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The authors develop a new method to mine genomic cancer data to uncover complex indels. These simultaneous deletions and insertions have been over-looked by previous sequencing data analysis methods, and the Pindel-C algorithm uncovers new information about their potential contribution to tumorigenesis.
The authors analyze the extent of intratumor heterogeneity across 12 tumor types to reveal that increased heterogeneity is a general phenomenon and has a biphasic contribution to tumor progression.
An international consortium of colorectal cancer researchers undertakes a large-scale data sharing project to achieve a consensus molecular classification of colorectal cancers.
