styles
    • , Clare F. Quarnstrom
    • , Korey A. Walter
    • , Thomas J. Ketas
    • , Traci Legere
    • , Pradeep Babu Jagadeesh Reddy
    • , Sudhir Pai Kasturi
    • , Anthony Tsai
    • , Bertrand Z. Yeung
    • , Shakti Gupta
    • , Mark Tomai
    • , John Vasilakos
    • , George M. Shaw
    • , Chil-Yong Kang
    • , John P. Moore
    • , Shankar Subramaniam
    • , Purvesh Khatri
    • , David Montefiori
    • , Pamela A. Kozlowski
    • , Cynthia A. Derdeyn
    • , Eric Hunter
    • , David Masopust
    • , Rama R. Amara
    •  & Bali Pulendran
  • Article |

    Intraventricularly delivered monovalent and trivalent CAR T cells exhibit greater therapeutic efficacy as compared with intravenously delivered CAR T cells in medulloblastoma xenograft mouse models and show potency in ependymoma xenograft mouse models.

    • Laura K. Donovan
    • , Alberto Delaidelli
    • , Sujith K. Joseph
    • , Kevin Bielamowicz
    • , Kristen Fousek
    • , Borja L. Holgado
    • , Alex Manno
    • , Dilakshan Srikanthan
    • , Ahmed Z. Gad
    • , Randy Van Ommeren
    • , David Przelicki
    • , Cory Richman
    • , Vijay Ramaswamy
    • , Craig Daniels
    • , Jonelle G. Pallota
    • , Tajana Douglas
    • , Alyssa C. M. Joynt
    • , Joonas Haapasalo
    • , Carolina Nor
    • , Maria C. Vladoiu
    • , Claudia M. Kuzan-Fischer
    • , Livia Garzia
    • , Stephen C. Mack
    • , Srinidhi Varadharajan
    • , Matthew L. Baker
    • , Liam Hendrikse
    • , Michelle Ly
    • , Kaitlin Kharas
    • , Polina Balin
    • , Xiaochong Wu
    • , Lei Qin
    • , Ning Huang
    • , Ana Guerreiro Stucklin
    • , A. Sorana Morrissy
    • , Florence M. G. Cavalli
    • , Betty Luu
    • , Raul Suarez
    • , Pasqualino De Antonellis
    • , Antony Michealraj
    • , Avesta Rastan
    • , Meenakshi Hegde
    • , Martin Komosa
    • , Olga Sirbu
    • , Sachin A. Kumar
    • , Zied Abdullaev
    • , Claudia C. Faria
    • , Stephen Yip
    • , Juliette Hukin
    • , Uri Tabori
    • , Cynthia Hawkins
    • , Ken Aldape
    • , Mads Daugaard
    • , John M. Maris
    • , Poul H. Sorensen
    • , Nabil Ahmed
    •  & Michael D. Taylor
  • Article |

    In a first-in-human phase I trial of patients with advanced lung cancer, infusions of autologous T cells edited to delete the PD-1 gene via CRISPR–Cas9 were well tolerated and did not lead to severe treatment-related adverse events.

    • You Lu
    • , Jianxin Xue
    • , Tao Deng
    • , Xiaojuan Zhou
    • , Kun Yu
    • , Lei Deng
    • , Meijuan Huang
    • , Xin Yi
    • , Maozhi Liang
    • , Yu Wang
    • , Haige Shen
    • , Ruizhan Tong
    • , Wenbo Wang
    • , Li Li
    • , Jin Song
    • , Jing Li
    • , Xiaoxing Su
    • , Zhenyu Ding
    • , Youling Gong
    • , Jiang Zhu
    • , Yongsheng Wang
    • , Bingwen Zou
    • , Yan Zhang
    • , Yanying Li
    • , Lin Zhou
    • , Yongmei Liu
    • , Min Yu
    • , Yuqi Wang
    • , Xuanwei Zhang
    • , Limei Yin
    • , Xuefeng Xia
    • , Yong Zeng
    • , Qiao Zhou
    • , Binwu Ying
    • , Chong Chen
    • , Yuquan Wei
    • , Weimin Li
    •  & Tony Mok
  • Article
    | Open Access

    Fine-scale geospatial mapping of overweight and wasting (two components of the double burden of malnutrition) in 105 LMICs shows that overweight has increased from 5.2% in 2000 to 6.0% in children under 5 in 2017. Although overall wasting decreased over the same period, most countries are not on track to meet the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025.

