Articles in 2015

In this Perspective, attendees of the Herrenhausen Tumour Heterogeneity meeting discuss the challenges in understanding tumour heterogeneity and propose ways forward for overcoming these hurdles.

In this Perspective, the authors discuss the importance of intrinsic and extrinsic factors in muscle regeneration, and they conclude that both are necessary for the action of muscle stem cells in the aging process.

During renal fibrosis, epithelial cells undergo a partial epithelial-to-mesenchymal transition that can be targeted to reverse established disease.

Charles Serhan and colleagues report four new resolvins produced under inflammatory conditions that speed resolution of bacterial infection in mice.

Myostatin is shown to directly promote osteoclast differentiation, and its inhibition improves arthritic bone loss in two mouse models.

During renal fibrosis epithelial cells undergo a partial epithelial-to-mesenchymal transition that can be targeted to reverse established disease.

Neutrophils infiltrate the CNS and promote Alzheimer's disease–like pathology and memory loss.

The gut and oral microbiomes are altered in individuals with rheumatoid arthritis, and these changes can be used to stratify individuals for diagnostic and prognostic purposes.

Clinical testing of BCR inhibition on DLBCL reveals determinants of response.

A searchable pan-cancer resource generated using data from nearly 18,000 human tumors reveals links between tumor infiltration by particular leukocyte subsets, tumor expression of particular gene signatures, and patient prognosis.

Carl June and colleagues report the results of a phase I/II trial of adoptively transferred engineered T cells in patients with advanced multiple myeloma.

In response to signals from afferent TRPV1⁺ C-fibers, STAT3-dependent upregulation of LCN2 in reactive astrocytes of the spinal dorsal horn amplifies itch signaling in multiple rodent models of atopic and contact dermatitis.

Lineage tracing shows that, contrary to a recent report, c-kit⁺ cells take on a vascular endothelial cell fate, not an epithelial one, after lung injury or during normal homeostasis.

Preconditioning the niche after lung injury allows better engraftment by fetal lung tissue and repair.

Genomic profiling of carcinogen-induced skin tumors in mice provides a comprehensive characterization of their mutational landscape.

Nicotinamide N-methyltransferase acts through its product, N¹-methylnicotinamide, to stabilize Sirt1 and thus regulate hepatic glucose and lipid metabolism.

Intravenous administration of a fluorescently labeled c-Met–binding peptide enables visualization of polyps not detected using white light.