Articles

  • Article |

    Simultaneous single-cell protein and transcriptome analysis identifies a baseline immune circuit associated with antibody responses to vaccination in healthy individuals and the severity of disease flares in patients with a subtype of systemic lupus erythematosus.

    • Yuri Kotliarov
    • , Rachel Sparks
    • , Andrew J. Martins
    • , Matthew P. Mulè
    • , Yong Lu
    • , Meghali Goswami
    • , Lela Kardava
    • , Romain Banchereau
    • , Virginia Pascual
    • , Angélique Biancotto
    • , Jinguo Chen
    • , Pamela L. Schwartzberg
    • , Neha Bansal
    • , Candace C. Liu
    • , Foo Cheung
    • , Susan Moir
    •  & John S. Tsang
  • Article |

    Microscopy and 16S rRNA sequencing suggest that there is a limited bacterial presence in the human fetal intestine, with one enriched Micrococcus species exhibiting immunomodulatory activity ex vivo.

    • E. Rackaityte
    • , J. Halkias
    • , E. M. Fukui
    • , V. F. Mendoza
    • , C. Hayzelden
    • , E. D. Crawford
    • , K. E. Fujimura
    • , T. D. Burt
    •  & S. V. Lynch
  • Article |

    Integrative analysis in patients with diffuse large B-cell lymphoma uncovers that biallelic mutations on TMEM30A are associated with a favorable outcome and enhanced sensitivity to CD47 blockade.

    • Daisuke Ennishi
    • , Shannon Healy
    • , Ali Bashashati
    • , Saeed Saberi
    • , Christoffer Hother
    • , Anja Mottok
    • , Fong Chun Chan
    • , Lauren Chong
    • , Libin Abraham
    • , Robert Kridel
    • , Merrill Boyle
    • , Barbara Meissner
    • , Tomohiro Aoki
    • , Katsuyoshi Takata
    • , Bruce W. Woolcock
    • , Elena Viganò
    • , Michael Gold
    • , Laurie L. Molday
    • , Robert S. Molday
    • , Adele Telenius
    • , Michael Y. Li
    • , Nicole Wretham
    • , Nancy Dos Santos
    • , Mark Wong
    • , Natasja N. Viller
    • , Robert A. Uger
    • , Gerben Duns
    • , Abigail Baticados
    • , Angel Madero
    • , Brianna N. Bristow
    • , Pedro Farinha
    • , Graham W. Slack
    • , Susana Ben-Neriah
    • , Daniel Lai
    • , Allen W. Zhang
    • , Sohrab Salehi
    • , Hennady P. Shulha
    • , Derek S. Chiu
    • , Sara Mostafavi
    • , Alina S. Gerrie
    • , Da Wei Huang
    • , Christopher Rushton
    • , Diego Villa
    • , Laurie H. Sehn
    • , Kerry J. Savage
    • , Andrew J. Mungall
    • , Andrew P. Weng
    • , Marcel B. Bally
    • , Ryan D. Morin
    • , Gabriela V. Cohen Freue
    • , Louis M. Staudt
    • , Joseph M. Connors
    • , Marco A. Marra
    • , Sohrab P. Shah
    • , Randy D. Gascoyne
    • , David W. Scott
    •  & Christian Steidl
  • Article |

    A step-wedged cluster randomized trial, carried out in six villages in Tumbes, Peru, with 2,376 participants, demonstrates population-wide reductions in blood pressure, which appear to be higher in individuals with hypertension, as well as reductions in risk of hypertension by around 50% for those without hypertension at baseline, after community-wide replacement of regular salt with a potassium-enriched alternative.

    • Antonio Bernabe-Ortiz
    • , Víctor G. Sal y Rosas
    • , Vilarmina Ponce-Lucero
    • , María K. Cárdenas
    • , Rodrigo M. Carrillo-Larco
    • , Francisco Diez-Canseco
    • , M. Amalia Pesantes
    • , Katherine A. Sacksteder
    • , Robert H. Gilman
    •  & J. Jaime Miranda
  • Article |

    In germ-free mice colonized with human microbiota, mucosal IL-22 signaling promotes the growth of succinate-consuming commensal bacteria via host mucus glycosylation, and transplantation of these bacteria limits Clostridioides difficile infection.

    • Hiroko Nagao-Kitamoto
    • , Jhansi L. Leslie
    • , Sho Kitamoto
    • , Chunsheng Jin
    • , Kristina A. Thomsson
    • , Merritt G. Gillilland III
    • , Peter Kuffa
    • , Yoshiyuki Goto
    • , Robert R. Jenq
    • , Chiharu Ishii
    • , Akiyoshi Hirayama
    • , Anna M. Seekatz
    • , Eric C. Martens
    • , Kathryn A. Eaton
    • , John Y. Kao
    • , Shinji Fukuda
    • , Peter D. R. Higgins
    • , Niclas G. Karlsson
    • , Vincent B. Young
    •  & Nobuhiko Kamada
  • Article |

    Alum coupled to protein immunogens via site-specific phosphoserine-containing linkers enhances long-lived B cell responses and can selectively direct antibodies toward protective neutralizing epitopes.

    • Tyson J. Moyer
    • , Yu Kato
    • , Wuhbet Abraham
    • , Jason Y. H. Chang
    • , Daniel W. Kulp
    • , Nicki Watson
    • , Hannah L. Turner
    • , Sergey Menis
    • , Robert K. Abbott
    • , Jinal N. Bhiman
    • , Mariane B. Melo
    • , Hayley A. Simon
    • , Sara Herrera-De la Mata
    • , Shu Liang
    • , Gregory Seumois
    • , Yash Agarwal
    • , Na Li
    • , Dennis R. Burton
    • , Andrew B. Ward
    • , William R. Schief
    • , Shane Crotty
    •  & Darrell J. Irvine
  • Article |

    Genetic analysis of data from over 400,000 participants in the UK Biobank Study shows that circulating testosterone levels have sex-specific implications for cardiometabolic diseases and cancer outcomes.

    • Katherine S Ruth
    • , Felix R Day
    • , Jessica Tyrrell
    • , Deborah J Thompson
    • , Andrew R Wood
    • , Anubha Mahajan
    • , Robin N Beaumont
    • , Laura Wittemans
    • , Susan Martin
    • , Alexander S. Busch
    • , A. Mesut Erzurumluoglu
    • , Benjamin Hollis
    • , Tracy A. O’Mara
    • , Mark I McCarthy
    • , Claudia Langenberg
    • , Douglas F Easton
    • , Nicholas J Wareham
    • , Stephen Burgess
    • , Anna Murray
    • , Ken K Ong
    • , Timothy M Frayling
    •  & John R. B. Perry
  • Article |

    Single-cell analysis of lung cancer progression uncovers developmental and regenerative programs co-opted by cancer cells and immune-mediated pruning during metastatic outbreak

    • Ashley M. Laughney
    • , Jing Hu
    • , Nathaniel R. Campbell
    • , Samuel F. Bakhoum
    • , Manu Setty
    • , Vincent-Philippe Lavallée
    • , Yubin Xie
    • , Ignas Masilionis
    • , Ambrose J. Carr
    • , Sanjay Kottapalli
    • , Viola Allaj
    • , Marissa Mattar
    • , Natasha Rekhtman
    • , Joao B. Xavier
    • , Linas Mazutis
    • , John T. Poirier
    • , Charles M. Rudin
    • , Dana Pe’er
    •  & Joan Massagué
  • Article |

    iPSC-derived midbrain dopaminergic neurons from patients with young-onset Parkinson’s disease exhibit molecular abnormalities, including elevated α-synuclein and lysosomal dysfunction, which can be normalized with phorbol ester treatment.

