In this compassionate use study, treatment of adult patients with H3K27M-mutant diffuse midline glioma with a long peptide vaccine targeting H3K27M led to vaccine-induced peripheral T cell immune responses and encouraging clinical efficacy in the majority of patients, including a durable complete response.

A low rate of Clostridioides difficile transmission within an intensive care unit supports the effectiveness of prevention practices and highlights the greater risk to carriers of toxigenic C. difficile.

We asked leading researchers to share new discoveries about SARS-CoV-2 and COVID-19, from how the virus spreads and the risk of long COVID to the impact of vaccines and masks.

Nigeria’s new mental health act establishes human rights protections for patients and promotes community-based care, offering a roadmap for other countries, despite ongoing challenges.

In the LUMINA-1 trial for fibrodysplasia ossificans progressiva, garetosmab, an activin A monoclonal antibody, did not lead to significant changes in heterotopic ossification lesion activity in pre-existing lesions in period 1. Garetosmab prevented the formation of new lesions in both periods 1 and 2.

Analysis using a combination of molecular and genetic epidemiological approaches reveals an interaction between female sex and the genetic variant PNPLA3 p.I148M that might explain why some women have increased susceptibility to fatty liver disease after onset of menopause.

In patients with Crohn’s disease, CD4⁺ T cells with cytotoxic T_H1 cell-like effector functions reactive against dietary and commensal yeasts are increased in blood and inflamed tissue compared with patients with ulcerative colitis and healthy controls.

A model investigating 26 possible malaria treatment policy intervention scenarios showed that introducing multiple first-line antimalarial therapies is the most effective single policy change in slowing the spread of artemisinin-resistant pfkelch R561H mutations in Rwanda over 5 years.

In this compassionate use study, treatment of adult patients with H3K27M-mutant diffuse midline glioma with a long peptide vaccine targeting H3K27M led to vaccine-induced peripheral T cell immune responses and encouraging clinical efficacy in the majority of patients, including a durable complete response.

A low rate of Clostridioides difficile transmission within an intensive care unit supports the effectiveness of prevention practices and highlights the greater risk to carriers of toxigenic C. difficile.

As healthcare systems perform better, their resource footprints have an increasingly negative impact on the environment and health — requiring innovative strategies to break this vicious cycle.

Grown from stem cells, the models recapitulate the hallmarks of post-implantation human embryos up to day 14, opening new avenues of research into early human development.

We asked leading researchers to share new discoveries about SARS-CoV-2 and COVID-19, from how the virus spreads and the risk of long COVID to the impact of vaccines and masks.

Produce prescriptions improved fruit and vegetable intake, reduced food insecurity and improved biomarkers of cardiometabolic health, according to a large, retrospective, US-based study.

A monumental challenge to scientists due to its repetitive sequences, the human Y chromosome has now been fully sequenced — revealing new structures in regions critical for fertility.