Letters

  • Letter |

    Expansion of pathogenic Candida species coupled with bacterial dysbiosis in the gut precedes Candida bloodstream infections in hematopoietic cell transplant recipients.

    • Bing Zhai
    • , Mihaela Ola
    • , Thierry Rolling
    • , Nicholas L. Tosini
    • , Sari Joshowitz
    • , Eric R. Littmann
    • , Luigi A. Amoretti
    • , Emily Fontana
    • , Roberta J. Wright
    • , Edwin Miranda
    • , Charlotte A. Veelken
    • , Sejal M. Morjaria
    • , Jonathan U. Peled
    • , Marcel R. M. van den Brink
    • , N. Esther Babady
    • , Geraldine Butler
    • , Ying Taur
    •  & Tobias M. Hohl
  • Letter |

    A prospective, multicenter, case–control clinical trial evaluates the potential of artificial intelligence for providing accurate bedside diagnosis of patients with brain tumors.

    • Todd C. Hollon
    • , Balaji Pandian
    • , Arjun R. Adapa
    • , Esteban Urias
    • , Akshay V. Save
    • , Siri Sahib S. Khalsa
    • , Daniel G. Eichberg
    • , Randy S. D’Amico
    • , Zia U. Farooq
    • , Spencer Lewis
    • , Petros D. Petridis
    • , Tamara Marie
    • , Ashish H. Shah
    • , Hugh J. L. Garton
    • , Cormac O. Maher
    • , Jason A. Heth
    • , Erin L. McKean
    • , Stephen E. Sullivan
    • , Shawn L. Hervey-Jumper
    • , Parag G. Patil
    • , B. Gregory Thompson
    • , Oren Sagher
    • , Guy M. McKhann II
    • , Ricardo J. Komotar
    • , Michael E. Ivan
    • , Matija Snuderl
    • , Marc L. Otten
    • , Timothy D. Johnson
    • , Michael B. Sisti
    • , Jeffrey N. Bruce
    • , Karin M. Muraszko
    • , Jay Trautman
    • , Christian W. Freudiger
    • , Peter Canoll
    • , Honglak Lee
    • , Sandra Camelo-Piragua
    •  & Daniel A. Orringer
  • Letter |

    Analysis of a mass cytometry dataset for different human solid tumors coupled with murine reverse translational experiments suggests that targeting CD73 could enhance the efficacy of checkpoint inhibitor therapy in glioblastoma.

    • Sangeeta Goswami
    • , Thomas Walle
    • , Andrew E. Cornish
    • , Sreyashi Basu
    • , Swetha Anandhan
    • , Irina Fernandez
    • , Luis Vence
    • , Jorge Blando
    • , Hao Zhao
    • , Shalini Singh Yadav
    • , Martina Ott
    • , Ling Y. Kong
    • , Amy B. Heimberger
    • , John de Groot
    • , Boris Sepesi
    • , Michael Overman
    • , Scott Kopetz
    • , James P. Allison
    • , Dana Pe’er
    •  & Padmanee Sharma
  • Letter |

    Aptamer-based proteomic analysis of plasma from healthy individuals aged 18–95 years reveals wave-like patterns of protein expression that are associated with age-related diseases and phenotypic traits.

    • Benoit Lehallier
    • , David Gate
    • , Nicholas Schaum
    • , Tibor Nanasi
    • , Song Eun Lee
    • , Hanadie Yousef
    • , Patricia Moran Losada
    • , Daniela Berdnik
    • , Andreas Keller
    • , Joe Verghese
    • , Sanish Sathyan
    • , Claudio Franceschi
    • , Sofiya Milman
    • , Nir Barzilai
    •  & Tony Wyss-Coray
  • Letter |

    Analysis of known viruses in stool samples from young children with high genetic risk for type 1 diabetes shows that sustained enterovirus B (EV-B) infections, rather than independent, short-duration EV-B infections, might be involved in the development of islet autoimmunity, but not type 1 diabetes.

    • Kendra Vehik
    • , Kristian F. Lynch
    • , Matthew C. Wong
    • , Xiangjun Tian
    • , Matthew C. Ross
    • , Richard A. Gibbs
    • , Nadim J. Ajami
    • , Joseph F. Petrosino
    • , Marian Rewers
    • , Jorma Toppari
    • , Anette G. Ziegler
    • , Jin-Xiong She
    • , Ake Lernmark
    • , Beena Akolkar
    • , William A. Hagopian
    • , Desmond A. Schatz
    • , Jeffrey P. Krischer
    • , Heikki Hyöty
    •  & Richard E. Lloyd
  • Letter |

    Large-scale aptamer-based scanning of plasma proteins coupled with machine learning demonstrates proof-of-concept and feasibility of an individualized health check using a single blood sample.

    • Stephen A. Williams
    • , Mika Kivimaki
    • , Claudia Langenberg
    • , Aroon D. Hingorani
    • , J. P. Casas
    • , Claude Bouchard
    • , Christian Jonasson
    • , Mark A. Sarzynski
    • , Martin J. Shipley
    • , Leigh Alexander
    • , Jessica Ash
    • , Tim Bauer
    • , Jessica Chadwick
    • , Gargi Datta
    • , Robert Kirk DeLisle
    • , Yolanda Hagar
    • , Michael Hinterberg
    • , Rachel Ostroff
    • , Sophie Weiss
    • , Peter Ganz
    •  & Nicholas J. Wareham
  • Letter |

    A new assay combining genotypic and phenotypic information accelerates accurate clinical antibiotic susceptibility testing.

    • Roby P. Bhattacharyya
    • , Nirmalya Bandyopadhyay
    • , Peijun Ma
    • , Sophie S. Son
    • , Jamin Liu
    • , Lorrie L. He
    • , Lidan Wu
    • , Rustem Khafizov
    • , Rich Boykin
    • , Gustavo C. Cerqueira
    • , Alejandro Pironti
    • , Robert F. Rudy
    • , Milesh M. Patel
    • , Rui Yang
    • , Jennifer Skerry
    • , Elizabeth Nazarian
    • , Kimberly A. Musser
    • , Jill Taylor
    • , Virginia M. Pierce
    • , Ashlee M. Earl
    • , Lisa A. Cosimi
    • , Noam Shoresh
    • , Joseph Beechem
    • , Jonathan Livny
    •  & Deborah T. Hung
  • Letter |

    The degree of sequence divergence between patient MHC class I alleles influences the response to immune checkpoint blockade therapy independently of tumor mutational burden.

    • Diego Chowell
    • , Chirag Krishna
    • , Federica Pierini
    • , Vladimir Makarov
    • , Naiyer A. Rizvi
    • , Fengshen Kuo
    • , Luc G. T. Morris
    • , Nadeem Riaz
    • , Tobias L. Lenz
    •  & Timothy A. Chan
  • Letter |

    Large-scale sequencing of coding exons of MRAP2 in 9,418 adults and adolescents identifies loss-of-function mutations that are associated with monogenic obesity, hypertension and hyperglycemia.

    • Morgane Baron
    • , Julie Maillet
    • , Marlène Huyvaert
    • , Aurélie Dechaume
    • , Raphaël Boutry
    • , Hélène Loiselle
    • , Emmanuelle Durand
    • , Bénédicte Toussaint
    • , Emmanuel Vaillant
    • , Julien Philippe
    • , Jérémy Thomas
    • , Amjad Ghulam
    • , Sylvia Franc
    • , Guillaume Charpentier
    • , Jean-Michel Borys
    • , Claire Lévy-Marchal
    • , Maïthé Tauber
    • , Raphaël Scharfmann
    • , Jacques Weill
    • , Cécile Aubert
    • , Julie Kerr-Conte
    • , François Pattou
    • , Ronan Roussel
    • , Beverley Balkau
    • , Michel Marre
    • , Mathilde Boissel
    • , Mehdi Derhourhi
    • , Stefan Gaget
    • , Mickaël Canouil
    • , Philippe Froguel
    •  & Amélie Bonnefond
  • Letter |

    Targeting the adipokine adipsin and its downstream pathway may provide an approach for preservation of beta cell loss in type 2 diabetes.

