Browse Articles

  • Article | | open

    New immune biomarkers of exposure to tuberculosis may require a rethink of evidence of Mycobacterium tuberculosis infection and control.

    • Lenette L. Lu
    • , Malisa T. Smith
    • , Krystle K. Q. Yu
    • , Corinne Luedemann
    • , Todd J. Suscovich
    • , Patricia S. Grace
    • , Adam Cain
    • , Wen Han Yu
    • , Tanya R. McKitrick
    • , Douglas Lauffenburger
    • , Richard D. Cummings
    • , Harriet Mayanja-Kizza
    • , Thomas R. Hawn
    • , W. Henry Boom
    • , Catherine M. Stein
    • , Sarah M. Fortune
    • , Chetan Seshadri
    •  & Galit Alter
  • News Feature |

    Researchers studying insect-borne disease hope to bring down the exorbitant cost of mosquitoes.

    • Monique Brouillette
  • Letter |

    A pick-the-winner clinical trial design in patients with metastatic triple-negative breast cancer shows that immune induction with doxorubicin or cisplatin may improve clinical responses to PD-1 blockade and induce a more favorable tumor microenvironment.

    • Leonie Voorwerk
    • , Maarten Slagter
    • , Hugo M. Horlings
    • , Karolina Sikorska
    • , Koen K. van de Vijver
    • , Michiel de Maaker
    • , Iris Nederlof
    • , Roelof J. C. Kluin
    • , Sarah Warren
    • , SuFey Ong
    • , Terry G. Wiersma
    • , Nicola S. Russell
    • , Ferry Lalezari
    • , Philip C. Schouten
    • , Noor A. M. Bakker
    • , Steven L. C. Ketelaars
    • , Dennis Peters
    • , Charlotte A. H. Lange
    • , Erik van Werkhoven
    • , Harm van Tinteren
    • , Ingrid A. M. Mandjes
    • , Inge Kemper
    • , Suzanne Onderwater
    • , Myriam Chalabi
    • , Sofie Wilgenhof
    • , John B. A. G. Haanen
    • , Roberto Salgado
    • , Karin E. de Visser
    • , Gabe S. Sonke
    • , Lodewyk F. A. Wessels
    • , Sabine C. Linn
    • , Ton N. Schumacher
    • , Christian U. Blank
    •  & Marleen Kok
  • Article |

    The detrimental effects of aged blood on cognition and nervous system function in mice can be combatted by targeting brain endothelial cell dysfunction via inhibition of aberrant VCAM1 signaling at the blood–brain barrier.

    • Hanadie Yousef
    • , Cathrin J. Czupalla
    • , Davis Lee
    • , Michelle B. Chen
    • , Ashley N. Burke
    • , Kristy A. Zera
    • , Judith Zandstra
    • , Elisabeth Berber
    • , Benoit Lehallier
    • , Vidhu Mathur
    • , Ramesh V. Nair
    • , Liana N. Bonanno
    • , Andrew C. Yang
    • , Todd Peterson
    • , Husein Hadeiba
    • , Taylor Merkel
    • , Jakob Körbelin
    • , Markus Schwaninger
    • , Marion S. Buckwalter
    • , Stephen R. Quake
    • , Eugene C. Butcher
    •  & Tony Wyss-Coray
  • Editorial |

    Immune interventions capable of preventing or eradicating HIV infection have yet to achieve broad success in humans. Renewed vigor in the clinical trial arena may bring us closer to that goal.

  • Resource |

    Systematic metabolite profiling across cancer cell lines uncovers patterns associated with genetic and epigenetic features and reveals dysregulated metabolic states that can be exploited for anticancer therapy

    • Haoxin Li
    • , Shaoyang Ning
    • , Mahmoud Ghandi
    • , Gregory V. Kryukov
    • , Shuba Gopal
    • , Amy Deik
    • , Amanda Souza
    • , Kerry Pierce
    • , Paula Keskula
    • , Desiree Hernandez
    • , Julie Ann
    • , Dojna Shkoza
    • , Verena Apfel
    • , Yilong Zou
    • , Francisca Vazquez
    • , Jordi Barretina
    • , Raymond A. Pagliarini
    • , Giorgio G. Galli
    • , David E. Root
    • , William C. Hahn
    • , Aviad Tsherniak
    • , Marios Giannakis
    • , Stuart L. Schreiber
    • , Clary B. Clish
    • , Levi A. Garraway
    •  & William R. Sellers
  • Turning Points |

