Editorial: Potential and ethics

Latest Research

  • Article |

    Recovery of skilled motor function in rodents after stroke correlates with the restoration of low-frequency quasi-oscillatory activity in the motor cortex, and neuromodulatory electrical stimulation targeting this activity can further accelerate recovery.

    • Dhakshin S. Ramanathan
    • , Ling Guo
    • , Tanuj Gulati
    • , Gray Davidson
    • , April K. Hishinuma
    • , Seok-Joon Won
    • , Robert T. Knight
    • , Edward F. Chang
    • , Raymond A. Swanson
    •  & Karunesh Ganguly
  • Letter |

    CRISPR–Cas9-induced DNA damage triggers p53 to limit the efficiency of gene editing in human pluripotent cells.

    • Robert J. Ihry
    • , Kathleen A. Worringer
    • , Max R. Salick
    • , Elizabeth Frias
    • , Daniel Ho
    • , Kraig Theriault
    • , Sravya Kommineni
    • , Julie Chen
    • , Marie Sondey
    • , Chaoyang Ye
    • , Ranjit Randhawa
    • , Tripti Kulkarni
    • , Zinger Yang
    • , Gregory McAllister
    • , Carsten Russ
    • , John Reece-Hoyes
    • , William Forrester
    • , Gregory R. Hoffman
    • , Ricardo Dolmetsch
    •  & Ajamete Kaykas
  • Article |

    Post-translational modification of microtubules by detyrosination is prevalent in failing human cardiomyocytes and inhibits cardiomyocyte contraction, suggesting a new therapeutic strategy for improving heart function.

    • Christina Yingxian Chen
    • , Matthew A. Caporizzo
    • , Kenneth Bedi
    • , Alexia Vite
    • , Alexey I. Bogush
    • , Patrick Robison
    • , Julie G. Heffler
    • , Alex K. Salomon
    • , Neil A. Kelly
    • , Apoorva Babu
    • , Michael P. Morley
    • , Kenneth B. Margulies
    •  & Benjamin L. Prosser
  • Article |

    Reactive astrocytes expressing STAT3 support the metastatic growth of tumor cells colonizing the brain and can be pharmacologically targeted to improve the clinical management of patients with secondary brain tumors.

    • Neibla Priego
    • , Lucía Zhu
    • , Cátia Monteiro
    • , Manon Mulders
    • , David Wasilewski
    • , Wendy Bindeman
    • , Laura Doglio
    • , Liliana Martínez
    • , Elena Martínez-Saez
    • , Santiago Ramón y Cajal
    • , Diego Megías
    • , Elena Hernández-Encinas
    • , Carmen Blanco-Aparicio
    • , Lola Martínez
    • , Eduardo Zarzuela
    • , Javier Muñoz
    • , Coral Fustero-Torres
    • , Elena Pineiro
    • , Aurelio Hernández-Laín
    • , Luca Bertero
    • , Valeria Poli
    • , Melchor Sánchez-Martínez
    • , Javier A. Menendez
    • , Riccardo Soffietti
    • , Joaquim Bosch-Barrera
    •  & Manuel Valiente
  • Letter |

    Agonism of microglial glucagon-like peptide-1 receptor (GLP1R) using a brain-penetrant peptide prevents the generation of neurotoxic astrocytes and ameliorates disease progression in two rodent models of Parkinson’s disease.

    • Seung Pil Yun
    • , Tae-In Kam
    • , Nikhil Panicker
    • , SangMin Kim
    • , Yumin Oh
    • , Jong-Sung Park
    • , Seung-Hwan Kwon
    • , Yong Joo Park
    • , Senthilkumar S. Karuppagounder
    • , Hyejin Park
    • , Sangjune Kim
    • , Nayeon Oh
    • , Nayoung Alice Kim
    • , Saebom Lee
    • , Saurav Brahmachari
    • , Xiaobo Mao
    • , Jun Hee Lee
    • , Manoj Kumar
    • , Daniel An
    • , Sung-Ung Kang
    • , Yunjong Lee
    • , Kang Choon Lee
    • , Dong Hee Na
    • , Donghoon Kim
    • , Sang Hun Lee
    • , Viktor V. Roschke
    • , Shane A. Liddelow
    • , Zoltan Mari
    • , Ben A. Barres
    • , Valina L. Dawson
    • , Seulki Lee
    • , Ted M. Dawson
    •  & Han Seok Ko

News & Comment

  • News & Views |

    A large retrospective study involving 62,565 Danish men shows that those who have been overweight in childhood have a lower risk of having type 2 diabetes in adulthood if they had remission of overweight before 13 years of age.

    • Daniel S. Hsia
    •  & Steven B. Heymsfield
  • Editorial |

    With the ongoing demand for assisted reproduction, the need and ability to study the fundamentals of human reproduction at a cellular level have never been greater. At this juncture, we join other Nature Research Journals in formalizing our ethical guidelines for papers in this growing field.

  • News Feature |

    Chronotherapy looks beyond to treating more than just cancer

    • Shraddha Chakradhar