    • Nicolás Gómez-Banoy
    • , J. Sawalla Guseh
    • , Ge Li
    • , Alfonso Rubio-Navarro
    • , Tong Chen
    • , BreAnne Poirier
    • , Gregory Putzel
    • , Carolina Rosselot
    • , Maria A. Pabón
    • , João Paulo Camporez
    • , Vijeta Bhambhani
    • , Shih-Jen Hwang
    • , Chen Yao
    • , Rachel J. Perry
    • , Sushmita Mukherjee
    • , Martin G. Larson
    • , Daniel Levy
    • , Lukas E. Dow
    • , Gerald I. Shulman
    • , Noah Dephoure
    • , Adolfo Garcia-Ocana
    • , Mingming Hao
    • , Bruce M. Spiegelman
    • , Jennifer E. Ho
    •  & James C. Lo
  • Letter |

    Pluripotent stem cells can generate functional lungs when injected into blastocyst-stage mouse embryos, a step toward the goal of growing human lungs in large animals for disease modeling and therapeutic applications.

    • Munemasa Mori
    • , Kazuhiro Furuhashi
    • , Jennifer A. Danielsson
    • , Yuichi Hirata
    • , Miwako Kakiuchi
    • , Chyuan-Sheng Lin
    • , Mayu Ohta
    • , Paul Riccio
    • , Yusuke Takahashi
    • , Xinjing Xu
    • , Charles W. Emala
    • , Chao Lu
    • , Hiromitsu Nakauchi
    •  & Wellington V. Cardoso
  • Letter |

    Epigenetic regulators modulating chromatin accessibility dictate sensitivity to anthracycline-based therapy in early breast cancer and represent potential biomarkers for patient stratification.

    • Jose A. Seoane
    • , Jacob G. Kirkland
    • , Jennifer L. Caswell-Jin
    • , Gerald R. Crabtree
    •  & Christina Curtis
  • Letter |

    A single-arm multicenter phase 2 trial demonstrates clinical efficacy of neoadjuvant PD-L1 blockade in patients with resectable muscle-invasive bladder cancer ineligible for cisplatin and examines biomarkers associated with patient outcome.

    • Thomas Powles
    • , Mark Kockx
    • , Alejo Rodriguez-Vida
    • , Ignacio Duran
    • , Simon J. Crabb
    • , Michiel S. Van Der Heijden
    • , Bernadett Szabados
    • , Albert Font Pous
    • , Gwenaelle Gravis
    • , Urbano Anido Herranz
    • , Andrew Protheroe
    • , Alain Ravaud
    • , Denis Maillet
    • , Maria Jose Mendez
    • , Cristina Suarez
    • , Mark Linch
    • , Aaron Prendergast
    • , Pieter-Jan van Dam
    • , Diana Stanoeva
    • , Sofie Daelemans
    • , Sanjeev Mariathasan
    • , Joy S. Tea
    • , Kelly Mousa
    • , Romain Banchereau
    •  & Daniel Castellano
  • Letter |

    Characterization of the genomic landscape of fetal and placental postpartum tissues shows that chromosomal instability associated with in vitro fertilization (IVF) is not preserved at later stages of prenatal development. Thus rates of de novo numerical aberrations or large structural DNA imbalances are similar between IVF and naturally conceived live-born neonates.

    • Masoud Zamani Esteki
    • , Triin Viltrop
    • , Olga Tšuiko
    • , Airi Tiirats
    • , Mariann Koel
    • , Margit Nõukas
    • , Olga Žilina
    • , Katre Teearu
    • , Heidi Marjonen
    • , Hanna Kahila
    • , Jeroen Meekels
    • , Viveca Söderström-Anttila
    • , Anne-Maria Suikkari
    • , Aila Tiitinen
    • , Reedik Mägi
    • , Sulev Kõks
    • , Nina Kaminen-Ahola
    • , Ants Kurg
    • , Thierry Voet
    • , Joris Robert Vermeesch
    •  & Andres Salumets
  • Letter |

    Neurological phenotypes of PTEN loss are driven by aberrant mTORC2 signaling, and therapeutic inhibition of the mTORC2 component Rictor by antisense oligonucleotides reverses seizures, social interaction deficits and memory impairments in rodents.

    • Chien-Ju Chen
    • , Martina Sgritta
    • , Jacqunae Mays
    • , Hongyi Zhou
    • , Rocco Lucero
    • , Jin Park
    • , I-Ching Wang
    • , Jun Hyoung Park
    • , Benny Abraham Kaipparettu
    • , Loredana Stoica
    • , Paymaan Jafar-Nejad
    • , Frank Rigo
    • , Jeannie Chin
    • , Jeffrey L. Noebels
    •  & Mauro Costa-Mattioli
  • Letter |

    Antibodies in CSF specific for viral peptides implicate enteroviruses in acute flaccid myelitis.

    • Ryan D. Schubert
    • , Isobel A. Hawes
    • , Prashanth S. Ramachandran
    • , Akshaya Ramesh
    • , Emily D. Crawford
    • , John E. Pak
    • , Wesley Wu
    • , Carly K. Cheung
    • , Brian D. O’Donovan
    • , Cristina M. Tato
    • , Amy Lyden
    • , Michelle Tan
    • , Rene Sit
    • , Gavin A. Sowa
    • , Hannah A. Sample
    • , Kelsey C. Zorn
    • , Debarko Banerji
    • , Lillian M. Khan
    • , Riley Bove
    • , Stephen L. Hauser
    • , Amy A. Gelfand
    • , Bethany L. Johnson-Kerner
    • , Kendall Nash
    • , Kalpathy S. Krishnamoorthy
    • , Tanuja Chitnis
    • , Joy Z. Ding
    • , Hugh J. McMillan
    • , Charles Y. Chiu
    • , Benjamin Briggs
    • , Carol A. Glaser
    • , Cynthia Yen
    • , Victoria Chu
    • , Debra A. Wadford
    • , Samuel R. Dominguez
    • , Terry Fei Fan Ng
    • , Rachel L. Marine
    • , Adriana S. Lopez
    • , W. Allan Nix
    • , Ariane Soldatos
    • , Mark P. Gorman
    • , Leslie Benson
    • , Kevin Messacar
    • , Jennifer L. Konopka-Anstadt
    • , M. Steven Oberste
    • , Joseph L. DeRisi
    •  & Michael R. Wilson
  • Letter |

    A gene therapy vector expressing micro-utrophin provides functional replacement of lost dystrophin, and lacks the adverse immunogenicity associated with direct dystrophin therapy, in rodent and canine models of Duchenne muscular dystrophy.

    • Yafeng Song
    • , Leon Morales
    • , Alock S. Malik
    • , Andrew F. Mead
    • , Christopher D. Greer
    • , Marilyn A. Mitchell
    • , Mihail T. Petrov
    • , Leonard T. Su
    • , Margaret E. Choi
    • , Shira T. Rosenblum
    • , Xiangping Lu
    • , Daniel J. VanBelzen
    • , Ranjith K. Krishnankutty
    • , Frederick J. Balzer
    • , Emanuele Loro
    • , Robert French
    • , Kathleen J. Propert
    • , Shangzhen Zhou
    • , Benjamin W. Kozyak
    • , Peter P. Nghiem
    • , Tejvir S. Khurana
    • , Joe N. Kornegay
    •  & Hansell H. Stedman
  • Letter |

    A luminal unfolding microneedle injector device (LUMI) is engineered as a custom capsule capable of efficient biologic macromolecular drug delivery into the bloodstream via selective deployment within the gastrointestinal tract.