    Max Nieuwdorp is an internist, endocrinologist and vascular medicine specialist at Amsterdam University Medical Centers. He chairs the Diabetes Center there and is chief of the Department and Laboratory of Vascular Medicine.

    • Max Nieuwdorp
  • Article |

    Personalized omics profiling can lead to actionable health discoveries and stimulate lifestyle changes.

    • Sophia Miryam Schüssler-Fiorenza Rose
    • , Kévin Contrepois
    • , Kegan J. Moneghetti
    • , Wenyu Zhou
    • , Tejaswini Mishra
    • , Samson Mataraso
    • , Orit Dagan-Rosenfeld
    • , Ariel B. Ganz
    • , Jessilyn Dunn
    • , Daniel Hornburg
    • , Shannon Rego
    • , Dalia Perelman
    • , Sara Ahadi
    • , M. Reza Sailani
    • , Yanjiao Zhou
    • , Shana R. Leopold
    • , Jieming Chen
    • , Melanie Ashland
    • , Jeffrey W. Christle
    • , Monika Avina
    • , Patricia Limcaoco
    • , Camilo Ruiz
    • , Marilyn Tan
    • , Atul J. Butte
    • , George M. Weinstock
    • , George M. Slavich
    • , Erica Sodergren
    • , Tracey L. McLaughlin
    • , Francois Haddad
    •  & Michael P. Snyder
  • Research Highlight |

    • Hannah Stower
  • Turning Points |

    Ami Bhatt is a physician-scientist and assistant professor of medicine and genetics at Stanford University. Her research deploys next-generation sequencing to explore host–microbiome interactions, including those in cancer.

    • Ami S. Bhatt
  • News & Views |

    Multi-omics longitudinal profiling of individuals can detect subtle changes in health status at the earliest possible time point, allowing preemptive initiation of mechanism-appropriate disease-prevention strategies.

    • Steven R. Steinhubl
  • Perspective |

    The use and promotion of probiotics is widespread, but debatable in many cases. Prospective large-scale randomized studies that assess their effectiveness in promoting health and curing disease and take into account personalized responses of discrete human subpopulations will help clarify specific indications in which probiotics may be safe and beneficial.

    • Jotham Suez
    • , Niv Zmora
    • , Eran Segal
    •  & Eran Elinav
  • Article |

    Elevated activity of the methionine cycle is essential for cancer stem cell tumorigenesis and represents a therapeutic vulnerability.

    • Zhenxun Wang
    • , Lian Yee Yip
    • , Jia Hui Jane Lee
    • , Zhengwei Wu
    • , Hui Yi Chew
    • , Pooi Kiat William Chong
    • , Chin Chye Teo
    • , Heather Yin-Kuan Ang
    • , Kai Lay Esther Peh
    • , Ju Yuan
    • , Siming Ma
    • , Li Shi Kimberly Choo
    • , Nurhidayah Basri
    • , Xia Jiang
    • , Qiang Yu
    • , Axel M. Hillmer
    • , Wan Teck Lim
    • , Tony Kiat Hon Lim
    • , Angela Takano
    • , Eng Huat Tan
    • , Daniel Shao Weng Tan
    • , Ying Swan Ho
    • , Bing Lim
    •  & Wai Leong Tam
  • Letter |

    Brain organoids derived from human iPSCs are used to study the effects of hypoxia on early cortical neurodevelopment and identify defects in specific human progenitor populations that likely contribute to encephalopathy of prematurity.

