News & Views

  • News & Views |

    A metastatic hormone receptor–positive breast cancer, usually resistant to immunotherapy, is successfully treated with tumor-infiltrating lymphocytes enriched for neoantigen reactivity, underscoring the broad potential of this immunotherapeutic approach.

    • Laszlo G. Radvanyi
  • News & Views |

    Complete leukemic responses to chimeric antigen receptor–modified T cells are invariably accompanied by severe toxicity. Recently developed animal models allow mechanistic dissection and prevention of toxicity without loss of therapeutic benefit.

    • Cliona Rooney
    •  & Tim Sauer
  • News & Views |

    Anti-GD2 chimeric antigen receptor (CAR)-modified T cells may be a new and innovative approach for the treatment of pediatric H3-K27M-mutant diffuse midline gliomas.

    • Vijay Ramaswamy
    •  & Michael D Taylor
  • News & Views |

    A crucial role for glucose metabolism has been identified in wound repair and in the pathogenesis of chronic inflammatory skin diseases, indicating that targeting metabolism is an approach for treating psoriasis.

    • Paul Hiebert
    •  & Sabine Werner
  • News & Views |

    In triple-negative breast cancer, therapeutic response to carboplatin and docetaxel is similar. However, carboplatin therapy is superior to docetaxel in patients with germline BRCA1 or BRCA2 mutations, but ‘BRCAness’ does not predict sensitivity to carboplatin. 

    • Ana C. Garrido-Castro
    •  & Eric P. Winer
  • News & Views |

    An artificial intelligence (AI) using a deep-learning approach can classify retinal images from optical coherence tomography for early diagnosis of retinal diseases and has the potential to be used in other image-based medical diagnoses.

    • Daniel S. W. Ting
    • , Yong Liu
    • , Philippe Burlina
    • , Xinxing Xu
    • , Neil M. Bressler
    •  & Tien Y. Wong
  • News & Views |

    A key molecular mechanism has been identified that dictates whether memory will maintain or lose its details over time and that is relevant in post-traumatic stress disorder and dementia.

    • Josue Haubrich
    •  & Karim Nader
  • News & Views |

    The presence of multiple inflammatory cytokines predicts the failure of a topical 1% tenofovir microbicide gel to protect women against HIV infection.

    • Thomas J Hope
  • News & Views |

    Mass cytometry of acute B cell lymphoblastic leukemias at diagnosis reveals intrapatient phenotypic heterogeneity and specific signatures that mimic cell developmental stage and predict future relapse.

    • José Ignacio Martín-Subero
  • News & Views |

    A newly discovered antibody epitope on the liver-infective form of the parasite that causes malaria opens new doors for vaccine development.

    • Simon J Draper
    •  & Matthew K Higgins
  • News & Views |

    Studies in metastatic melanoma, non-small-cell lung carcinoma and renal cell carcinoma indicate certain bacteria within the gut microbiota enhance clinical responses to checkpoint blockade.

    • Cynthia L Sears
    •  & Drew M Pardoll
  • News & Views |

    In a nonhuman primate model of Zika virus infection, structural and cellular pathology deficits that could have a long-lasting impact on neural development and neurocognitive function are detected in offspring of infected mothers.

    • Kimberly M Christian
    • , Hongjun Song
    •  & Guo-li Ming
  • News & Views |

    An active immunosuppressive pathway is identified in colon cancer that confers immune evasion by the cancer and can be targeted to synergize with immunotherapies.

    • Antoine Marçais
    •  & Thierry Walzer
  • News & Views |

    In a recent study using cytomegalovirus (CMV)-vectored vaccines in rhesus macaques, prevention of tuberculosis in over 40% of vaccinated animals is shown and is attributed to reprogrammed innate immunity and CMV's maintenance of vaccine-elicited effector memory T cells.

    • Stephen M Carpenter
    •  & Samuel M Behar
  • News & Views |

    A recent study investigates the contribution of epigenomic plasticity to lung metastasis in osteosarcoma. Changes in the enhancer landscape were found to be nonrandom and driven by selective forces in the microenvironment.

    • Heinrich Kovar
  • News & Views |

    A recent study identifies an immune cell type known as classical monocytes in the peripheral blood as a potential biomarker for response to anti-PD-1 immune checkpoint therapy in metastatic melanoma.

    • Sangeeta Goswami
    • , Sreyashi Basu
    •  & Padmanee Sharma
  • News & Views |

    A Children's Oncology Group study of nearly 1,000 pediatric acute myeloid leukemia (AML) cases reveals marked differences between the genomic landscapes of pediatric and adult AML and offers directions for future work.

    • Andrew M Brunner
    •  & Timothy A Graubert
  • News & Views |

    In a recent study of hepatic ischemia–reperfusion injury (IRI), Zhang et al. use tandem 'omics' approaches in mice, pigs, and nonhuman primates to identify lipid metabolic reprogramming as a key determinant of IRI, thus providing novel mechanistic and therapeutic insights.

    • Satdarshan P Monga
  • News & Views |

    Signals that govern immune cells in the heart remain poorly defined. A new report in mice shows that pathways involved in sensing viruses orchestrate monocyte and macrophage activation through recognition of DNA derived from dying cardiomyocytes following myocardial infarction.

    • Kory J Lavine
    •  & Douglas L Mann
  • News & Views |

    A new study shows that deleting uncoupling protein 1 activates Ca2+ cycling thermogenesis within beige fat, protecting mice against cold-induced hypothermia and dysglycemia following diet-induced obesity.