    • Alex Abramson
    • , Ester Caffarel-Salvador
    • , Vance Soares
    • , Daniel Minahan
    • , Ryan Yu Tian
    • , Xiaoya Lu
    • , David Dellal
    • , Yuan Gao
    • , Soyoung Kim
    • , Jacob Wainer
    • , Joy Collins
    • , Siddartha Tamang
    • , Alison Hayward
    • , Tadayuki Yoshitake
    • , Hsiang-Chieh Lee
    • , James Fujimoto
    • , Johannes Fels
    • , Morten Revsgaard Frederiksen
    • , Ulrik Rahbek
    • , Niclas Roxhed
    • , Robert Langer
    •  & Giovanni Traverso
  • Letter |

    Deep convolutional neural networks predict survival of mesothelioma patients and identify histological features associated with outcome that transcend current histological classifications.

    • Pierre Courtiol
    • , Charles Maussion
    • , Matahi Moarii
    • , Elodie Pronier
    • , Samuel Pilcer
    • , Meriem Sefta
    • , Pierre Manceron
    • , Sylvain Toldo
    • , Mikhail Zaslavskiy
    • , Nolwenn Le Stang
    • , Nicolas Girard
    • , Olivier Elemento
    • , Andrew G. Nicholson
    • , Jean-Yves Blay
    • , Françoise Galateau-Sallé
    • , Gilles Wainrib
    •  & Thomas Clozel
  • Letter |

    TRACERx Lung: Intratumoral transcriptional heterogeneity, which often hinders the development of clinically useful RNA-expression-biased biomarkers for cancer, can now be overcome with an approach for the identification of clonal expression biomarkers.

    • Dhruva Biswas
    • , Nicolai J. Birkbak
    • , Rachel Rosenthal
    • , Crispin T. Hiley
    • , Emilia L. Lim
    • , Krisztian Papp
    • , Stefan Boeing
    • , Marcin Krzystanek
    • , Dijana Djureinovic
    • , Linnea La Fleur
    • , Maria Greco
    • , Balázs Döme
    • , János Fillinger
    • , Hans Brunnström
    • , Yin Wu
    • , David A. Moore
    • , Marcin Skrzypski
    • , Christopher Abbosh
    • , Kevin Litchfield
    • , Maise Al Bakir
    • , Thomas B. K. Watkins
    • , Selvaraju Veeriah
    • , Gareth A. Wilson
    • , Mariam Jamal-Hanjani
    • , Judit Moldvay
    • , Johan Botling
    • , Arul M. Chinnaiyan
    • , Patrick Micke
    • , Allan Hackshaw
    • , Jiri Bartek
    • , Istvan Csabai
    • , Zoltan Szallasi
    • , Javier Herrero
    • , Nicholas McGranahan
    • , Charles Swanton
    • , Charles Swanton
    • , Mariam Jamal-Hanjani
    • , Christopher Abbosh
    • , Yin Wu
    • , Selvaraju Veeriah
    • , Marcin Skrzypski
    • , Rachel Rosenthal
    • , Dhruva Biswas
    • , Nicholas McGranahan
    • , Gareth A. Wilson
    • , Emilia L. Lim
    • , Crispin T. Hiley
    • , Nicolai J. Birkbak
    • , Maria Greco
    • , David A. Moore
    • , Javier Herrero
    • , Allan Hackshaw
    • , Thomas B. K. Watkins
    • , Maise Al Bakir
    • , Kevin Litchfield
    • , Istvan Csabai
    • , Stefan Boeing
    • , Zoltan Szallasi
    • , Yenting Ngai
    • , Abigail Sharp
    • , Cristina Rodrigues
    • , Oliver Pressey
    • , Sean Smith
    • , Nicole Gower
    • , Harjot Dhanda
    • , Miklos Diossy
    • , Mickael Escudero
    • , Aengus Stewart
    • , Andrew Rowan
    • , Jacki Goldman
    • , Peter Van Loo
    • , Richard Kevin Stone
    • , Tamara Denner
    • , Emma Nye
    • , Sophia Ward
    • , Jerome Nicod
    • , Clare Puttick
    • , Katey Enfield
    • , Emma Colliver
    • , Brittany Campbell
    • , Robert E. Hynds
    • , Andrew Georgiou
    • , Mariana Werner Sunderland
    • , James L. Reading
    • , Sergio A. Quezada
    • , Karl S. Peggs
    • , Teresa Marafioti
    • , John A. Hartley
    • , Pat Gorman
    • , Helen L. Lowe
    • , Leah Ensell
    • , Victoria Spanswick
    • , Angeliki Karamani
    • , Maryam Razaq
    • , Stephan Beck
    • , Ariana Huebner
    • , Michelle Dietzen
    • , Cristina Naceur-Lombardelli
    • , Mita Afroza Akther
    • , Haoran Zhai
    • , Nnennaya Kannu
    • , Elizabeth Manzano
    • , Supreet Kaur Bola
    • , Ehsan Ghorani
    • , Marc Robert de Massy
    • , Elena Hoxha
    • , Emine Hatipoglu
    • , Stephanie Ogwuru
    • , Benny Chain
    • , David Lawrence
    • , Martin Hayward
    • , Nikolaos Panagiotopoulos
    • , Robert George
    • , Davide Patrini
    • , Mary Falzon
    • , Elaine Borg
    • , Reena Khiroya
    • , Asia Ahmed
    • , Magali Taylor
    • , Junaid Choudhary
    • , Penny Shaw
    • , Sam M. Janes
    • , Martin Forster
    • , Tanya Ahmad
    • , Siow Ming Lee
    • , Dawn Carnell
    • , Ruheena Mendes
    • , Jeremy George
    • , Neal Navani
    • , Dionysis Papadatos-Pastos
    • , Marco Scarci
    • , Elisa Bertoja
    • , Robert C. M. Stephens
    • , Emilie Martinoni Hoogenboom
    • , James W. Holding
    • , Steve Bandula
    • , Gillian Price
    • , Sylvie Dubois-Marshall
    • , Keith Kerr
    • , Shirley Palmer
    • , Heather Cheyne
    • , Joy Miller
    • , Keith Buchan
    • , Mahendran Chetty
    • , Mohammed Khalil
    • , Veni Ezhil
    • , Vineet Prakash
    • , Girija Anand
    • , Sajid Khan
    • , Kelvin Lau
    • , Michael Sheaff
    • , Peter Schmid
    • , Louise Lim
    • , John Conibear
    • , Roland Schwarz
    • , Jonathan Tugwood
    • , Jackie Pierce
    • , Caroline Dive
    • , Ged Brady
    • , Dominic G. Rothwell
    • , Francesca Chemi
    • , Elaine Kilgour
    • , Fiona Blackhall
    • , Lynsey Priest
    • , Matthew G. Krebs
    • , Philip Crosbie
    • , John Le Quesne
    • , Joan Riley
    • , Lindsay Primrose
    • , Luke Martinson
    • , Nicolas Carey
    • , Jacqui A. Shaw
    • , Dean Fennell
    • , Apostolos Nakas
    • , Sridhar Rathinam
    • , Louise Nelson
    • , Kim Ryanna
    • , Mohamad Tuffail
    • , Amrita Bajaj
    • , Jan Brozik
    • , Fiona Morgan
    • , Malgorzata Kornaszewska
    • , Richard Attanoos
    • , Haydn Adams
    • , Helen Davies
    • , Mathew Carter
    • , Colin R. Lindsay
    • , Fabio Gomes
    • , Roberto Salgado
    • , Hugo Aerts
    • , Alan Kirk
    • , Mo Asif
    • , John Butler
    • , Rocco Bilanca
    • , Nikos Kostoulas
    • , Mairead MacKenzie
    • , Maggie Wilcox
    • , Sara Busacca
    • , Alan Dawson
    • , Mark R. Lovett
    • , Michael Shackcloth
    • , Sarah Feeney
    • , Julius Asante-Siaw
    • , John Gosney
    • , Angela Leek
    • , Nicola Totten
    • , Jack Davies Hodgkinson
    • , Rachael Waddington
    • , Jane Rogan
    • , Katrina Moore
    • , William Monteiro
    • , Hilary Marshall
    • , Kevin G. Blyth
    • , Craig Dick
    • , Andrew Kidd
    • , Eric Lim
    • , Paulo De Sousa
    • , Simon Jordan
    • , Alexandra Rice
    • , Hilgardt Raubenheimer
    • , Harshil Bhayani
    • , Morag Hamilton
    • , Lyn Ambrose
    • , Anand Devaraj
    • , Hema Chavan
    • , Sofina Begum
    • , Aleksander Mani
    • , Daniel Kaniu
    • , Mpho Malima
    • , Sarah Booth
    • , Andrew G. Nicholson
    • , Nadia Fernandes
    • , Jessica E. Wallen
    • , Pratibha Shah
    • , Sarah Danson
    • , Jonathan Bury
    • , John Edwards
    • , Jennifer Hill
    • , Sue Matthews
    • , Yota Kitsanta
    • , Jagan Rao
    • , Sara Tenconi
    • , Laura Socci
    • , Kim Suvarna
    • , Faith Kibutu
    • , Patricia Fisher
    • , Robin Young
    • , Joann Barker
    • , Fiona Taylor
    • , Kirsty Lloyd
    • , Teresa Light
    • , Tracey Horey
    • , Dionysis Papadatos-Pastos
    • , Peter Russell
    • , Sara Lock
    • , Kayleigh Gilbert
    • , Babu Naidu
    • , Gerald Langman
    • , Andrew Robinson
    • , Hollie Bancroft
    • , Amy Kerr
    • , Salma Kadiri
    • , Charlotte Ferris
    • , Gary Middleton
    • , Madava Djearaman
    • , Akshay Patel
    • , Christian Ottensmeier
    • , Serena Chee
    • , Benjamin Johnson
    • , Aiman Alzetani
    • , Emily Shaw
    • , Jason Lester
    • , Yvonne Summers
    • , Raffaele Califano
    • , Paul Taylor
    • , Rajesh Shah
    • , Piotr Krysiak
    • , Kendadai Rammohan
    • , Eustace Fontaine
    • , Richard Booton
    • , Matthew Evison
    • , Stuart Moss
    • , Juliette Novasio
    • , Leena Joseph
    • , Paul Bishop
    • , Anshuman Chaturvedi
    • , Helen Doran
    • , Felice Granato
    • , Vijay Joshi
    • , Elaine Smith
    •  & Angeles Montero
  • Letter |