    • Anca M. Pașca
    • , Jin-Young Park
    • , Hyun-Woo Shin
    • , Qihao Qi
    • , Omer Revah
    • , Rebecca Krasnoff
    • , Ruth O’Hara
    • , A. Jeremy Willsey
    • , Theo D. Palmer
    •  & Sergiu P. Pașca
  • News Feature |

    • Hannah Valantine
    • , Elizabeth Travis
    • , Wafa El-Adhami
    • , Isabelle Vernos
    • , Laura Mosqueda
    • , Elizabeth Wayne
    • , Fiona Kearns-Zimmerman
    • , Lauren Bonefont
    • , Sandhya S. Visweswariah
    • , Wuraola Akande-Sholabi
    •  & Jessica Polka
  • News & Views |

    Human survivors of Ebola virus disease are more likely than uninfected controls to develop memory loss, uveitis, and other abnormal conditions, and Ebola virus remains in semen much longer than previously thought.

    • Daniel S. Chertow
  • Letter |

    GITR agonism can be exploited in combination with checkpoint blockade to overcome immune refractoriness in solid tumors.

    • Roberta Zappasodi
    • , Cynthia Sirard
    • , Yanyun Li
    • , Sadna Budhu
    • , Mohsen Abu-Akeel
    • , Cailian Liu
    • , Xia Yang
    • , Hong Zhong
    • , Walter Newman
    • , Jingjing Qi
    • , Phillip Wong
    • , David Schaer
    • , Henry Koon
    • , Vamsidhar Velcheti
    • , Matthew D. Hellmann
    • , Michael A. Postow
    • , Margaret K. Callahan
    • , Jedd D. Wolchok
    •  & Taha Merghoub
  • News & Views |

    Three innovative precision medicine studies show the utility of evidence beyond that from tumor DNA sequencing to guide therapy in patients with cancer.

    • Christophe Le Tourneau
    • , Edith Borcoman
    •  & Maud Kamal
  • Article |

    A robust signature of circulating inflammatory proteins is causally associated with 10-year risk of progression to end-stage renal disease in diabetic patients

    • Monika A. Niewczas
    • , Meda E. Pavkov
    • , Jan Skupien
    • , Adam Smiles
    • , Zaipul I. Md Dom
    • , Jonathan M. Wilson
    • , Jihwan Park
    • , Viji Nair
    • , Andrew Schlafly
    • , Pierre-Jean Saulnier
    • , Eiichiro Satake
    • , Christopher A. Simeone
    • , Hetal Shah
    • , Chengxiang Qiu
    • , Helen C. Looker
    • , Paolo Fiorina
    • , Carl F. Ware
    • , Jennifer K. Sun
    • , Alessandro Doria
    • , Matthias Kretzler
    • , Katalin Susztak
    • , Kevin L. Duffin
    • , Robert G. Nelson
    •  & Andrzej S. Krolewski
  • Letter |

    Fusion proteins in cancers with low mutational burden represent functional neoantigens that elicit T cell activation and mediate responses to immunotherapy.

    • Wei Yang
    • , Ken-Wing Lee
    • , Raghvendra M. Srivastava
    • , Fengshen Kuo
    • , Chirag Krishna
    • , Diego Chowell
    • , Vladimir Makarov
    • , Douglas Hoen
    • , Martin G. Dalin
    • , Leonard Wexler
    • , Ronald Ghossein
    • , Nora Katabi
    • , Zaineb Nadeem
    • , Marc A. Cohen
    • , S. Ken Tian
    • , Nicolas Robine
    • , Kanika Arora
    • , Heather Geiger
    • , Phaedra Agius
    • , Nancy Bouvier
    • , Kety Huberman
    • , Katelynd Vanness
    • , Jonathan J. Havel
    • , Jennifer S. Sims
    • , Robert M. Samstein
    • , Rajarsi Mandal
    • , Justin Tepe
    • , Ian Ganly
    • , Alan L. Ho
    • , Nadeem Riaz
    • , Richard J. Wong
    • , Neerav Shukla
    • , Timothy A. Chan
    •  & Luc G. T. Morris
  • Resource |

    A biobank of ovarian cancer organoids recapitulates the histopathological and molecular hallmarks of patient tumors and provides a resource for preclinical research.

