Raising the bar for clinical research

Latest Research

  • Letter |

    TRACERx Lung: Intratumoral transcriptional heterogeneity, which often hinders the development of clinically useful RNA-expression-biased biomarkers for cancer, can now be overcome with an approach for the identification of clonal expression biomarkers.

    • Dhruva Biswas
    • , Nicolai J. Birkbak
    • , Rachel Rosenthal
    • , Crispin T. Hiley
    • , Emilia L. Lim
    • , Krisztian Papp
    • , Stefan Boeing
    • , Marcin Krzystanek
    • , Dijana Djureinovic
    • , Linnea La Fleur
    • , Maria Greco
    • , Balázs Döme
    • , János Fillinger
    • , Hans Brunnström
    • , Yin Wu
    • , David A. Moore
    • , Marcin Skrzypski
    • , Christopher Abbosh
    • , Kevin Litchfield
    • , Maise Al Bakir
    • , Thomas B. K. Watkins
    • , Selvaraju Veeriah
    • , Gareth A. Wilson
    • , Mariam Jamal-Hanjani
    • , Judit Moldvay
    • , Johan Botling
    • , Arul M. Chinnaiyan
    • , Patrick Micke
    • , Allan Hackshaw
    • , Jiri Bartek
    • , Istvan Csabai
    • , Zoltan Szallasi
    • , Javier Herrero
    • , Nicholas McGranahan
    •  & Charles Swanton
  • Letter |

    Pulmonary venous tumor cells disseminating before tumor resection are heterogeneous, predict relapse and seed future metastasis of lung cancer

    • Francesca Chemi
    • , Dominic G. Rothwell
    • , Nicholas McGranahan
    • , Sakshi Gulati
    • , Chris Abbosh
    • , Simon P. Pearce
    • , Cong Zhou
    • , Gareth A. Wilson
    • , Mariam Jamal-Hanjani
    • , Nicolai Birkbak
    • , Jackie Pierce
    • , Chang Sik Kim
    • , Saba Ferdous
    • , Deborah J. Burt
    • , Daniel Slane-Tan
    • , Fabio Gomes
    • , David Moore
    • , Rajesh Shah
    • , Maise Al Bakir
    • , Crispin Hiley
    • , Selvaraju Veeriah
    • , Yvonne Summers
    • , Philip Crosbie
    • , Sophia Ward
    • , Barbara Mesquita
    • , Marek Dynowski
    • , Dhruva Biswas
    • , Jonathan Tugwood
    • , Fiona Blackhall
    • , Crispin Miller
    • , Allan Hackshaw
    • , Ged Brady
    • , Charles Swanton
    •  & Caroline Dive
  • Resource |

    Genetic variants in the germ line modulate DNA methylation in tumors and contribute to the aggressiveness of prostate cancer.

    • Kathleen E. Houlahan
    • , Yu-Jia Shiah
    • , Alexander Gusev
    • , Jiapei Yuan
    • , Musaddeque Ahmed
    • , Anamay Shetty
    • , Susmita G. Ramanand
    • , Cindy Q. Yao
    • , Connor Bell
    • , Edward O’Connor
    • , Vincent Huang
    • , Michael Fraser
    • , Lawrence E. Heisler
    • , Julie Livingstone
    • , Takafumi N. Yamaguchi
    • , Alexandre Rouette
    • , Adrien Foucal
    • , Shadrielle Melijah G. Espiritu
    • , Ankit Sinha
    • , Michelle Sam
    • , Lee Timms
    • , Jeremy Johns
    • , Ada Wong
    • , Alex Murison
    • , Michèle Orain
    • , Valérie Picard
    • , Hélène Hovington
    • , Alain Bergeron
    • , Louis Lacombe
    • , Mathieu Lupien
    • , Yves Fradet
    • , Bernard Têtu
    • , John D. McPherson
    • , Bogdan Pasaniuc
    • , Thomas Kislinger
    • , Melvin L. K. Chua
    • , Mark M. Pomerantz
    • , Theodorus van der Kwast
    • , Matthew L. Freedman
    • , Ram S. Mani
    • , Housheng H. He
    • , Robert G. Bristow
    •  & Paul C. Boutros
  • Article |

    A first-in-human, phase 1 dose-escalation trial demonstrates the safety and feasibility of autologous macrophage therapy in adults with liver cirrhosis.