    • A. H. Laperle
    • , S. Sances
    • , N. Yucer
    • , V. J. Dardov
    • , V. J. Garcia
    • , R. Ho
    • , A. N. Fulton
    • , M. R. Jones
    • , K. M. Roxas
    • , P. Avalos
    • , D. West
    • , M. G. Banuelos
    • , Z. Shu
    • , R. Murali
    • , N. T. Maidment
    • , J. E. Van Eyk
    • , M. Tagliati
    •  & C. N. Svendsen
  • Article |

    A newly developed PET tracer allows visualization of AMPA receptors in the living human brain, providing a new tool to study their potential involvement in neurological or psychiatric disorders.

    • Tomoyuki Miyazaki
    • , Waki Nakajima
    • , Mai Hatano
    • , Yusuke Shibata
    • , Yoko Kuroki
    • , Tetsu Arisawa
    • , Asami Serizawa
    • , Akane Sano
    • , Sayaka Kogami
    • , Tomomi Yamanoue
    • , Kimito Kimura
    • , Yushi Hirata
    • , Yuuki Takada
    • , Yoshinobu Ishiwata
    • , Masaki Sonoda
    • , Masaki Tokunaga
    • , Chie Seki
    • , Yuji Nagai
    • , Takafumi Minamimoto
    • , Kazunori Kawamura
    • , Ming-Rong Zhang
    • , Naoki Ikegaya
    • , Masaki Iwasaki
    • , Naoto Kunii
    • , Yuichi Kimura
    • , Fumio Yamashita
    • , Masataka Taguri
    • , Hideaki Tani
    • , Nobuhiro Nagai
    • , Teruki Koizumi
    • , Shinichiro Nakajima
    • , Masaru Mimura
    • , Michisuke Yuzaki
    • , Hiroki Kato
    • , Makoto Higuchi
    • , Hiroyuki Uchida
    •  & Takuya Takahashi
  • Article |

    In a first-in-human, phase I trial in patients with B-cell lymphoma, CD19 CAR T cells with fully human binding domains exhibit lower neurologic toxicity, but similar clinical activity, to previously tested CD19 CAR T cells with murine binding domains.

    • Jennifer N. Brudno
    • , Norris Lam
    • , Danielle Vanasse
    • , Yueh-wei Shen
    • , Jeremy J. Rose
    • , John Rossi
    • , Allen Xue
    • , Adrian Bot
    • , Nathalie Scholler
    • , Lekha Mikkilineni
    • , Mark Roschewski
    • , Robert Dean
    • , Raul Cachau
    • , Philippe Youkharibache
    • , Rashmika Patel
    • , Brenna Hansen
    • , David F. Stroncek
    • , Steven A. Rosenberg
    • , Ronald E. Gress
    •  & James N. Kochenderfer
  • Article |

    Integrated use of an animal model, a biobank for common diseases and a rare Mendelian disease leads to the discovery of a new syndrome and its pathological mechanism.

    • Gokhan Unlu
    • , Xinzi Qi
    • , Eric R. Gamazon
    • , David B. Melville
    • , Nisha Patel
    • , Amy R. Rushing
    • , Mais Hashem
    • , Abdullah Al-Faifi
    • , Rui Chen
    • , Bingshan Li
    • , Nancy J. Cox
    • , Fowzan S. Alkuraya
    •  & Ela W. Knapik
  • Article |

    Comprising data from over 18,000 people, a new atlas of drug–metabolite associations for 87 commonly prescribed drugs and 150 metabolites assessed by proton nuclear magnetic resonance provides a web-based tool to aid research on drug efficacy, safety and repurposing.

    • Jun Liu
    • , Lies Lahousse
    • , Michel G. Nivard
    • , Mariska Bot
    • , Lianmin Chen
    • , Jan Bert van Klinken
    • , Carisha S. Thesing
    • , Marian Beekman
    • , Erik Ben van den Akker
    • , Roderick C. Slieker
    • , Eveline Waterham
    • , Carla J. H. van der Kallen
    • , Irene de Boer
    • , Ruifang Li-Gao
    • , Dina Vojinovic
    • , Najaf Amin
    • , Djawad Radjabzadeh
    • , Robert Kraaij
    • , Louise J. M. Alferink
    • , Sarwa Darwish Murad
    • , André G. Uitterlinden
    • , Gonneke Willemsen
    • , Rene Pool
    • , Yuri Milaneschi
    • , Diana van Heemst
    • , H. Eka D. Suchiman
    • , Femke Rutters
    • , Petra J. M. Elders
    • , Joline W. J. Beulens
    • , Amber A. W. A. van der Heijden
    • , Marleen M. J. van Greevenbroek
    • , Ilja C. W. Arts
    • , Gerrit L. J. Onderwater
    • , Arn M. J. M. van den Maagdenberg
    • , Dennis O. Mook-Kanamori
    • , Thomas Hankemeier
    • , Gisela M. Terwindt
    • , Coen D. A. Stehouwer
    • , Johanna M. Geleijnse
    • , Leen M. ‘t Hart
    • , P. Eline Slagboom
    • , Ko Willems van Dijk
    • , Alexandra Zhernakova
    • , Jingyuan Fu
    • , Brenda W. J. H. Penninx
    • , Dorret I. Boomsma
    • , Ayşe Demirkan
    • , Bruno H. C. Stricker
    •  & Cornelia M. van Duijn
  • Article |

    Cross-sectional analysis of data from the Adolescent Brain Cognitive Development Study shows that children from families with low income are at increased risk of cognitive impairment associated with high lead-exposure risk when compared with children from families with high income.

    • Andrew T. Marshall
    • , Samantha Betts
    • , Eric C. Kan
    • , Rob McConnell
    • , Bruce P. Lanphear
    •  & Elizabeth R. Sowell
  • Article |

    Single-nucleus RNA sequencing in a mouse model of Aβ accumulation and postmortem brain tissue from people with Alzheimer’s disease reveals substantial species-specific differences in transcriptional signatures, but both point to the contribution of glia and the importance of TREM2.

