In this compassionate use study, treatment of adult patients with H3K27M-mutant diffuse midline glioma with a long peptide vaccine targeting H3K27M led to vaccine-induced peripheral T cell immune responses and encouraging clinical efficacy in the majority of patients, including a durable complete response.

A low rate of Clostridioides difficile transmission within an intensive care unit supports the effectiveness of prevention practices and highlights the greater risk to carriers of toxigenic C. difficile.

We asked leading researchers to share new discoveries about SARS-CoV-2 and COVID-19, from how the virus spreads and the risk of long COVID to the impact of vaccines and masks.

Nigeria’s new mental health act establishes human rights protections for patients and promotes community-based care, offering a roadmap for other countries, despite ongoing challenges.

In the first-in-human trial of elranatamab, patients with refractory or relapsed multiple myeloma who received the bispecific antibody against BCMA and CD3 experienced no dose-limiting toxicities during dose escalation, and the agent showed promising clinical efficacy.

In a phase 2 trial, the combination of gemcitabine, cisplatin and anti-PD-1 led to a clinical complete response in 43% of patients with muscle-invasive bladder cancer, which facilitated bladder sparing and was associated with long-term bladder-intact metastasis-free survival.

Reactivation of latent SIV with an IAP antagonist, coupled with immunotherapeutic approaches, reduced replication-competent SIV in lymph node CD4⁺ T cells in rhesus macaques. Further exploration targeting these pathways to reduce the HIV viral reservoir is warranted.

New treatments are essential for methicillin-susceptible Staphylococcus aureus bacteremia, but progress is slow. In this phase III–IV trial, cloxacillin plus fosfomycin failed to show superiority over cloxacillin alone, underscoring the challenges to improving patient outcomes.

In a prospective study, an autism screening app administered using a tablet computer to young children showed high diagnostic accuracy and may facilitate a scalable approach to autism screening.

In the LUMINA-1 trial for fibrodysplasia ossificans progressiva, garetosmab, an activin A monoclonal antibody, did not lead to significant changes in heterotopic ossification lesion activity in pre-existing lesions in period 1. Garetosmab prevented the formation of new lesions in both periods 1 and 2.

Nature Medicine explores the latest translation and clinical research news, with results from a clinical trial of Novartis' discontinued gene therapy to restore fetal hemoglobin.

As healthcare systems perform better, their resource footprints have an increasingly negative impact on the environment and health — requiring innovative strategies to break this vicious cycle.

Grown from stem cells, the models recapitulate the hallmarks of post-implantation human embryos up to day 14, opening new avenues of research into early human development.

We asked leading researchers to share new discoveries about SARS-CoV-2 and COVID-19, from how the virus spreads and the risk of long COVID to the impact of vaccines and masks.

Produce prescriptions improved fruit and vegetable intake, reduced food insecurity and improved biomarkers of cardiometabolic health, according to a large, retrospective, US-based study.