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A monumental challenge to scientists due to its repetitive sequences, the human Y chromosome has now been fully sequenced — revealing new structures in regions critical for fertility.
A low rate of Clostridioides difficile transmission within an intensive care unit supports the effectiveness of prevention practices and highlights the greater risk to carriers of toxigenic C. difficile.
The approval of two vaccines and a monoclonal antibody that target respiratory syncytial virus could shift the tide on the prevention and treatment of infection with this virus.
Results from the phase 3 placebo-controlled MAPP2 trial show that MDMA-assisted therapy reduces post-traumatic stress disorder (PTSD) symptoms and functional impairment in a diverse population with moderate to severe PTSD.
Second-line treatment with axicabtagene ciloleucel, a CD19-targeting CAR-T cell therapy, resulted in high response rates and durable remissions in patients with high-risk large B cell lymphoma deemed ineligible for autologous stem cell transplantation.
The combination of a bispecific antibody against EGFR and MET with a tyrosine kinase inhibitor (TKI) in patients with TKI-relapsed, chemotherapy-naive, EGFR-mutated advanced NSCLC is safe and shows preliminary efficacy.
A reinforcement learning algorithm achieved superior insulin titration optimization versus other deep learning models and standard clinical methods in a prospective cohort and in a proof-of-concept feasibility trial.
Analysis of monkeypox virus (MPXV) isolates circulating in Nigeria before the 2022 global outbreak of MPXV sheds light on the diversification of the virus that eventually gave rise to the 2022 MPXV lineage.
Using pathology data from Twitter, researchers have built a visual-language model for classifying and retrieving histopathology images — representing a milestone in the development of multifunctional foundational artificial intelligence models in computational pathology.
In a pooled analysis of six international studies involving about 17,900 female survivors of childhood cancer, the use of doxorubicin was associated with a dose-dependent risk of subsequent breast cancer, irrespective of prior chest radiotherapy exposure.
An analysis of viral genomes and epidemiological data from the 2022 mpox outbreak in Portugal sheds light on the heterogeneity of early transmission events, with national and international linkages.
In people with HIV-1 undergoing antiretroviral treatment interruption, lefitolimod combined with broadly neutralizing antibodies (bNAbs) did not delay viral rebound beyond that achieved with bNAbs alone, raising the question of how to optimize combination immunotherapy to control HIV-1.
A meta-analysis of longitudinal studies representing 16 countries found that hobby engagement was associated with better mental and self-reported health in adults aged 65 years and older as well as correlation with higher life expectancy and national happiness levels.
Nature Medicine explores the latest translation and clinical research news, with two separate groups announcing that genetically modified pig kidneys are functional in brain-dead human hosts.
