The potential of evinacumab, a monoclonal antibody targeting angiopoietin-like 3, for reducing triglyceride levels was tested in patients with severe hypertriglyceridemia due to differing genetic etiologies.

A deep-learning algorithm was developed to identify skin lesions caused by the mpox virus and was then implemented in a web-based app designed for patient use.

Clinical, genomic and transcriptomic analyses of paired samples of synchronous bilateral female breast cancer identify associations between tumor concordance and immune infiltrates levels and response to neoadjuvant treatment.

Nature Medicine explores the latest translational and clinical research news, with a monoclonal antibody that blocks the transfer of maternal immunoglobulins in pregnancy.

Integrated analyses reveal that multiomics captured the heterogeneity of metabolic states accompanying obesity and changes in metabolic health in response to lifestyle intervention that are not apparent in body mass index measurements.

A new multilevel clustering approach applied retrospectively to 13,000 transcriptomes of different tumors reveals a new diagnostic classification of childhood cancers, in some cases allowing a better prediction of disease outcomes.

A flexible and compact database containing rare variant genotypes and phenotypes of 77,539 participants sequenced by the 100,000 Genomes Project enables the identification of new disease-causing genes.

A machine learning model that uses longitudinal ctDNA metrics robustly predicts survival in two phase 3 trials of patients with metastatic NSCLC, which may improve therapy selection and risk stratification.

The integration of DNA methylation profiling and targeted sequencing with neuropathology improves the diagnostic accuracy of central nervous system tumors in a population-based cohort of more than 1,200 newly diagnosed pediatric patients.

The combination of neoadjuvant nivolumab, ipilimumab and chemotherapy showed promising efficacy in patients with resectable non-small cell lung cancer, with higher tumor immune cell infiltration and tertiary lymphoid structures after treatment compared with neoadjuvant nivolumab plus chemotherapy.

For patients with advanced, resectable melanoma, treatment with pembrolizumab before as well as after surgery led to improved outcomes — without additional toxicity.

For people taking statins, inflammation contributes more to cardiovascular disease risk than residual cholesterol does — and could be targeted with adjunct therapy.

Paleogenomics can help elucidate the genetic basis of modern diseases, including inborn errors of immunity that impair the response to infections, providing a tool for drug development.

ChatGPT and other large language models may be able to enhance healthcare delivery and patients’ quality of life. But they will need to be tailored to specific clinical needs first.

Nature Medicine explores the latest translational and clinical research news, with Heartseed and Novo Nordisk’s clinical trial of iPSC–derived cardiomyocytes for the treatment of heart failure.