    • Francesca Moroni
    • , Benjamin J. Dwyer
    • , Catriona Graham
    • , Chloe Pass
    • , Laura Bailey
    • , Lisa Ritchie
    • , Donna Mitchell
    • , Alison Glover
    • , Audrey Laurie
    • , Stuart Doig
    • , Emily Hargreaves
    • , Alasdair R. Fraser
    • , Marc L. Turner
    • , John D. M. Campbell
    • , Neil W. A. McGowan
    • , Jacqueline Barry
    • , Joanna K. Moore
    • , Peter C. Hayes
    • , Diana J. Leeming
    • , Mette J. Nielsen
    • , Kishwar Musa
    • , Jonathan A. Fallowfield
    •  & Stuart J. Forbes
  • Article |

    Expansion of human hematopoietic stem cells present in cord blood or bone marrow can be achieved by cell culture in a hydrogel, potentially facilitating clinical applications of hematopoietic cell transplantation.

    • Tao Bai
    • , Jianqiang Li
    • , Andrew Sinclair
    • , Suzan Imren
    • , Fabiola Merriam
    • , Fang Sun
    • , Mary Beth O’Kelly
    • , Cynthia Nourigat
    • , Priyesh Jain
    • , Jeffrey J. Delrow
    • , Ryan S. Basom
    • , Hsiang-Chieh Hung
    • , Peng Zhang
    • , Bowen Li
    • , Shelly Heimfeld
    • , Shaoyi Jiang
    •  & Colleen Delaney
  • Resource |

    Rectal cancer organoids retain the pathological features of matched patient tumors and recapitulate clinical responses to chemoradiation.

    • Karuna Ganesh
    • , Chao Wu
    • , Kevin P. O’Rourke
    • , Bryan C. Szeglin
    • , Youyun Zheng
    • , Charles-Etienne Gabriel Sauvé
    • , Mohammad Adileh
    • , Isaac Wasserman
    • , Michael R. Marco
    • , Amanda S. Kim
    • , Maha Shady
    • , Francisco Sanchez-Vega
    • , Wouter R. Karthaus
    • , Helen H. Won
    • , Seo-Hyun Choi
    • , Raphael Pelossof
    • , Afsar Barlas
    • , Peter Ntiamoah
    • , Emmanouil Pappou
    • , Arthur Elghouayel
    • , James S. Strong
    • , Chin-Tung Chen
    • , Jennifer W. Harris
    • , Martin R. Weiser
    • , Garrett M. Nash
    • , Jose G. Guillem
    • , Iris H. Wei
    • , Richard N. Kolesnick
    • , Harini Veeraraghavan
    • , Eduardo J. Ortiz
    • , Iva Petkovska
    • , Andrea Cercek
    • , Katia O. Manova-Todorova
    • , Leonard B. Saltz
    • , Jessica A. Lavery
    • , Ronald P. DeMatteo
    • , Joan Massagué
    • , Philip B. Paty
    • , Rona Yaeger
    • , Xi Chen
    • , Sujata Patil
    • , Hans Clevers
    • , Michael F. Berger
    • , Scott W. Lowe
    • , Jinru Shia
    • , Paul B. Romesser
    • , Lukas E. Dow
    • , Julio Garcia-Aguilar
    • , Charles L. Sawyers
    •  & J. Joshua Smith

News & Comment

  • News & Views |

    A novel oral capsule can deploy microneedle patches that release drugs into the intestinal wall for uptake into the bloodstream as shown in animal studies, thereby avoiding injections.

    • Mark R. Prausnitz
    • , Yasmine Gomaa
    •  & Wei Li
  • Editorial |

    Nature Medicine is taking a comprehensive approach for reporting clinical studies with the aim to increase transparency, promote rigorous reporting standards and engage with the community to meet the challenges of contemporary medicine.

  • News & Views |

    An engineered truncated gene derived from the dystrophin-related protein (utrophin), prevents pathology without an immune response in an animal model of Duchenne muscular dystrophy (DMD) gene therapy.

    • Kay E. Davies
    •  & Jeffrey S. Chamberlain

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