    • Damaris K. Kinyoki
    • , Jennifer M. Ross
    • , Alice Lazzar-Atwood
    • , Sandra B. Munro
    • , Lauren E. Schaeffer
    • , Mahdieh Abbasalizad-Farhangi
    • , Masoumeh Abbasi
    • , Hedayat Abbastabar
    • , Ahmed Abdelalim
    • , Amir Abdoli
    • , Mohammad Abdollahi
    • , Ibrahim Abdollahpour
    • , Rizwan Suliankatchi Abdulkader
    • , Nebiyu Dereje Abebe
    • , Teshome Abuka Abebo
    • , Kedir Hussein Abegaz
    • , Hassan Abolhassani
    • , Lucas Guimarães Abreu
    • , Michael R. M. Abrigo
    • , Abdelrahman I. Abushouk
    • , Manfred Mario Kokou Accrombessi
    • , Dilaram Acharya
    • , Maryam Adabi
    • , Akindele Olupelumi Adebiyi
    • , Isaac Akinkunmi Adedeji
    • , Victor Adekanmbi
    • , Abiodun Moshood Adeoye
    • , Olatunji O. Adetokunboh
    • , Davoud Adham
    • , Posi Emmanuel Aduroja
    • , Shailesh M. Advani
    • , Mohsen Afarideh
    • , Mohammad Aghaali
    • , Anurag Agrawal
    • , Tauseef Ahmad
    • , Keivan Ahmadi
    • , Sepideh Ahmadi
    • , Muktar Beshir Ahmed
    • , Rushdia Ahmed
    • , Olufemi Ajumobi
    • , Chalachew Genet Akal
    • , Temesgen Yihunie Akalu
    • , Tomi Akinyemiju
    • , Blessing Akombi
    • , Ziyad Al-Aly
    • , Samiah Alam
    • , Genet Melak Alamene
    • , Turki M. Alanzi
    • , Jacqueline Elizabeth Alcalde Rabanal
    • , Niguse Meles Alema
    • , Beriwan Abdulqadir Ali
    • , Muhammad Ali
    • , Mehran Alijanzadeh
    • , Cyrus Alinia
    • , Vahid Alipour
    • , Hesam Alizade
    • , Syed Mohamed Aljunid
    • , Afshin Almasi
    • , Amir Almasi-Hashiani
    • , Hesham M. Al-Mekhlafi
    • , Rajaa M. Al-Raddadi
    • , Khalid Altirkawi
    • , Nelson Alvis-Guzman
    • , Nelson J. Alvis-Zakzuk
    • , Azmeraw T. Amare
    • , Adeladza Kofi Amegah
    • , Saeed Amini
    • , Mostafa Amini Rarani
    • , Fatemeh Amiri
    • , Arianna Maever Loreche Amit
    • , Nahla Hamed Anber
    • , Catalina Liliana Andrei
    • , Fereshteh Ansari
    • , Alireza Ansari-Moghaddam
    • , Zelalem Alamrew Anteneh
    • , Carl Abelardo T. Antonio
    • , Ernoiz Antriyandarti
    • , Davood Anvari
    • , Razique Anwer
    • , Seth Christopher Yaw Appiah
    • , Jalal Arabloo
    • , Morteza Arab-Zozani
    • , Ephrem Mebrahtu Araya
    • , Zohreh Arefi
    • , Olatunde Aremu
    • , Johan Ärnlöv
    • , Afsaneh Arzani
    • , Mehran Asadi-Aliabadi
    • , Ali A. Asadi-Pooya
    • , Samaneh Asgari
    • , Babak Asghari
    • , Alebachew Fasil Ashagre
    • , Anemaw A. Asrat
    • , Bahar Ataeinia
    • , Hagos Tasew Atalay
    • , Desta Debalkie Atnafu
    • , Maha Moh’d Wahbi Atout
    • , Marcel Ausloos
    • , Euripide F. G. A. Avokpaho
    • , Ashish Awasthi
    • , Beatriz Paulina Ayala Quintanilla
    • , Martin Amogre Ayanore
    • , Yared A. Asmare Aynalem
    • , Abbas Azadmehr
    • , Samad Azari
    • , Ghasem Azarian
    • , Zelalem Nigussie Azene
    • , Ebrahim Babaee
    • , Alaa Badawi
    • , Ashish D. Badiye
    • , Mohamad Amin Bahrami
    • , Atif Amin A. Baig
    • , Ahad Bakhtiari
    • , Shankar M. Bakkannavar
    • , Senthilkumar Balakrishnan
    • , Ayele Geleto Bali
    • , Maciej Banach
    • , Palash Chandra Banik
    • , Zahra Baradaran-Seyed
    • , Adhanom Gebreegziabher Baraki
    • , Miguel A. Barboza
    • , Till Winfried Bärnighausen
    • , Lingkan Barua
    • , Huda Basaleem
    • , Sanjay Basu
    • , Mohsen Bayati
    • , Mulat Tirfie Bayih
    • , Habtamu Wondifraw Baynes
    • , Neeraj Bedi
    • , Masoud Behzadifar
    • , Meysam Behzadifar
    • , Yibeltal Alemu Bekele
    • , Derrick A. Bennett
    • , Dessalegn Ajema Berbada
    • , Kidanemaryam Berhe
    • , Abadi Kidanemariam Berhe
    • , Adam E. Berman
    • , Robert S. Bernstein
    • , Reshmi Bhageerathy
    • , Dinesh Bhandari
    • , Pankaj Bharadwaj
    • , Natalia V. Bhattacharjee
    • , Krittika Bhattacharyya
    • , Ali Bijani
    • , Boris Bikbov
    • , Ver Bilano
    • , Nigus Bililign
    • , Muhammad Shahdaat Bin Sayeed
    • , Setognal Birara
    • , Minuye Biniam Biniam Birhane
    • , Minyichil Birhanu
    • , Raaj Kishore Biswas
    • , Zebenay Workneh Bitew
    • , Kassawmar Angaw Bogale
    • , Somayeh Bohlouli
    • , Srinivasa Rao Bolla
    • , Archith Boloor
    • , Antonio M. Borzì
    • , Shiva Borzouei
    • , Oliver J. Brady
    • , Nicola Luigi Bragazzi
    • , Dejana Braithwaite
    • , Nikolay Ivanovich Briko
    • , Gabrielle Britton
    • , Shyam S. Budhathoki
    • , Sharath Burugina Nagaraja
    • , Reinhard Busse
    • , Zahid A. Butt
    • , Lucero Cahuana-Hurtado
    • , Luis Alberto Cámera
    • , Ismael R. Campos-Nonato
    • , Jorge Cano
    • , Josip Car
    • , Rosario Cárdenas
    • , Juan J. Carrero
    • , Félix Carvalho
    • , João Mauricio Castaldelli-Maia
    • , Carlos A. Castañeda-Orjuela
    • , Franz Castro
    • , Ester Cerin
    • , Collins Chansa
    • , Jaykaran Charan
    • , Pranab Chatterjee
    • , Vijay Kumar Chattu
    • , Bal Govind Chauhan
    • , Ali Reza Chavshin
    • , Mohammad Chehrazi
    • , Tesfaye Yitna Chichiabellu
    • , Ken Lee Chin
    • , Devasahayam J. Christopher
    • , Dinh-Toi Chu
    • , Flavia M. Cicuttini
    • , Michael L. Collison
    • , Michael A. Cork
    • , Natalie Cormier
    • , Paolo Angelo Cortesi
    • , Vera M. Costa
    • , Abel Fekadu Fekadu Dadi
    • , Baye Dagnew
    • , Saad M. A. Dahlawi
    • , Giovanni Damiani
    • , Amira Hamed Darwish
    • , Ahmad Daryani
    • , Jai K. Das
    • , Rajat Das Gupta
    • , Claudio Dávila-Cervantes
    • , Nicole Davis Weaver
    • , Diego De Leo
    • , Jan-Walter De Neve
    • , Feleke Mekonnen Demeke
    • , Asmamaw Bizuneh Demis
    • , Dereje Bayissa Demissie
    • , Gebre Teklemariam Demoz
    • , Edgar Denova-Gutiérrez
    • , Kebede Deribe
    • , Rupak Desai
    • , Beruk Berhanu Desalegn
    • , Assefa Desalew
    • , Aniruddha Deshpande
    • , Sagnik Dey
    • , Samath Dhamminda Dharmaratne
    • , Preeti Dhillon
    • , Meghnath Dhimal
    • , Govinda Prasad Dhungana
    • , Mostafa Dianati Nasab
    • , Daniel Diaz
    • , Zahra Sadat Dibaji Forooshani