    • Yingyue Zhou
    • , Wilbur M. Song
    • , Prabhakar S. Andhey
    • , Amanda Swain
    • , Tyler Levy
    • , Kelly R. Miller
    • , Pietro L. Poliani
    • , Manuela Cominelli
    • , Shikha Grover
    • , Susan Gilfillan
    • , Marina Cella
    • , Tyler K. Ulland
    • , Konstantin Zaitsev
    • , Akinori Miyashita
    • , Takeshi Ikeuchi
    • , Makoto Sainouchi
    • , Akiyoshi Kakita
    • , David A. Bennett
    • , Julie A. Schneider
    • , Michael R. Nichols
    • , Sean A. Beausoleil
    • , Jason D. Ulrich
    • , David M. Holtzman
    • , Maxim N. Artyomov
    •  & Marco Colonna
  • Article |

    Injection of AAV–shRNA below the pial surface of the spinal cord prevents onset or ameliorates progression in a mouse model of ALS, and achieves widespread delivery to the spinal cord and brain motor centers in adult pigs and non-human primates.

    • Mariana Bravo-Hernandez
    • , Takahiro Tadokoro
    • , Michael R. Navarro
    • , Oleksandr Platoshyn
    • , Yoshiomi Kobayashi
    • , Silvia Marsala
    • , Atsushi Miyanohara
    • , Stefan Juhas
    • , Jana Juhasova
    • , Helena Skalnikova
    • , Zoltan Tomori
    • , Ivo Vanicky
    • , Hana Studenovska
    • , Vladimir Proks
    • , PeiXi Chen
    • , Noe Govea-Perez
    • , Dara Ditsworth
    • , Joseph D. Ciacci
    • , Shang Gao
    • , Wenlian Zhu
    • , Eric T. Ahrens
    • , Shawn P. Driscoll
    • , Thomas D. Glenn
    • , Melissa McAlonis-Downes
    • , Sandrine Da Cruz
    • , Samuel L. Pfaff
    • , Brian K. Kaspar
    • , Don W. Cleveland
    •  & Martin Marsala
  • Article |

    Genetic analysis of paternal sperm from families with a child affected by autism reveals that the recurrent risk for transmitting disease-associated de novo mutations to future offspring is near 0% for most couples but is substantially higher for a small fraction of couples.

    • Martin W. Breuss
    • , Danny Antaki
    • , Renee D. George
    • , Morgan Kleiber
    • , Kiely N. James
    • , Laurel L. Ball
    • , Oanh Hong
    • , Ileena Mitra
    • , Xiaoxu Yang
    • , Sara A. Wirth
    • , Jing Gu
    • , Camila A. B. Garcia
    • , Madhusudan Gujral
    • , William M. Brandler
    • , Damir Musaev
    • , An Nguyen
    • , Jennifer McEvoy-Venneri
    • , Renatta Knox
    • , Evan Sticca
    • , Martha Cristina Cancino Botello
    • , Javiera Uribe Fenner
    • , Maria Cárcel Pérez
    • , Maria Arranz
    • , Andrea B. Moffitt
    • , Zihua Wang
    • , Amaia Hervás
    • , Orrin Devinsky
    • , Melissa Gymrek
    • , Jonathan Sebat
    •  & Joseph G. Gleeson
  • Article |

    Herpes simplex virus-1 encephalitis is linked to variants in a small nucleolar RNA, suggesting a new mechanism for antiviral immunity in cortical neurons.

    • Fabien G. Lafaille
    • , Oliver Harschnitz
    • , Yoon Seung Lee
    • , Peng Zhang
    • , Mary L. Hasek
    • , Gaspard Kerner
    • , Yuval Itan
    • , Osefame Ewaleifoh
    • , Franck Rapaport
    • , Thomas M. Carlile
    • , Madalina E. Carter-Timofte
    • , Dominik Paquet
    • , Kerry Dobbs
    • , Bastian Zimmer
    • , Daxing Gao
    • , Maria F. Rojas-Duran
    • , Dylan Kwart
    • , Vimel Rattina
    • , Michael J. Ciancanelli
    • , Jessica L. McAlpine
    • , Lazaro Lorenzo
    • , Soraya Boucherit
    • , Flore Rozenberg
    • , Rabih Halwani
    • , Benoit Henry
    • , Naima Amenzoui
    • , Zobaida Alsum
    • , Laura Marques
    • , Joseph A. Church
    • , Saleh Al-Muhsen
    • , Marc Tardieu
    • , Ahmed Aziz Bousfiha
    • , Søren R. Paludan
    • , Trine Hyrup Mogensen
    • , Lluis Quintana-Murci
    • , Marc Tessier-Lavigne
    • , Gregory A. Smith
    • , Luigi D. Notarangelo
    • , Lorenz Studer
    • , Wendy Gilbert
    • , Laurent Abel
    • , Jean-Laurent Casanova
    •  & Shen-Ying Zhang
  • Article |

    Imaging of muscle fibrosis with a handheld device could potentially serve as a biomarker for disease progression and response to therapy in patients with Duchenne muscular dystrophy.

    • Adrian P. Regensburger
    • , Lina M. Fonteyne
    • , Jörg Jüngert
    • , Alexandra L. Wagner
    • , Teresa Gerhalter
    • , Armin M. Nagel
    • , Rafael Heiss
    • , Florian Flenkenthaler
    • , Matthias Qurashi
    • , Markus F. Neurath
    • , Nikolai Klymiuk
    • , Elisabeth Kemter
    • , Thomas Fröhlich
    • , Michael Uder
    • , Joachim Woelfle
    • , Wolfgang Rascher
    • , Regina Trollmann
    • , Eckhard Wolf
    • , Maximilian J. Waldner
    •  & Ferdinand Knieling
  • Article |

    A combination of high-resolution imaging and modeling approaches facilitates the study of the mechanisms and clinical progression of non-alcoholic fatty liver disease in humans.

    • Fabián Segovia-Miranda
    • , Hernán Morales-Navarrete
    • , Michael Kücken
    • , Vincent Moser
    • , Sarah Seifert
    • , Urska Repnik
    • , Fabian Rost
    • , Mario Brosch
    • , Alexander Hendricks
    • , Sebastian Hinz
    • , Christoph Röcken
    • , Dieter Lütjohann
    • , Yannis Kalaidzidis
    • , Clemens Schafmayer
    • , Lutz Brusch
    • , Jochen Hampe
    •  & Marino Zerial
  • Article |

    The first BCL-XL-degrading PROTAC achieves safer and more potent antitumor activity than dual BCL-XL and BCL-2 inhibitor navitoclax because of reduced dose-limiting platelet toxicity and high target specificity.

    • Sajid Khan
    • , Xuan Zhang
    • , Dongwen Lv
    • , Qi Zhang
    • , Yonghan He
    • , Peiyi Zhang
    • , Xingui Liu
    • , Dinesh Thummuri
    • , Yaxia Yuan
    • , Janet S. Wiegand
    • , Jing Pei
    • , Weizhou Zhang
    • , Abhisheak Sharma
    • , Christopher R. McCurdy
    • , Vinitha M. Kuruvilla
    • , Natalia Baran
    • , Adolfo A. Ferrando
    • , Yong-mi Kim
    • , Anna Rogojina
    • , Peter J. Houghton
    • , Guangcun Huang
    • , Robert Hromas
    • , Marina Konopleva
    • , Guangrong Zheng
    •  & Daohong Zhou
  • Article |

    Prenatal androgen exposure causes transgenerational increases in offspring susceptibility to polycystic ovary syndrome in adulthood.

