Letters

  • Letter |

    A cohort of asymptomatic patients infected with SARS-CoV-2 had significantly lower levels of virus-specific IgG antibodies compared to a cohort of age- and sex-matched symptomatic infected patients.

    • Quan-Xin Long
    • , Xiao-Jun Tang
    • , Qiu-Lin Shi
    • , Qin Li
    • , Hai-Jun Deng
    • , Jun Yuan
    • , Jie-Li Hu
    • , Wei Xu
    • , Yong Zhang
    • , Fa-Jin Lv
    • , Kun Su
    • , Fan Zhang
    • , Jiang Gong
    • , Bo Wu
    • , Xia-Mao Liu
    • , Jin-Jing Li
    • , Jing-Fu Qiu
    • , Juan Chen
    •  & Ai-Long Huang
  • Letter |

    A new epidemiological study shows reduced susceptibility to SARS-CoV-2 and decreased risk of developing severe symptoms in people aged younger than 20 years, suggesting that children have limited contribution to spread of COVID-19.

    • Nicholas G. Davies
    • , Petra Klepac
    • , Yang Liu
    • , Kiesha Prem
    • , Mark Jit
    • , Carl A. B. Pearson
    • , Billy J. Quilty
    • , Adam J. Kucharski
    • , Hamish Gibbs
    • , Samuel Clifford
    • , Amy Gimma
    • , Kevin van Zandvoort
    • , James D. Munday
    • , Charlie Diamond
    • , W. John Edmunds
    • , Rein M. G. J. Houben
    • , Joel Hellewell
    • , Timothy W. Russell
    • , Sam Abbott
    • , Sebastian Funk
    • , Nikos I. Bosse
    • , Yueqian Fiona Sun
    • , Stefan Flasche
    • , Alicia Rosello
    • , Christopher I. Jarvis
    •  & Rosalind M. Eggo
  • Letter |

    Projection of the number of COVID-19 cases and the associated burden on healthcare resources using a modified SEIR model reveals that rural regions in the United States are at risk of higher per capita case burdens, which could lead to health systems being overwhelmed in these areas.

    • Ian F. Miller
    • , Alexander D. Becker
    • , Bryan T. Grenfell
    •  & C. Jessica E. Metcalf
  • Letter |

    Single-cell transcriptomic analysis identifies changes in peripheral immune cells in seven hospitalized patients with COVID-19, including HLA class II downregulation, a heterogeneous interferon-stimulated gene signature and low pro-inflammatory cytokine gene expression in monocytes and lymphocytes.

    • Aaron J. Wilk
    • , Arjun Rustagi
    • , Nancy Q. Zhao
    • , Jonasel Roque
    • , Giovanny J. Martínez-Colón
    • , Julia L. McKechnie
    • , Geoffrey T. Ivison
    • , Thanmayi Ranganath
    • , Rosemary Vergara
    • , Taylor Hollis
    • , Laura J. Simpson
    • , Philip Grant
    • , Aruna Subramanian
    • , Angela J. Rogers
    •  & Catherine A. Blish
  • Letter |

    In a phase 2 clinical trial cohort of patients with leptomeningeal disease, anti-PD-1 monotherapy was safe and associated with a 3-month overall survival of 60%.

    • Priscilla K. Brastianos
    • , Eudocia Quant Lee
    • , Justine V. Cohen
    • , Sara M. Tolaney
    • , Nancy U. Lin
    • , Nancy Wang
    • , Ugonma Chukwueke
    • , Michael D. White
    • , Naema Nayyar
    • , Albert Kim
    • , Christopher Alvarez-Breckenridge
    • , Ian Krop
    • , Maura Keeley Mahar
    • , Mia S. Bertalan
    • , Brian Shaw
    • , Joana L. Mora
    • , Nathaniel Goss
    • , Megha Subramanian
    • , Lakshmi Nayak
    • , Jorg Dietrich
    • , Deborah A. Forst
    • , Brian V. Nahed
    • , Tracy T. Batchelor
    • , Helen A. Shih
    • , Elizabeth R. Gerstner
    • , Beverly Moy
    • , Donald Lawrence
    • , Anita Giobbie-Hurder
    • , Scott L. Carter
    • , Kevin Oh
    • , Daniel P. Cahill
    •  & Ryan J. Sullivan
  • Letter |

    An IgG-cleaving endopeptidase can degrade circulating anti-adeno-associated virus antibodies in mice and nonhuman primates in vivo, as well as in human plasma in vitro, offering a potential solution for a major hurdle in gene therapy.

    • Christian Leborgne
    • , Elena Barbon
    • , Jeffrey M. Alexander
    • , Hayley Hanby
    • , Sandrine Delignat
    • , Daniel M. Cohen
    • , Fanny Collaud
    • , Saghana Muraleetharan
    • , Dan Lupo
    • , Joseph Silverberg
    • , Karen Huang
    • , Laetitia van Wittengerghe
    • , Béatrice Marolleau
    • , Adeline Miranda
    • , Anna Fabiano
    • , Victoria Daventure
    • , Heena Beck
    • , Xavier M. Anguela
    • , Giuseppe Ronzitti
    • , Sean M. Armour
    • , Sebastien Lacroix-Desmazes
    •  & Federico Mingozzi
  • Letter |

    Identification of a DNA-damage signature induced by colibactin, a toxin expressed by some strains of Escherichia coli, is enriched in human colorectal cancers.

    • Paulina J. Dziubańska-Kusibab
    • , Hilmar Berger
    • , Federica Battistini
    • , Britta A. M. Bouwman
    • , Amina Iftekhar
    • , Riku Katainen
    • , Tatiana Cajuso
    • , Nicola Crosetto
    • , Modesto Orozco
    • , Lauri A. Aaltonen
    •  & Thomas F. Meyer
  • Letter
    | Open Access

    Analysis of large genomic datasets, including gnomAD, reveals that partial LRRK2 loss of function is not strongly associated with diseases, serving as an example of how human genetics can be leveraged for target validation in drug discovery.