    • , Girmaye Deye Dinsa
    • , Isaac Oluwafemi Dipeolu
    • , Shirin Djalalinia
    • , Hoa Thi Do
    • , Huyen Phuc Do
    • , Paul Narh Doku
    • , Fariba Dorostkar
    • , Leila Doshmangir
    • , Manisha Dubey
    • , Bereket Duko Adema
    • , Susanna J. Dunachie
    • , Bruce B. Duncan
    • , Ewerton Cousin
    • , Andre R. Durães
    • , Lucas Earl
    • , Hamed Ebrahimzadeh Leylabadlo
    • , Aziz Eftekhari
    • , Iman El Sayed
    • , Maysaa El Sayed Zaki
    • , Maha El Tantawi
    • , Iffat Elbarazi
    • , Demelash Abewa Elemineh
    • , Shaimaa I. El-Jaafary
    • , Ziad El-Khatib
    • , Aisha Elsharkawy
    • , Yasser Mohamed El-Sherbiny
    • , Iqbal R. F. Elyazar
    • , Mohammad Hassan Emamian
    • , Shymaa Enany
    • , Daniel Adane Endalew
    • , Melese Linger Endalifer
    • , Khalil Eskandari
    • , Sharareh Eskandarieh
    • , Saman Esmaeilnejad
    • , Alireza Esteghamati
    • , Arash Etemadi
    • , Atkilt Esaiyas Etisso
    • , Jessica Fanzo
    • , Mohammad Farahmand
    • , Anwar Faraj
    • , Sajjad Farashi
    • , Mohammad Fareed
    • , Andrea Farioli
    • , Andre Faro
    • , Farshad Farzadfar
    • , Hossein Farzam
    • , Syeda Sadia Fatima
    • , Nazir Fattahi
    • , Nelsensius Klau Fauk
    • , Ali Akbar Fazaeli
    • , Netsanet Fentahun
    • , Tomas Y. Ferede
    • , Seyed-Mohammad Fereshtehnejad
    • , Eduarda Fernandes
    • , João C. Fernandes
    • , Garumma Tolu Feyissa
    • , Irina Filip
    • , Florian Fischer
    • , Carsten Flohr
    • , Nataliya A. Foigt
    • , Morenike Oluwatoyin Folayan
    • , Artem Alekseevich Fomenkov
    • , Masoud Foroutan
    • , Jana Förster
    • , Joel Msafiri Francis
    • , Takeshi Fukumoto
    • , Reta Tsegaye Gayesa
    • , Biniyam Sahiledengle Geberemariyam
    • , Tsegaye Tewelde Gebrehiwot
    • , Hadush Gebremariam
    • , Kidane Tadesse Gebremariam
    • , Ketema Bizuwork Bizuwork Gebremedhin
    • , Gebreamlak Gebremedhn Gebremeskel
    • , Assefa Ayalew Ayalew Gebreslassie
    • , Gebretsadkan G. G. Gebretsadik
    • , Getnet Azeze Gedefaw
    • , Yilma Chisha Dea Geramo
    • , Hailay Abrha Gesesew
    • , Birhanu Geta
    • , Agegnehu Bante Getenet
    • , Kebede Embaye Gezae
    • , Fatemeh Ghaffarifar
    • , Mansour Ghafourifard
    • , Alireza Ghajar
    • , Mahsa Ghajarzadeh
    • , Ahmad Ghashghaee
    • , Hesam Ghiasvand
    • , Asadollah Gholamian
    • , Syed Amir Gilani
    • , Tiffany K. Gill
    • , Ibrahim Abdelmageed Ginawi
    • , Srinivas Goli
    • , Nelson G. M. Gomes
    • , Sameer Vali Gopalani
    • , Houman Goudarzi
    • , Alessandra C. Goulart
    • , Arunkumar Govindakarnavar
    • , Ayman Grada
    • , Michal Grivna
    • , Rafael Alves Guimarães
    • , Rashid Abdi Guled
    • , Yuming Guo
    • , Rahul Gupta
    • , Rajeev Gupta
    • , Nima Hafezi-Nejad
    • , Michael Tamene Haile
    • , Arvin Haj-Mirzaian
    • , Arya Haj-Mirzaian
    • , Brian J. Hall
    • , Iman Halvaei
    • , Randah R. Hamadeh
    • , Yadollah Hamidi
    • , Demelash Woldeyohannes Handiso
    • , Graeme J. Hankey
    • , Hamidreza Haririan
    • , Ninuk Hariyani
    • , Ahmed I. Hasaballah
    • , Md. Mehedi Hasan
    • , Milad Hasankhani
    • , Edris Hasanpoor
    • , Amir Hasanzadeh
    • , Maryam Hashemian
    • , Soheil Hassanipour
    • , Hamid Yimam Hassen
    • , Rasmus Havmoeller
    • , Corinna Hawkes
    • , Khezar Hayat
    • , Desta Haftu Hayelom
    • , Behnam Heidari
    • , Reza Heidari-Soureshjani
    • , Delia Hendrie
    • , Andualem Henok
    • , Nathaniel J. Henry
    • , Mario Herrero
    • , Claudiu Herteliu
    • , Fatemeh Heydarpour
    • , Hagos D. de Hidru
    • , Chi Linh Hoang
    • , Hans W. Hoek
    • , Michael K. Hole
    • , Ramesh Holla
    • , Gillian Hollerich
    • , Enayatollah Homaie Rad
    • , Sung Hwi Hong
    • , Praveen Hoogar
    • , Masako Horino
    • , Naznin Hossain
    • , Mostafa Hosseini
    • , Mehdi Hosseinzadeh
    • , Mihaela Hostiuc
    • , Sorin Hostiuc
    • , Mowafa Househ
    • , Mohamed Hsairi
    • , Guoqing Hu
    • , Tanvir M. Huda
    • , Ayesha Humayun
    • , Bing-Fang Hwang
    • , Segun Emmanuel Ibitoye
    • , Olayinka Stephen Ilesanmi
    • , Milena D. Ilic
    • , Mohammad Hasan Imani-Nasab
    • , Leeberk Raja Inbaraj
    • , Usman Iqbal
    • , Seyed Sina Naghibi Irvani
    • , Sheikh Mohammed Shariful Islam
    • , Chidozie C. D. Iwu
    • , Chinwe Juliana Iwu
    • , Neda Izadi
    • , Jalil Jaafari
    • , Anelisa Jaca
    • , Farhad Jadidi-Niaragh
    • , Nader Jafari Balalami
    • , Morteza Jafarinia
    • , Mohammad Ali Jahani
    • , Mihajlo Jakovljevic
    • , Amir Jalali
    • , Farzad Jalilian
    • , Achala Upendra Jayatilleke
    • , Panniyammakal Jeemon
    • , Fyezah Jehan
    • , Ensiyeh Jenabi
    • , Ravi Prakash Jha
    • , Vivekanand Jha
    • , John S. Ji
    • , Peng Jia
    • , Oommen John
    • , Yetunde O. John-Akinola
    • , Kimberly B. Johnson
    • , Jost B. Jonas
    • , Nitin Joseph
    • , Farahnaz Joukar
    • , Jacek Jerzy Jozwiak
    • , Suresh Banayya Jungari
    • , Mikk Jürisson
    • , Ali Kabir
    • , Zubair Kabir
    • , Amaha Kahsay
    • , Molla Kahssay
    • , Hamed Kalani
    • , Leila L. Kalankesh
    • , Rohollah Kalhor
    • , Zahra Kamiab
    • , Tanuj Kanchan
    • , Umesh Kapil
    • , Neeti Kapoor
    • , Manoochehr Karami
    • , Behzad Karami Matin
    • , André Karch
    • , Mohd A. Karim
    • , Surendra Karki
    • , Amir Kasaeian
    • , Gebremicheal Gebreslassie Kasahun
    • , Habtamu Kebebe Kasaye
    • , Tesfaye Dessale Kassa
    • , Hagazi Gebremedhin Kassaye
    • , Nicholas J. Kassebaum
    • , Ali Kazemi Karyani
    • , Andre Pascal Kengne
    • , Daniel Bekele Ketema
    • , Yousef Saleh Khader
    • , Morteza Abdullatif Khafaie
    • , Mojtaba Khaksarian
    • , Nauman Khalid
    • , Ibrahim A. Khalil
    • , Rovshan Khalilov
    • , Asad Khan
    • , Ejaz Ahmad Khan
    • , Md Nuruzzaman Khan
    • , Mohammad Saud Khan
    • , Muhammad Shahzeb Khan
    • , Khaled Khatab
    • , Amir Khater
    • , Mona M. Khater
    • , Mahalqua Nazli Khatib