    • Sanjiv Risal
    • , Yu Pei
    • , Haojiang Lu
    • , Maria Manti
    • , Romina Fornes
    • , Han-Pin Pui
    • , Zhiyi Zhao
    • , Julie Massart
    • , Claes Ohlsson
    • , Eva Lindgren
    • , Nicolas Crisosto
    • , Manuel Maliqueo
    • , Barbara Echiburú
    • , Amanda Ladrón de Guevara
    • , Teresa Sir-Petermann
    • , Henrik Larsson
    • , Mina A. Rosenqvist
    • , Carolyn E. Cesta
    • , Anna Benrick
    • , Qiaolin Deng
    •  & Elisabet Stener-Victorin
  • Article
    | Open Access

    Analysis of fully clinically annotated and sequenced melanoma tumor samples collected before anti-PD1 treatment suggests that determinants of response differ on the basis of previous anti-CTLA4 therapy, and that tumor mutational burden may not be a strong predictor of response across melanoma subtypes.

    • David Liu
    • , Bastian Schilling
    • , Derek Liu
    • , Antje Sucker
    • , Elisabeth Livingstone
    • , Livnat Jerby-Arnon
    • , Lisa Zimmer
    • , Ralf Gutzmer
    • , Imke Satzger
    • , Carmen Loquai
    • , Stephan Grabbe
    • , Natalie Vokes
    • , Claire A. Margolis
    • , Jake Conway
    • , Meng Xiao He
    • , Haitham Elmarakeby
    • , Felix Dietlein
    • , Diana Miao
    • , Adam Tracy
    • , Helen Gogas
    • , Simone M. Goldinger
    • , Jochen Utikal
    • , Christian U. Blank
    • , Ricarda Rauschenberg
    • , Dagmar von Bubnoff
    • , Angela Krackhardt
    • , Benjamin Weide
    • , Sebastian Haferkamp
    • , Felix Kiecker
    • , Ben Izar
    • , Levi Garraway
    • , Aviv Regev
    • , Keith Flaherty
    • , Annette Paschen
    • , Eliezer M. Van Allen
    •  & Dirk Schadendorf
  • Article |

    Ultra-sensitive cell-free DNA (cfDNA) sequencing uncovers clonal hematopoiesis as a major source of somatic cfDNA variants in healthy individuals and patients with cancer, and underscores the importance of matched white blood cell DNA sequencing in liquid biopsy procedures.

    • Pedram Razavi
    • , Bob T. Li
    • , David N. Brown
    • , Byoungsok Jung
    • , Earl Hubbell
    • , Ronglai Shen
    • , Wassim Abida
    • , Krishna Juluru
    • , Ino De Bruijn
    • , Chenlu Hou
    • , Oliver Venn
    • , Raymond Lim
    • , Aseem Anand
    • , Tara Maddala
    • , Sante Gnerre
    • , Ravi Vijaya Satya
    • , Qinwen Liu
    • , Ling Shen
    • , Nicholas Eattock
    • , Jeanne Yue
    • , Alexander W. Blocker
    • , Mark Lee
    • , Amy Sehnert
    • , Hui Xu
    • , Megan P. Hall
    • , Angie Santiago-Zayas
    • , William F. Novotny
    • , James M. Isbell
    • , Valerie W. Rusch
    • , George Plitas
    • , Alexandra S. Heerdt
    • , Marc Ladanyi
    • , David M. Hyman
    • , David R. Jones
    • , Monica Morrow
    • , Gregory J. Riely
    • , Howard I. Scher
    • , Charles M. Rudin
    • , Mark E. Robson
    • , Luis A. Diaz Jr.
    • , David B. Solit
    • , Alexander M. Aravanis
    •  & Jorge S. Reis-Filho
  • Article |

    Analysis of data from over 400,000 UK Biobank participants shows that eGFR measured by cystatin C, but not serum creatinine, is strongly associated with cardiovascular disease outcomes and mortality.

    • Jennifer S. Lees
    • , Claire E. Welsh
    • , Carlos A. Celis-Morales
    • , Daniel Mackay
    • , James Lewsey
    • , Stuart R. Gray
    • , Donald M. Lyall
    • , John G. Cleland
    • , Jason M. R. Gill
    • , Pardeep S. Jhund
    • , Jill Pell
    • , Naveed Sattar
    • , Paul Welsh
    •  & Patrick B. Mark
  • Article |

    The beneficial effects of exercise on cardiovascular disease are linked to decreased inflammation through crosstalk between adipose tissue and hematopoietic progenitor cells in the bone marrow.

    • Vanessa Frodermann
    • , David Rohde
    • , Gabriel Courties
    • , Nicolas Severe
    • , Maximilian J. Schloss
    • , Hajera Amatullah
    • , Cameron S. McAlpine
    • , Sebastian Cremer
    • , Friedrich F. Hoyer
    • , Fei Ji
    • , Ian D. van Koeverden
    • , Fanny Herisson
    • , Lisa Honold
    • , Gustavo Santos Masson
    • , Shuang Zhang
    • , Jana Grune
    • , Yoshiko Iwamoto
    • , Stephen P. Schmidt
    • , Gregory R. Wojtkiewicz
    • , I-Hsiu Lee
    • , Karin Gustafsson
    • , Gerard Pasterkamp
    • , Saskia C. A. de Jager
    • , Ruslan I. Sadreyev
    • , Jean MacFadyen
    • , Peter Libby
    • , Paul Ridker
    • , David T. Scadden
    • , Kamila Naxerova
    • , Kate L. Jeffrey
    • , Filip K. Swirski
    •  & Matthias Nahrendorf
  • Article |

    A first-in-class engineered receptor decoy that neutralizes CLCF1–CNTFR signaling exhibits antitumor activity in preclinical models of lung adenocarcinoma driven by some mutant KRAS variants and other oncogenic genotypes.

    • Jun W. Kim
    • , Cesar P. Marquez
    • , Kaja Kostyrko
    • , Amanda L. Koehne
    • , Kieren Marini
    • , David R. Simpson
    • , Alex G. Lee
    • , Stanley G. Leung
    • , Leanne C. Sayles
    • , Joseph Shrager
    • , Irene Ferrer
    • , Luis Paz-Ares
    • , Melanie Hayden Gephart
    • , Silvestre Vicent
    • , Jennifer R. Cochran
    •  & E. Alejandro Sweet-Cordero
  • Article |

    Disrupting the normal maturation of the infant gut microbiota induced late-onset sepsis in mice, which could be prevented by administering specific bacteria.

    • Jeffrey R. Singer
    • , Emily G. Blosser
    • , Carlene L. Zindl
    • , Daniel J. Silberger
    • , Sean Conlan
    • , Vincent A. Laufer
    • , Daniel DiToro
    • , Clay Deming
    • , Ranjit Kumar
    • , Casey D. Morrow
    • , Julia A. Segre
    • , Michael J. Gray
    • , David A. Randolph
    •  & Casey T. Weaver
  • Article |

    Analysis of monoclonal antibody responses to the Ebola virus vaccine rVSV-ZEBOV in human volunteers.

