Review Articles

Filter By:

  • Certain acute infections (including SARS-CoV-2) are associated with an unexplained chronic disability in a minority of patients; this Review summarizes what is known about these understudied and complex illnesses.

    • Jan Choutka
    • Viraj Jansari
    • Akiko Iwasaki
    Review Article
  • Oncology is trailblazing the field of engineered cellular therapeutics. This Review discusses the goals of cellular immunotherapy in cancer, key challenges facing the field and strategies to overcome them—paving the way for treatment of other diseases.

    • Amanda V. Finck
    • Tatiana Blanchard
    • Carl H. June
    Review Article
  • There exists tremendous opportunity to target microorganisms in the gut and other niches to help treat or even prevent cancer. This Review outlines how microbial targeting could become a pillar of personalized cancer care over the next 5 to 10 years.

    • Elizabeth M. Park
    • Manoj Chelvanambi
    • Jennifer A. Wargo
    Review Article
  • Technological advances are producing exquisitely sensitive cancer detection tests. This Review discusses who should be tested, and how—and looks to the future of personalized, risk-based cancer screening.

    • Rebecca C. Fitzgerald
    • Antonis C. Antoniou
    • Nitzan Rosenfeld
    Review Article
  • This Review aims to support clinical decision-making by providing an overview of the evidence for immunotherapy strategies in patients with COVID-19.

    • Frank L. van de Veerdonk
    • Evangelos Giamarellos-Bourboulis
    • Mihai G. Netea
    Review Article
  • AI has the potential to reshape medicine and make healthcare more accurate, efficient and accessible; this Review discusses recent progress, opportunities and challenges toward achieving this goal.

    • Pranav Rajpurkar
    • Emma Chen
    • Eric J. Topol
    Review Article
  • As the development of biomarkers for neurodegenerative diseases advances, new opportunities arise for their implementation in clinical practice and trials.

    • Oskar Hansson
    Review Article
  • Recent advances in machine learning techniques have created opportunities to improve medical diagnostics, but implementing these advances in the clinic will not be without challenge.

    • Jeroen van der Laak
    • Geert Litjens
    • Francesco Ciompi
    Review Article
  • Examination of the vaccine strategies and technical platforms used for the COVID-19 pandemic in the context of those used for previous emerging and reemerging infectious diseases and pandemics can offer critical lessons to prepare for future public health emergencies.

    • Jean-Louis Excler
    • Melanie Saville
    • Jerome H. Kim
    Review Article
  • A comprehensive review of the current literature on post-acute COVID-19, also referred to as long COVID, its pathophysiology and its organ-specific sequelae highlights the need for multidisciplinary follow-up and care of COVID-19 survivors.

    • Ani Nalbandian
    • Kartik Sehgal
    • Elaine Y. Wan
    Review Article
  • Increased understanding of the biology of metastases allows improved targeting and outcomes for patients with both micro- and macrometastases.

    • Karuna Ganesh
    • Joan Massagué
    Review Article
  • The COVID-19 pandemic has resulted in an accelerated development of applications for digital health, including symptom monitoring and contact tracing. Their potential is wide ranging and must be integrated into conventional approaches to public health for best effect.

    • Jobie Budd
    • Benjamin S. Miller
    • Rachel A. McKendry
    Review Article
  • Recent clinical observations have prompted clinicians to think of COVID-19 as being more than a respiratory disease.

    • Aakriti Gupta
    • Mahesh V. Madhavan
    • Donald W. Landry
    Review Article