    • Nicola Whiffin
    • , Irina M. Armean
    • , Aaron Kleinman
    • , Jamie L. Marshall
    • , Eric V. Minikel
    • , Julia K. Goodrich
    • , Nicholas M. Quaife
    • , Joanne B. Cole
    • , Qingbo Wang
    • , Konrad J. Karczewski
    • , Beryl B. Cummings
    • , Laurent Francioli
    • , Kristen Laricchia
    • , Anna Guan
    • , Babak Alipanahi
    • , Peter Morrison
    • , Marco A. S. Baptista
    • , Kalpana M. Merchant
    • , Jessica Alföldi
    • , Irina M. Armean
    • , Eric Banks
    • , Louis Bergelson
    • , Kristian Cibulskis
    • , Ryan L. Collins
    • , Kristen M. Connolly
    • , Miguel Covarrubias
    • , Beryl Cummings
    • , Mark J. Daly
    • , Stacey Donnelly
    • , Yossi Farjoun
    • , Steven Ferriera
    • , Laurent Francioli
    • , Stacey Gabriel
    • , Laura D. Gauthier
    • , Jeff Gentry
    • , Namrata Gupta
    • , Thibault Jeandet
    • , Diane Kaplan
    • , Konrad J. Karczewski
    • , Kristen M. Laricchia
    • , Christopher Llanwarne
    • , Eric V. Minikel
    • , Ruchi Munshi
    • , Benjamin M. Neale
    • , Sam Novod
    • , Anne H. O’Donnell-Luria
    • , Nikelle Petrillo
    • , Timothy Poterba
    • , David Roazen
    • , Valentin Ruano-Rubio
    • , Andrea Saltzman
    • , Kaitlin E. Samocha
    • , Molly Schleicher
    • , Cotton Seed
    • , Matthew Solomonson
    • , Jose Soto
    • , Grace Tiao
    • , Kathleen Tibbetts
    • , Charlotte Tolonen
    • , Christopher Vittal
    • , Gordon Wade
    • , Arcturus Wang
    • , Qingbo Wang
    • , James S. Ware
    • , Nicholas A. Watts
    • , Ben Weisburd
    • , Nicola Whiffin
    • , Carlos A. Aguilar-Salinas
    • , Tariq Ahmad
    • , Christine M. Albert
    • , Diego Ardissino
    • , Gil Atzmon
    • , John Barnard
    • , Laurent Beaugerie
    • , Emelia J. Benjamin
    • , Michael Boehnke
    • , Lori L. Bonnycastle
    • , Erwin P. Bottinger
    • , Donald W. Bowden
    • , Matthew J. Bown
    • , John C. Chambers
    • , Juliana C. Chan
    • , Daniel Chasman
    • , Judy Cho
    • , Mina K. Chung
    • , Bruce Cohen
    • , Adolfo Correa
    • , Dana Dabelea
    • , Mark J. Daly
    • , Dawood Darbar
    • , Ravindranath Duggirala
    • , Josée Dupuis
    • , Patrick T. Ellinor
    • , Roberto Elosua
    • , Jeanette Erdmann
    • , Tõnu Esko
    • , Martti Färkkilä
    • , Jose Florez
    • , Andre Franke
    • , Gad Getz
    • , Benjamin Glaser
    • , Stephen J. Glatt
    • , David Goldstein
    • , Clicerio Gonzalez
    • , Leif Groop
    • , Christopher Haiman
    • , Craig Hanis
    • , Matthew Harms
    • , Mikko Hiltunen
    • , Matti M. Holi
    • , Christina M. Hultman
    • , Mikko Kallela
    • , Jaakko Kaprio
    • , Sekar Kathiresan
    • , Bong-Jo Kim
    • , Young Jin Kim
    • , George Kirov
    • , Jaspal Kooner
    • , Seppo Koskinen
    • , Harlan M. Krumholz
    • , Subra Kugathasan
    • , Soo Heon Kwak
    • , Markku Laakso
    • , Terho Lehtimäki
    • , Ruth J. F. Loos
    • , Steven A. Lubitz
    • , Ronald C. W. Ma
    • , Daniel G. MacArthur
    • , Jaume Marrugat
    • , Kari M. Mattila
    • , Steven McCarroll
    • , Mark I. McCarthy
    • , Dermot McGovern
    • , Ruth McPherson
    • , James B. Meigs
    • , Olle Melander
    • , Andres Metspalu
    • , Benjamin M. Neale
    • , Peter M. Nilsson
    • , Michael C. O’Donovan
    • , Dost Ongur
    • , Lorena Orozco
    • , Michael J. Owen
    • , Colin N. A. Palmer
    • , Aarno Palotie
    • , Kyong Soo Park
    • , Carlos Pato
    • , Ann E. Pulver
    • , Nazneen Rahman
    • , Anne M. Remes
    • , John D. Riou
    • , Samuli Ripatti
    • , Dan M. Roden
    • , Danish Saleheen
    • , Veikko Salomaa
    • , Nilesh J. Samani
    • , Jeremiah Scharf
    • , Heribert Schunkert
    • , Moore B. Shoemaker
    • , Pamela Sklar
    • , Hilkka Soininen
    • , Harry Sokol
    • , Tim Spector
    • , Patrick F. Sullivan
    • , Jaana Suvisaari
    • , E. Shyong Tai
    • , Yik Ying Teo
    • , Tuomi Tiinamaija
    • , Ming Tsuang
    • , Dan Turner
    • , Teresa Tusie-Luna
    • , Erkki Vartiainen
    • , James S. Ware
    • , Hugh Watkins
    • , Rinse K. Weersma
    • , Maija Wessman
    • , James G. Wilson
    • , Ramnik J. Xavier
    • , James S. Ware
    • , Aki S. Havulinna
    • , Bozenna Iliadou
    • , Jung-Jin Lee
    • , Girish N. Nadkarni
    • , Cole Whiteman
    • , Michelle Agee
    • , Adam Auton
    • , Robert K. Bell
    • , Katarzyna Bryc
    • , Sarah L. Elson
    • , Pierre Fontanillas
    • , Nicholas A. Furlotte
    • , Barry Hicks
    • , David A. Hinds
    • , Karen E. Huber
    • , Ethan M. Jewett
    • , Yunxuan Jiang
    • , Keng-Han Lin
    • , Nadia K. Litterman
    • , Matthew H. McIntyre
    • , Kimberly F. McManus
    • , Joanna L. Mountain
    • , Elizabeth S. Noblin
    • , Carrie A. M. Northover
    • , Steven J. Pitts
    • , G. David Poznik
    • , J. Fah Sathirapongsasuti
    • , Janie F. Shelton
    • , Suyash Shringarpure
    • , Chao Tian
    • , Joyce Y. Tung
    • , Vladimir Vacic
    • , Xin Wang
    • , Catherine H. Wilson
    • , Mark Daly
    • , Tõnu Esko
    • , Christina Hultman
    • , Ruth J. F. Loos
    • , Lili Milani
    • , Aarno Palotie
    • , Carlos Pato
    • , Michele Pato
    • , Danish Saleheen
    • , Patrick F. Sullivan
    • , Jessica Alföldi
    • , Paul Cannon
    •  & Daniel G. MacArthur
  • Letter |

    Multiregion spatial histology, exome and transcriptome data from patients with non-small cell lung cancer suggest that cancer subclones from immune cold regions diversify later than subclones from immune hot regions