    • Stefanie A. Ehrhardt
    • , Matthias Zehner
    • , Verena Krähling
    • , Hadas Cohen-Dvashi
    • , Christoph Kreer
    • , Nadav Elad
    • , Henning Gruell
    • , Meryem S. Ercanoglu
    • , Philipp Schommers
    • , Lutz Gieselmann
    • , Ralf Eggeling
    • , Christine Dahlke
    • , Timo Wolf
    • , Nico Pfeifer
    • , Marylyn M. Addo
    • , Ron Diskin
    • , Stephan Becker
    •  & Florian Klein
  • Article |

    A survey of T cell repertoire evolution in the tumors, healthy tissue and blood of patients with early-stage untreated lung cancer offers an opportunity to monitor and identify neoantigen-specific T cells for personalized immunotherapy.

    • Kroopa Joshi
    • , Marc Robert de Massy
    • , Mazlina Ismail
    • , James L. Reading
    • , Imran Uddin
    • , Annemarie Woolston
    • , Emine Hatipoglu
    • , Theres Oakes
    • , Rachel Rosenthal
    • , Thomas Peacock
    • , Tahel Ronel
    • , Mahdad Noursadeghi
    • , Virginia Turati
    • , Andrew J. S. Furness
    • , Andrew Georgiou
    • , Yien Ning Sophia Wong
    • , Assma Ben Aissa
    • , Mariana Werner Sunderland
    • , Mariam Jamal-Hanjani
    • , Selvaraju Veeriah
    • , Nicolai J. Birkbak
    • , Gareth A. Wilson
    • , Crispin T. Hiley
    • , Ehsan Ghorani
    • , José Afonso Guerra-Assunção
    • , Javier Herrero
    • , Tariq Enver
    • , Sine R. Hadrup
    • , Allan Hackshaw
    • , Karl S. Peggs
    • , Nicholas McGranahan
    • , Charles Swanton
    • , Charles Swanton
    • , Mariam Jamal-Hanjani
    • , Andrew Georgiou
    • , Mariana Werner Sunderland
    • , James L. Reading
    • , Karl S. Peggs
    • , Ehsan Ghorani
    • , Marc Robert de Massy
    • , Emine Hatipoglu
    • , Sergio A. Quezada
    • , Benny Chain
    • , Nicholas McGranahan
    • , Allan Hackshaw
    • , Crispin T. Hiley
    • , Selvaraju Veeriah
    • , Rachel Rosenthal
    • , Gareth A. Wilson
    • , Javier Herrero
    • , Nicolai J. Birkbak
    • , Yenting Ngai
    • , Abigail Sharp
    • , Cristina Rodrigues
    • , Oliver Pressey
    • , Sean Smith
    • , Nicole Gower
    • , Harjot Dhanda
    • , Thomas B. K. Watkins
    • , Mickael Escudero
    • , Aengus Stewart
    • , Andrew Rowan
    • , Jacki Goldman
    • , Peter Van Loo
    • , Richard Kevin Stone
    • , Tamara Denner
    • , Emma Nye
    • , Sophia Ward
    • , Emilia Lim
    • , Stefan Boeing
    • , Maria Greco
    • , Maise Al Bakir
    • , Kevin Litchfield
    • , Jerome Nicod
    • , Clare Puttick
    • , Katey Enfield
    • , Emma Colliver
    • , Brittany Campbell
    • , Christopher Abbosh
    • , Yin Wu
    • , Marcin Skrzypski
    • , Robert E. Hynds
    • , Teresa Marafioti
    • , John A. Hartley
    • , Pat Gorman
    • , Helen L. Lowe
    • , Leah Ensell
    • , Victoria Spanswick
    • , Angeliki Karamani
    • , David Moore
    • , Dhruva Biswas
    • , Maryam Razaq
    • , Stephan Beck
    • , Ariana Huebner
    • , Michelle Dietzen
    • , Cristina Naceur-Lombardelli
    • , Mita Afroza Akther
    • , Haoran Zhai
    • , Nnennaya Kannu
    • , Elizabeth Manzano
    • , Supreet Kaur Bola
    • , Elena Hoxha
    • , Stephanie Ogwuru
    • , David Lawrence
    • , Martin Hayward
    • , Nikolaos Panagiotopoulos
    • , Robert George
    • , Davide Patrini
    • , Mary Falzon
    • , Elaine Borg
    • , Reena Khiroya
    • , Asia Ahmed
    • , Magali Taylor
    • , Junaid Choudhary
    • , Penny Shaw
    • , Sam M. Janes
    • , Martin Forster
    • , Tanya Ahmad
    • , Siow Ming Lee
    • , Dawn Carnell
    • , Ruheena Mendes
    • , Jeremy George
    • , Neal Navani
    • , Dionysis Papadatos-Pastos
    • , Marco Scarci
    • , Elisa Bertoja
    • , Robert C. M. Stephens
    • , Emilie Martinoni Hoogenboom
    • , James W. Holding
    • , Steve Bandula
    • , Gillian Price
    • , Sylvie Dubois-Marshall
    • , Keith Kerr
    • , Shirley Palmer
    • , Heather Cheyne
    • , Joy Miller
    • , Keith Buchan
    • , Mahendran Chetty
    • , Mohammed Khalil
    • , Veni Ezhil
    • , Vineet Prakash
    • , Girija Anand
    • , Sajid Khan
    • , Kelvin Lau
    • , Michael Sheaff
    • , Peter Schmid
    • , Louise Lim
    • , John Conibear
    • , Roland Schwarz
    • , Jonathan Tugwood
    • , Jackie Pierce
    • , Caroline Dive
    • , Ged Brady
    • , Dominic G. Rothwell
    • , Francesca Chemi
    • , Elaine Kilgour
    • , Fiona Blackhall
    • , Lynsey Priest
    • , Matthew G. Krebs
    • , Philip Crosbie
    • , John Le Quesne
    • , Joan Riley
    • , Lindsay Primrose
    • , Luke Martinson
    • , Nicolas Carey
    • , Jacqui A. Shaw
    • , Dean Fennell
    • , Apostolos Nakas
    • , Sridhar Rathinam
    • , Louise Nelson
    • , Kim Ryanna
    • , Mohamad Tuffail
    • , Amrita Bajaj
    • , Jan Brozik
    • , Fiona Morgan
    • , Malgorzata Kornaszewska
    • , Richard Attanoos
    • , Haydn Adams
    • , Helen Davies
    • , Mathew Carter
    • , Colin R. Lindsay
    • , Fabio Gomes
    • , Zoltan Szallasi
    • , Roberto Salgado
    • , Istvan Csabai
    • , Miklos Diossy
    • , Hugo Aerts
    • , Alan Kirk
    • , Mo Asif
    • , John Butler
    • , Rocco Bilanca
    • , Nikos Kostoulas
    • , Mairead MacKenzie
    • , Maggie Wilcox
    • , Sara Busacca
    • , Alan Dawson
    • , Mark R. Lovett
    • , Michael Shackcloth
    • , Sarah Feeney
    • , Julius Asante-Siaw
    • , John Gosney
    • , Angela Leek
    • , Nicola Totten
    • , Jack Davies Hodgkinson
    • , Rachael Waddington
    • , Jane Rogan
    • , Katrina Moore
    • , William Monteiro
    • , Hilary Marshall
    • , Kevin G. Blyth
    • , Craig Dick
    • , Andrew Kidd
    • , Eric Lim
    • , Paulo De Sousa
    • , Simon Jordan
    • , Alexandra Rice
    • , Hilgardt Raubenheimer
    • , Harshil Bhayani
    • , Morag Hamilton
    • , Lyn Ambrose
    • , Anand Devaraj
    • , Hema Chavan
    • , Sofina Begum
    • , Aleksander Mani
    • , Daniel Kaniu
    • , Mpho Malima
    • , Sarah Booth
    • , Andrew G. Nicholson
    • , Nadia Fernandes
    • , Jessica E. Wallen
    • , Pratibha Shah
    • , Sarah Danson
    • , Jonathan Bury
    • , John Edwards
    • , Jennifer Hill
    • , Sue Matthews
    • , Yota Kitsanta
    • , Jagan Rao
    • , Sara Tenconi
    • , Laura Socci
    • , Kim Suvarna
    • , Faith Kibutu
    • , Patricia Fisher
    • , Robin Young
    • , Joann Barker
    • , Fiona Taylor
    • , Kirsty Lloyd
    • , Teresa Light
    • , Tracey Horey
    • , Dionysis Papadatos-Pastos
    • , Peter Russell
    • , Sara Lock
    • , Kayleigh Gilbert
    • , Babu Naidu
    • , Gerald Langman
    • , Andrew Robinson
    • , Hollie Bancroft
    • , Amy Kerr
    • , Salma Kadiri
    • , Charlotte Ferris
    • , Gary Middleton
    • , Madava Djearaman
    • , Akshay Patel
    • , Christian Ottensmeier
    • , Serena Chee
    • , Benjamin Johnson
    • , Aiman Alzetani
    • , Emily Shaw
    • , Jason Lester
    • , Yvonne Summers
    • , Raffaele Califano
    • , Paul Taylor
    • , Rajesh Shah
    • , Piotr Krysiak
    • , Kendadai Rammohan
    • , Eustace Fontaine
    • , Richard Booton
    • , Matthew Evison
    • , Stuart Moss
    • , Juliette Novasio
    • , Leena Joseph
    • , Paul Bishop
    • , Anshuman Chaturvedi
    • , Helen Doran
    • , Felice Granato
    • , Vijay Joshi
    • , Elaine Smith
    • , Angeles Montero
    • , Sergio A. Quezada
    •  & Benny Chain
  • Article |

