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Unexpectedly, new data show that clonal hematopoiesis is associated with protection from Alzheimer’s disease; it is imperative that future studies unravel the complex tissue–disease contexts in which clonal hematopoiesis arises and contributes to aging-associated diseases.
A new study showing that genetic and non-genetic factors contribute to autistic traits calls for a fundamental realignment of the concepts and methods of genomics, with a critical understanding of the biosocial complexity of autism.
A new study strengthens the association between urbanicity and mental health with more granularity than before, but a causative mechanism remains elusive.
For women who choose nonhormonal therapy for hot flashes, fezolinetant appears to be one of several modestly efficacious and safe options — but women want more.
An antisense oligonucleotide therapy substantially reduced tau expression in a phase 1b trial; whether this translates to clinical improvement remains to be seen, but it could have far-reaching implications for neurodegenerative diseases more broadly.
Adding an oncolytic virus to classic immune checkpoint inhibition elicits treatment responses and survival benefit for select immunologically ‘cold’ recurrent glioblastomas, although creative treatment strategies are still needed for patients with highly anti-inflammatory tumors.
Diagnosis of kidney allograft rejection remains complex and somewhat subjective; but an automated version of the gold-standard Banff classification could streamline assessment and improve diagnostic accuracy.
Single-cell analyses in humans and mice have revealed the identity of the erythropoietin producing cells of the kidney — opening up new avenues of research for anemia and related disorders.
The CanScreen5 project provides a tool for monitoring the performance and improving the quality of global cancer screening programs — and highlights the importance of robust quality assurance in this setting.
A new study highlights the importance of dietary intake and a health-promoting food environment for diabetes prevention, but translating this into meaningful outcomes requires urgent government action.
Salt substitutes can lower blood pressure and the incidence of cardiovascular disease, according to a new study — that also provides reassurance on safety.
The composition of the intestinal microbiome may predict clinical outcomes of CAR-T cell therapy for lymphoma, which could inform microbiota-based intervention strategies.
Integrative approaches continue to improve diagnostic accuracy for pediatric brain cancers, but much more is needed from researchers, governments and regulators if precision medicine with curative treatments are to become a reality.
The NEOSTAR trial is a key step on route to better outcomes; but the best approach is likely to be an individualized one, reflecting the many factors that influence treatment response.
Epidural spinal cord stimulation improved upper limb function in two participants after stroke, revealing a potentially exciting new tool for stroke recovery.
The widely used artificial sweetener erythritol affects platelet function and is associated with major cardiovascular events — fuelling calls for a re-evaluation of the use and regulation of non-nutritive sweeteners.
High-resolution meta-omics have enabled the discovery of the microbial enzymes that inactivate an ulcerative colitis drug and predict subsequent treatment failure, an approach that could enable more personalized treatment of inflammatory bowel disease.
Pre-symptomatic gene editing in preclinical models of hypertrophic cardiomyopathy shows therapeutic promise; clinical studies are now needed to assess safety and efficacy in humans.
A study prospectively evaluating a stratified approach to selecting treatment heralds a new era of precision medicine for type 2 diabetes, which should incorporate ongoing discovery, social determinants of health and healthcare transformation.
