Editorial: 2021: a new year for the WHO

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Latest Research

  • Review Article |

    Increased understanding of the biology of metastases allows improved targeting and outcomes for patients with both micro- and macrometastases.

    • Karuna Ganesh
    •  & Joan Massagué
  • Article |

    An algorithmic, machine-learning approach to measuring severe pain from osteoarthritis applied to X-ray images of knees suggests that reported disparities in knee pain in underserved populations can be reduced by comparison with use of standard radiographic measures of disease severity.

    • Emma Pierson
    • , David M. Cutler
    • , Jure Leskovec
    • , Sendhil Mullainathan
    •  & Ziad Obermeyer
  • Article |

    Cabozantinib, an inhibitor of multiple receptor tyrosine kinases, has efficacy in a mouse model of neurofibromatosis type I and has clinical activity in reducing plexiform neurofibroma volume in a phase II trial of patients with NF1.

    • Michael J. Fisher
    • , Chie-Schin Shih
    • , Steven D. Rhodes
    • , Amy E. Armstrong
    • , Pamela L. Wolters
    • , Eva Dombi
    • , Chi Zhang
    • , Steven P. Angus
    • , Gary L. Johnson
    • , Roger J. Packer
    • , Jeffrey C. Allen
    • , Nicole J. Ullrich
    • , Stewart Goldman
    • , David H. Gutmann
    • , Scott R. Plotkin
    • , Tena Rosser
    • , Kent A. Robertson
    • , Brigitte C. Widemann
    • , Abbi E. Smith
    • , Waylan K. Bessler
    • , Yongzheng He
    • , Su-Jung Park
    • , Julie A. Mund
    • , Li Jiang
    • , Khadijeh Bijangi-Vishehsaraei
    • , Coretta Thomas Robinson
    • , Gary R. Cutter
    • , Bruce R. Korf
    • , Chie-Schin Shih
    • , Amy E. Armstrong
    • , Jaishri O. Blakeley
    •  & D. Wade Clapp
  • Brief Communication |

    A comprehensive census of the dynamics of death and regeneration of cells and tissues provides an estimation of the distribution of cellular turnover in the human body.

    • Ron Sender
    •  & Ron Milo
  • Article |

    An in vitro human tonsil tissue-based system captures key features of a functional germinal center and can be used to study humoral immune responses to vaccines, new antigens and adjuvants.

    • Lisa E. Wagar
    • , Ameen Salahudeen
    • , Christian M. Constantz
    • , Ben S. Wendel
    • , Michael M. Lyons
    • , Vamsee Mallajosyula
    • , Lauren P. Jatt
    • , Julia Z. Adamska
    • , Lisa K. Blum
    • , Neha Gupta
    • , Katherine J. L. Jackson
    • , Fan Yang
    • , Katharina Röltgen
    • , Krishna M. Roskin
    • , Kelly M. Blaine
    • , Kara D. Meister
    • , Iram N. Ahmad
    • , Mario Cortese
    • , Emery G. Dora
    • , Sean N. Tucker
    • , Anne I. Sperling
    • , Aarti Jain
    • , D. Huw Davies
    • , Philip L. Felgner
    • , Gregory B. Hammer
    • , Peter S. Kim
    • , William H. Robinson
    • , Scott D. Boyd
    • , Calvin J. Kuo
    •  & Mark M. Davis

News & Comment

Milestone

Cancer Milestones

Chris Ryan

Cancer Milestones

The ancient physician Hippocrates described the projection of blood vessels from a collection of cells as ‘karkinos’, the Greek word for crab.

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