    Single-cell proteomic and transcriptional profiling of atherosclerotic lesions from human carotid arteries reveals specific features of lesional T cells and macrophages associated with symptomatic disease.

    • Dawn M. Fernandez
    • , Adeeb H. Rahman
    • , Nicolas F. Fernandez
    • , Aleksey Chudnovskiy
    • , El-ad David Amir
    • , Letizia Amadori
    • , Nayaab S. Khan
    • , Christine K. Wong
    • , Roza Shamailova
    • , Christopher A. Hill
    • , Zichen Wang
    • , Romain Remark
    • , Jennifer R. Li
    • , Christian Pina
    • , Christopher Faries
    • , Ahmed J. Awad
    • , Noah Moss
    • , Johan L. M. Bjorkegren
    • , Seunghee Kim-Schulze
    • , Sacha Gnjatic
    • , Avi Ma’ayan
    • , J Mocco
    • , Peter Faries
    • , Miriam Merad
    •  & Chiara Giannarelli
  • Article |

    A first-in-human, phase 1 dose-escalation trial demonstrates the safety and feasibility of autologous macrophage therapy in adults with liver cirrhosis.

    • Francesca Moroni
    • , Benjamin J. Dwyer
    • , Catriona Graham
    • , Chloe Pass
    • , Laura Bailey
    • , Lisa Ritchie
    • , Donna Mitchell
    • , Alison Glover
    • , Audrey Laurie
    • , Stuart Doig
    • , Emily Hargreaves
    • , Alasdair R. Fraser
    • , Marc L. Turner
    • , John D. M. Campbell
    • , Neil W. A. McGowan
    • , Jacqueline Barry
    • , Joanna K. Moore
    • , Peter C. Hayes
    • , Diana J. Leeming
    • , Mette J. Nielsen
    • , Kishwar Musa
    • , Jonathan A. Fallowfield
    •  & Stuart J. Forbes
  • Article |

    Expansion of human hematopoietic stem cells present in cord blood or bone marrow can be achieved by cell culture in a hydrogel, potentially facilitating clinical applications of hematopoietic cell transplantation.

    • Tao Bai
    • , Jianqiang Li
    • , Andrew Sinclair
    • , Suzan Imren
    • , Fabiola Merriam
    • , Fang Sun
    • , Mary Beth O’Kelly
    • , Cynthia Nourigat
    • , Priyesh Jain
    • , Jeffrey J. Delrow
    • , Ryan S. Basom
    • , Hsiang-Chieh Hung
    • , Peng Zhang
    • , Bowen Li
    • , Shelly Heimfeld
    • , Shaoyi Jiang
    •  & Colleen Delaney
  • Article |

    Stress reduces the effects of various cancer therapies, such as chemotherapy and immunotherapy, in mice; this is mediated, at least partially, through Tsc22d3 upregulation in tumor-infiltrating dendritic cells, which leads to immunosuppression.

    • Heng Yang
    • , Lin Xia
    • , Jian Chen
    • , Shuqing Zhang
    • , Vincent Martin
    • , Qingqing Li
    • , Shangqing Lin
    • , Jinfeng Chen
    • , Joseph Calmette
    • , Min Lu
    • , Lingyi Fu
    • , Jie Yang
    • , Zhizhong Pan
    • , Kuai Yu
    • , Jingjing He
    • , Eric Morand
    • , Géraldine Schlecht-Louf
    • , Roman Krzysiek
    • , Laurence Zitvogel
    • , Boxi Kang
    • , Zeming Zhang
    • , Andrew Leader
    • , Penghui Zhou
    • , Laurence Lanfumey
    • , Minxin Shi
    • , Guido Kroemer
    •  & Yuting Ma
  • Article |

    A biomimetic culture system is developed by reverse engineering to replicate key features of the human ocular surface at cellular, tissue and organ levels, and is used as an in vitro model of dry-eye disease compatible with drug-screening approaches.

    • Jeongyun Seo
    • , Woo Y. Byun
    • , Farid Alisafaei
    • , Andrei Georgescu
    • , Yoon-Suk Yi
    • , Mina Massaro-Giordano
    • , Vivek B. Shenoy
    • , Vivian Lee
    • , Vatinee Y. Bunya
    •  & Dongeun Huh
  • Article |

    The human coronary artery disease gene TCF21 promotes the transformation of smooth muscle cells within atherosclerotic plaques into a newly identified population of fibroblast-like cells that contribute to plaque stability.

