Integration of longitudinal single-cell analysis of relapsed and refractory multiple myeloma patients in a prospective clinical trial uncovers new pathways of drug resistance and identifies potential actionable targets.

First-in-human test of topical application of a commensal bacterium on skin of individuals with atopic dermatitis reduces colonization by proinflammatory Staphylococcus aureus.

A genetic link suggests that interventions that halve the risk of malaria episodes could reduce the prevalence of iron deficiency in African children by nearly 50%.

Biallelic loss of BCMA caused a patient with multiple myeloma to relapse after anti-BCMA CAR T cell treatment. Baseline heterozygous BCMA deletions might be a risk factor for this form of resistance.

Songling virus is a newly discovered orthonairovirus found in the blood of patients hospitalized with febrile illness and having a history of tick bites.

Neoadjuvant treatment with nivolumab plus ipilimumab is well tolerated and demonstrates clinical efficacy in patients with early stage lung cancer.

A B cell–depleting therapy is less effective in patients with low synovial B cell gene expression.

An artificial intelligence-enabled drug screen finds small molecules that can correct dysfunctional gene networks in aortic valve disease.

Understanding disparities between genders in career equity could help promote equal pay and equal opportunity for women in academia.