    • , Maryam Khayamzadeh
    • , Maryam Khazaei-Pool
    • , Mohammad Khazaei
    • , Salman Khazaei
    • , Mohammad Taghi Khodayari
    • , Mohammad Hossein Khosravi
    • , Roba Khundkar
    • , Ali Kiadaliri
    • , Neda Kianipour
    • , Daniel N. Kiirithio
    • , Yun Jin Kim
    • , Ruth W. Kimokoti
    • , Adnan Kisa
    • , Sezer Kisa
    • , Tufa Kolola
    • , Hamidreza Komaki
    • , Shivakumar K. M. Kondlahalli
    • , Ali Koolivand
    • , Parvaiz A. Koul
    • , Ai Koyanagi
    • , Moritz U. G. Kraemer
    • , Kewal Krishan
    • , Kris J. Krohn
    • , Nuworza Kugbey
    • , Manasi Kumar
    • , Pushpendra Kumar
    • , Vivek Kumar
    • , Om P. Kurmi
    • , Oluwatosin Kuti
    • , Carlo La Vecchia
    • , Ben Lacey
    • , Deepesh P. Lad
    • , Aparna Lal
    • , Dharmesh Kumar Lal
    • , Faris Hasan Lami
    • , Prabhat Lamichhane
    • , Justin J. Lang
    • , Van C. Lansingh
    • , Savita Lasrado
    • , Georgy Lebedev
    • , Paul H. Lee
    • , Shaun Wen Huey Lee
    • , Mostafa Leili
    • , Ian D. Letourneau
    • , Sonia Lewycka
    • , Shanshan Li
    • , Lee-Ling Lim
    • , Shai Linn
    • , Shiwei Liu
    • , Simin Liu
    • , Rakesh Lodha
    • , Joshua Longbottom
    • , Jaifred Christian F. Lopez
    • , Stefan Lorkowski
    • , Erlyn Rachelle King Macarayan
    • , Mohammed Madadin
    • , Hassan Magdy Abd El Razek
    • , Muhammed Magdy Abd El Razek
    • , Dhaval P. Maghavani
    • , Phetole Walter Mahasha
    • , Narayan Bahadur Mahotra
    • , Venkatesh Maled
    • , Afshin Maleki
    • , Shokofeh Maleki
    • , Deborah Carvalho Malta
    • , Ali Manafi
    • , Farzad Manafi
    • , Navid Manafi
    • , Narendar Dawanu Manohar
    • , Fariborz Mansour-Ghanaei
    • , Borhan Mansouri
    • , Mohammad Ali Mansournia
    • , Chabila Christopher Mapoma
    • , Dadi Marami
    • , Laurie B. Marczak
    • , Carlos Alberto Marrugo Arnedo
    • , Francisco Rogerlândio Martins-Melo
    • , Anthony Masaka
    • , Benjamin Ballard Massenburg
    • , Pallab K. Maulik
    • , Benjamin K. Mayala
    • , Mohsen Mazidi
    • , Man Mohan Mehndiratta
    • , Freshteh Mehri
    • , Kala M. Mehta
    • , Wahengbam Bigyananda Meitei
    • , Fantahun Ayenew Mekonnen
    • , Teferi Mekonnen
    • , Gebrekiros Gebremichael Meles
    • , Hagazi Gebre Meles
    • , Addisu Melese
    • , Walter Mendoza
    • , Ritesh G. Menezes
    • , Meresa Berwo Mengesha
    • , George A. Mensah
    • , Tuomo J. Meretoja
    • , Tomasz Miazgowski
    • , Neda Milevska Kostova
    • , Ted R. Miller
    • , Edward J. Mills
    • , G. K. Mini
    • , Seyed Mostafa Mir
    • , Mohammad Miri
    • , Hamed Mirjalali
    • , Erkin M. Mirrakhimov
    • , Hamed Mirzaei
    • , Maryam Mirzaei
    • , Roya Mirzaei
    • , Mehdi Mirzaei-Alavijeh
    • , Prasanna Mithra
    • , Babak Moazen
    • , Efat Mohamadi
    • , Amjad Mohamadi-Bolbanabad
    • , Karzan Abdulmuhsin Mohammad
    • , Yousef Mohammad
    • , Dara K. Mohammad
    • , Aso Mohammad Darwesh
    • , Naser Mohammad Gholi Mezerji
    • , Abdollah Mohammadian-Hafshejani
    • , Mousa Mohammadnia-Afrouzi
    • , Milad Mohammadoo-Khorasani
    • , Reza Mohammadpourhodki
    • , Salahuddin Mohammed
    • , Shafiu Mohammed
    • , Jemal Abdu Mohammed
    • , Ammas Siraj Mohammed
    • , Farnam Mohebi
    • , Amin Mokari
    • , Ali H. Mokdad
    • , Julio Cesar Montañez
    • , Pablo A. Montero-Zamora
    • , Yoshan Moodley
    • , Maryam Moossavi
    • , Ghobad Moradi
    • , Masoud Moradi
    • , Yousef Moradi
    • , Mohammad Moradi-Joo
    • , Maziar Moradi-Lakeh
    • , Farhad Moradpour
    • , Rahmatollah Moradzadeh
    • , Paula Moraga
    • , Shane Douglas Morrison
    • , Abbas Mosapour
    • , Jonathan F. Mosser
    • , Simin Mouodi
    • , Amin Mousavi Khaneghah
    • , Dariush Mozaffarian
    • , Ulrich Otto Mueller
    • , Christopher J. L. Murray
    • , G. V. S. Murthy
    • , Kamarul Imran Musa
    • , Ghulam Mustafa
    • , Saravanan Muthupandian
    • , Behnam Nabavizadeh
    • , Mehdi Naderi
    • , Girish N. Nadkarni
    • , Ahamarshan Jayaraman Nagarajan
    • , Mohsen Naghavi
    • , Aliya Naheed
    • , Gurudatta Naik
    • , Farid Najafi
    • , Jobert Richie Nansseu
    • , K. M. Venkat Narayan
    • , Bruno Ramos Nascimento
    • , Vinod Nayak
    • , Javad Nazari
    • , Duduzile Edith Ndwandwe
    • , Ionut Negoi
    • , Ruxandra Irina Negoi
    • , Josephine W. Ngunjiri
    • , Cuong Tat Nguyen
    • , Huong Lan Thi Nguyen
    • , Dabere Nigatu
    • , Yeshambel T. Nigatu
    • , Rajan Nikbakhsh
    • , Dina Nur Anggraini Ningrum
    • , Chukwudi A. Nnaji
    • , Vuong Minh Nong
    • , Jean Jacques Noubiap
    • , Christoph Nowak
    • , Bogdan Oancea
    • , Richard Ofori-Asenso
    • , Onome Bright Oghenetega
    • , In-Hwan Oh
    • , Olanrewaju Oladimeji
    • , Morteza Oladnabi
    • , Andrew T. Olagunju
    • , Tinuke O. Olagunju
    • , Bolajoko Olubukunola Olusanya
    • , Jacob Olusegun Olusanya
    • , Mojisola Morenike Oluwasanu
    • , Muktar Omer Omer
    • , Obinna E. Onwujekwe
    • , Kwaku Oppong Asante
    • , Eyal Oren
    • , Orish Ebere Orisakwe
    • , Alberto Ortiz
    • , Osayomwanbo Osarenotor
    • , Aaron E. Osgood-Zimmerman
    • , Mayowa Ojo Owolabi
    • , Mahesh P. A.
    • , Jagadish Rao Padubidri
    • , Keyvan Pakshir
    • , Adrian Pana
    • , Songhomitra Panda-Jonas
    • , Hadi Parsian
    • , Tahereh Pashaei
    • , Deepak Kumar Pasupula
    • , Sangram Kishor Patel
    • , Ashish Pathak
    • , Mona Pathak
    • , Sanghamitra Pati
    • , Ajay Patle
    • , George C. Patton
    • , Kebreab Paulos
    • , Hamidreza Pazoki Toroudi
    • , Veincent Christian Filipino Pepito
    • , Norberto Perico
    • , William A. Petri
    • , Brandon V. Pickering
    • , David M. Pigott
    • , Majid Pirestani
    • , Bakhtiar Piroozi
    • , Meghdad Pirsaheb
    • , Khem Narayan Pokhrel
    • , Maarten J. Postma
    • , Hadi Pourjafar
    • , Farshad Pourmalek
    • , Reza Pourmirza Kalhori
    • , Akram Pourshams
    • , Hossein Poustchi
    • , Sergio I. Prada
    • , Liliana Preotescu