    • Robert C. Wirka
    • , Dhananjay Wagh
    • , David T. Paik
    • , Milos Pjanic
    • , Trieu Nguyen
    • , Clint L. Miller
    • , Ramen Kundu
    • , Manabu Nagao
    • , John Coller
    • , Tiffany K. Koyano
    • , Robyn Fong
    • , Y. Joseph Woo
    • , Boxiang Liu
    • , Stephen B. Montgomery
    • , Joseph C. Wu
    • , Kuixi Zhu
    • , Rui Chang
    • , Melissa Alamprese
    • , Michelle D. Tallquist
    • , Juyong B. Kim
    •  & Thomas Quertermous
  • Article |

    A machine learning approach using high-dimensional phenotypic and functional profiling data identifies a multiple sclerosis-specific T cell population that is reduced following treatment.

    • Edoardo Galli
    • , Felix J. Hartmann
    • , Bettina Schreiner
    • , Florian Ingelfinger
    • , Eirini Arvaniti
    • , Martin Diebold
    • , Dunja Mrdjen
    • , Franziska van der Meer
    • , Carsten Krieg
    • , Faiez Al Nimer
    • , Nicholas Sanderson
    • , Christine Stadelmann
    • , Mohsen Khademi
    • , Fredrik Piehl
    • , Manfred Claassen
    • , Tobias Derfuss
    • , Tomas Olsson
    •  & Burkhard Becher
  • Article |

    On the basis of the personalized data of over 300,000 individuals with urinary tract infections, a machine-learning algorithm can help select an antibiotic for treatment of a urinary tract infection to which the infecting pathogen is not already resistant.

    • Idan Yelin
    • , Olga Snitser
    • , Gal Novich
    • , Rachel Katz
    • , Ofir Tal
    • , Miriam Parizade
    • , Gabriel Chodick
    • , Gideon Koren
    • , Varda Shalev
    •  & Roy Kishony
  • Article |

    Zinc finger protein transcription factors are developed for the selective silencing of the mutant huntingtin gene in human neurons in vitro and multiple animal models of Huntington’s disease in vivo while preserving expression of the wild-type allele.

    • Bryan Zeitler
    • , Steven Froelich
    • , Kimberly Marlen
    • , David A Shivak
    • , Qi Yu
    • , Davis Li
    • , Jocelynn R Pearl
    • , Jeffrey C Miller
    • , Lei Zhang
    • , David E Paschon
    • , Sarah J Hinkley
    • , Irina Ankoudinova
    • , Stephen Lam
    • , Dmitry Guschin
    • , Lexi Kopan
    • , Jennifer M Cherone
    • , Hoang-Oanh B Nguyen
    • , Guijuan Qiao
    • , Yasaman Ataei
    • , Matthew C Mendel
    • , Rainier Amora
    • , Richard Surosky
    • , Josee Laganiere
    • , B Joseph Vu
    • , Anand Narayanan
    • , Yalda Sedaghat
    • , Karsten Tillack
    • , Christina Thiede
    • , Annette Gärtner
    • , Seung Kwak
    • , Jonathan Bard
    • , Ladislav Mrzljak
    • , Larry Park
    • , Taneli Heikkinen
    • , Kimmo K Lehtimäki
    • , Marie M Svedberg
    • , Jenny Häggkvist
    • , Lenke Tari
    • , Miklós Tóth
    • , Andrea Varrone
    • , Christer Halldin
    • , Andrea E Kudwa
    • , Sylvie Ramboz
    • , Michelle Day
    • , Jyothisri Kondapalli
    • , D James Surmeier
    • , Fyodor D Urnov
    • , Philip D Gregory
    • , Edward J Rebar
    • , Ignacio Muñoz-Sanjuán
    •  & H Steve Zhang
  • Article |

    Bacteriotherapy using gut-derived bacteria from healthy human infants, but not infants with food allergies, suppresses food allergy symptoms in mice via induction of Foxp3 + Rorγt + regulatory T cells

    • Azza Abdel-Gadir
    • , Emmanuel Stephen-Victor
    • , Georg K. Gerber
    • , Magali Noval Rivas
    • , Sen Wang
    • , Hani Harb
    • , Leighanne Wang
    • , Ning Li
    • , Elena Crestani
    • , Sara Spielman
    • , William Secor
    • , Heather Biehl
    • , Nicholas DiBenedetto
    • , Xiaoxi Dong
    • , Dale T. Umetsu
    • , Lynn Bry
    • , Rima Rachid
    •  & Talal A. Chatila
  • Article |

    Single-cell transcriptomics reveals immune and stromal compartment remodeling, including the enrichment of unique populations of epithelial cells and CD4+ T cells, in asthmatic lungs

    • Felipe A. Vieira Braga
    • , Gozde Kar
    • , Marijn Berg
    • , Orestes A. Carpaij
    • , Krzysztof Polanski
    • , Lukas M. Simon
    • , Sharon Brouwer
    • , Tomás Gomes
    • , Laura Hesse
    • , Jian Jiang
    • , Eirini S. Fasouli
    • , Mirjana Efremova
    • , Roser Vento-Tormo
    • , Carlos Talavera-López
    • , Marnix R. Jonker
    • , Karen Affleck
    • , Subarna Palit
    • , Paulina M. Strzelecka
    • , Helen V. Firth
    • , Krishnaa T. Mahbubani
    • , Ana Cvejic
    • , Kerstin B. Meyer
    • , Kourosh Saeb-Parsy
    • , Marjan Luinge
    • , Corry-Anke Brandsma
    • , Wim Timens
    • , Ilias Angelidis
    • , Maximilian Strunz
    • , Gerard H. Koppelman
    • , Antoon J. van Oosterhout
    • , Herbert B. Schiller
    • , Fabian J. Theis
    • , Maarten van den Berge
    • , Martijn C. Nawijn
    •  & Sarah A. Teichmann
  • Article |

    Ancestry and socioeconomic factors influence predictable changes in the vaginal microbiome that occur early in pregnancy in women who experience normal term birth.

    • Myrna G. Serrano
    • , Hardik I. Parikh
    • , J. Paul Brooks
    • , David J. Edwards
    • , Tom J. Arodz
    • , Laahirie Edupuganti
    • , Bernice Huang
    • , Philippe H. Girerd
    • , Yahya A. Bokhari
    • , Steven P. Bradley
    • , Jamie L. Brooks
    • , Molly R. Dickinson
    • , Jennifer I. Drake
    • , Robert A. Duckworth III
    • , Stephen S. Fong
    • , Abigail L. Glascock
    • , Sophonie Jean
    • , Nicole R. Jimenez
    • , Joseph Khoury
    • , Vishal N. Koparde
    • , Ana M. Lara
    • , Vladimir Lee
    • , Andrey V. Matveyev
    • , Sarah H. Milton
    • , Shreni D. Mistry
    • , Sarah K. Rozycki
    • , Nihar U. Sheth
    • , Ekaterina Smirnova
    • , Stephany C. Vivadelli
    • , N. Romesh Wijesooriya
    • , Jie Xu
    • , Ping Xu
    • , Donald O. Chaffin
    • , Amber L. Sexton
    • , Michael G. Gravett
    • , Craig E. Rubens
    • , Karen D. Hendricks-Muñoz
    • , Kimberly K. Jefferson
    • , Jerome F. Strauss III
    • , Jennifer M. Fettweis
    •  & Gregory A. Buck
  • Article
    | Open Access

    As part of the second phase of Human Microbiome Project, the Multi-Omic Microbiome Study: Pregnancy Initiative presents a community resource to help better understand how microbiome and host profiles change throughout pregnancy as well as to identify new opportunities for assessment of the risk of preterm birth.

