News & Views

  • News & Views |

    Animal models of AIDS continue to surprise researchers with results that can be difficult to explain. However, most researchers still believe that animal models are essential to progress in understanding the disease. But which animal model is best? (pages 321–329)

    • James Stott
    •  & Neil Almond
  • News & Views |

    A previously undescribed tissue connection may provide an explanation for some forms of tension headache. It also proves that common beliefs aboutanatomical research reaching its limits are unfounded.

    • Van P. Thompson
  • News & Views |

    Ribozymes can inhibit gene expression in a sequence-specific manner by catalysing cleavage of target messenger RNAs. They can also be used to for DIY (do-it-yourself) surgery on defective RNAs. The potential therapeutic applications of these ribozyme properties were discussed at a recent meeting.

    • Saghir Akhtar
    • , Helen James
    •  & Ian Gibson
  • News & Views |

    Genetic testing for cancer predisposition is available now, but demand for testing is difficult to predict given the complex issues faced by candidates for testing.

    • Katherine A. Schneider
    • , Andrea Farkas Patenaude
    •  & Judy E. Garber
  • News & Views |

    The generation of cytotoxic T lymphocyte response may be an essential part of an effective immune response to HIV infection. It may also do more harm than good (pages 330–336).

    • Bonnie J. Mathieson
  • News & Views |

    Transplantation of fetal mesencephalic tissue into patients suffering from Parkinson's disease has had mixed clinical results. Perhaps antioxidant therapy can increase the odds of success (pages 226–231).

    • Lisa J. Fisher
    •  & Fred H. Gage
  • News & Views |

    Activation of the enzyme telomerase is associated with neuroblastoma and other cancers. Is it an effect or a cause of tumour formation (pages 249–255)?

    • Garrett M. Brodeur
  • News & Views |

    Recent publication of the results of the Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial has led to the Woman's Health Initiative(WHI) to rethink the protocols for its own large trial.

    • Loretta P. Finnegan
    • , Jacques Rossouw
    •  & William R. Harlan
  • News & Views |

    The antidepressant drug rolipram inhibits tumor necrosis factor-α. This may make it an effective treatment for multiple sclerosis (pages 244–248).

    • Cedric S. Raine
  • News & Views |

    Borna virus causes neurological disease in animals. It may be responsible for human disorders as well (pp. 232–236).

    • Joanna M. Pyper
  • News & Views |

    Engineering chylomicron vesicles to target drugs to the liver may provide effective new treatments for hepatitis B and other liver diseases (pages 221–225).

    • Nadeem Hassan
    •  & George Y. Wu
  • News & Views |

    A demonstration of inhibition of β-sheets in both reactive amyloid, using an in vivo mouse model, and synthetic Alzheimer (β) amyloid, in vitro (pages 143–148).

    • Scott R. Diehl
  • News & Views |

    It is reported that DNA fragmentation (indicating apoptosis) is rarely observed in HIV-1 or SIV-producing infected cells, and HIV-1 or SIV RNA is rarely (0-1%) observed in apoptotic cells. What is the role of apoptosis in the pathogenicity of HIV infection? (pages 129–134)

    • Giuseppe Pantaleo
    •  & Anthony S. Fauci
  • News & Views |

    Examination of the effects of three new drugs shows that the destruction of the immune system in AIDS reflects fulminant HIV production, which eventually overwhelms the immune system's prodigious powers of regeneration.

    • Nicholas Short
  • News & Views |

    Three articles claim to have identified the spinal muscular atrophy gene, yet they do not appear to have enough in common to identify the same gene.

    • T. Conrad Gilliam
  • News & Views |

    Removal of a primary tumour can result in a burst of growth in previously ‘dormant’ micrometastases and is associated with onset of angiogenesis and a reduced incidence of apoptosis (see pages 149–153)

    • Cliff Murray
  • News & Views |

    Caplen et al. (pages 39–46) demonstrate that it is feasible to use liposomes to transfer a human gene in vivo. Can this vector mimic the ability of viruses to effectively transfer genetic information into target cells?

    • Ronald G. Crystal
  • News & Views |

    Skinner and colleagues (pages 69–73) show that MRI can be used to evaluate atherosclerotic lesions, non-invasively and in vivo

    • Peter Libby
  • News & Views |

    By careful microscopic examination of in vitro fertilization (pages 47–52) Simerly et al. demonstrate the paternal origin of the human centrosome and reveal steps at which fertilization may fail.

    • Tim Stearns
  • News & Views |

    Two recent reports provide further evidence for a link between coxsackieviruses and the onset of IDDM, although a careful examination suggests it is still too early to conclude a definitive role.

    • Michele Solimena
    •  & Pietro De Camilli
  • News & Views |

    Further progress in organ transplantation must overcome two key problems: a shortage of organs and long term immunological tolerance. Xenografts and immunological conditioning may help

    • R. Y. Calne
  • News & Views |

    For many years cholesterol was seen as the worst enemy of coronary arteries. Recent advances show that interactions between lipoproteins, coagulation and growth factors are important in atherosclerosis.

    • Michael R. Hayden
    •  & Michael Reidy
  • News & Views |

    The demonstration, by Rutkowski et al. (page 80), that human Schwann cells can now be expanded to around 1 × 108 cells, provides a new opportunity for the study and therapy of myelin disorders.

    • Hugo W. Moser