    • , Dimas Ria Angga Pribadi
    • , Zahiruddin Quazi Syed
    • , Mohammad Rabiee
    • , Navid Rabiee
    • , Amir Radfar
    • , Alireza Rafiei
    • , Fakher Rahim
    • , Vafa Rahimi-Movaghar
    • , Muhammad Aziz Rahman
    • , Sajjad ur Rahman
    • , Rajesh Kumar Rai
    • , Ali Rajabpour-Sanati
    • , Fatemeh Rajati
    • , Kiana Ramezanzadeh
    • , Saleem Muhammad Rana
    • , Chhabi Lal Ranabhat
    • , Sowmya J. Rao
    • , Davide Rasella
    • , Vahid Rashedi
    • , Prateek Rastogi
    • , Priya Rathi
    • , Salman Rawaf
    • , David Laith Rawaf
    • , Lal Rawal
    • , Sarah E. Ray
    • , Giuseppe Remuzzi
    • , Vishnu Renjith
    • , Andre M. N. Renzaho
    • , Serge Resnikoff
    • , Nima Rezaei
    • , Shahab Rezaeian
    • , Mohammad Sadegh Rezai
    • , Aziz Rezapour
    • , Seyed Mohammad Riahi
    • , Ana Isabel Ribeiro
    • , Jennifer Rickard
    • , Alina Rodriguez
    • , Leonardo Roever
    • , Elias Merdassa Roro
    • , Gholamreza Roshandel
    • , Ali Rostami
    • , Enrico Rubagotti
    • , Anas M. Saad
    • , Seyedmohammad Saadatagah
    • , Yogesh Damodar Sabde
    • , Siamak Sabour
    • , Ehsan Sadeghi
    • , Masoumeh Sadeghi
    • , Saeed Safari
    • , Yahya Safari
    • , Hamid Safarpour
    • , Rajesh Sagar
    • , Amirhossein Sahebkar
    • , Mohammad Ali Sahraian
    • , S. Mohammad Sajadi
    • , Mohammad Reza Salahshoor
    • , Nasir Salam
    • , Farkhonde Salehi
    • , Saleh Salehi Zahabi
    • , Hosni Salem
    • , Marwa R. Rashad Salem
    • , Yahya Salimi
    • , Hamideh Salimzadeh
    • , Hossein Samadi Kafil
    • , Evanson Zondani Sambala
    • , Abdallah M. Samy
    • , Itamar S. Santos
    • , Bruno Piassi Sao Jose
    • , Sivan Yegnanarayana Iyer Saraswathy
    • , Abdur Razzaque Sarker
    • , Benn Sartorius
    • , Arash Sarveazad
    • , Brijesh Sathian
    • , Maheswar Satpathy
    • , Sonia Saxena
    • , Mehdi Sayyah
    • , Alyssa N. Sbarra
    • , Megan F. Schipp
    • , Maria Inês Schmidt
    • , Aletta Elisabeth Schutte
    • , David C. Schwebel
    • , Anbissa Muleta Senbeta
    • , Subramanian Senthilkumaran
    • , Seyedmojtaba Seyedmousavi
    • , Faramarz Shaahmadi
    • , Omid Shafaat
    • , Saeed Shahabi
    • , Masood Ali Shaikh
    • , Ali S. Shalash
    • , Mehran Shams-Beyranvand
    • , Amir Shamshirian
    • , Morteza Shamsizadeh
    • , Mohammed Shannawaz
    • , Kiomars Sharafi
    • , Mehdi Sharif
    • , Rajesh Sharma
    • , Hatem Samir Shehata
    • , Abbas Sheikhtaheri
    • , Kenji Shibuya
    • , Wondimeneh Shibabaw Shiferaw
    • , Mika Shigematsu
    • , Jae Il Shin
    • , Rahman Shiri
    • , Reza Shirkoohi
    • , Ivy Shiue
    • , Kerem Shuval
    • , Soraya Siabani
    • , Tariq J. Siddiqi
    • , Inga Dora Sigfusdottir
    • , Diego Augusto Santos Silva
    • , Biagio Simonetti
    • , Ambrish Singh
    • , Pushpendra Singh
    • , Virendra Singh
    • , Jasvinder A. Singh
    • , Pankaj Kumar Singh
    • , Dhirendra Narain Sinha
    • , Yitagesu Sintayehu
    • , Malede Mequanent M. Sisay
    • , Amin Soheili
    • , Bija Soleymani
    • , Farzaneh Soltani
    • , Shahin Soltani
    • , Joan B. Soriano
    • , Muluken Bekele Sorrie
    • , Sergey Soshnikov
    • , Ireneous N. Soyiri
    • , Adel Spotin
    • , Chandrashekhar T. Sreeramareddy
    • , Rajni Kant Kant Srivastava
    • , Antonina Starodubova
    • , Agus Sudaryanto
    • , Mu’awiyyah Babale Sufiyan
    • , Hafiz Ansar Rasul Suleria
    • , Gerhard Sulo
    • , Bruno F. Sunguya
    • , Bryan L. Sykes
    • , Rafael Tabarés-Seisdedos
    • , Takahiro Tabuchi
    • , Birkneh Tilahun Tadesse
    • , Amir Taherkhani
    • , Koku Sisay Tamirat
    • , Segen Gebremeskel Tassew
    • , Nuno Taveira
    • , Berhane Fseha Teklehaimanot
    • , Gebretsadkan Hintsa Tekulu
    • , Mohamad-Hani Temsah
    • , Abdullah Sulieman Terkawi
    • , Zemenu Tadesse Tessema
    • , Nihal Thomas
    • , Mariya Vladimirovna Titova
    • , Kenean Getaneh Tlaye
    • , Hamid Reza Tohidinik
    • , Marcello Tonelli
    • , Marcos Roberto Tovani-Palone
    • , Eugenio Traini
    • , Khanh Bao Tran
    • , Manjari Tripathi
    • , Riaz Uddin
    • , Irfan Ullah
    • , Bhaskaran Unnikrishnan
    • , Era Upadhyay
    • , Ushotanefe Useh
    • , Muhammad Shariq Usman
    • , Olalekan A. Uthman
    • , Marco Vacante
    • , Masoud Vaezghasemi
    • , Pascual R. Valdez
    • , John VanderHeide
    • , Elena Varavikova
    • , Santosh Varughese
    • , Tommi Juhani Vasankari
    • , Yasser Vasseghian
    • , Yousef Veisani
    • , Srinivasaraghavan Venkatesh
    • , Narayanaswamy Venketasubramanian
    • , Madhur Verma
    • , Simone Vidale
    • , Francesco S. Violante
    • , Vasily Vlassov
    • , Sebastian Vollmer
    • , Rade Vukovic
    • , Yasir Waheed
    • , Haidong Wang
    • , Yafeng Wang
    • , Yuan-Pang Wang
    • , Girmay Teklay Weldesamuel
    • , Andrea Werdecker
    • , Taweewat Wiangkham
    • , Kirsten E. Wiens
    • , Tissa Wijeratne
    • , Haileab Fekadu Wolde
    • , Dawit Zewdu Wondafrash
    • , Tewodros Eshete Wonde
    • , Adam Belay Wondmieneh
    • , Ai-Min Wu
    • , Gelin Xu
    • , Abbas Yadegar
    • , Ali Yadollahpour
    • , Seyed Hossein Yahyazadeh Jabbari
    • , Tomohide Yamada
    • , Yuichiro Yano
    • , Sanni Yaya
    • , Vahid Yazdi-Feyzabadi
    • , Alex Yeshaneh
    • , Yigizie Yeshaw
    • , Yordanos Gizachew Yeshitila
    • , Mekdes Tigistu Yilma
    • , Paul Yip
    • , Naohiro Yonemoto
    • , Seok-Jun Yoon
    • , Yoosik Youm
    • , Mustafa Z. Younis
    • , Zabihollah Yousefi
    • , Hebat-Allah Salah A. Yousof
    • , Chuanhua Yu
    • , Hasan Yusefzadeh
    • , Telma Zahirian Moghadam
    • , Leila Zaki
    • , Sojib Bin Zaman
    • , Mohammad Zamani
    • , Maryam Zamanian
    • , Hamed Zandian
    • , Hadi Zarafshan
    • , Nejimu Biza Zepro
    • , Taddese Alemu Zerfu
    • , Taye Abuhay Zewale
    • , Yunquan Zhang
    • , Zhi-Jiang Zhang
    • , Xiu-Ju Zhao
    • , Sanjay Zodpey
    • , Kamiar Zomorodian
    • , Francis Bruno Zotor
    • , Ashkan Afshin
    •  & Simon I. Hay
  • Article |

