Editorial: 2021: a new year for the WHO

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Editorial | 13 January 2021

2021: a new year for the WHO
News Feature | 13 January 2021

Eight ways machine learning is assisting medicine
- Mike May
Correspondence | 23 November 2020

Indirect benefits are a crucial consideration when evaluating SARS-CoV-2 vaccine candidates
- Molly E. Gallagher
- , Andrew J. Sieben
- , Kristin N. Nelson
- , Alicia N. M. Kraay
- , Walter A. Orenstein
- , Ben Lopman
- , Andreas Handel
- & Katia Koelle
Perspective | 13 January 2021

Immune determinants of COVID-19 disease presentation and severity
- Petter Brodin
Review Article | 13 January 2021

Targeting metastatic cancer
- Karuna Ganesh
- & Joan Massagué
Brief Communication | 11 January 2021

The distribution of cellular turnover in the human body
- Ron Sender
- & Ron Milo

Featured

The distribution of cellular turnover in the human body

Looking forward to a new year, experts share six trends for the biomedical community in 2021.
Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals

Analyses from the gut microbiome of over 1,000 individuals from the PREDICT 1 study, for which detailed long-term diet information as well as hundreds of fasting and same-meal postprandial cardiometabolic blood marker measurements are available, unveil new associations between specific gut microbes, dietary habits and cardiometabolic health.
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Latest Research

Letter
21 January 2021 | Open Access

The effects of tobacco control policies on global smoking prevalence

Analysis of global smoking prevalence trends from 2009 to 2017 demonstrates that, when implemented, national-level tobacco control policies are highly effective; however, considerable gaps remain in the universal adoption of anti-tobacco interventions.
- Luisa S. Flor
- , Marissa B. Reitsma
- , Vinay Gupta
- , Marie Ng
- & Emmanuela Gakidou
Article | 21 January 2021

Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma

Personalized neoantigen vaccination in patients with melanoma elicits durable and specific memory T cell clones that have cytotoxic gene signatures and can diversify to include nonvaccine neoantigen specificities.
- Zhuting Hu
- , Donna E. Leet
- , Rosa L. Allesøe
- , Giacomo Oliveira
- , Shuqiang Li
- , Adrienne M. Luoma
- , Jinyan Liu
- , Juliet Forman
- , Teddy Huang
- , J. Bryan Iorgulescu
- , Rebecca Holden
- , Siranush Sarkizova
- , Satyen H. Gohil
- , Robert A. Redd
- , Jing Sun
- , Liudmila Elagina
- , Anita Giobbie-Hurder
- , Wandi Zhang
- , Lauren Peter
- , Zoe Ciantra
- , Scott Rodig
- , Oriol Olive
- , Keerthi Shetty
- , Jason Pyrdol
- , Mohamed Uduman
- , Patrick C. Lee
- , Pavan Bachireddy
- , Elizabeth I. Buchbinder
- , Charles H. Yoon
- , Donna Neuberg
- , Bradley L. Pentelute
- , Nir Hacohen
- , Kenneth J. Livak
- , Sachet A. Shukla
- , Lars Rønn Olsen
- , Dan H. Barouch
- , Kai W. Wucherpfennig
- , Edward F. Fritsch
- , Derin B. Keskin
- , Catherine J. Wu
- & Patrick A. Ott
Article | 21 January 2021

Effect of a plant-based, low-fat diet versus an animal-based, ketogenic diet on ad libitum energy intake

In an inpatient, randomized controlled crossover trial, participants consumed 550–700 kcal day⁻¹ fewer calories when following a plant-based, low-fat diet with a high glycemic load compared with an animal-based, low-carbohydrate diet with a low glycemic load; weight loss was comparable between the two diets and there were no significant differences in hunger or enjoyment of the meals.
- Kevin D. Hall
- , Juen Guo
- , Amber B. Courville
- , James Boring
- , Robert Brychta
- , Kong Y. Chen
- , Valerie Darcey
- , Ciaran G. Forde
- , Ahmed M. Gharib
- , Isabelle Gallagher
- , Rebecca Howard
- , Paule V. Joseph
- , Lauren Milley
- , Ronald Ouwerkerk
- , Klaudia Raisinger
- , Irene Rozga
- , Alex Schick
- , Michael Stagliano
- , Stephan Torres
- , Mary Walter
- , Peter Walter
- , Shanna Yang
- & Stephanie T. Chung
Perspective | 19 January 2021

Looking beyond COVID-19 vaccine phase 3 trials

A comprehensive strategy for the next steps to ensure vaccination of the global population against SARS-CoV-2 is now required, and key steps and challenges are detailed in this Perspective.
- Jerome H. Kim
- , Florian Marks
- & John D. Clemens
Brief Communication | 18 January 2021

State-dependent responses to intracranial brain stimulation in a patient with depression

Acute mapping of responses to focal electrical neuromodulation in a patient with treatment-resistant depression reveals distinct mood and symptom changes that are highly context dependent.
- Katherine W. Scangos
- , Ghassan S. Makhoul
- , Leo P. Sugrue
- , Edward F. Chang
- & Andrew D. Krystal
Article | 18 January 2021

The androgen receptor is a tumor suppressor in estrogen receptor–positive breast cancer

Functional interplay of sex hormones in estrogen receptor–positive breast cancer unveils the therapeutic potential of androgen receptor agonists.
- Theresa E. Hickey
- , Luke A. Selth
- , Kee Ming Chia
- , Geraldine Laven-Law
- , Heloisa H. Milioli
- , Daniel Roden
- , Shalini Jindal
- , Mun Hui
- , Jessica Finlay-Schultz
- , Esmaeil Ebrahimie
- , Stephen N. Birrell
- , Suzan Stelloo
- , Richard Iggo
- , Sarah Alexandrou
- , C. Elizabeth Caldon
- , Tarek M. Abdel-Fatah
- , Ian O. Ellis
- , Wilbert Zwart
- , Carlo Palmieri
- , Carol A. Sartorius
- , Alex Swarbrick
- , Elgene Lim
- , Jason S. Carroll
- & Wayne D. Tilley