    Pulmonary venous tumor cells disseminating before tumor resection are heterogeneous, predict relapse and seed future metastasis of lung cancer

    • Francesca Chemi
    • , Dominic G. Rothwell
    • , Nicholas McGranahan
    • , Sakshi Gulati
    • , Chris Abbosh
    • , Simon P. Pearce
    • , Cong Zhou
    • , Gareth A. Wilson
    • , Mariam Jamal-Hanjani
    • , Nicolai Birkbak
    • , Jackie Pierce
    • , Chang Sik Kim
    • , Saba Ferdous
    • , Deborah J. Burt
    • , Daniel Slane-Tan
    • , Fabio Gomes
    • , David Moore
    • , Rajesh Shah
    • , Maise Al Bakir
    • , Crispin Hiley
    • , Selvaraju Veeriah
    • , Yvonne Summers
    • , Philip Crosbie
    • , Sophia Ward
    • , Barbara Mesquita
    • , Marek Dynowski
    • , Dhruva Biswas
    • , Jonathan Tugwood
    • , Fiona Blackhall
    • , Crispin Miller
    • , Allan Hackshaw
    • , Ged Brady
    • , Charles Swanton
    • , Caroline Dive
    • , Charles Swanton
    • , Mariam Jamal-Hanjani
    • , Jonathan Tugwood
    • , Jackie Pierce
    • , Dominic G. Rothwell
    • , Caroline Dive
    • , Ged Brady
    • , Francesca Chemi
    • , Fabio Gomes
    • , Fiona Blackhall
    • , Philip Crosbie
    • , Crispin Hiley
    • , Nicholas McGranahan
    • , Allan Hackshaw
    • , Chris Abbosh
    • , Selvaraju Veeriah
    • , David Moore
    • , Gareth A. Wilson
    • , Nicolai Birkbak
    • , Sophia Ward
    • , Maise Al Bakir
    • , Dhruva Biswas
    • , Rajesh Shah
    • , Yvonne Summers
    • , Yenting Ngai
    • , Abigail Sharp
    • , Cristina Rodrigues
    • , Oliver Pressey
    • , Sean Smith
    • , Nicole Gower
    • , Harjot Dhanda
    • , Elaine Kilgour
    • , Lynsey Priest
    • , Matthew G. Krebs
    • , Mathew Carter
    • , Colin R. Lindsay
    • , Thomas B. K. Watkins
    • , Rachel Rosenthal
    • , Mickael Escudero
    • , Aengus Stewart
    • , Andrew Rowan
    • , Jacki Goldman
    • , Peter Van Loo
    • , Richard Kevin Stone
    • , Tamara Denner
    • , Emma Nye
    • , Emilia Lim
    • , Stefan Boeing
    • , Maria Greco
    • , Kevin Litchfield
    • , Jerome Nicod
    • , Clare Puttick
    • , Katey Enfield
    • , Emma Colliver
    • , Brittany Campbell
    • , Yin Wu
    • , Marcin Skrzypski
    • , Robert E. Hynds
    • , Andrew Georgiou
    • , Mariana Werner Sunderland
    • , James L. Reading
    • , Sergio A. Quezada
    • , Karl S. Peggs
    • , Teresa Marafioti
    • , John A. Hartley
    • , Pat Gorman
    • , Helen L. Lowe
    • , Leah Ensell
    • , Victoria Spanswick
    • , Angeliki Karamani
    • , Maryam Razaq
    • , Stephan Beck
    • , Ariana Huebner
    • , Michelle Dietzen
    • , Cristina Naceur-Lombardelli
    • , Mita Afroza Akther
    • , Haoran Zhai
    • , Nnennaya Kannu
    • , Elizabeth Manzano
    • , Supreet Kaur Bola
    • , Ehsan Ghorani
    • , Marc Robert de Massy
    • , Elena Hoxha
    • , Emine Hatipoglu
    • , Stephanie Ogwuru
    • , Benny Chain
    • , Raffaele Califano
    • , Paul Taylor
    • , Piotr Krysiak
    • , Kendadai Rammohan
    • , Eustace Fontaine
    • , Richard Booton
    • , Matthew Evison
    • , Stuart Moss
    • , Juliette Novasio
    • , Leena Joseph
    • , Paul Bishop
    • , Anshuman Chaturvedi
    • , Helen Doran
    • , Felice Granato
    • , Vijay Joshi
    • , Elaine Smith
    • , Angeles Montero
    • , Gillian Price
    • , Sylvie Dubois-Marshall
    • , Keith Kerr
    • , Shirley Palmer
    • , Heather Cheyne
    • , Joy Miller
    • , Keith Buchan
    • , Mahendran Chetty
    • , Mohammed Khalil
    • , Veni Ezhil
    • , Vineet Prakash
    • , Girija Anand
    • , Sajid Khan
    • , Kelvin Lau
    • , Michael Sheaff
    • , Peter Schmid
    • , Louise Lim
    • , John Conibear
    • , Roland Schwarz
    • , John Le Quesne
    • , Joan Riley
    • , Lindsay Primrose
    • , Luke Martinson
    • , Nicolas Carey
    • , Jacqui A. Shaw
    • , Dean Fennell
    • , Apostolos Nakas
    • , Sridhar Rathinam
    • , Louise Nelson
    • , Kim Ryanna
    • , Mohamad Tuffail
    • , Amrita Bajaj
    • , Jan Brozik
    • , Fiona Morgan
    • , Malgorzata Kornaszewska
    • , Richard Attanoos
    • , Haydn Adams
    • , Helen Davies
    • , Zoltan Szallasi
    • , Roberto Salgado
    • , Istvan Csabai
    • , Miklos Diossy
    • , Hugo Aerts
    • , Alan Kirk
    • , Mo Asif
    • , John Butler
    • , Rocco Bilanca
    • , Nikos Kostoulas
    • , Mairead MacKenzie
    • , Maggie Wilcox
    • , Sara Busacca
    • , Alan Dawson