    Results from the NICHE study show remarkable pathological responses to neoadjuvant combination immunotherapy in patients with early-stage colon cancer and uncover potential biomarkers of response.

    • Myriam Chalabi
    • , Lorenzo F. Fanchi
    • , Krijn K. Dijkstra
    • , José G. Van den Berg
    • , Arend G. Aalbers
    • , Karolina Sikorska
    • , Marta Lopez-Yurda
    • , Cecile Grootscholten
    • , Geerard L. Beets
    • , Petur Snaebjornsson
    • , Monique Maas
    • , Marjolijn Mertz
    • , Vivien Veninga
    • , Gergana Bounova
    • , Annegien Broeks
    • , Regina G. Beets-Tan
    • , Thomas R. de Wijkerslooth
    • , Anja U. van Lent
    • , Hendrik A. Marsman
    • , Elvira Nuijten
    • , Niels F. Kok
    • , Maria Kuiper
    • , Wieke H. Verbeek
    • , Marleen Kok
    • , Monique E. Van Leerdam
    • , Ton N. Schumacher
    • , Emile E. Voest
    •  & John B. Haanen
  • Article |

    A phase 2 proof-of-mechanism trial shows that a κ-opioid receptor antagonist improves reward-related functioning in the brain and a clinical measure of anhedonia in patients with mood and anxiety disorders, serving as a model for implementing the ‘fast-fail’ approach to psychiatric treatment development.