    • Oded Kopper
    • , Chris J. de Witte
    • , Kadi Lõhmussaar
    • , Jose Espejo Valle-Inclan
    • , Nizar Hami
    • , Lennart Kester
    • , Anjali Vanita Balgobind
    • , Jeroen Korving
    • , Natalie Proost
    • , Harry Begthel
    • , Lise M. van Wijk
    • , Sonia Aristín Revilla
    • , Rebecca Theeuwsen
    • , Marieke van de Ven
    • , Markus J. van Roosmalen
    • , Bas Ponsioen
    • , Victor W. H. Ho
    • , Benjamin G. Neel
    • , Tjalling Bosse
    • , Katja N. Gaarenstroom
    • , Harry Vrieling
    • , Maaike P. G. Vreeswijk
    • , Paul J. van Diest
    • , Petronella O. Witteveen
    • , Trudy Jonges
    • , Johannes L. Bos
    • , Alexander van Oudenaarden
    • , Ronald P. Zweemer
    • , Hugo J. G. Snippert
    • , Wigard P. Kloosterman
    •  & Hans Clevers
  • Letter |

    Sequencing of circulating tumor DNA from cancer patients is a cost-efficient approach with turnaround time compatible with clinical practice to inform treatment decision-making in a phase 1 trial setting

    • Dominic G. Rothwell
    • , Mahmood Ayub
    • , Natalie Cook
    • , Fiona Thistlethwaite
    • , Louise Carter
    • , Emma Dean
    • , Nigel Smith
    • , Shaun Villa
    • , Joanne Dransfield
    • , Alexandra Clipson
    • , Daniel White
    • , Kamrun Nessa
    • , Saba Ferdous
    • , Matthew Howell
    • , Avinash Gupta
    • , Bedirhan Kilerci
    • , Sumitra Mohan
    • , Kris Frese
    • , Sakshi Gulati
    • , Crispin Miller
    • , Allan Jordan
    • , Helen Eaton
    • , Nicholas Hickson
    • , Ciara O’Brien
    • , Donna Graham
    • , Claire Kelly
    • , Sreeja Aruketty
    • , Robert Metcalf
    • , Jaseela Chiramel
    • , Nadina Tinsley
    • , Alexander J. Vickers
    • , Roopa Kurup
    • , Hannah Frost
    • , Julie Stevenson
    • , Siobhan Southam
    • , Dónal Landers
    • , Andrew Wallace
    • , Richard Marais
    • , Andrew M. Hughes
    • , Ged Brady
    • , Caroline Dive
    •  & Matthew G. Krebs
  • Letter |

    A prospective clinical study of cancer patients (I-PREDICT) demonstrated the feasibility of matching genomic alterations found in tumors to combined drug treatments.

    • Jason K. Sicklick
    • , Shumei Kato
    • , Ryosuke Okamura
    • , Maria Schwaederle
    • , Michael E. Hahn
    • , Casey B. Williams
    • , Pradip De
    • , Amy Krie
    • , David E. Piccioni
    • , Vincent A. Miller
    • , Jeffrey S. Ross
    • , Adam Benson
    • , Jennifer Webster
    • , Philip J. Stephens
    • , J. Jack Lee
    • , Paul T. Fanta
    • , Scott M. Lippman
    • , Brian Leyland-Jones
    •  & Razelle Kurzrock
  • Letter |

    A new anti-CD19 CAR T cell therapy induces potent antitumor responses without causing severe cytokine-release syndrome or neurotoxicity in patients with lymphoma.

