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The generation of cytotoxic T lymphocyte response may be an essential part of an effective immune response to HIV infection. It may also do more harm than good (pages 330–336).
Despite the prevalence of Hodgkin's disease and non-Hodgkin's lymphoma, the specific causes are poorly understood. A recent study makes the strongest case to date for a genetic link.
Animal models of AIDS continue to surprise researchers with results that can be difficult to explain. However, most researchers still believe that animal models are essential to progress in understanding the disease. But which animal model is best? (pages 321–329)
Ribozymes can inhibit gene expression in a sequence-specific manner by catalysing cleavage of target messenger RNAs. They can also be used to for DIY (do-it-yourself) surgery on defective RNAs. The potential therapeutic applications of these ribozyme properties were discussed at a recent meeting.