    • Andrew D. Krystal
    • , Diego A. Pizzagalli
    • , Moria Smoski
    • , Sanjay J. Mathew
    • , John Nurnberger Jr
    • , Sarah H. Lisanby
    • , Dan Iosifescu
    • , James W. Murrough
    • , Hongqiu Yang
    • , Richard D. Weiner
    • , Joseph R. Calabrese
    • , Gerard Sanacora
    • , Gretchen Hermes
    • , Richard S. E. Keefe
    • , Allen Song
    • , Wayne Goodman
    • , Steven T. Szabo
    • , Alexis E. Whitton
    • , Keming Gao
    •  & William Z. Potter
  • Article |

    A scalable mass cytometry-based method for morphometrically classifying hematopoietic cells demonstrates diagnostic utility when applied to clinical samples.

    • Albert G. Tsai
    • , David R. Glass
    • , Marisa Juntilla
    • , Felix J. Hartmann
    • , Jean S. Oak
    • , Sebastian Fernandez-Pol
    • , Robert S. Ohgami
    •  & Sean C. Bendall
  • Article |

    Site-specific hyperphosphorylations of tau in the cerebrospinal fluid change with disease course, and correlate with pathology and cognitive decline in dominantly inherited Alzheimer’s disease.

    • Nicolas R. Barthélemy
    • , Yan Li
    • , Nelly Joseph-Mathurin
    • , Brian A. Gordon
    • , Jason Hassenstab
    • , Tammie. L. S. Benzinger
    • , Virginia Buckles
    • , Anne M. Fagan
    • , Richard J. Perrin
    • , Alison M. Goate
    • , John C. Morris
    • , Celeste M. Karch
    • , Chengjie Xiong
    • , Ricardo Allegri
    • , Patricio Chrem Mendez
    • , Sarah B. Berman
    • , Takeshi Ikeuchi
    • , Hiroshi Mori
    • , Hiroyuki Shimada
    • , Mikio Shoji
    • , Kazushi Suzuki
    • , James Noble
    • , Martin Farlow
    • , Jasmeer Chhatwal
    • , Neill R. Graff-Radford
    • , Stephen Salloway
    • , Peter R. Schofield
    • , Colin L. Masters
    • , Ralph N. Martins
    • , Antoinette O’Connor
    • , Nick C. Fox
    • , Johannes Levin
    • , Mathias Jucker
    • , Audrey Gabelle
    • , Sylvain Lehmann
    • , Chihiro Sato
    • , Randall J. Bateman
    • , Eric McDade
    • , Ricardo Allegri
    • , Randy Bateman
    • , Jacob Bechara
    • , Tammie Benzinger
    • , Sarah Berman
    • , Courtney Bodge
    • , Susan Brandon
    • , William (Bill) Brooks
    • , Jill Buck
    • , Virginia Buckles
    • , Sochenda Chea
    • , Jasmeer Chhatwal
    • , Patricio Chrem Mendez
    • , Helena Chui
    • , Jake Cinco
    • , Jack Clifford
    • , Carlos Cruchaga
    • , Tamara Donahue
    • , Jane Douglas
    • , Noelia Edigo
    • , Nilufer Erekin-Taner
    • , Anne Fagan
    • , Martin Farlow
    • , Colleen Fitzpatrick
    • , Gigi Flynn
    • , Nick Fox
    • , Erin Franklin
    • , Hisako Fujii
    • , Cortaiga Gant
    • , Samantha Gardener
    • , Bernardino Ghetti
    • , Alison Goate
    • , Jill Goldman
    • , Brian Gordon
    • , Neill Graff-Radford
    • , Julia Gray
    • , Alexander Groves
    • , Jason Hassenstab
    • , Laura Hoechst-Swisher
    • , David Holtzman
    • , Russ Hornbeck
    • , Siri Houeland DiBari
    • , Takeshi Ikeuchi
    • , Snezana Ikonomovic
    • , Gina Jerome
    • , Mathias Jucker
    • , Celeste Karch
    • , Kensaku Kasuga
    • , Takeshi Kawarabayashi
    • , William (Bill) Klunk
    • , Robert Koeppe
    • , Elke Kuder-Buletta
    • , Christoph Laske
    • , Jae-Hong Lee
    • , Johannes Levin
    • , Ralph Martins
    • , Neal Scott Mason
    • , Colin Masters
    • , Denise Maue-Dreyfus
    • , Eric McDade
    • , Hiroshi Mori
    • , John Morris
    • , Akem Nagamatsu
    • , Katie Neimeyer
    • , James Noble
    • , Joanne Norton
    • , Richard Perrin
    • , Marc Raichle
    • , Alan Renton
    • , John Ringman
    • , Jee Hoon Roh
    • , Stephen Salloway
    • , Peter Schofield
    • , Hiroyuki Shimada
    • , Wendy Sigurdson
    • , Hamid Sohrabi
    • , Paige Sparks
    • , Kazushi Suzuki
    • , Kevin Taddei
    • , Peter Wang
    • , Chengjie Xiong
    •  & Xiong Xu
  • Article |

    Soft electronic patches worn on the skin of infants or children in intensive-care units have a wide range of capabilities in aiding critical care, including monitoring of hemodynamic parameters, cardiac activity, movement and crying.

    • Ha Uk Chung
    • , Alina Y. Rwei
    • , Aurélie Hourlier-Fargette
    • , Shuai Xu
    • , KunHyuck Lee
    • , Emma C. Dunne
    • , Zhaoqian Xie
    • , Claire Liu
    • , Andrea Carlini
    • , Dong Hyun Kim
    • , Dennis Ryu
    • , Elena Kulikova
    • , Jingyue Cao
    • , Ian C. Odland
    • , Kelsey B. Fields
    • , Brad Hopkins
    • , Anthony Banks
    • , Christopher Ogle
    • , Dominic Grande
    • , Jun Bin Park
    • , Jongwon Kim
    • , Masahiro Irie
    • , Hokyung Jang
    • , JooHee Lee
    • , Yerim Park
    • , Jungwoo Kim
    • , Han Heul Jo
    • , Hyoungjo Hahm
    • , Raudel Avila
    • , Yeshou Xu
    • , Myeong Namkoong
    • , Jean Won Kwak
    • , Emily Suen
    • , Max A. Paulus
    • , Robin J. Kim
    • , Blake V. Parsons
    • , Kelia A. Human
    • , Seung Sik Kim
    • , Manish Patel
    • , William Reuther
    • , Hyun Soo Kim
    • , Sung Hoon Lee
    • , John D. Leedle
    • , Yeojeong Yun
    • , Sarah Rigali
    • , Taeyoung Son
    • , Inhwa Jung
    • , Hany Arafa
    • , Vinaya R. Soundararajan
    • , Ayelet Ollech
    • , Avani Shukla
    • , Allison Bradley
    • , Molly Schau
    • , Casey M. Rand
    • , Lauren E. Marsillio
    • , Zena L. Harris
    • , Yonggang Huang
    • , Aaron Hamvas
    • , Amy S. Paller
    • , Debra E. Weese-Mayer
    • , Jong Yoon Lee
    •  & John A. Rogers
  • Article |

    A machine-learning algorithm based on an array of demographic, physiological and clinical information is able to predict, hours in advance, circulatory failure of patients in the intensive-care unit.

    • Stephanie L. Hyland
    • , Martin Faltys
    • , Matthias Hüser
    • , Xinrui Lyu
    • , Thomas Gumbsch
    • , Cristóbal Esteban
    • , Christian Bock
    • , Max Horn
    • , Michael Moor
    • , Bastian Rieck
    • , Marc Zimmermann
    • , Dean Bodenham
    • , Karsten Borgwardt
    • , Gunnar Rätsch
    •  & Tobias M. Merz
  • Article |

    Plasma P-tau18 level increased with progression of Alzheimer’s disease (AD) and differentiated AD dementia from other neurodegenerative diseases, supporting its further development as a blood-based biomarker for AD.

    • Shorena Janelidze
    • , Niklas Mattsson
    • , Sebastian Palmqvist
    • , Ruben Smith
    • , Thomas G. Beach
    • , Geidy E. Serrano
    • , Xiyun Chai
    • , Nicholas K. Proctor
    • , Udo Eichenlaub
    • , Henrik Zetterberg
    • , Kaj Blennow
    • , Eric M. Reiman
    • , Erik Stomrud
    • , Jeffrey L. Dage
    •  & Oskar Hansson
  • Article |

    Plasma pTau181 concentrations are elevated specifically in patients diagnosed with Alzheimer’s disease compared to those diagnosed with frontotemporal lobar degeneration or elderly controls, supporting its further development as a blood-based biomarker for AD.