    • Daniel Gamu
    •  & A Russell Tupling
  • News & Views |

    In an article published recently in Nature Medicine, the authors generate organoid models of liver neoplasia. In doing so, they highlight both the diversity of current organoid methodologies and their application to cancer modeling and therapeutics discovery.

    • Amber R Smith
    •  & Calvin J Kuo
  • News & Views |

    In a recent study, Maciocia et al. develop a novel T cell receptor beta (TCRB) constant C1-chain-directed cellular immunotherapy for the treatment of T cell malignancies.

    • Teresa Palomero
    •  & Adolfo Ferrando
  • News & Views |

    A recent study identifies a population of CXCR5+ natural killer (NK) cells patrolling B cell follicles in simian immunodeficiency virus (SIV)-infected African green monkeys that might contribute to the lack of disease progression in this nonpathogenic model.

    • Madeleine J Bunders
    •  & Marcus Altfeld
  • News & Views |

    A recent study describes a role for hypoxic signaling in the small intestine in the etiology of nonalcoholic fatty liver disease (NAFLD) and suggests that HIF-2α inhibitors may be an effective option for the treatment of this disease.

    • Edward L LaGory
    •  & Amato J Giaccia
  • News & Views |

    Recent research has identified sympathetic neuron–associated macrophages in adipose tissue that take up and degrade catecholamines released from neurons. Obesity and aging enhance this system, decreasing responses to cold stress and starvation.

    • Michael P Czech
  • News & Views |

    A recent study finds that the N6-methyladenosine (m6A) modifier METTL3 regulates proliferation and differentiation in myeloid cells and acute myeloid leukemia (AML).

    • Alexandra C Schmiechen
    •  & Pedro J Batista
  • News & Views |

    A new mouse model of Rett syndrome, in which MECP2 can be selectively biotinylated, allows for the investigation of cell-specific effects of Rett-causing mutations on gene expression, particularly in female mice.

    • Patricia M Horvath
    •  & Lisa M Monteggia
  • News & Views |

    Three recent studies in mice have identified a specific receptor, GFRAL, for the known anorectic peptide GDF15. The finding increases mechanistic understanding of its effect and paves the way for the development of novel anti-obesity therapeutics.

    • Irene Cimino
    • , Anthony P Coll
    •  & Giles S H Yeo
  • News & Views |

    Cancer-associated mutations in speckle-type POZ (pox virus and zinc-finger) protein confer neomorphic activity, altering its substrate affinities and its response to bromodomain and extraterminal inhibitors in prostate and endometrial cancer.

    • Katie A Fennell
    •  & Mark A Dawson
  • News & Views |

    A recent study reveals sexually dimorphic disease-associated gene-expression modules and hub genes in postmortem brains from female and male individuals with depression. These modules are conserved in mouse models of depression.

    • Ronald S Duman
  • News & Views |

    Using interleukin (IL)-9-deficient mice, Rauber and colleagues unveil a crucial role for group 2 innate lymphoid cells (ILC2s) in the resolution phase of arthritic inflammation, opening up new therapeutic avenues for chronic inflammatory disease.

    • Ben Roediger
    •  & Wolfgang Weninger
  • News & Views |

    A new study that uses a triple-drug combination to overcome a major mechanism of drug resistance in cancer provides insights into the evolutionary paths taken by tumors in the face of selective pressure.

    • Ari J Firestone
    •  & Jeff Settleman
  • News & Views |

    Enhanced conversion of dietary cholesterol to bile acids through the alternative pathway leads to cold-associated, metabolically beneficial changes in the intestinal microbiome and to elevated bile acid levels that contribute to adaptive thermogenesis.

    • Folkert Kuipers
    •  & Albert K Groen
  • News & Views |

    A mouse model with combined renal epithelium-specific deletion of Vhl, Trp53 and Rb1 that develops clear-cell renal cell carcinoma provides a research tool for investigating the mechanisms that drive this cancer, and for evaluating the efficacy of novel therapeutic agents.

    • Laura S Schmidt
    •  & W Marston Linehan
  • News & Views |

    A recent study has found that rhinovirus-induced exacerbation of asthma is in part mediated by the release of neutrophil extracellular traps and double-stranded DNA by neutrophils in the airway.

    • William W Busse
  • News & Views |

    A new study that uses an integrated single-cell transcriptomics approach to characterize cancer stem cell populations during treatment with molecularly targeted therapies offers insights into disease evolution and points to new therapeutic targets.

    • Christopher A Eide
    •  & Brian J Druker
  • News & Views |

    New evidence in mouse models reveals that exposure to Δ9-tetrahydrocannabinol (THC), the main psychoactive component in Cannabis sativa, might improve cognitive performance in aging animals.

    • Andrés Ozaita
    •  & Ester Aso
  • News & Views |

    A new study identifies oncostatin M (OSM) as a potential biomarker and therapeutic target for anti-tumor necrosis factor (TNF)-refractory inflammatory bowel disease (IBD), and pinpoints mucosal stromal cells as key players in OSM-mediated inflammation.

    • Walter M Kim
    • , Arthur Kaser
    •  & Richard S Blumberg
  • News & Views |

    A recent study using a humanized mouse model shows that HIV-1 can persist in macrophages during antiretroviral therapy (ART), and suggests that macrophages may represent an obstacle to efforts to cure HIV-1 infection.

    • Mario Stevenson
  • News & Views |

    A new study in mice suggests that a single drug, thymosin α1, may simultaneously rectify the impaired trafficking of the cystic fibrosis transmembrane conductance regulator (CFTR) in cystic fibrosis (CF) and reduce inflammation, offering new hope for CF treatment.

    • André M Cantin
    •  & John W Hanrahan