    • Jennifer M. Fettweis
    • , Myrna G. Serrano
    • , J. Paul Brooks
    • , David J. Edwards
    • , Philippe H. Girerd
    • , Hardik I. Parikh
    • , Bernice Huang
    • , Tom J. Arodz
    • , Laahirie Edupuganti
    • , Abigail L. Glascock
    • , Jie Xu
    • , Nicole R. Jimenez
    • , Stephany C. Vivadelli
    • , Stephen S. Fong
    • , Nihar U. Sheth
    • , Sophonie Jean
    • , Vladimir Lee
    • , Yahya A. Bokhari
    • , Ana M. Lara
    • , Shreni D. Mistry
    • , Robert A. Duckworth III
    • , Steven P. Bradley
    • , Vishal N. Koparde
    • , X. Valentine Orenda
    • , Sarah H. Milton
    • , Sarah K. Rozycki
    • , Andrey V. Matveyev
    • , Michelle L. Wright
    • , Snehalata V. Huzurbazar
    • , Eugenie M. Jackson
    • , Ekaterina Smirnova
    • , Jonas Korlach
    • , Yu-Chih Tsai
    • , Molly R. Dickinson
    • , Jamie L. Brooks
    • , Jennifer I. Drake
    • , Donald O. Chaffin
    • , Amber L. Sexton
    • , Michael G. Gravett
    • , Craig E. Rubens
    • , N. Romesh Wijesooriya
    • , Karen D. Hendricks-Muñoz
    • , Kimberly K. Jefferson
    • , Jerome F. Strauss III
    •  & Gregory A. Buck
  • Article
    | Open Access

    New immune biomarkers of exposure to tuberculosis may require a rethink of evidence of Mycobacterium tuberculosis infection and control.

    • Lenette L. Lu
    • , Malisa T. Smith
    • , Krystle K. Q. Yu
    • , Corinne Luedemann
    • , Todd J. Suscovich
    • , Patricia S. Grace
    • , Adam Cain
    • , Wen Han Yu
    • , Tanya R. McKitrick
    • , Douglas Lauffenburger
    • , Richard D. Cummings
    • , Harriet Mayanja-Kizza
    • , Thomas R. Hawn
    • , W. Henry Boom
    • , Catherine M. Stein
    • , Sarah M. Fortune
    • , Chetan Seshadri
    •  & Galit Alter
  • Article |

    The detrimental effects of aged blood on cognition and nervous system function in mice can be combatted by targeting brain endothelial cell dysfunction via inhibition of aberrant VCAM1 signaling at the blood–brain barrier.

    • Hanadie Yousef
    • , Cathrin J. Czupalla
    • , Davis Lee
    • , Michelle B. Chen
    • , Ashley N. Burke
    • , Kristy A. Zera
    • , Judith Zandstra
    • , Elisabeth Berber
    • , Benoit Lehallier
    • , Vidhu Mathur
    • , Ramesh V. Nair
    • , Liana N. Bonanno
    • , Andrew C. Yang
    • , Todd Peterson
    • , Husein Hadeiba
    • , Taylor Merkel
    • , Jakob Körbelin
    • , Markus Schwaninger
    • , Marion S. Buckwalter
    • , Stephen R. Quake
    • , Eugene C. Butcher
    •  & Tony Wyss-Coray
  • Article |

    Personalized omics profiling can lead to actionable health discoveries and stimulate lifestyle changes.

    • Sophia Miryam Schüssler-Fiorenza Rose
    • , Kévin Contrepois
    • , Kegan J. Moneghetti
    • , Wenyu Zhou
    • , Tejaswini Mishra
    • , Samson Mataraso
    • , Orit Dagan-Rosenfeld
    • , Ariel B. Ganz
    • , Jessilyn Dunn
    • , Daniel Hornburg
    • , Shannon Rego
    • , Dalia Perelman
    • , Sara Ahadi
    • , M. Reza Sailani
    • , Yanjiao Zhou
    • , Shana R. Leopold
    • , Jieming Chen
    • , Melanie Ashland
    • , Jeffrey W. Christle
    • , Monika Avina
    • , Patricia Limcaoco
    • , Camilo Ruiz
    • , Marilyn Tan
    • , Atul J. Butte
    • , George M. Weinstock
    • , George M. Slavich
    • , Erica Sodergren
    • , Tracey L. McLaughlin
    • , Francois Haddad
    •  & Michael P. Snyder
  • Article |

    Elevated activity of the methionine cycle is essential for cancer stem cell tumorigenesis and represents a therapeutic vulnerability.

    • Zhenxun Wang
    • , Lian Yee Yip
    • , Jia Hui Jane Lee
    • , Zhengwei Wu
    • , Hui Yi Chew
    • , Pooi Kiat William Chong
    • , Chin Chye Teo
    • , Heather Yin-Kuan Ang
    • , Kai Lay Esther Peh
    • , Ju Yuan
    • , Siming Ma
    • , Li Shi Kimberly Choo
    • , Nurhidayah Basri
    • , Xia Jiang
    • , Qiang Yu
    • , Axel M. Hillmer
    • , Wan Teck Lim
    • , Tony Kiat Hon Lim
    • , Angela Takano
    • , Eng Huat Tan
    • , Daniel Shao Weng Tan
    • , Ying Swan Ho
    • , Bing Lim
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    • Monika A. Niewczas
    • , Meda E. Pavkov
    • , Jan Skupien
    • , Adam Smiles
    • , Zaipul I. Md Dom
    • , Jonathan M. Wilson
    • , Jihwan Park
    • , Viji Nair
    • , Andrew Schlafly
    • , Pierre-Jean Saulnier
    • , Eiichiro Satake
    • , Christopher A. Simeone
    • , Hetal Shah
    • , Chengxiang Qiu
    • , Helen C. Looker
    • , Paolo Fiorina
    • , Carl F. Ware
    • , Jennifer K. Sun
    • , Alessandro Doria
    • , Matthias Kretzler
    • , Katalin Susztak
    • , Kevin L. Duffin
    • , Robert G. Nelson
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    In situ vaccine recruits and activates cross-presenting dendritic cells and augments PD1 blockade efficacy in patients with indolent non-Hodgkin’s lymphoma.

    • Linda Hammerich
    • , Thomas U. Marron
    • , Ranjan Upadhyay
    • , Judit Svensson-Arvelund
    • , Maxime Dhainaut
    • , Shafinaz Hussein
    • , Yougen Zhan
    • , Dana Ostrowski
    • , Michael Yellin
    • , Henry Marsh
    • , Andres M. Salazar
    • , Adeeb H. Rahman
    • , Brian D. Brown
    • , Miriam Merad
    •  & Joshua D. Brody