    • Khalid AbdulJabbar
    • , Shan E. Ahmed Raza
    • , Rachel Rosenthal
    • , Mariam Jamal-Hanjani
    • , Selvaraju Veeriah
    • , Ayse Akarca
    • , Tom Lund
    • , David A. Moore
    • , Roberto Salgado
    • , Maise Al Bakir
    • , Luis Zapata
    • , Crispin T. Hiley
    • , Leah Officer
    • , Marco Sereno
    • , Claire Rachel Smith
    • , Sherene Loi
    • , Allan Hackshaw
    • , Teresa Marafioti
    • , Sergio A. Quezada
    • , Nicholas McGranahan
    • , John Le Quesne
    • , Charles Swanton
    • , Mariam Jamal-Hanjani
    • , John Le Quesne
    • , Allan Hackshaw
    • , Sergio A. Quezada
    • , Nicholas McGranahan
    • , Rachel Rosenthal
    • , Crispin T. Hiley
    • , Selvaraju Veeriah
    • , David A. Moore
    • , Maise Al Bakir
    • , Teresa Marafioti
    • , Roberto Salgado
    • , Yenting Ngai
    • , Abigail Sharp
    • , Cristina Rodrigues
    • , Oliver Pressey
    • , Sean Smith
    • , Nicole Gower
    • , Harjot Dhanda
    • , Joan Riley
    • , Lindsay Primrose
    • , Luke Martinson
    • , Nicolas Carey
    • , Jacqui A. Shaw
    • , Dean Fennell
    • , Gareth A. Wilson
    • , Nicolai J. Birkbak
    • , Thomas B. K. Watkins
    • , Mickael Escudero
    • , Aengus Stewart
    • , Andrew Rowan
    • , Jacki Goldman
    • , Peter Van Loo
    • , Richard Kevin Stone
    • , Tamara Denner
    • , Emma Nye
    • , Sophia Ward
    • , Emilia L. Lim
    • , Stefan Boeing
    • , Maria Greco
    • , Kevin Litchfield
    • , Jerome Nicod
    • , Clare Puttick
    • , Katey Enfield
    • , Emma Colliver
    • , Brittany Campbell
    • , Christopher Abbosh
    • , Yin Wu
    • , Marcin Skrzypski
    • , Robert E. Hynds
    • , Andrew Georgiou
    • , Mariana Werner Sunderland
    • , James L. Reading
    • , Karl S. Peggs
    • , John A. Hartley
    • , Pat Gorman
    • , Helen L. Lowe
    • , Leah Ensell
    • , Victoria Spanswick
    • , Angeliki Karamani
    • , Dhruva Biswas
    • , Maryam Razaq
    • , Stephan Beck
    • , Ariana Huebner
    • , Michelle Dietzen
    • , Cristina Naceur-Lombardelli
    • , Mita Afroza Akther
    • , Haoran Zhai
    • , Nnennaya Kannu
    • , Elizabeth Manzano
    • , Supreet Kaur Bola
    • , Ehsan Ghorani
    • , Marc Robert de Massy
    • , Elena Hoxha
    • , Emine Hatipoglu
    • , Stephanie Ogwuru
    • , Benny Chain
    • , Gillian Price
    • , Sylvie Dubois-Marshall
    • , Keith Kerr
    • , Shirley Palmer
    • , Heather Cheyne
    • , Joy Miller
    • , Keith Buchan
    • , Mahendran Chetty
    • , Mohammed Khalil
    • , Veni Ezhil
    • , Vineet Prakash
    • , Girija Anand
    • , Sajid Khan
    • , Kelvin Lau
    • , Michael Sheaff
    • , Peter Schmid
    • , Louise Lim
    • , John Conibear
    • , Roland Schwarz
    • , Jonathan Tugwood
    • , Jackie Pierce
    • , Caroline Dive
    • , Ged Brady
    • , Dominic G. Rothwell
    • , Francesca Chemi
    • , Elaine Kilgour
    • , Fiona Blackhall
    • , Lynsey Priest
    • , Matthew G. Krebs
    • , Philip Crosbie
    • , Apostolos Nakas
    • , Sridhar Rathinam
    • , Louise Nelson
    • , Kim Ryanna
    • , Mohamad Tuffail
    • , Amrita Bajaj
    • , Jan Brozik
    • , Fiona Morgan
    • , Malgorzata Kornaszewska
    • , Richard Attanoos
    • , Haydn Adams
    • , Helen Davies
    • , Mathew Carter
    • , C. R. Lindsay
    • , Fabio Gomes
    • , Zoltan Szallasi
    • , Istvan Csabai
    • , Miklos Diossy
    • , Hugo Aerts
    • , Alan Kirk
    • , Mo Asif
    • , John Butler
    • , Rocco Bilanca
    • , Nikos Kostoulas
    • , Mairead MacKenzie
    • , Maggie Wilcox
    • , Sara Busacca
    • , Alan Dawson
    • , Mark R. Lovett
    • , Michael Shackcloth
    • , Sarah Feeney
    • , Julius Asante-Siaw
    • , John Gosney
    • , Angela Leek
    • , Nicola Totten
    • , Jack Davies Hodgkinson
    • , Rachael Waddington
    • , Jane Rogan
    • , Katrina Moore
    • , William Monteiro
    • , Hilary Marshall
    • , Kevin G. Blyth
    • , Craig Dick
    • , Andrew Kidd
    • , Eric Lim
    • , Paulo De Sousa
    • , Simon Jordan
    • , Alexandra Rice
    • , Hilgardt Raubenheimer
    • , Harshil Bhayani
    • , Morag Hamilton
    • , Lyn Ambrose
    • , Anand Devaraj
    • , Hema Chavan
    • , Sofina Begum
    • , Aleksander Mani
    • , Daniel Kaniu
    • , Mpho Malima
    • , Sarah Booth
    • , Andrew G. Nicholson
    • , Nadia Fernandes
    • , Jessica E. Wallen
    • , Pratibha Shah
    • , Sarah Danson
    • , Jonathan Bury
    • , John Edwards
    • , Jennifer Hill
    • , Sue Matthews
    • , Yota Kitsanta
    • , Jagan Rao
    • , Sara Tenconi
    • , Laura Socci
    • , Kim Suvarna
    • , Faith Kibutu
    • , Patricia Fisher
    • , Robin Young
    • , Joann Barker
    • , Fiona Taylor
    • , Kirsty Lloyd
    • , Teresa Light
    • , Tracey Horey
    • , Dionysis Papadatos-Pastos
    • , Peter Russell
    • , Sara Lock
    • , Kayleigh Gilbert
    • , David Lawrence
    • , Martin Hayward
    • , Nikolaos Panagiotopoulos
    • , Robert George
    • , Davide Patrini
    • , Mary Falzon
    • , Elaine Borg
    • , Reena Khiroya
    • , Asia Ahmed
    • , Magali Taylor
    • , Junaid Choudhary
    • , Penny Shaw
    • , Sam M. Janes
    • , Martin Forster
    • , Tanya Ahmad
    • , Siow Ming Lee
    • , Javier Herrero
    • , Dawn Carnell
    • , Ruheena Mendes
    • , Jeremy George
    • , Neal Navani
    • , Marco Scarci
    • , Elisa Bertoja
    • , Robert C. M. Stephens
    • , Emilie Martinoni Hoogenboom
    • , James W. Holding
    • , Steve Bandula
    • , Babu Naidu
    • , Gerald Langman
    • , Andrew Robinson
    • , Hollie Bancroft
    • , Amy Kerr
    • , Salma Kadiri
    • , Charlotte Ferris
    • , Gary Middleton
    • , Madava Djearaman
    • , Akshay Patel
    • , Christian Ottensmeier
    • , Serena Chee
    • , Benjamin Johnson
    • , Aiman Alzetani
    • , Emily Shaw
    • , Jason Lester
    • , Yvonne Summers
    • , Raffaele Califano
    • , Paul Taylor
    • , Rajesh Shah
    • , Piotr Krysiak
    • , Kendadai Rammohan
    • , Eustace Fontaine
    • , Richard Booton
    • , Matthew Evison
    • , Stuart Moss
    • , Juliette Novasio
    • , Leena Joseph
    • , Paul Bishop
    • , Anshuman Chaturvedi
    • , Helen Doran
    • , Felice Granato
    • , Vijay Joshi
    • , Elaine Smith
    • , Angeles Montero
    • , Charles Swanton
    •  & Yinyin Yuan
  • Letter |

    Results from the phase IIa COMBAT trial combining CXCR4 and PD-1 inhibition in patients with metastatic cancer show encouraging clinical responses in association with enhanced antitumor immune activation.

    • Bruno Bockorny
    • , Valerya Semenisty
    • , Teresa Macarulla
    • , Erkut Borazanci
    • , Brian M. Wolpin
    • , Salomon M. Stemmer
    • , Talia Golan
    • , Ravit Geva
    • , Mitesh J. Borad
    • , Katrina S. Pedersen
    • , Joon Oh Park
    • , Robert A. Ramirez
    • , David G. Abad
    • , Jaime Feliu
    • , Andres Muñoz
    • , Mariano Ponz-Sarvise
    • , Amnon Peled
    • , Tzipora M. Lustig
    • , Osnat Bohana-Kashtan
    • , Stephen M. Shaw
    • , Ella Sorani
    • , Marya Chaney
    • , Shaul Kadosh
    • , Abi Vainstein Haras
    • , Daniel D. Von Hoff
    •  & Manuel Hidalgo
  • Letter |

    Artificial intelligence algorithms integrating chest computed tomography scans and clinical information can diagnose COVID-19 with similar accuracy as compared to a senior radiologist.

    • Xueyan Mei
    • , Hao-Chih Lee
    • , Kai-yue Diao
    • , Mingqian Huang
    • , Bin Lin
    • , Chenyu Liu
    • , Zongyu Xie
    • , Yixuan Ma
    • , Philip M. Robson
    • , Michael Chung
    • , Adam Bernheim
    • , Venkatesh Mani
    • , Claudia Calcagno
    • , Kunwei Li
    • , Shaolin Li
    • , Hong Shan
    • , Jian Lv
    • , Tongtong Zhao
    • , Junli Xia
    • , Qihua Long
    • , Sharon Steinberger
    • , Adam Jacobi
    • , Timothy Deyer
    • , Marta Luksza
    • , Fang Liu
    • , Brent P. Little
    • , Zahi A. Fayad
    •  & Yang Yang
  • Letter |

    Bat and human intestinal organoids can support replication of SARS-CoV-2, enabling further characterization of the virus lifecycle and investigation of potential mechanisms of enteric infection in COVID-19.

    • Jie Zhou
    • , Cun Li
    • , Xiaojuan Liu
    • , Man Chun Chiu
    • , Xiaoyu Zhao
    • , Dong Wang
    • , Yuxuan Wei
    • , Andrew Lee
    • , Anna Jinxia Zhang
    • , Hin Chu
    • , Jian-Piao Cai
    • , Cyril Chik-Yan Yip
    • , Ivy Hau-Yee Chan
    • , Kenneth Kak-Yuen Wong
    • , Owen Tak-Yin Tsang
    • , Kwok-Hung Chan
    • , Jasper Fuk-Woo Chan
    • , Kelvin Kai-Wang To
    • , Honglin Chen
    •  & Kwok Yung Yuen
  • Letter |

    In a retrospective analysis of data from three clinical trials, increased baseline peripheral and tumor IL-8 levels were associated with worse clinical outcomes in patients with metastatic urothelial carcinoma and metastatic renal cell carcinoma treated with anti-PD-L1 therapy.

    • Kobe C. Yuen
    • , Li-Fen Liu
    • , Vinita Gupta
    • , Shravan Madireddi
    • , Shilpa Keerthivasan
    • , Congfen Li
    • , Deepali Rishipathak
    • , Patrick Williams
    • , Edward E. Kadel III
    • , Hartmut Koeppen
    • , Ying-Jiun Chen
    • , Zora Modrusan
    • , Jane L. Grogan
    • , Romain Banchereau
    • , Ning Leng
    • , AnnChristine Thastrom
    • , Xiadong Shen
    • , Kenji Hashimoto
    • , Darren Tayama
    • , Michiel S. van der Heijden
    • , Jonathan E. Rosenberg
    • , David F. McDermott
    • , Thomas Powles
    • , Priti S. Hegde
    • , Mahrukh A. Huseni
    •  & Sanjeev Mariathasan
  • Letter |

    By using data from electrocardiograms, a deep learning algorithm outperforms traditional risk scores in predicting death over the course of the next year and identifies at-risk individuals with seemingly normal electrocardiograms.

