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Tichauer et al. describe a dual-tracer approach to quantify cancer cell receptor concentrations, in this case epidermal growth factor receptor, in lymph nodes, that can also correct for nonspecific uptake.
Activation of the transcription factor FoxO1 ameliorates vascular remodeling in pulmonary hypertension, pointing to a potential new therapeutic strategy for this disease.
Two papers in this issue, by Bruns et al. and Zhao et al., show that megakaryocytes constitute a niche for hematopoietic stem cells in the mouse bone marrow and produce factors that regulate hematopoietic stem cell quiescence and proliferation.
The next generation of genetically engineered mouse models of pancreatic cancer involving a new inducible dual-recombinase system that combines Flp-FRT and Cre-loxP.
Tau cleavage and aggregation, key processes in many neurodegenerative diseases, can be reduced by blocking the activity of a protease called asparagine endopeptidase.
Two papers in this issue, by Bruns et al. and Zhao et al., show that megakaryocytes constitute a niche for hematopoietic stem cells in the mouse bone marrow and produce factors that regulate hematopoietic stem cell quiescence and proliferation.
A new study shows that Wnt16 inhibits osteoclast formation, suggesting it may be a possible therapeutic option for treating bone fractures in osteoporosis.