    • , Mark R. Lovett
    • , Michael Shackcloth
    • , Sarah Feeney
    • , Julius Asante-Siaw
    • , John Gosney
    • , Angela Leek
    • , Nicola Totten
    • , Jack Davies Hodgkinson
    • , Rachael Waddington
    • , Jane Rogan
    • , Katrina Moore
    • , William Monteiro
    • , Hilary Marshall
    • , Kevin G. Blyth
    • , Craig Dick
    • , Andrew Kidd
    • , Eric Lim
    • , Paulo De Sousa
    • , Simon Jordan
    • , Alexandra Rice
    • , Hilgardt Raubenheimer
    • , Harshil Bhayani
    • , Morag Hamilton
    • , Lyn Ambrose
    • , Anand Devaraj
    • , Hema Chavan
    • , Sofina Begum
    • , Aleksander Mani
    • , Daniel Kaniu
    • , Mpho Malima
    • , Sarah Booth
    • , Andrew G. Nicholson
    • , Nadia Fernandes
    • , Jessica E. Wallen
    • , Pratibha Shah
    • , Sarah Danson
    • , Jonathan Bury
    • , John Edwards
    • , Jennifer Hill
    • , Sue Matthews
    • , Yota Kitsanta
    • , Jagan Rao
    • , Sara Tenconi
    • , Laura Socci
    • , Kim Suvarna
    • , Faith Kibutu
    • , Patricia Fisher
    • , Robin Young
    • , Joann Barker
    • , Fiona Taylor
    • , Kirsty Lloyd
    • , Teresa Light
    • , Tracey Horey
    • , Dionysis Papadatos-Pastos
    • , Peter Russell
    • , Sara Lock
    • , Kayleigh Gilbert
    • , David Lawrence
    • , Martin Hayward
    • , Nikolaos Panagiotopoulos
    • , Robert George
    • , Davide Patrini
    • , Mary Falzon
    • , Elaine Borg
    • , Reena Khiroya
    • , Asia Ahmed
    • , Magali Taylor
    • , Junaid Choudhary
    • , Penny Shaw
    • , Sam M. Janes
    • , Martin Forster
    • , Tanya Ahmad
    • , Siow Ming Lee
    • , Javier Herrero
    • , Dawn Carnell
    • , Ruheena Mendes
    • , Jeremy George
    • , Neal Navani
    • , Dionysis Papadatos-Pastos
    • , Marco Scarci
    • , Elisa Bertoja
    • , Robert C. M. Stephens
    • , Emilie Martinoni Hoogenboom
    • , James W. Holding
    • , Steve Bandula
    • , Babu Naidu
    • , Gerald Langman
    • , Andrew Robinson
    • , Hollie Bancroft
    • , Amy Kerr
    • , Salma Kadiri
    • , Charlotte Ferris
    • , Gary Middleton
    • , Madava Djearaman
    • , Akshay Patel
    • , Christian Ottensmeier
    • , Serena Chee
    • , Benjamin Johnson
    • , Aiman Alzetani
    • , Emily Shaw
    •  & Jason Lester
  • Letter |

    Whole-genome sequencing in triple-negative breast cancer supports the prognostic value of the HRDetect mutational-signature-based algorithm for improving patient stratification in a real-world, population-based clinical diagnostic setting.

    • Johan Staaf
    • , Dominik Glodzik
    • , Ana Bosch
    • , Johan Vallon-Christersson
    • , Christel Reuterswärd
    • , Jari Häkkinen
    • , Andrea Degasperi
    • , Tauanne Dias Amarante
    • , Lao H. Saal
    • , Cecilia Hegardt
    • , Hilary Stobart
    • , Anna Ehinger
    • , Christer Larsson
    • , Lisa Rydén
    • , Niklas Loman
    • , Martin Malmberg
    • , Anders Kvist
    • , Hans Ehrencrona
    • , Helen R. Davies
    • , Åke Borg
    •  & Serena Nik-Zainal
  • Letter |

    An analysis of T cell specificities sufficient to sustain a neutralizing anti-drug antibody response offers a potential approach for enhancing the clinical efficacy of a therapeutic humanized antibody.

    • Antonino Cassotta
    • , Vincent Mikol
    • , Thomas Bertrand
    • , Stéphanie Pouzieux
    • , Josiane Le Parc
    • , Paul Ferrari
    • , Jacques Dumas
    • , Michael Auer
    • , Florian Deisenhammer
    • , Matteo Gastaldi
    • , Diego Franciotta
    • , Chiara Silacci-Fregni
    • , Blanca Fernandez Rodriguez
    • , Isabella Giacchetto-Sasselli
    • , Mathilde Foglierini
    • , David Jarrossay
    • , Roger Geiger
    • , Federica Sallusto
    • , Antonio Lanzavecchia
    •  & Luca Piccoli
  • Letter |

    Analysis of the UK Biobank reveals new genetic loci associated with estimated visceral adipose tissue (VAT) mass, and suggests that VAT is potentially an independent risk factor for various cardiovascular and metabolic diseases, such as hypertension and type 2 diabetes.

    • Torgny Karlsson
    • , Mathias Rask-Andersen
    • , Gang Pan
    • , Julia Höglund
    • , Claes Wadelius
    • , Weronica E. Ek
    •  & Åsa Johansson
  • Letter |

    In an early-phase lentiviral gene therapy trial, gene-corrected autologous hematopoietic stem cells show sustained engraftment and phenotypic correction in non-conditioned patients with Fanconi anemia.