    • Sushravya Raghunath
    • , Alvaro E. Ulloa Cerna
    • , Linyuan Jing
    • , David P. vanMaanen
    • , Joshua Stough
    • , Dustin N. Hartzel
    • , Joseph B. Leader
    • , H. Lester Kirchner
    • , Martin C. Stumpe
    • , Ashraf Hafez
    • , Arun Nemani
    • , Tanner Carbonati
    • , Kipp W. Johnson
    • , Katelyn Young
    • , Christopher W. Good
    • , John M. Pfeifer
    • , Aalpen A. Patel
    • , Brian P. Delisle
    • , Amro Alsaid
    • , Dominik Beer
    • , Christopher M. Haggerty
    •  & Brandon K. Fornwalt
  • Letter |

    A new study models the potential effects of preferentially deploying recovered individuals, who are seropositive for anti-SARS-CoV-2 antibodies, into the community to reduce the number of interactions between susceptible and infected people, thereby limiting transmission of the virus.

    • Joshua S. Weitz
    • , Stephen J. Beckett
    • , Ashley R. Coenen
    • , David Demory
    • , Marian Dominguez-Mirazo
    • , Jonathan Dushoff
    • , Chung-Yin Leung
    • , Guanlin Li
    • , Andreea Măgălie
    • , Sang Woo Park
    • , Rogelio Rodriguez-Gonzalez
    • , Shashwat Shivam
    •  & Conan Y. Zhao
  • Letter |

    CAR T cells administered intracerebroventricularly or intratumorally exhibit more rapid kinetics, reduced systemic toxicity and greater therapeutic potency as compared to intravenously delivered CAR T cells in atypical teratoid/rhabdoid tumor xenograft mouse models.

    • Johanna Theruvath
    • , Elena Sotillo
    • , Christopher W. Mount
    • , Claus Moritz Graef
    • , Alberto Delaidelli
    • , Sabine Heitzeneder
    • , Louai Labanieh
    • , Shaurya Dhingra
    • , Amaury Leruste
    • , Robbie G. Majzner
    • , Peng Xu
    • , Sabine Mueller
    • , Derek W. Yecies
    • , Martina A. Finetti
    • , Daniel Williamson
    • , Pascal D. Johann
    • , Marcel Kool
    • , Stefan Pfister
    • , Martin Hasselblatt
    • , Michael C. Frühwald
    • , Olivier Delattre
    • , Didier Surdez
    • , Franck Bourdeaut
    • , Stephanie Puget
    • , Sakina Zaidi
    • , Siddhartha S. Mitra
    • , Samuel Cheshier
    • , Poul H. Sorensen
    • , Michelle Monje
    •  & Crystal L. Mackall
  • Letter |

    Detailed clinical and virologic characteristics of the first 12 individuals with COVID-19 in the United States from the US Centers for Disease Control and Prevention.

    • Stephanie A. Kujawski
    • , Karen K. Wong
    • , Jennifer P. Collins
    • , Lauren Epstein
    • , Marie E. Killerby
    • , Claire M. Midgley
    • , Glen R. Abedi
    • , N. Seema Ahmed
    • , Olivia Almendares
    • , Francisco N. Alvarez
    • , Kayla N. Anderson
    • , Sharon Balter
    • , Vaughn Barry
    • , Karri Bartlett
    • , Karlyn Beer
    • , Michael A. Ben-Aderet
    • , Isaac Benowitz
    • , Holly M. Biggs
    • , Alison M. Binder
    • , Stephanie R. Black
    • , Brandon Bonin
    • , Catherine H. Bozio
    • , Catherine M. Brown
    • , Hollianne Bruce
    • , Jonathan Bryant-Genevier
    • , Alicia Budd
    • , Diane Buell
    • , Rachel Bystritsky
    • , Jordan Cates
    • , E. Matt Charles
    • , Kevin Chatham-Stephens
    • , Nora Chea
    • , Howard Chiou
    • , Demian Christiansen
    • , Victoria Chu
    • , Sara Cody
    • , Max Cohen
    • , Erin E. Conners
    • , Aaron T. Curns
    • , Vishal Dasari
    • , Patrick Dawson
    • , Traci DeSalvo
    • , George Diaz
    • , Matthew Donahue
    • , Suzanne Donovan
    • , Lindsey M. Duca
    • , Keith Erickson
    • , Mathew D. Esona
    • , Suzanne Evans
    • , Jeremy Falk
    • , Leora R. Feldstein
    • , Martin Fenstersheib
    • , Marc Fischer
    • , Rebecca Fisher
    • , Chelsea Foo
    • , Marielle J. Fricchione
    • , Oren Friedman
    • , Alicia Fry
    • , Romeo R. Galang
    • , Melissa M. Garcia
    • , Susan I. Gerber
    • , Graham Gerrard
    • , Isaac Ghinai
    • , Prabhu Gounder
    • , Jonathan Grein
    • , Cheri Grigg
    • , Jeffrey D. Gunzenhauser
    • , Gary I. Gutkin
    • , Meredith Haddix
    • , Aron J. Hall
    • , George S. Han
    • , Jennifer Harcourt
    • , Kathleen Harriman
    • , Thomas Haupt
    • , Amber K. Haynes
    • , Michelle Holshue
    • , Cora Hoover
    • , Jennifer C. Hunter
    • , Max W. Jacobs
    • , Claire Jarashow
    • , Kiran Joshi
    • , Talar Kamali
    • , Shifaq Kamili
    • , Lindsay Kim
    • , Moon Kim
    • , Jan King
    • , Hannah L. Kirking
    • , Amanda Kita-Yarbro
    • , Rachel Klos
    • , Miwako Kobayashi
    • , Anna Kocharian
    • , Kenneth K. Komatsu
    • , Ram Koppaka
    • , Jennifer E. Layden
    • , Yan Li
    • , Scott Lindquist
    • , Stephen Lindstrom
    • , Ruth Link-Gelles
    • , Joana Lively
    • , Michelle Livingston
    • , Kelly Lo
    • , Jennifer Lo
    • , Xiaoyan Lu
    • , Brian Lynch
    • , Larry Madoff
    • , Lakshmi Malapati
    • , Gregory Marks
    • , Mariel Marlow
    • , Glenn E. Mathisen
    • , Nancy McClung
    • , Olivia McGovern
    • , Tristan D. McPherson
    • , Mitali Mehta
    • , Audrey Meier
    • , Lynn Mello
    • , Sung-sil Moon
    • , Margie Morgan
    • , Ruth N. Moro
    • , Janna’ Murray
    • , Rekha Murthy
    • , Shannon Novosad
    • , Sara E. Oliver
    • , Jennifer O’Shea
    • , Massimo Pacilli
    • , Clinton R. Paden
    • , Mark A. Pallansch
    • , Manisha Patel
    • , Sajan Patel
    • , Isabel Pedraza
    • , Satish K. Pillai
    • , Talia Pindyck
    • , Ian Pray
    • , Krista Queen
    • , Nichole Quick
    • , Heather Reese
    • , Roshan Reporter
    • , Brian Rha
    • , Heather Rhodes
    • , Susan Robinson
    • , Philip Robinson
    • , Melissa A. Rolfes
    • , Janell A. Routh
    • , Rachel Rubin
    • , Sarah L. Rudman
    • , Senthilkumar K. Sakthivel
    • , Sarah Scott
    • , Christopher Shepherd
    • , Varun Shetty
    • , Ethan A. Smith
    • , Shanon Smith
    • , Bryan Stierman
    • , William Stoecker
    • , Rebecca Sunenshine
    • , Regina Sy-Santos
    • , Azaibi Tamin
    • , Ying Tao
    • , Dawn Terashita
    • , Natalie J. Thornburg
    • , Suxiang Tong
    • , Elizabeth Traub
    • , Ahmet Tural
    • , Anna Uehara
    • , Timothy M. Uyeki
    • , Grace Vahey
    • , Jennifer R. Verani
    • , Elsa Villarino
    • , Megan Wallace
    • , Lijuan Wang
    • , John T. Watson
    • , Matthew Westercamp
    • , Brett Whitaker
    • , Sarah Wilkerson
    • , Rebecca C. Woodruff
    • , Jonathan M. Wortham
    • , Tiffany Wu
    • , Amy Xie
    • , Anna Yousaf
    • , Matthew Zahn
    •  & Jing Zhang
  • Letter |

    A new epidemiological model, termed SIDARTHE, distinguishes between diagnosed and undiagnosed cases of SARS-CoV-2 infection, as well as modeling effects of social distancing and widespread testing, to predict possible outcomes of the COVID-19 epidemic in Italy.