    • Zhitao Ying
    • , Xue F. Huang
    • , Xiaoyu Xiang
    • , Yanling Liu
    • , Xi Kang
    • , Yuqin Song
    • , Xiaokai Guo
    • , Hanzhi Liu
    • , Ning Ding
    • , Tingting Zhang
    • , Panpan Duan
    • , Yufu Lin
    • , Wen Zheng
    • , Xiaopei Wang
    • , Ningjing Lin
    • , Meifeng Tu
    • , Yan Xie
    • , Chen Zhang
    • , Weiping Liu
    • , Lijuan Deng
    • , Shunyu Gao
    • , Lingyan Ping
    • , Xuejuan Wang
    • , Nina Zhou
    • , Junqing Zhang
    • , Yulong Wang
    • , Songfeng Lin
    • , Mierzhati Mamuti
    • , Xueyun Yu
    • , Lizhu Fang
    • , Shuai Wang
    • , Haifeng Song
    • , Guan Wang
    • , Lindsey Jones
    • , Jun Zhu
    •  & Si-Yi Chen
  • Letter |

    Prospective analysis of transcriptomic and genomic alterations increases the proportion of patients with solid cancer who are eligible for receiving matched therapies and shows promise in improving clinical outcomes.

    • Jordi Rodon
    • , Jean-Charles Soria
    • , Raanan Berger
    • , Wilson H. Miller
    • , Eitan Rubin
    • , Aleksandra Kugel
    • , Apostolia Tsimberidou
    • , Pierre Saintigny
    • , Aliza Ackerstein
    • , Irene Braña
    • , Yohann Loriot
    • , Mohammad Afshar
    • , Vincent Miller
    • , Fanny Wunder
    • , Catherine Bresson
    • , Jean-François Martini
    • , Jacques Raynaud
    • , John Mendelsohn
    • , Gerald Batist
    • , Amir Onn
    • , Josep Tabernero
    • , Richard L. Schilsky
    • , Vladimir Lazar
    • , J. Jack Lee
    •  & Razelle Kurzrock
  • Author Correction |

    • Junfei Zhao
    • , Andrew X. Chen
    • , Robyn D. Gartrell
    • , Andrew M. Silverman
    • , Luis Aparicio
    • , Tim Chu
    • , Darius Bordbar
    • , David Shan
    • , Jorge Samanamud
    • , Aayushi Mahajan
    • , Ioan Filip
    • , Rose Orenbuch
    • , Morgan Goetz
    • , Jonathan T. Yamaguchi
    • , Michael Cloney
    • , Craig Horbinski
    • , Rimas V. Lukas
    • , Jeffrey Raizer
    • , Ali I. Rae
    • , Jinzhou Yuan
    • , Peter Canoll
    • , Jeffrey N. Bruce
    • , Yvonne M. Saenger
    • , Peter Sims
    • , Fabio M. Iwamoto
    • , Adam M. Sonabend
    •  & Raul Rabadan
  • Article |

    In situ vaccine recruits and activates cross-presenting dendritic cells and augments PD1 blockade efficacy in patients with indolent non-Hodgkin’s lymphoma.

    • Linda Hammerich
    • , Thomas U. Marron
    • , Ranjan Upadhyay
    • , Judit Svensson-Arvelund
    • , Maxime Dhainaut
    • , Shafinaz Hussein
    • , Yougen Zhan
    • , Dana Ostrowski
    • , Michael Yellin
    • , Henry Marsh
    • , Andres M. Salazar
    • , Adeeb H. Rahman
    • , Brian D. Brown
    • , Miriam Merad
    •  & Joshua D. Brody
  • Editorial |

    The use of electronic cigarettes is on the rise, but we need more evidence about their risks as well as their value in curbing tobacco use. Ultimately, we need to design better, smarter vaping tools for smoking cessation.

  • Turning Points |

    Lars Zender is professor and chairman of internal medicine at University Hospital Tubingen in Germany. He has received many awards, including the Gottfried Wilhelm Leibniz Prize of the German Research Foundation.

    • Lars Zender
  • Comment |

    It has been only recently that scientists come to realize the existence of a lymphatic system within the central nervous system. However, an Italian anatomist had already found and described the system in fine detail over 200 years ago.

