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A reinforcement learning algorithm achieved superior insulin titration optimization versus other deep learning models and standard clinical methods in a prospective cohort and in a proof-of-concept feasibility trial.
Analysis of monkeypox virus (MPXV) isolates circulating in Nigeria before the 2022 global outbreak of MPXV sheds light on the diversification of the virus that eventually gave rise to the 2022 MPXV lineage.
Using pathology data from Twitter, researchers have built a visual-language model for classifying and retrieving histopathology images — representing a milestone in the development of multifunctional foundational artificial intelligence models in computational pathology.
In a pooled analysis of six international studies involving about 17,900 female survivors of childhood cancer, the use of doxorubicin was associated with a dose-dependent risk of subsequent breast cancer, irrespective of prior chest radiotherapy exposure.
An analysis of viral genomes and epidemiological data from the 2022 mpox outbreak in Portugal sheds light on the heterogeneity of early transmission events, with national and international linkages.
In people with HIV-1 undergoing antiretroviral treatment interruption, lefitolimod combined with broadly neutralizing antibodies (bNAbs) did not delay viral rebound beyond that achieved with bNAbs alone, raising the question of how to optimize combination immunotherapy to control HIV-1.
A meta-analysis of longitudinal studies representing 16 countries found that hobby engagement was associated with better mental and self-reported health in adults aged 65 years and older as well as correlation with higher life expectancy and national happiness levels.
Nature Medicine explores the latest translation and clinical research news, with two separate groups announcing that genetically modified pig kidneys are functional in brain-dead human hosts.
By integrating genomic and in vitro functional analysis, this study uncovers tumor-intrinsic mechanisms of resistance to immunotherapies that target B cell maturation antigen (BCMA) or the orphan G-protein-coupled-receptor GPRC5D in multiple myeloma (MM), highlighting a pivotal role for mutations in the genes encoding BCMA and GPRC5D in driving clinical relapse. These insights provide crucial guidance for the selection of therapeutic strategies and the development of next-generation targeted immunotherapies in MM.
Nigeria’s new mental health act establishes human rights protections for patients and promotes community-based care, offering a roadmap for other countries, despite ongoing challenges.
Our study exposes the determinants of healthy aging in Latin America, underscoring the importance of the effects of social and health disparities compared with traditional factors such as age and sex. Our findings highlight an urgent need for more targeted detection of health risks, interventions and policies, particularly in low-income regions.
Despite an urgent need, approved and clinically usable biomarkers for non-alcoholic steatohepatitis (NASH) remain elusive — but a new study moves the field closer to this goal.
The first feasibility study of orally delivered senolytic therapy in Alzheimer’s disease reports favorable safety data and penetrance of dasatinib into the brain with a modest impact on Alzheimer’s and aging biomarkers.
The NIMBLE biomarker qualification project evaluated the diagnostic performance of five blood-based biomarkers in a cohort of individuals with non-alcoholic fatty liver disease and showed good discriminative performance over commonly used laboratory tests in detecting various stages of non-alcoholic steatohepatitis progression.
This Review summarizes recent advances in biomarkers and therapies for Alzheimer disease—the products of decades of research—and discusses the challenges, gaps and clinical implications.
Addition of the COX inhibitor piroxicam to levonorgestrel, a standard emergency contraceptive, increased its efficacy without increasing adverse events.
Longitudinal proteomic profiling of over 1,800 patients revealed two distinct profiles of blood biomarkers measured on admission to hospital for COVID-19, which predict cognitive deficits 6 and 12 months later.