    • Giulia Giordano
    • , Franco Blanchini
    • , Raffaele Bruno
    • , Patrizio Colaneri
    • , Alessandro Di Filippo
    • , Angela Di Matteo
    •  & Marta Colaneri
  • Letter |

    Mutations in Klebsiella pneumoniae that lead to gain or loss of capsule production affect pathogenicity and associate with bloodstream or urinary tract infections, respectively.

    • Christoph M. Ernst
    • , Julian R. Braxton
    • , Carlos A. Rodriguez-Osorio
    • , Anna P. Zagieboylo
    • , Li Li
    • , Alejandro Pironti
    • , Abigail L. Manson
    • , Anil V. Nair
    • , Maura Benson
    • , Kaelyn Cummins
    • , Anne E. Clatworthy
    • , Ashlee M. Earl
    • , Lisa A. Cosimi
    •  & Deborah T. Hung
  • Letter |

    In a large and prospective cohort, higher polygenic risk is associated with higher risk and earlier age of onset for cardiometabolic disorders and cancer, and has added value to clinical risk scores in clinical disease prediction.

    • Nina Mars
    • , Jukka T. Koskela
    • , Pietari Ripatti
    • , Tuomo T. J. Kiiskinen
    • , Aki S. Havulinna
    • , Joni V. Lindbohm
    • , Ari Ahola-Olli
    • , Mitja Kurki
    • , Juha Karjalainen
    • , Priit Palta
    • , Aarno Palotie
    • , Mark Daly
    • , Howard Jacob
    • , Athena Matakidou
    • , Heiko Runz
    • , Sally John
    • , Robert Plenge
    • , Mark McCarthy
    • , Julie Hunkapiller
    • , Meg Ehm
    • , Dawn Waterworth
    • , Caroline Fox
    • , Anders Malarstig
    • , Kathy Klinger
    • , Kathy Call
    • , Tomi Mäkelä
    • , Jaakko Kaprio
    • , Petri Virolainen
    • , Kari Pulkki
    • , Terhi Kilpi
    • , Markus Perola
    • , Jukka Partanen
    • , Anne Pitkäranta
    • , Riitta Kaarteenaho
    • , Seppo Vainio
    • , Kimmo Savinainen
    • , Veli-Matti Kosma
    • , Urho Kujala
    • , Outi Tuovila
    • , Minna Hendolin
    • , Raimo Pakkanen
    • , Jeff Waring
    • , Bridget Riley-Gillis
    • , Athena Matakidou
    • , Heiko Runz
    • , Jimmy Liu
    • , Shameek Biswas
    • , Julie Hunkapiller
    • , Dawn Waterworth
    • , Meg Ehm
    • , Dorothee Diogo
    • , Caroline Fox
    • , Anders Malarstig
    • , Catherine Marshall
    • , Xinli Hu
    • , Kathy Call
    • , Kathy Klinger
    • , Matthias Gossel
    • , Samuli Ripatti
    • , Johanna Schleutker
    • , Markus Perola
    • , Mikko Arvas
    • , Olli Carpen
    • , Reetta Hinttala
    • , Johannes Kettunen
    • , Reijo Laaksonen
    • , Arto Mannermaa
    • , Juha Paloneva
    • , Urho Kujala
    • , Outi Tuovila
    • , Minna Hendolin
    • , Raimo Pakkanen
    • , Hilkka Soininen
    • , Valtteri Julkunen
    • , Anne Remes
    • , Reetta Kälviäinen
    • , Mikko Hiltunen
    • , Jukka Peltola
    • , Pentti Tienari
    • , Juha Rinne
    • , Adam Ziemann
    • , Jeffrey Waring
    • , Sahar Esmaeeli
    • , Nizar Smaoui
    • , Anne Lehtonen
    • , Susan Eaton
    • , Heiko Runz
    • , Sanni Lahdenperä
    • , Shameek Biswas
    • , John Michon
    • , Geoff Kerchner
    • , Julie Hunkapiller
    • , Natalie Bowers
    • , Edmond Teng
    • , John Eicher
    • , Vinay Mehta
    • , Padhraig Gormley
    • , Kari Linden
    • , Christopher Whelan
    • , Fanli Xu
    • , David Pulford
    • , Martti Färkkilä
    • , Sampsa Pikkarainen
    • , Airi Jussila
    • , Timo Blomster
    • , Mikko Kiviniemi
    • , Markku Voutilainen
    • , Bob Georgantas
    • , Graham Heap
    • , Jeffrey Waring
    • , Nizar Smaoui
    • , Fedik Rahimov
    • , Anne Lehtonen
    • , Keith Usiskin
    • , Joseph Maranville
    • , Tim Lu
    • , Natalie Bowers
    • , Danny Oh
    • , John Michon
    • , Vinay Mehta
    • , Kirsi Kalpala
    • , Melissa Miller
    • , Xinli Hu
    • , Linda McCarthy
    • , Kari Eklund
    • , Antti Palomäki
    • , Pia Isomäki
    • , Laura Pirilä
    • , Oili Kaipiainen-Seppänen
    • , Johanna Huhtakangas
    • , Bob Georgantas
    • , Jeffrey Waring
    • , Fedik Rahimov
    • , Apinya Lertratanakul
    • , Nizar Smaoui
    • , Anne Lehtonen
    • , David Close
    • , Marla Hochfeld
    • , Natalie Bowers
    • , John Michon
    • , Dorothee Diogo
    • , Vinay Mehta
    • , Kirsi Kalpala
    • , Nan Bing
    • , Xinli Hu
    • , Jorge Esparza Gordillo
    • , Nina Mars
    • , Tarja Laitinen
    • , Margit Pelkonen
    • , Paula Kauppi
    • , Hannu Kankaanranta
    • , Terttu Harju
    • , Nizar Smaoui
    • , David Close
    • , Steven Greenberg
    • , Hubert Chen
    • , Natalie Bowers
    • , John Michon
    • , Vinay Mehta
    • , Jo Betts
    • , Soumitra Ghosh
    • , Veikko Salomaa
    • , Teemu Niiranen
    • , Markus Juonala
    • , Kaj Metsärinne
    • , Mika Kähönen
    • , Juhani Junttila
    • , Markku Laakso
    • , Jussi Pihlajamäki
    • , Juha Sinisalo
    • , Marja-Riitta Taskinen
    • , Tiinamaija Tuomi
    • , Jari Laukkanen
    • , Ben Challis
    • , Andrew Peterson
    • , Julie Hunkapiller
    • , Natalie Bowers
    • , John Michon
    • , Dorothee Diogo
    • , Audrey Chu
    • , Vinay Mehta
    • , Jaakko Parkkinen
    • , Melissa Miller
    • , Anthony Muslin
    • , Dawn Waterworth
    • , Heikki Joensuu
    • , Tuomo Meretoja
    • , Olli Carpen
    • , Lauri Aaltonen
    • , Annika Auranen
    • , Peeter Karihtala
    • , Saila Kauppila
    • , Päivi Auvinen
    • , Klaus Elenius
    • , Relja Popovic
    • , Jeffrey Waring
    • , Bridget Riley-Gillis
    • , Anne Lehtonen
    • , Athena Matakidou
    • , Jennifer Schutzman
    • , Julie Hunkapiller
    • , Natalie Bowers
    • , John Michon
    • , Vinay Mehta
    • , Andrey Loboda
    • , Aparna Chhibber
    • , Heli Lehtonen
    • , Stefan McDonough
    • , Marika Crohns
    • , Diptee Kulkarni
    • , Kai Kaarniranta
    • , Joni Turunen
    • , Terhi Ollila
    • , Sanna Seitsonen
    • , Hannu Uusitalo
    • , Vesa Aaltonen
    • , Hannele Uusitalo-Järvinen
    • , Marja Luodonpää
    • , Nina Hautala
    • , Heiko Runz
    • , Erich Strauss
    • , Natalie Bowers
    • , Hao Chen
    • , John Michon
    • , Anna Podgornaia
    • , Vinay Mehta
    • , Dorothee Diogo
    • , Joshua Hoffman
    • , Kaisa Tasanen
    • , Laura Huilaja
    • , Katariina Hannula-Jouppi
    • , Teea Salmi
    • , Sirkku Peltonen
    • , Leena Koulu
    • , Ilkka Harvima
    • , Kirsi Kalpala
    • , Ying Wu
    • , David Choy
    • , John Michon
    • , Nizar Smaoui
    • , Fedik Rahimov
    • , Anne Lehtonen
    • , Dawn Waterworth
    • , Anu Jalanko
    • , Risto Kajanne
    • , Ulrike Lyhs
    • , Mari Kaunisto
    • , Justin Wade Davis
    • , Bridget Riley-Gillis
    • , Danjuma Quarless
    • , Slavé Petrovski
    • , Jimmy Liu
    • , Chia-Yen Chen
    • , Paola Bronson
    • , Robert Yang
    • , Joseph Maranville
    • , Shameek Biswas
    • , Diana Chang
    • , Julie Hunkapiller
    • , Tushar Bhangale
    • , Natalie Bowers
    • , Dorothee Diogo
    • , Emily Holzinger
    • , Padhraig Gormley
    • , Xulong Wang
    • , Xing Chen
    • , Åsa Hedman
    • , Kirsi Auro
    • , Clarence Wang
    • , Ethan Xu
    • , Franck Auge
    • , Clement Chatelain
    • , Mitja Kurki
    • , Samuli Ripatti
    • , Mark Daly
    • , Juha Karjalainen
    • , Aki Havulinna
    • , Anu Jalanko
    • , Kimmo Palin
    • , Priit Palta
    • , Pietro Della Briotta Parolo
    • , Wei Zhou
    • , Susanna Lemmelä
    • , Manuel Rivas
    • , Jarmo Harju
    • , Aarno Palotie
    • , Arto Lehisto
    • , Andrea Ganna
    • , Vincent Llorens
    • , Antti Karlsson
    • , Kati Kristiansson
    • , Mikko Arvas
    • , Kati Hyvärinen
    • , Jarmo Ritari
    • , Tiina Wahlfors
    • , Miika Koskinen
    • , Olli Carpen
    • , Johannes Kettunen
    • , Katri Pylkäs
    • , Marita Kalaoja
    • , Minna Karjalainen
    • , Tuomo Mantere
    • , Eeva Kangasniemi
    • , Sami Heikkinen
    • , Arto Mannermaa
    • , Eija Laakkonen
    • , Juha Kononen
    • , Anu Loukola
    • , Päivi Laiho
    • , Tuuli Sistonen
    • , Essi Kaiharju
    • , Markku Laukkanen
    • , Elina Järvensivu
    • , Sini Lähteenmäki
    • , Lotta Männikkö
    • , Regis Wong
    • , Kati Kristiansson
    • , Hannele Mattsson
    • , Susanna Lemmelä
    • , Tero Hiekkalinna
    • , Manuel González Jiménez
    • , Kati Donner
    • , Priit Palta
    • , Kalle Pärn
    • , Javier Nunez-Fontarnau
    • , Jarmo Harju
    • , Elina Kilpeläinen
    • , Timo P. Sipilä
    • , Georg Brein
    • , Alexander Dada
    • , Ghazal Awaisa
    • , Anastasia Shcherban
    • , Tuomas Sipilä
    • , Hannele Laivuori
    • , Aki Havulinna
    • , Susanna Lemmelä
    • , Tuomo Kiiskinen
    • , Tarja Laitinen
    • , Harri Siirtola
    • , Javier Gracia Tabuenca
    • , Lila Kallio
    • , Sirpa Soini
    • , Jukka Partanen
    • , Kimmo Pitkänen
    • , Seppo Vainio
    • , Kimmo Savinainen
    • , Veli-Matti Kosma
    • , Teijo Kuopio
    • , Benjamin M. Neale
    • , Mark Daly
    • , Veikko Salomaa
    • , Aarno Palotie
    • , Elisabeth Widén
    •  & Samuli Ripatti
  • Letter |

