Analyses of eight dietary patterns revealed that adherence to low insulinemic, low inflammatory or diabetes risk-reducing diets was associated with the largest risk reduction of cardiometabolic diseases and cancer in US men and women.

Conserved microbiome features across clinical and geographical variations may enable microbiome-based predictions of outcomes in CD19-targeted CAR-T cell immunotherapy

Cardiometabolic health is tightly linked to diet and the gut microbiome. This Review explains how meta-omics technologies are revealing the intricate links between them and discusses the most promising paths to clinical translation.

DeepGlioma, a multimodal deep learning approach for intraoperative diagnostic screening of diffuse glioma, trained on stimulated Raman histology and large-scale public genomic data, can predict molecular alterations for diffuse glioma diagnosis with high accuracy.

Analysis from a population cohort in Israel found that a third booster dose of the BNT162b2 mRNA vaccine in mothers before or during pregnancy was associated with greater protection against COVID-19 hospitalization in their infants compared to two doses.

Integrated analyses reveal that multiomics captured the heterogeneity of metabolic states accompanying obesity and changes in metabolic health in response to lifestyle intervention that are not apparent in body mass index measurements.

A new multilevel clustering approach applied retrospectively to 13,000 transcriptomes of different tumors reveals a new diagnostic classification of childhood cancers, in some cases allowing a better prediction of disease outcomes.

A flexible and compact database containing rare variant genotypes and phenotypes of 77,539 participants sequenced by the 100,000 Genomes Project enables the identification of new disease-causing genes.

A machine learning model that uses longitudinal ctDNA metrics robustly predicts survival in two phase 3 trials of patients with metastatic NSCLC, which may improve therapy selection and risk stratification.

According to a randomized trial, home-based monitoring of complicated pregnancies could be a safe alternative to hospital admission.

For patients with advanced, resectable melanoma, treatment with pembrolizumab before as well as after surgery led to improved outcomes — without additional toxicity.

For people taking statins, inflammation contributes more to cardiovascular disease risk than residual cholesterol does — and could be targeted with adjunct therapy.

Paleogenomics can help elucidate the genetic basis of modern diseases, including inborn errors of immunity that impair the response to infections, providing a tool for drug development.