    • Elisabeth H. Thijssen
    • , Renaud La Joie
    • , Amy Wolf
    • , Amelia Strom
    • , Ping Wang
    • , Leonardo Iaccarino
    • , Viktoriya Bourakova
    • , Yann Cobigo
    • , Hilary Heuer
    • , Salvatore Spina
    • , Lawren VandeVrede
    • , Xiyun Chai
    • , Nicholas K. Proctor
    • , David C. Airey
    • , Sergey Shcherbinin
    • , Cynthia Duggan Evans
    • , John R. Sims
    • , Henrik Zetterberg
    • , Kaj Blennow
    • , Anna M. Karydas
    • , Charlotte E. Teunissen
    • , Joel H. Kramer
    • , Lea T. Grinberg
    • , William W. Seeley
    • , Howie Rosen
    • , Bradley F. Boeve
    • , Bruce L. Miller
    • , Gil D. Rabinovici
    • , Jeffrey L. Dage
    • , Julio C. Rojas
    • , Adam L. Boxer
    • , Leah Forsberg
    • , David S. Knopman
    • , Neill Graff-Radford
    • , Murray Grossman
    • , Edward H. Huey
    • , Chiadi Onyike
    • , Daniel Kaufer
    • , Erik Roberson
    • , Nupur Ghoshal
    • , Sandra Weintraub
    • , Brian Appleby
    • , Irene Litvan
    • , Diana Kerwin
    • , Mario Mendez
    • , Yvette Bordelon
    • , Giovanni Coppola
    • , Eliana Marisa Ramos
    • , M. Carmela Tartaglia
    • , Ging-Yuek Hsiung
    • , Ian MacKenzie
    • , Kimiko Domoto-Reilly
    • , Tatiana Foroud
    •  & Bradford C. Dickerson
  • Article |

    Simultaneous single-cell protein and transcriptome analysis identifies a baseline immune circuit associated with antibody responses to vaccination in healthy individuals and the severity of disease flares in patients with a subtype of systemic lupus erythematosus.

    • Yuri Kotliarov
    • , Rachel Sparks
    • , Andrew J. Martins
    • , Matthew P. Mulè
    • , Yong Lu
    • , Meghali Goswami
    • , Lela Kardava
    • , Romain Banchereau
    • , Virginia Pascual
    • , Angélique Biancotto
    • , Jinguo Chen
    • , Pamela L. Schwartzberg
    • , Neha Bansal
    • , Candace C. Liu
    • , Foo Cheung
    • , Susan Moir
    •  & John S. Tsang
  • Article |

    Microscopy and 16S rRNA sequencing suggest that there is a limited bacterial presence in the human fetal intestine, with one enriched Micrococcus species exhibiting immunomodulatory activity ex vivo.

    • E. Rackaityte
    • , J. Halkias
    • , E. M. Fukui
    • , V. F. Mendoza
    • , C. Hayzelden
    • , E. D. Crawford
    • , K. E. Fujimura
    • , T. D. Burt
    •  & S. V. Lynch
  • Article |

    Integrative analysis in patients with diffuse large B-cell lymphoma uncovers that biallelic mutations on TMEM30A are associated with a favorable outcome and enhanced sensitivity to CD47 blockade.

    • Daisuke Ennishi
    • , Shannon Healy
    • , Ali Bashashati
    • , Saeed Saberi
    • , Christoffer Hother
    • , Anja Mottok
    • , Fong Chun Chan
    • , Lauren Chong
    • , Libin Abraham
    • , Robert Kridel
    • , Merrill Boyle
    • , Barbara Meissner
    • , Tomohiro Aoki
    • , Katsuyoshi Takata
    • , Bruce W. Woolcock
    • , Elena Viganò
    • , Michael Gold
    • , Laurie L. Molday
    • , Robert S. Molday
    • , Adele Telenius
    • , Michael Y. Li
    • , Nicole Wretham
    • , Nancy Dos Santos
    • , Mark Wong
    • , Natasja N. Viller
    • , Robert A. Uger
    • , Gerben Duns
    • , Abigail Baticados
    • , Angel Madero
    • , Brianna N. Bristow
    • , Pedro Farinha
    • , Graham W. Slack
    • , Susana Ben-Neriah
    • , Daniel Lai
    • , Allen W. Zhang
    • , Sohrab Salehi
    • , Hennady P. Shulha
    • , Derek S. Chiu
    • , Sara Mostafavi
    • , Alina S. Gerrie
    • , Da Wei Huang
    • , Christopher Rushton
    • , Diego Villa
    • , Laurie H. Sehn
    • , Kerry J. Savage
    • , Andrew J. Mungall
    • , Andrew P. Weng
    • , Marcel B. Bally
    • , Ryan D. Morin
    • , Gabriela V. Cohen Freue
    • , Louis M. Staudt
    • , Joseph M. Connors
    • , Marco A. Marra
    • , Sohrab P. Shah
    • , Randy D. Gascoyne
    • , David W. Scott
    •  & Christian Steidl
  • Article |

    A step-wedged cluster randomized trial, carried out in six villages in Tumbes, Peru, with 2,376 participants, demonstrates population-wide reductions in blood pressure, which appear to be higher in individuals with hypertension, as well as reductions in risk of hypertension by around 50% for those without hypertension at baseline, after community-wide replacement of regular salt with a potassium-enriched alternative.

    • Antonio Bernabe-Ortiz
    • , Víctor G. Sal y Rosas
    • , Vilarmina Ponce-Lucero
    • , María K. Cárdenas
    • , Rodrigo M. Carrillo-Larco
    • , Francisco Diez-Canseco
    • , M. Amalia Pesantes
    • , Katherine A. Sacksteder
    • , Robert H. Gilman
    •  & J. Jaime Miranda
  • Article |

    In germ-free mice colonized with human microbiota, mucosal IL-22 signaling promotes the growth of succinate-consuming commensal bacteria via host mucus glycosylation, and transplantation of these bacteria limits Clostridioides difficile infection.

    • Hiroko Nagao-Kitamoto
    • , Jhansi L. Leslie
    • , Sho Kitamoto
    • , Chunsheng Jin
    • , Kristina A. Thomsson
    • , Merritt G. Gillilland III
    • , Peter Kuffa
    • , Yoshiyuki Goto
    • , Robert R. Jenq
    • , Chiharu Ishii
    • , Akiyoshi Hirayama
    • , Anna M. Seekatz
    • , Eric C. Martens
    • , Kathryn A. Eaton
    • , John Y. Kao
    • , Shinji Fukuda
    • , Peter D. R. Higgins
    • , Niclas G. Karlsson
    • , Vincent B. Young
    •  & Nobuhiko Kamada