    A new cross-validated neuroimaging biomarker that reflects striatal dysfunctioning can be used to distinguish patients with schizophrenia from healthy controls, and is associated with treatment response to antipsychotics.

    • Ang Li
    • , Andrew Zalesky
    • , Weihua Yue
    • , Oliver Howes
    • , Hao Yan
    • , Yong Liu
    • , Lingzhong Fan
    • , Kirstie J Whitaker
    • , Kaibin Xu
    • , Guangxiang Rao
    • , Jin Li
    • , Shu Liu
    • , Meng Wang
    • , Yuqing Sun
    • , Ming Song
    • , Peng Li
    • , Jun Chen
    • , Yunchun Chen
    • , Huaning Wang
    • , Wenming Liu
    • , Zhigang Li
    • , Yongfeng Yang
    • , Hua Guo
    • , Ping Wan
    • , Luxian Lv
    • , Lin Lu
    • , Jun Yan
    • , Yuqing Song
    • , Huiling Wang
    • , Hongxing Zhang
    • , Huawang Wu
    • , Yuping Ning
    • , Yuhui Du
    • , Yuqi Cheng
    • , Jian Xu
    • , Xiufeng Xu
    • , Dai Zhang
    • , Xiaoqun Wang
    • , Tianzi Jiang
    •  & Bing Liu
  • Letter |

    Single-cell RNA-sequencing of blood from HIV-1-infected individuals obtained before initiation of antiretroviral therapy provides insights into the initial immune responses during early infection that might shape future outcomes.

    • Samuel W. Kazer
    • , Toby P. Aicher
    • , Daniel M. Muema
    • , Shaina L. Carroll
    • , Jose Ordovas-Montanes
    • , Vincent N. Miao
    • , Ang A. Tu
    • , Carly G. K. Ziegler
    • , Sarah K. Nyquist
    • , Emily B. Wong
    • , Nasreen Ismail
    • , Mary Dong
    • , Amber Moodley
    • , Bonnie Berger
    • , J. Christopher Love
    • , Krista L. Dong
    • , Alasdair Leslie
    • , Zaza M. Ndhlovu
    • , Thumbi Ndung’u
    • , Bruce D. Walker
    •  & Alex K. Shalek
  • Letter |

    Cross-biobank analysis reveals that polygenic risk scores (PRS) for hypertension and obesity are associated with shorter lifespan, serving as a proof-of-principle that PRS could pinpoint causal risk factors that affect long-term health outcomes.

    • Saori Sakaue
    • , Masahiro Kanai
    • , Juha Karjalainen
    • , Masato Akiyama
    • , Mitja Kurki
    • , Nana Matoba
    • , Atsushi Takahashi
    • , Makoto Hirata
    • , Michiaki Kubo
    • , Koichi Matsuda
    • , Yoshinori Murakami
    • , Mark J. Daly
    • , Yoichiro Kamatani
    •  & Yukinori Okada
  • Letter |

    Immune checkpoint blockade has been proposed as a potentially curative strategy to reduce the HIV reservoir. Studies in monkeys now show that this approach alone is ineffective at enabling viral control after antiretroviral treatment interruption.

    • Justin Harper
    • , Shari Gordon
    • , Chi Ngai Chan
    • , Hong Wang
    • , Emily Lindemuth
    • , Cristin Galardi
    • , Shane D. Falcinelli
    • , Samuel L. M. Raines
    • , Jenna L. Read
    • , Kevin Nguyen
    • , Colleen S McGary
    • , Michael Nekorchuk
    • , Kathleen Busman-Sahay
    • , James Schawalder
    • , Colin King
    • , Maria Pino
    • , Luca Micci
    • , Barbara Cervasi
    • , Sherrie Jean
    • , Andrew Sanderson
    • , Brian Johns
    • , A. Alicia Koblansky
    • , Heather Amrine-Madsen
    • , Jeffrey Lifson
    • , David M. Margolis
    • , Guido Silvestri
    • , Katharine J. Bar
    • , David Favre
    • , Jacob D. Estes
    •  & Mirko Paiardini
  • Letter |

    A single therapeutic base edit of the BCL11A enhancer in human HSPCs can ameliorate cellular defects associated with sickle cell disease and β-thalassemia in vitro and efficiently induce fetal hemoglobin expression upon engraftment in mice in vivo.

    • Jing Zeng
    • , Yuxuan Wu
    • , Chunyan Ren
    • , Jasmine Bonanno
    • , Anne H. Shen
    • , Devlin Shea
    • , Jason M. Gehrke
    • , Kendell Clement
    • , Kevin Luk
    • , Qiuming Yao
    • , Rachel Kim
    • , Scot A. Wolfe
    • , John P. Manis
    • , Luca Pinello
    • , J. Keith Joung
    •  & Daniel E. Bauer
  • Letter |

    The relative concentrations of four metabolites in maternal blood at 36 weeks of gestation predict fetal growth restriction in infants subsequently born at term, enabling enhanced fetal monitoring in pregnancies at risk.