    • Stefano Sandrone
    • , Daniel Moreno-Zambrano
    • , Jonathan Kipnis
    •  & Jan van Gijn
  • Article |

    Blockade of intrahepatic accumulation and function of platelets represents a potential approach to treat non-alcoholic steatohepatitis (NASH) and prevent subsequent progression to hepatocellular carcinoma

    • Mohsen Malehmir
    • , Dominik Pfister
    • , Suchira Gallage
    • , Marta Szydlowska
    • , Donato Inverso
    • , Elena Kotsiliti
    • , Valentina Leone
    • , Moritz Peiseler
    • , Bas G. J. Surewaard
    • , Dominik Rath
    • , Adnan Ali
    • , Monika Julia Wolf
    • , Hannah Drescher
    • , Marc E. Healy
    • , Daniel Dauch
    • , Daniela Kroy
    • , Oliver Krenkel
    • , Marlene Kohlhepp
    • , Thomas Engleitner
    • , Alexander Olkus
    • , Tjeerd Sijmonsma
    • , Julia Volz
    • , Carsten Deppermann
    • , David Stegner
    • , Patrick Helbling
    • , César Nombela-Arrieta
    • , Anahita Rafiei
    • , Martina Hinterleitner
    • , Marcel Rall
    • , Florian Baku
    • , Oliver Borst
    • , Caroline L. Wilson
    • , Jack Leslie
    • , Tracy O’Connor
    • , Christopher J. Weston
    • , David H. Adams
    • , Lozan Sheriff
    • , Ana Teijeiro
    • , Marco Prinz
    • , Ruzhica Bogeska
    • , Natasha Anstee
    • , Malte N. Bongers
    • , Mike Notohamiprodjo
    • , Tobias Geisler
    • , Dominic J. Withers
    • , Jerry Ware
    • , Derek A. Mann
    • , Hellmut G. Augustin
    • , Alexandros Vegiopoulos
    • , Michael D. Milsom
    • , Adam J. Rose
    • , Patricia F. Lalor
    • , Josep M. Llovet
    • , Roser Pinyol
    • , Frank Tacke
    • , Roland Rad
    • , Matthias Matter
    • , Nabil Djouder
    • , Paul Kubes
    • , Percy A. Knolle
    • , Kristian Unger
    • , Lars Zender
    • , Bernhard Nieswandt
    • , Meinrad Gawaz
    • , Achim Weber
    •  & Mathias Heikenwalder
  • Article |

    Cross-study analysis defines fecal microbial species associated with colorectal cancer.

    • Jakob Wirbel
    • , Paul Theodor Pyl
    • , Ece Kartal
    • , Konrad Zych
    • , Alireza Kashani
    • , Alessio Milanese
    • , Jonas S. Fleck
    • , Anita Y. Voigt
    • , Albert Palleja
    • , Ruby Ponnudurai
    • , Shinichi Sunagawa
    • , Luis Pedro Coelho
    • , Petra Schrotz-King
    • , Emily Vogtmann
    • , Nina Habermann
    • , Emma Niméus
    • , Andrew M. Thomas
    • , Paolo Manghi
    • , Sara Gandini
    • , Davide Serrano
    • , Sayaka Mizutani
    • , Hirotsugu Shiroma
    • , Satoshi Shiba
    • , Tatsuhiro Shibata
    • , Shinichi Yachida
    • , Takuji Yamada
    • , Levi Waldron
    • , Alessio Naccarati
    • , Nicola Segata
    • , Rashmi Sinha
    • , Cornelia M. Ulrich
    • , Hermann Brenner
    • , Manimozhiyan Arumugam
    • , Peer Bork
    •  & Georg Zeller
  • Article |

    A small molecule that restores the integrity of the intestinal barrier provides a novel therapeutic strategy for inflammatory bowel diseases.

    • W. Vallen Graham
    • , Weiqi He
    • , Amanda M. Marchiando
    • , Juanmin Zha
    • , Gurminder Singh
    • , Hua-Shan Li
    • , Amlan Biswas
    • , Ma. Lora Drizella M. Ong
    • , Zhi-Hui Jiang
    • , Wangsun Choi
    • , Harmon Zuccola
    • , Yitang Wang
    • , James Griffith
    • , Jingshing Wu
    • , Harry J. Rosenberg
    • , Yingmin Wang
    • , Scott B. Snapper
    • , David Ostrov
    • , Stephen C. Meredith
    • , Lawrence W. Miller
    •  & Jerrold R. Turner