    • Paula Río
    • , Susana Navarro
    • , Wei Wang
    • , Rebeca Sánchez-Domínguez
    • , Roser M. Pujol
    • , José C. Segovia
    • , Massimo Bogliolo
    • , Eva Merino
    • , Ning Wu
    • , Rocío Salgado
    • , María L. Lamana
    • , Rosa M. Yañez
    • , José A. Casado
    • , Yari Giménez
    • , Francisco J. Román-Rodríguez
    • , Lara Álvarez
    • , Omaira Alberquilla
    • , Anna Raimbault
    • , Guillermo Guenechea
    • , M. Luz Lozano
    • , Laura Cerrato
    • , Miriam Hernando
    • , Eva Gálvez
    • , Raquel Hladun
    • , Irina Giralt
    • , Jordi Barquinero
    • , Anne Galy
    • , Nagore García de Andoín
    • , Ricardo López
    • , Albert Catalá
    • , Jonathan D. Schwartz
    • , Jordi Surrallés
    • , Jean Soulier
    • , Manfred Schmidt
    • , Cristina Díaz de Heredia
    • , Julián Sevilla
    •  & Juan A. Bueren
  • Letter |

    Direct prospective comparison of circulating tumor DNA and tissue biopsy sequencing shows the superiority of liquid biopsies for capturing clinically relevant alterations mediating resistance to targeted therapies in cancer patients.

    • Aparna R. Parikh
    • , Ignaty Leshchiner
    • , Liudmila Elagina
    • , Lipika Goyal
    • , Chaya Levovitz
    • , Giulia Siravegna
    • , Dimitri Livitz
    • , Kahn Rhrissorrakrai
    • , Elizabeth E. Martin
    • , Emily E. Van Seventer
    • , Megan Hanna
    • , Kara Slowik
    • , Filippo Utro
    • , Christopher J. Pinto
    • , Alicia Wong
    • , Brian P. Danysh
    • , Ferran Fece de la Cruz
    • , Isobel J. Fetter
    • , Brandon Nadres
    • , Heather A. Shahzade
    • , Jill N. Allen
    • , Lawrence S. Blaszkowsky
    • , Jeffrey W. Clark
    • , Bruce Giantonio
    • , Janet E. Murphy
    • , Ryan D. Nipp
    • , Eric Roeland
    • , David P. Ryan
    • , Colin D. Weekes
    • , Eunice L. Kwak
    • , Jason E. Faris
    • , Jennifer Y. Wo
    • , François Aguet
    • , Ipsita Dey-Guha
    • , Mehlika Hazar-Rethinam
    • , Dora Dias-Santagata
    • , David T. Ting
    • , Andrew X. Zhu
    • , Theodore S. Hong
    • , Todd R. Golub
    • , A. John Iafrate
    • , Viktor A. Adalsteinsson
    • , Alberto Bardelli
    • , Laxmi Parida
    • , Dejan Juric
    • , Gad Getz
    •  & Ryan B. Corcoran
  • Letter |

    A new compound that inhibits HIV capsid assembly and nuclear transport functions offers potential as a long-acting antiretroviral.

    • Stephen R. Yant
    • , Andrew Mulato
    • , Derek Hansen
    • , Winston C. Tse
    • , Anita Niedziela-Majka
    • , Jennifer R. Zhang
    • , George J. Stepan
    • , Debi Jin
    • , Melanie H. Wong
    • , Jill M. Perreira
    • , Eric Singer
    • , Giuseppe A. Papalia
    • , Eric Y. Hu
    • , Jim Zheng
    • , Bing Lu
    • , Scott D. Schroeder
    • , Kevin Chou
    • , Shekeba Ahmadyar
    • , Albert Liclican
    • , Helen Yu
    • , Nikolai Novikov
    • , Eric Paoli
    • , Daniel Gonik
    • , Renee R. Ram
    • , Magdeleine Hung
    • , William M. McDougall
    • , Abraham L. Brass
    • , Wesley I. Sundquist
    • , Tomas Cihlar
    •  & John O. Link
  • Letter |

    A new prosthetic leg that can transmit sensory signals via implanted electrodes is shown to restore meaningful sensory feedback that improves walking performance and lowers phantom limb pain during use in two human lower-limb amputees.

    • Francesco Maria Petrini
    • , Marko Bumbasirevic
    • , Giacomo Valle
    • , Vladimir Ilic
    • , Pavle Mijović
    • , Paul Čvančara
    • , Federica Barberi
    • , Natalija Katic
    • , Dario Bortolotti
    • , David Andreu
    • , Knut Lechler
    • , Aleksandar Lesic
    • , Sanja Mazic
    • , Bogdan Mijović
    • , David Guiraud
    • , Thomas Stieglitz
    • , Asgeir Alexandersson
    • , Silvestro Micera
    •  & Stanisa Raspopovic
  • Letter |

    New low-affinity anti-CD19 CAR T cells exhibit peripheral expansion and persistence without inducing severe cytokine-response syndrome in pediatric patients with relapsed or refractory B cell acute lymphoblastic leukemia.

    • Sara Ghorashian
    • , Anne Marijn Kramer
    • , Shimobi Onuoha
    • , Gary Wright
    • , Jack Bartram
    • , Rachel Richardson
    • , Sarah J. Albon
    • , Joan Casanovas-Company
    • , Fernanda Castro
    • , Bilyana Popova
    • , Krystle Villanueva
    • , Jenny Yeung
    • , Winston Vetharoy
    • , Aleks Guvenel
    • , Patrycja A. Wawrzyniecka
    • , Leila Mekkaoui
    • , Gordon Weng-Kit Cheung
    • , Danielle Pinner
    • , Jan Chu
    • , Giovanna Lucchini
    • , Juliana Silva
    • , Oana Ciocarlie
    • , Arina Lazareva
    • , Sarah Inglott
    • , Kimberly C. Gilmour
    • , Gulrukh Ahsan
    • , Mathieu Ferrari
    • , Somayya Manzoor
    • , Kim Champion
    • , Tony Brooks
    • , Andre Lopes
    • , Allan Hackshaw
    • , Farzin Farzaneh
    • , Robert Chiesa
    • , Kanchan Rao
    • , Denise Bonney
    • , Sujith Samarasinghe
    • , Nicholas Goulden
    • , Ajay Vora
    • , Paul Veys
    • , Rachael Hough
    • , Robert Wynn
    • , Martin A. Pule
    •  & Persis J. Amrolia
  • Letter |

    Genetic predispositions and lifestyle factors can interact to either confer protection against, or elevate risk for, development of clinical dementia in a prospective cohort of over 6,000 individuals from the population-based Rotterdam Study.

    • Silvan Licher
    • , Shahzad Ahmad
    • , Hata Karamujić-Čomić
    • , Trudy Voortman
    • , Maarten J. G. Leening
    • , M. Arfan Ikram
    •  & M. Kamran Ikram
  • Letter |

    A subset of patients treated with selective TRK inhibitors (including the newly approved larotrectinib) develop off-target resistance mediated by genomic acquisition of MAPK pathway-activating alterations, and may benefit from combined targeted therapy.

    • Emiliano Cocco
    • , Alison M. Schram
    • , Amanda Kulick
    • , Sandra Misale
    • , Helen H. Won
    • , Rona Yaeger
    • , Pedram Razavi
    • , Ryan Ptashkin
    • , Jaclyn F. Hechtman
    • , Eneda Toska
    • , James Cownie
    • , Romel Somwar
    • , Sophie Shifman
    • , Marissa Mattar
    • , S. Duygu Selçuklu
    • , Aliaksandra Samoila
    • , Sean Guzman
    • , Brian B. Tuch
    • , Kevin Ebata
    • , Elisa de Stanchina
    • , Rebecca J. Nagy
    • , Richard B. Lanman
    • , Brian Houck-Loomis
    • , Juber A. Patel
    • , Michael F. Berger
    • , Marc Ladanyi
    • , David M. Hyman
    • , Alexander Drilon
    •  & Maurizio Scaltriti
  • Letter |

    Mass antibiotic administration to preschool children in Nigerien communities alters the relative abundances of 35 bacterial species in the gut microbiome, including enteric pathogens, but also increases expression of macrolide resistance genes.