    • Ulla Sovio
    • , Neil Goulding
    • , Nancy McBride
    • , Emma Cook
    • , Francesca Gaccioli
    • , D. Stephen Charnock-Jones
    • , Debbie A. Lawlor
    •  & Gordon C. S. Smith
  • Letter |

    The development of an algorithm that can imperceptibly manipulate electrocardiographic data to fool a deep learning model for diagnosing cardiac arrhythmia highlights the potential vulnerability of artificial intelligence-enabled diagnosis to adversarial attacks.

    • Xintian Han
    • , Yuxuan Hu
    • , Luca Foschini
    • , Larry Chinitz
    • , Lior Jankelson
    •  & Rajesh Ranganath
  • Letter |

    Star-shaped, approximately 1-mm-wide ceramic particles, termed STAR particles, create micropores in the skin and, when added to topical formulations, enhance drug and vaccine delivery through the skin in mice.

    • Andrew R. Tadros
    • , Andrey Romanyuk
    • , Ian C. Miller
    • , Andrea Santiago
    • , Richard K. Noel
    • , Laura O’Farrell
    • , Gabriel A. Kwong
    •  & Mark R. Prausnitz
  • Letter |

    Early results from a first-in-human retinal gene therapy trial for X-linked retinitis pigmentosa indicate that, at an intermediate dose, AAV8-RPGR is safe and in a subset of patients can lead to gains in visual function.

    • Jasmina Cehajic-Kapetanovic
    • , Kanmin Xue
    • , Cristina Martinez-Fernandez de la Camara
    • , Anika Nanda
    • , Alexandra Davies
    • , Laura J. Wood
    • , Anna Paola Salvetti
    • , M. Dominik Fischer
    • , James W. Aylward
    • , Alun R. Barnard
    • , Jasleen K. Jolly
    • , Edmond Luo
    • , Brandon J. Lujan
    • , Tuyen Ong
    • , Aniz Girach
    • , Graeme C. M. Black
    • , Ninel Z. Gregori
    • , Janet L. Davis
    • , Potyra R. Rosa
    • , Andrew J. Lotery
    • , Byron L. Lam
    • , Paulo E. Stanga
    •  & Robert E. MacLaren
  • Letter |

    Distinct patterns of exposure to a first-line tuberculosis drug in separate lung lesions within patients are revealed by PET–CT imaging. Use of the technique might help optimize the duration and dosing of antimicrobial drugs.

    • Alvaro A. Ordonez
    • , Hechuan Wang
    • , Gesham Magombedze
    • , Camilo A. Ruiz-Bedoya
    • , Shashikant Srivastava
    • , Allen Chen
    • , Elizabeth W. Tucker
    • , Michael E. Urbanowski
    • , Lisa Pieterse
    • , E. Fabian Cardozo
    • , Martin A. Lodge
    • , Maunank R. Shah
    • , Daniel P. Holt
    • , William B. Mathews
    • , Robert F. Dannals
    • , Jogarao V. S. Gobburu
    • , Charles A. Peloquin
    • , Steven P. Rowe
    • , Tawanda Gumbo
    • , Vijay D. Ivaturi
    •  & Sanjay K. Jain
  • Letter |

    A new human challenge model of schistosomiasis, which affects more than 290 million people globally, will aid development of novel therapies and vaccines for this neglected tropical disease.

    • Marijke C. C. Langenberg
    • , Marie-Astrid Hoogerwerf
    • , Jan Pieter R. Koopman
    • , Jacqueline J. Janse
    • , Janneke Kos-van Oosterhoud
    • , Carola Feijt
    • , Simon P. Jochems
    • , Claudia J. de Dood
    • , Roos van Schuijlenburg
    • , Arifa Ozir-Fazalalikhan
    • , Mikhael D. Manurung
    • , Erliyani Sartono
    • , Martha T. van der Beek
    • , Béatrice M. F. Winkel
    • , Petra H. Verbeek-Menken
    • , Koen A. Stam
    • , Fijs W. B. van Leeuwen
    • , Pauline Meij
    • , Angela van Diepen
    • , Lisette van Lieshout
    • , Govert J. van Dam
    • , Paul L. A. M. Corstjens
    • , Cornelis H. Hokke
    • , Maria Yazdanbakhsh
    • , Leo G. Visser
    •  & Meta Roestenberg
  • Letter |

    Single-cell transcriptomic analysis identifies a distinct gene signature associated with peripheral monocyte populations that distinguishes people with sepsis from those with sterile inflammation and uninfected controls.

    • Miguel Reyes
    • , Michael R. Filbin
    • , Roby P. Bhattacharyya
    • , Kianna Billman
    • , Thomas Eisenhaure
    • , Deborah T. Hung
    • , Bruce D. Levy
    • , Rebecca M. Baron
    • , Paul C. Blainey
    • , Marcia B. Goldberg
    •  & Nir Hacohen
  • Letter |

    A framework of patient-partnered research allows patients with angiosarcoma to share their samples and clinical records securely to accelerate molecular characterization of tumors and identification of therapeutic approaches.

    • Corrie A. Painter
    • , Esha Jain
    • , Brett N. Tomson
    • , Michael Dunphy
    • , Rachel E. Stoddard
    • , Beena S. Thomas
    • , Alyssa L. Damon
    • , Shahrayz Shah
    • , Dewey Kim
    • , Jorge Gómez Tejeda Zañudo
    • , Jason L. Hornick
    • , Yen-Lin Chen
    • , Priscilla Merriam
    • , Chandrajit P. Raut
    • , George D. Demetri
    • , Brian A. Van Tine
    • , Eric S. Lander
    • , Todd R. Golub
    •  & Nikhil Wagle
  • Letter |

    Application of machine-learning models on very shallow RNA sequencing data maintains predictive performance across different tumor types.

    • Pedro Milanez-Almeida
    • , Andrew J. Martins
    • , Ronald N. Germain
    •  & John S. Tsang
  • Letter |

    Transcriptomic analysis of peripheral CD8+ T cells in a cohort of patients with metastatic melanoma receiving checkpoint inhibitors shows that the number of large clones early post-treatment is strongly associated with six-month clinical outcome.

    • Benjamin P. Fairfax
    • , Chelsea A. Taylor
    • , Robert A. Watson
    • , Isar Nassiri
    • , Sara Danielli
    • , Hai Fang
    • , Elise A. Mahé
    • , Rosalin Cooper
    • , Victoria Woodcock
    • , Zoe Traill
    • , M. Hussein Al-Mossawi
    • , Julian C. Knight
    • , Paul Klenerman
    • , Miranda Payne
    •  & Mark R. Middleton
  • Letter |

    T cell responses specific for HIV-1 Gag peptides increased in HIV-positive recipients of two broadly neutralizing antibodies with prolonged suppression of blood viremia during antiretroviral treatment interruption.

    • Julia Niessl
    • , Amy E. Baxter
    • , Pilar Mendoza
    • , Mila Jankovic
    • , Yehuda Z. Cohen
    • , Allison L. Butler
    • , Ching-Lan Lu
    • , Mathieu Dubé
    • , Irina Shimeliovich
    • , Henning Gruell
    • , Florian Klein
    • , Marina Caskey
    • , Michel C. Nussenzweig
    •  & Daniel E. Kaufmann
  • Letter |

    Zika virus vaccination elicits Zika and dengue virus cross-neutralizing antibodies in flavivirus-exposed individuals, potentially enhancing the protective efficacy of the vaccine in flavivirus-endemic regions.

    • Vincent Dussupt
    • , Rajeshwer S. Sankhala
    • , Gregory D. Gromowski
    • , Gina Donofrio
    • , Rafael A. De La Barrera
    • , Rafael A. Larocca
    • , Weam Zaky
    • , Letzibeth Mendez-Rivera
    • , Misook Choe
    • , Edgar Davidson
    • , Michael K. McCracken
    • , James D. Brien
    • , Peter Abbink
    • , Hongjun Bai
    • , Aubrey L. Bryan
    • , Candace Hope Bias
    • , Irina Maljkovic Berry
    • , Nubia Botero
    • , Tanya Cook
    • , Nicole A. Doria-Rose
    • , Ariadna Grinyo i Escuer
    • , Justice Akuoku Frimpong
    • , Aviva Geretz
    • , Mayda Hernandez
    • , Bradley S. Hollidge
    • , Ningbo Jian
    • , Kareem Kabra
    • , David J. Leggat
    • , Jinyan Liu
    • , Amelia K. Pinto
    • , Wiriya Rutvisuttinunt
    • , Ian Setliff
    • , Ursula Tran
    • , Samantha Townsley
    • , Benjamin J. Doranz
    • , Morgane Rolland
    • , Adrian B. McDermott
    • , Ivelin S. Georgiev
    • , Rasmi Thomas
    • , Merlin L. Robb
    • , Kenneth H. Eckels
    • , Elizabeth Barranco
    • , Michael Koren
    • , Darci R. Smith
    • , Richard G. Jarman
    • , Sarah L. George
    • , Kathryn E. Stephenson
    • , Dan H. Barouch
    • , Kayvon Modjarrad
    • , Nelson L. Michael
    • , M. Gordon Joyce
    •  & Shelly J. Krebs
  • Letter |

    Initial results from phase I/II lentiviral gene therapy trials provide early evidence supporting its safety and efficacy in treating patients with X-linked chronic granulomatous disease.

