News & Views

Recent studies on osteoclast apoptosis and TGF-β gene regulation provide new insights into the mechanisms by which estrogens and their analogues inhibit bone resorption (pages 1132–1136).

SIV vaginal transmission in monkeys may be enhanced by progesterone (pages 1084–1089).

Several STATs transduce signals and activate genes only in response to select cytokines—will all STATs prove so specific?

p53 gene therapy brings clinical benefits to lung cancer patients (pages 985-991).

Peripheral nerve grafts promote the growth of nerve fibers in severed rat spinal cords.

Inhibition of nitric oxide synthesis by 7-nitroindazole prevents destruction of dopamine neurons and parkinsonian symptoms in baboons treated with MPTP (page 1017–1021).

Angiogenic factors regulate adhesion of activated natural killer cells to the tumor vasculature (pages 992-997).

Stem cells in mismatched placental blood can safely reconstitute hemopoiesis in children.

Insight into the molecular mechanism of rapamycin's immunosuppressive effects provides the basis for a novel approach to regulating therapeutic gene expression (pages 1028-1032).

A genetic defect in the HIV-1 co-receptor provides resistance to infection.

Altered microsatellite DNA in the blood of cancer patients may provide a novel method for tumor detection (pages 1033-1037).

High-resolution X-ray computed tomography reveals the three-dimensional structure of microscopic biological tissue and has great clinical potential if the X-ray dose can be reduced (pages 933–935).

Recent evidence suggests that Chlamydia bacteria may play an etiological role in the formation of atherosclerotic plaques.

Seroepidemlologlcal evidence from two new serologlcal assays supports a role for HHV8 In Kaposi's sarcoma (pages 918–928).

Manipulating the immune system with DNA vaccines shows promise for protecting against pathogens and suppressing autoimmune disease (pages 888–905).

An unconventional operation for treating end-stage heart failure may prove beneficial for some patients waiting for heart transplants.

Stochastic resonance may be just a few steps away from a practical application to cochlear implants for treating deafness (pages 928–932).

A bacteriophage mediates the horizontal transfer of virulence genes between Vibrio cholerae with broad implications for the emergence of pathogenic strains.

Defining the molecular pathways of Alzheimer's disease raises new possibilities for treatment (pages 864–875).

Emerging technologies hold promise for correcting refractive errors of the eye.