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Mounting evidence, including the recent (and unprecedented) phase 2 data on retatrutide, supports a role for incretin hormone agonists in treating obesity. But with great power comes great responsibility.
Produce prescriptions improved fruit and vegetable intake, reduced food insecurity and improved biomarkers of cardiometabolic health, according to a large, retrospective, US-based study.
A model investigating 26 possible malaria treatment policy intervention scenarios showed that introducing multiple first-line antimalarial therapies is the most effective single policy change in slowing the spread of artemisinin-resistant pfkelch R561H mutations in Rwanda over 5 years.
In this compassionate use study, treatment of adult patients with H3K27M-mutant diffuse midline glioma with a long peptide vaccine targeting H3K27M led to vaccine-induced peripheral T cell immune responses and encouraging clinical efficacy in the majority of patients, including a durable complete response.
A monumental challenge to scientists due to its repetitive sequences, the human Y chromosome has now been fully sequenced — revealing new structures in regions critical for fertility.
A low rate of Clostridioides difficile transmission within an intensive care unit supports the effectiveness of prevention practices and highlights the greater risk to carriers of toxigenic C. difficile.
The approval of two vaccines and a monoclonal antibody that target respiratory syncytial virus could shift the tide on the prevention and treatment of infection with this virus.
Results from the phase 3 placebo-controlled MAPP2 trial show that MDMA-assisted therapy reduces post-traumatic stress disorder (PTSD) symptoms and functional impairment in a diverse population with moderate to severe PTSD.
Second-line treatment with axicabtagene ciloleucel, a CD19-targeting CAR-T cell therapy, resulted in high response rates and durable remissions in patients with high-risk large B cell lymphoma deemed ineligible for autologous stem cell transplantation.
The combination of a bispecific antibody against EGFR and MET with a tyrosine kinase inhibitor (TKI) in patients with TKI-relapsed, chemotherapy-naive, EGFR-mutated advanced NSCLC is safe and shows preliminary efficacy.
A reinforcement learning algorithm achieved superior insulin titration optimization versus other deep learning models and standard clinical methods in a prospective cohort and in a proof-of-concept feasibility trial.
Analysis of monkeypox virus (MPXV) isolates circulating in Nigeria before the 2022 global outbreak of MPXV sheds light on the diversification of the virus that eventually gave rise to the 2022 MPXV lineage.
Using pathology data from Twitter, researchers have built a visual-language model for classifying and retrieving histopathology images — representing a milestone in the development of multifunctional foundational artificial intelligence models in computational pathology.
In a pooled analysis of six international studies involving about 17,900 female survivors of childhood cancer, the use of doxorubicin was associated with a dose-dependent risk of subsequent breast cancer, irrespective of prior chest radiotherapy exposure.
An analysis of viral genomes and epidemiological data from the 2022 mpox outbreak in Portugal sheds light on the heterogeneity of early transmission events, with national and international linkages.