    • Donald B. Kohn
    • , Claire Booth
    • , Elizabeth M. Kang
    • , Sung-Yun Pai
    • , Kit L. Shaw
    • , Giorgia Santilli
    • , Myriam Armant
    • , Karen F. Buckland
    • , Uimook Choi
    • , Suk See De Ravin
    • , Morna J. Dorsey
    • , Caroline Y. Kuo
    • , Diego Leon-Rico
    • , Christine Rivat
    • , Natalia Izotova
    • , Kimberly Gilmour
    • , Katie Snell
    • , Jinhua Xu-Bayford Dip
    • , Jinan Darwish
    • , Emma C. Morris
    • , Dayna Terrazas
    • , Leo D. Wang
    • , Christopher A. Bauser
    • , Tobias Paprotka
    • , Douglas B. Kuhns
    • , John Gregg
    • , Hayley E. Raymond
    • , John K. Everett
    • , Geraldine Honnet
    • , Luca Biasco
    • , Peter E. Newburger
    • , Frederic D. Bushman
    • , Manuel Grez
    • , H. Bobby Gaspar
    • , David A. Williams
    • , Harry L. Malech
    • , Anne Galy
    • , Adrian J. Thrasher
    • , Karen F. Buckland
    • , Christopher A. Bauser
    • , Geraldine Honnet
    • , Manuel Grez
    • , H. Bobby Gaspar
    • , Anne Galy
    •  & Adrian J. Thrasher
  • Letter |

    CRISPR–Cas9-mediated gene editing restores dystrophin expression in both pig and human induced pluripotent stem cell models of Duchenne muscular dystrophy, with beneficial effects on skeletal muscle and cardiac function.

    • A. Moretti
    • , L. Fonteyne
    • , F. Giesert
    • , P. Hoppmann
    • , A. B. Meier
    • , T. Bozoglu
    • , A. Baehr
    • , C. M. Schneider
    • , D. Sinnecker
    • , K. Klett
    • , T. Fröhlich
    • , F. Abdel Rahman
    • , T. Haufe
    • , S. Sun
    • , V. Jurisch
    • , B. Kessler
    • , R. Hinkel
    • , R. Dirschinger
    • , E. Martens
    • , C. Jilek
    • , A. Graf
    • , S. Krebs
    • , G. Santamaria
    • , M. Kurome
    • , V. Zakhartchenko
    • , B. Campbell
    • , K. Voelse
    • , A. Wolf
    • , T. Ziegler
    • , S. Reichert
    • , S. Lee
    • , F. Flenkenthaler
    • , T. Dorn
    • , I. Jeremias
    • , H. Blum
    • , A. Dendorfer
    • , A. Schnieke
    • , S. Krause
    • , M. C. Walter
    • , N. Klymiuk
    • , K. L. Laugwitz
    • , E. Wolf
    • , W. Wurst
    •  & C. Kupatt
  • Letter |

    Single-cell RNA sequencing facilitates successful therapeutic treatment of a patient with a rare and severe drug-induced inflammatory skin reaction.

    • Doyoung Kim
    • , Tetsuro Kobayashi
    • , Benjamin Voisin
    • , Jay-Hyun Jo
    • , Keiko Sakamoto
    • , Seon-Pil Jin
    • , Michael Kelly
    • , Helena B. Pasieka
    • , Jessica L. Naff
    • , Jon H. Meyerle
    • , Ijeoma D. Ikpeama
    • , Gary A. Fahle
    • , Fred P. Davis
    • , Sergio D. Rosenzweig
    • , Julie C. Alejo
    • , Stefania Pittaluga
    • , Heidi H. Kong
    • , Alexandra F. Freeman
    •  & Keisuke Nagao
  • Letter |

    Inactivating mutations in a protein kinase, NEK10, cause a genetic bronchiectasis syndrome in humans that is characterized by short motile cilia and impaired mucociliary transport.

    • Raghu R. Chivukula
    • , Daniel T. Montoro
    • , Hui Min Leung
    • , Jason Yang
    • , Hanan E. Shamseldin
    • , Martin S. Taylor
    • , Gerard W. Dougherty
    • , Maimoona A. Zariwala
    • , Johnny Carson
    • , M. Leigh Anne Daniels
    • , Patrick R. Sears
    • , Katharine E. Black
    • , Lida P. Hariri
    • , Ibrahim Almogarri
    • , Evgeni M. Frenkel
    • , Vladimir Vinarsky
    • , Heymut Omran
    • , Michael R. Knowles
    • , Guillermo J. Tearney
    • , Fowzan S. Alkuraya
    •  & David M. Sabatini
  • Letter |

    Most infants with cystic fibrosis have poor early linear growth in their first year despite nutritional supplementation and treatment. Intestinal dysbiosis in these infants is associated with low length, suggesting a path for intervention.

    • Hillary S. Hayden
    • , Alexander Eng
    • , Christopher E. Pope
    • , Mitchell J. Brittnacher
    • , Anh T. Vo
    • , Eli J. Weiss
    • , Kyle R. Hager
    • , Bryan D. Martin
    • , Daniel H. Leung
    • , Sonya L. Heltshe
    • , Elhanan Borenstein
    • , Samuel I. Miller
    •  & Lucas R. Hoffman
  • Letter |

    Results from an expansion cohort of the PROFILE 1001 trial describe the anti-tumor activity of crizotinib in people with non-small-cell lung cancer harboring a MET exon 14 alteration.

    • Alexander Drilon
    • , Jeffrey W. Clark
    • , Jared Weiss
    • , Sai-Hong Ignatius Ou
    • , D. Ross Camidge
    • , Benjamin J. Solomon
    • , Gregory A. Otterson
    • , Liza C. Villaruz
    • , Gregory J. Riely
    • , Rebecca S. Heist
    • , Mark M. Awad
    • , Geoffrey I. Shapiro
    • , Miyako Satouchi
    • , Toyoaki Hida
    • , Hidetoshi Hayashi
    • , Danielle A. Murphy
    • , Sherry C. Wang
    • , Sherry Li
    • , Tiziana Usari
    • , Keith D. Wilner
    •  & Paul K. Paik
  • Letter |

    Longitudinal multiomics profiling of a cohort of healthy people reveals distinct aging patterns—termed ageotypes—in different individuals.

    • Sara Ahadi
    • , Wenyu Zhou
    • , Sophia Miryam Schüssler-Fiorenza Rose
    • , M. Reza Sailani
    • , Kévin Contrepois
    • , Monika Avina
    • , Melanie Ashland
    • , Anne Brunet
    •  & Michael Snyder
  • Letter |

    A retrospective analysis of existing computed tomography scans shows the feasibility of an automated process for evaluating osteoporotic fracture risk that could be used as an initial screening tool when FRAX inputs are unavailable.

    • Noa Dagan
    • , Eldad Elnekave
    • , Noam Barda
    • , Orna Bregman-Amitai
    • , Amir Bar
    • , Mila Orlovsky
    • , Eitan Bachmat
    •  & Ran D. Balicer
  • Letter |

    Leveraging the availability of nationwide electronic health records from over 500,000 pregnancies in Israel, a machine-learning approach offers an alternative means of predicting gestational diabetes at high accuracy in the early stages of pregnancy.

    • Nitzan Shalom Artzi
    • , Smadar Shilo
    • , Eran Hadar
    • , Hagai Rossman
    • , Shiri Barbash-Hazan
    • , Avi Ben-Haroush
    • , Ran D. Balicer
    • , Becca Feldman
    • , Arnon Wiznitzer
    •  & Eran Segal
  • Letter
    | Open Access

    Bayesian spatio-temporal modeling of mortality from injuries in the contiguous USA shows increases in the number of deaths attributable to abnormal temperature fluctuations due to global heating.

    • Robbie M. Parks
    • , James E. Bennett
    • , Helen Tamura-Wicks
    • , Vasilis Kontis
    • , Ralf Toumi
    • , Goodarz Danaei
    •  & Majid Ezzati