    • T. Doan
    • , A. Hinterwirth
    • , L. Worden
    • , A. M. Arzika
    • , R. Maliki
    • , A. Abdou
    • , S. Kane
    • , L. Zhong
    • , S. L. Cummings
    • , S. Sakar
    • , C. Chen
    • , C. Cook
    • , E. Lebas
    • , E. D. Chow
    • , I. Nachamkin
    • , T. C. Porco
    • , J. D. Keenan
    •  & T. M. Lietman
  • Letter |

    Following anti-PD-1 therapy in patients with basal or squamous cell carcinoma, the CD8+ T cell response largely consists of an expanded and exhausted repertoire of new T cell clones.

    • Kathryn E. Yost
    • , Ansuman T. Satpathy
    • , Daniel K. Wells
    • , Yanyan Qi
    • , Chunlin Wang
    • , Robin Kageyama
    • , Katherine L. McNamara
    • , Jeffrey M. Granja
    • , Kavita Y. Sarin
    • , Ryanne A. Brown
    • , Rohit K. Gupta
    • , Christina Curtis
    • , Samantha L. Bucktrout
    • , Mark M. Davis
    • , Anne Lynn S. Chang
    •  & Howard Y. Chang
  • Letter
    | Open Access

    Exclusive breastfeeding in Africa is highly varied within and between countries, with many countries unlikely to reach World Health Organization 2025 targets without urgent action.

    • Natalia V. Bhattacharjee
    • , Lauren E. Schaeffer
    • , Laurie B. Marczak
    • , Jennifer M. Ross
    • , Scott J. Swartz
    • , James Albright
    • , William M. Gardner
    • , Chloe Shields
    • , Amber Sligar
    • , Megan F. Schipp
    • , Brandon V. Pickering
    • , Nathaniel J. Henry
    • , Kimberly B. Johnson
    • , Celia Louie
    • , Michael A. Cork
    • , Krista M. Steuben
    • , Alice Lazzar-Atwood
    • , Dan Lu
    • , Damaris K. Kinyoki
    • , Aaron Osgood-Zimmerman
    • , Lucas Earl
    • , Jonathan F. Mosser
    • , Aniruddha Deshpande
    • , Roy Burstein
    • , Lauren P. Woyczynski
    • , Katherine F. Wilson
    • , John D. VanderHeide
    • , Kirsten E. Wiens
    • , Robert C. Reiner Jr
    • , Ellen G. Piwoz
    • , Rahul Rawat
    • , Benn Sartorius
    • , Nicole Davis Weaver
    • , Molly R. Nixon
    • , David L. Smith
    • , Nicholas J. Kassebaum
    • , Emmanuela Gakidou
    • , Stephen S. Lim
    • , Ali H. Mokdad
    • , Christopher J. L. Murray
    • , Laura Dwyer-Lindgren
    •  & Simon I. Hay
  • Letter |

    Modifying the gut microbiota, bile acid, or IL-22 may offer an alternative approach for the treatment of polycystic ovary syndrome.

    • Xinyu Qi
    • , Chuyu Yun
    • , Lulu Sun
    • , Jialin Xia
    • , Qing Wu
    • , Ying Wang
    • , Lina Wang
    • , Yangming Zhang
    • , Xianyi Liang
    • , Liying Wang
    • , Frank J. Gonzalez
    • , Andrew D. Patterson
    • , Huiying Liu
    • , Liangshan Mu
    • , Zehong Zhou
    • , Yue Zhao
    • , Rong Li
    • , Ping Liu
    • , Chao Zhong
    • , Yanli Pang
    • , Changtao Jiang
    •  & Jie Qiao
  • Letter |

    Fecal microbiome transplantation or probiotic therapy with Akkermansia muciniphila extends the lifespan and improves the health status of progeroid mice, pointing to the importance of the gut microbiome in regulating lifespan and healthspan.

    • Clea Bárcena
    • , Rafael Valdés-Mas
    • , Pablo Mayoral
    • , Cecilia Garabaya
    • , Sylvère Durand
    • , Francisco Rodríguez
    • , María Teresa Fernández-García
    • , Nuria Salazar
    • , Alicja M. Nogacka
    • , Nuria Garatachea
    • , Noélie Bossut
    • , Fanny Aprahamian
    • , Alejandro Lucia
    • , Guido Kroemer
    • , José M. P. Freije
    • , Pedro M. Quirós
    •  & Carlos López-Otín
  • Letter |

    Deep molecular profiling of a single case of severe anti-PD-1-induced neurotoxicity shows oligoclonal cytotoxic memory CD4+ T cells are enriched in inflamed brain tissue.

    • Douglas B. Johnson
    • , Wyatt J. McDonnell
    • , Paula I. Gonzalez-Ericsson
    • , Rami N. Al-Rohil
    • , Bret C. Mobley
    • , Joe-Elie Salem
    • , Daniel Y. Wang
    • , Violeta Sanchez
    • , Yu Wang
    • , Cody A. Chastain
    • , Kristi Barker
    • , Yan Liang
    • , Sarah Warren
    • , Joseph M. Beechem
    • , Alexander M. Menzies
    • , Martin Tio
    • , Georgina V. Long
    • , Justine V. Cohen
    • , Amanda C. Guidon
    • , Méabh O’Hare
    • , Sunandana Chandra
    • , Akansha Chowdhary
    • , Bénédicte Lebrun-Vignes
    • , Simone M. Goldinger
    • , Elisabeth J. Rushing
    • , Elizabeth I. Buchbinder
    • , Simon A. Mallal
    • , Chanjuan Shi
    • , Yaomin Xu
    • , Javid J. Moslehi
    • , Melinda E. Sanders
    • , Jeffrey A. Sosman
    •  & Justin M. Balko
  • Letter |

    Flaviviruses can cause either symptomatic or asymptomatic infection. Here, symptomatic flavivirus infection associated with a live-attenuated yellow fever viral vaccine was linked to the cellular state before vaccination.

    • Kuan Rong Chan
    • , Esther Shuyi Gan
    • , Candice Yuen Yue Chan
    • , Cui Liang
    • , John Zhong Heng Low
    • , Summer Li-Xin Zhang
    • , Eugenia Ziying Ong
    • , Ashwin Bhatta
    • , Limin Wijaya
    • , Yie Hou Lee
    • , Jenny Guek-Hong Low
    •  & Eng Eong Ooi
  • Letter |

    Nearly one-third of infants born to mothers with confirmed Zika virus (ZIKV) infection during pregnancy have developmental impairments that can be delayed in their presentation, warranting long-term monitoring of ZIKV-exposed children.

    • Karin Nielsen-Saines
    • , Patrícia Brasil
    • , Tara Kerin
    • , Zilton Vasconcelos
    • , Claudia Raja Gabaglia
    • , Luana Damasceno
    • , Marcos Pone
    • , Liege M. Abreu de Carvalho
    • , Sheila M. Pone
    • , Andrea A. Zin
    • , Irena Tsui
    • , Tania Regina S. Salles
    • , Denise Cotrim da Cunha
    • , Roozemerie Pereira Costa
    • , Jociele Malacarne
    • , Ana Beatriz Reis
    • , Renata Hydee Hasue
    • , Carolina Y. P. Aizawa
    • , Fernanda F. Genovesi
    • , Christa Einspieler
    • , Peter B Marschik
    • , José Paulo Pereira
    • , Stephanie L. Gaw
    • , Kristina Adachi
    • , James D. Cherry
    • , Zhiheng Xu
    • , Genhong Cheng
    •  & Maria Elisabeth Moreira
  • Letter |

    A genome-wide association study using electronic health record data in the Million Veteran Program uncovers new genetic loci associated specifically with peripheral artery disease, as compared to stroke or coronary artery disease.

