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The Clinical Pipeline

Growing interest in non-invasive brain–computer interfaces, rather than implants, might improve accessibility for patients, but resolution needs to be improved.

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  • Next-generation liquid biopsy technologies that target the detection of cell-free DNA with fragments of circulating tumor DNA could be a game-changer in early cancer detection, but their adoption requires further clinical testing and consideration of harm.

    Editorial
  • An early-phase trial suggests safety and improvements in vision after treatment with the CRISPR-based therapy EDIT-101, providing proof of concept for in vivo retinal gene editing.

    • Karen O’Leary
    Research Highlight
  • Final results of two studies — whose preliminary data led to regulatory approval of the gene therapy exagamglogene autotemcel — describe highly effective treatment of sickle-cell disease and transfusion-dependent β-thalassemia.

    • Karen O’Leary
    Research Highlight

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