Analysis of hematopoietic stem cells from six individuals with sickle cell disease who had been treated with autologous gene therapy revealed positive selective pressure on cells containing mutations in genes associated with clonal hematopoiesis and hematological malignancies.

In a phased prospective rollout, the implementation of AI as an additional reader for mammography screening improved the real-world early detection of breast cancer compared to standard double reading involving two independent radiologists.

This Review explores how research coproduction with Indigenous peoples is evolving; it discusses the challenges and complexities and makes recommendations for researchers wishing to pursue coproduction with Indigenous peoples in responsive and effective ways.

New data show that AI could enhance imaging-based screening for pancreatic cancer; however, its evaluation must be rigorous and adhere to the same standards used for conventional screening.

Deep learning enables comprehensive and interpretable scoring for breast cancer prognosis prediction, outperforming pathologists in multicenter validation and providing insight on prognostic biomarkers.

A four-arm cluster-randomized trial testing the effects of a low cash incentive, a high cash incentive, a health message and a placebo on COVID-19 vaccine uptake in villages in rural Ghana demonstrated highest uptake with a low cash incentive.

Genomic analysis of products of conception collected after spontaneous pregnancy loss in the first trimester reveals previously undetected chromosomal aberrations and a higher degree of mosaic chromosomal imbalances.

A deep learning model provides high accuracy in detecting pancreatic lesions in multicenter data, outperforming radiology specialists.

In a phase 2 trial, the oral type II RAF inhibitor tovorafenib exhibited an overall response rate of 67% in patients with BRAF-altered relapsed/refractory pediatric low-grade glioma.

Analysis of hematopoietic stem cells from six individuals with sickle cell disease who had been treated with autologous gene therapy revealed positive selective pressure on cells containing mutations in genes associated with clonal hematopoiesis and hematological malignancies.

In people with cardiovascular disease (without diabetes) and overweight or obesity, the GLP-1 receptor agonist semaglutide significantly reduced the risk of major cardiovascular events.

The adoption of medical AI devices in clinical practice is still in its infancy, with uneven usage across procedures and locations in the USA, which underscores the inequities in its real-world implementation.

Preclinical and initial human studies suggest that glucagon-like peptide-1 receptor agonists may be promising treatments for alcohol use disorder, but existing approved treatments should be used until safety and efficacy is demonstrated in clinical trials.

The report — the first of its kind from the WHO — is intended as a roadmap for building responsive and inclusive health systems for displaced people.

A citizen science approach has helped craft a resource-rich vaginal microbiome map with associations to lifestyle and events across a woman’s life course.

A year ago, we adopted an ethics framework to help with the assessment of and to increase transparency and accountability for research practices in studies involving partnerships between researchers in high- and low-income settings. We now reflect on our progress, what we learned and the way forward to champion ethical, inclusive and equitable partnerships in the content we publish.