    • Derek Klarin
    • , Julie Lynch
    • , Krishna Aragam
    • , Mark Chaffin
    • , Themistocles L. Assimes
    • , Jie Huang
    • , Kyung Min Lee
    • , Qing Shao
    • , Jennifer E. Huffman
    • , Pradeep Natarajan
    • , Shipra Arya
    • , Aeron Small
    • , Yan V. Sun
    • , Marijana Vujkovic
    • , Matthew S. Freiberg
    • , Lu Wang
    • , Jinbo Chen
    • , Danish Saleheen
    • , Jennifer S. Lee
    • , Donald R. Miller
    • , Peter Reaven
    • , Patrick R. Alba
    • , Olga V. Patterson
    • , Scott L. DuVall
    • , William E. Boden
    • , Joshua A. Beckman
    • , J. Michael Gaziano
    • , John Concato
    • , Daniel J. Rader
    • , Kelly Cho
    • , Kyong-Mi Chang
    • , Peter W. F. Wilson
    • , Christopher J. O’Donnell
    • , Sekar Kathiresan
    • , Philip S. Tsao
    •  & Scott M. Damrauer
  • Letter |

    Engineering of a menthol-controlled gene switch whose components are all of human origin may facilitate clinical translation of this approach, in which therapeutic protein production is triggered by topical application of menthol to the skin.

    • Peng Bai
    • , Ying Liu
    • , Shuai Xue
    • , Ghislaine Charpin-El Hamri
    • , Pratik Saxena
    • , Haifeng Ye
    • , Mingqi Xie
    •  & Martin Fussenegger
  • Letter
    | Open Access

    Typhoid toxin is not essential for the pathogenesis of typhoid fever in healthy humans challenged with Salmonella Typhi.

    • Malick M. Gibani
    • , Elizabeth Jones
    • , Amber Barton
    • , Celina Jin
    • , Juliette Meek
    • , Susana Camara
    • , Ushma Galal
    • , Eva Heinz
    • , Yael Rosenberg-Hasson
    • , Gerlinde Obermoser
    • , Claire Jones
    • , Danielle Campbell
    • , Charlotte Black
    • , Helena Thomaides-Brears
    • , Christopher Darlow
    • , Christina Dold
    • , Laura Silva-Reyes
    • , Luke Blackwell
    • , Maria Lara-Tejero
    • , Xuyao Jiao
    • , Gabrielle Stack
    • , Christoph J. Blohmke
    • , Jennifer Hill
    • , Brian Angus
    • , Gordon Dougan
    • , Jorge Galán
    •  & Andrew J. Pollard
  • Letter |

    Screening of Cas9 and gRNA combinations identifies the variant SaCas9-KKH that selectively disrupts the mutant Tmc1/TMC1 allele that causes hearing loss, prevents deafness and preserves inner-ear hair cell function in Tmc1 mutant Beethoven mice.

    • Bence György
    • , Carl Nist-Lund
    • , Bifeng Pan
    • , Yukako Asai
    • , K. Domenica Karavitaki
    • , Benjamin P. Kleinstiver
    • , Sara P. Garcia
    • , Mikołaj P. Zaborowski
    • , Paola Solanes
    • , Sofia Spataro
    • , Bernard L. Schneider
    • , J. Keith Joung
    • , Gwenaëlle S. G. Géléoc
    • , Jeffrey R. Holt
    •  & David P. Corey
  • Letter |

    Inhibition of histone and DNA methyltransferase activity enhances sensitivity to platinum-based and immunotherapy in a novel transgenic mouse model of metastatic bladder cancer.

    • Cristina Segovia
    • , Edurne San José-Enériz
    • , Ester Munera-Maravilla
    • , Mónica Martínez-Fernández
    • , Leire Garate
    • , Estíbaliz Miranda
    • , Amaia Vilas-Zornoza
    • , Iris Lodewijk
    • , Carolina Rubio
    • , Carmen Segrelles
    • , Luis Vitores Valcárcel
    • , Obdulia Rabal
    • , Noelia Casares
    • , Alejandra Bernardini
    • , Cristian Suarez-Cabrera
    • , Fernando F. López-Calderón
    • , Puri Fortes
    • , José A. Casado
    • , Marta Dueñas
    • , Felipe Villacampa
    • , Juan José Lasarte
    • , Félix Guerrero-Ramos
    • , Guillermo de Velasco
    • , Julen Oyarzabal
    • , Daniel Castellano
    • , Xabier Agirre
    • , Felipe Prósper
    •  & Jesús M. Paramio
  • Letter |

    Supplementation with Akkermansia muciniphila, a gut microbe previously associated with metabolic health in preclinical models, is safe and well tolerated in humans and may improve metabolic parameters in overweight and obese patients.

    • Clara Depommier
    • , Amandine Everard
    • , Céline Druart
    • , Hubert Plovier
    • , Matthias Van Hul
    • , Sara Vieira-Silva
    • , Gwen Falony
    • , Jeroen Raes
    • , Dominique Maiter
    • , Nathalie M. Delzenne
    • , Marie de Barsy
    • , Audrey Loumaye
    • , Michel P. Hermans
    • , Jean-Paul Thissen
    • , Willem M. de Vos
    •  & Patrice D. Cani
  • Letter |

    A recurrent gain-of-function mutation in ARAF causes lymphatic anomaly in two unrelated patients, and treating one of the patients with an FDA-approved MEK inhibitor resulted in a remarkable recovery, exemplifying the power of precision medicine.

    • Dong Li
    • , Michael E. March
    • , Alvaro Gutierrez-Uzquiza
    • , Charlly Kao
    • , Christoph Seiler
    • , Erin Pinto
    • , Leticia S. Matsuoka
    • , Mark R. Battig
    • , Elizabeth J. Bhoj
    • , Tara L. Wenger
    • , Lifeng Tian
    • , Nora Robinson
    • , Tiancheng Wang
    • , Yichuan Liu
    • , Brant M. Weinstein
    • , Matthew Swift
    • , Hyun Min Jung
    • , Courtney N. Kaminski
    • , Rosetta Chiavacci
    • , Jonathan A. Perkins
    • , Michael A. Levine
    • , Patrick M. A. Sleiman
    • , Patricia J. Hicks
    • , Janet T. Strausbaugh
    • , Jean B. Belasco
    • , Yoav Dori
    •  & Hakon Hakonarson
  • Letter |

    Epigenetic states reminiscent of the cell of origin define clinically relevant markers for stratification of patients with pancreatic neuroendocrine cancer.

    • Paloma Cejas
    • , Yotam Drier
    • , Koen M. A. Dreijerink
    • , Lodewijk A. A. Brosens
    • , Vikram Deshpande
    • , Charles B. Epstein
    • , Elfi B. Conemans
    • , Folkert H. M. Morsink
    • , Mindy K. Graham
    • , Gerlof D. Valk
    • , Menno R. Vriens
    • , Carlos Fernandez-del Castillo
    • , Cristina R. Ferrone
    • , Tomer Adar
    • , Michaela Bowden
    • , Holly J. Whitton
    • , Annacarolina Da Silva
    • , Alba Font-Tello
    • , Henry W. Long
    • , Elizabeth Gaskell
    • , Noam Shoresh
    • , Christopher M. Heaphy
    • , Ewa Sicinska
    • , Matthew H. Kulke
    • , Daniel C. Chung
    • , Bradley E. Bernstein
    •  & Ramesh A. Shivdasani