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The composition of the intestinal microbiome may predict clinical outcomes of CAR-T cell therapy for lymphoma, which could inform microbiota-based intervention strategies.
An in vitro technique to drop a Y chromosome and duplicate an X chromosome could expand the reach of fertility treatments in the future, although translation to humans remains an open question.
Findings from two conjoint experiments conducted in Austria and Italy revealed differences in the determinants of COVID-19 vaccine hesitancy and vaccine fatigue, suggesting that vaccination campaigns should be tailored to different groups according to previous vaccination status.
DeepGlioma, a multimodal deep learning approach for intraoperative diagnostic screening of diffuse glioma, trained on stimulated Raman histology and large-scale public genomic data, can predict molecular alterations for diffuse glioma diagnosis with high accuracy.
Analysis from a population cohort in Israel found that a third booster dose of the BNT162b2 mRNA vaccine in mothers before or during pregnancy was associated with greater protection against COVID-19 hospitalization in their infants compared to two doses.
Integrated analyses reveal that multiomics captured the heterogeneity of metabolic states accompanying obesity and changes in metabolic health in response to lifestyle intervention that are not apparent in body mass index measurements.
Integrative approaches continue to improve diagnostic accuracy for pediatric brain cancers, but much more is needed from researchers, governments and regulators if precision medicine with curative treatments are to become a reality.
Using a systems-level, multi-omics approach, we reveal several genes associated with arachnoid cysts and identify four phenotypic subtypes of arachnoid cysts, the severity of which correlates with the presence of protein-damaging de novo variants. All candidate genes are expressed in the developing brain and encode molecules implicated in chromatin modification or transcriptional regulation.
