Cutting out the liver fat

Latest Research

  • Article |

    Thyroid hormone improves mitochondrial function and dynamics in lung epithelium to reduce pulmonary fibrosis in mice.

    • Guoying Yu
    • , Argyris Tzouvelekis
    • , Rong Wang
    • , Jose D Herazo-Maya
    • , Gabriel H Ibarra
    • , Anup Srivastava
    • , Joao Pedro Werneck de Castro
    • , Giuseppe DeIuliis
    • , Farida Ahangari
    • , Tony Woolard
    • , Nachelle Aurelien
    • , Rafael Arrojo e Drigo
    • , Ye Gan
    • , Morven Graham
    • , Xinran Liu
    • , Robert J Homer
    • , Thomas S Scanlan
    • , Praveen Mannam
    • , Patty J Lee
    • , Erica L Herzog
    • , Antonio C Bianco
    •  & Naftali Kaminski
  • Article |

    Through injection of human Alzheimer's disease (AD) brain extracts containing pathological tau protein into transgenic mouse lines harboring different levels of amyloid plaque burden, the authors find that the presence of amyloid plaques modifies endogenous pools of tau protein, creating a unique environment required for the seeding and spreading of distinct tau pathologies.

    • Zhuohao He
    • , Jing L Guo
    • , Jennifer D McBride
    • , Sneha Narasimhan
    • , Hyesung Kim
    • , Lakshmi Changolkar
    • , Bin Zhang
    • , Ronald J Gathagan
    • , Cuiyong Yue
    • , Christopher Dengler
    • , Anna Stieber
    • , Magdalena Nitla
    • , Douglas A Coulter
    • , Ted Abel
    • , Kurt R Brunden
    • , John Q Trojanowski
    •  & Virginia M-Y Lee
  • Article |

    Degeneration of the retinal pigment epithelium is a hallmark of geographic atrophy, a type of age-related macular degeneration. Kerur et al. show that this degeneration results from a multistep pathway in which mitochondrial dysfunction in RPE cells, triggered by accumulation of Alu RNA, leads to activation of the noncanonical inflammasome via a cGAS–STING–IRF3 signaling axis.

    • Nagaraj Kerur
    • , Shinichi Fukuda
    • , Daipayan Banerjee
    • , Younghee Kim
    • , Dongxu Fu
    • , Ivana Apicella
    • , Akhil Varshney
    • , Reo Yasuma
    • , Benjamin J Fowler
    • , Elmira Baghdasaryan
    • , Kenneth M Marion
    • , Xiwen Huang
    • , Tetsuhiro Yasuma
    • , Yoshio Hirano
    • , Vlad Serbulea
    • , Meenakshi Ambati
    • , Vidya L Ambati
    • , Yuji Kajiwara
    • , Kameshwari Ambati
    • , Shuichiro Hirahara
    • , Ana Bastos-Carvalho
    • , Yuichiro Ogura
    • , Hiroko Terasaki
    • , Tetsuro Oshika
    • , Kyung Bo Kim
    • , David R Hinton
    • , Norbert Leitinger
    • , John C Cambier
    • , Joseph D Buxbaum
    • , M Cristina Kenney
    • , S Michal Jazwinski
    • , Hiroshi Nagai
    • , Isao Hara
    • , A Phillip West
    • , Katherine A Fitzgerald
    • , SriniVas R Sadda
    • , Bradley D Gelfand
    •  & Jayakrishna Ambati
  • Article |

    Fry et al. report the first results from a human trial of a CD22-directed chimeric antigen receptor (CAR) T cell therapy providing evidence of efficacy in the treatment of pre–B cell acute lymphoblastic leukemia that is immunotherapy-naive or resistant to CD19-directed CAR T cells.

    • Terry J Fry
    • , Nirali N Shah
    • , Rimas J Orentas
    • , Maryalice Stetler-Stevenson
    • , Constance M Yuan
    • , Sneha Ramakrishna
    • , Pamela Wolters
    • , Staci Martin
    • , Cindy Delbrook
    • , Bonnie Yates
    • , Haneen Shalabi
    • , Thomas J Fountaine
    • , Jack F Shern
    • , Robbie G Majzner
    • , David F Stroncek
    • , Marianna Sabatino
    • , Yang Feng
    • , Dimiter S Dimitrov
    • , Ling Zhang
    • , Sang Nguyen
    • , Haiying Qin
    • , Boro Dropulic
    • , Daniel W Lee
    •  & Crystal L Mackall
  • Article |

    Tumor organoids derived from the most common subtypes of primary liver cancer recapitulate the histologic and molecular features of the tissues of origin, even after long-term culture. These in vitro models, as well as those for colorectal cancer reported in Crespo et al. in a previous issue, are amenable for drug screening and allow the identification of therapeutic approaches with potential for cancer treatment.

    • Laura Broutier
    • , Gianmarco Mastrogiovanni
    • , Monique MA Verstegen
    • , Hayley E Francies
    • , Lena Morrill Gavarró
    • , Charles R Bradshaw
    • , George E Allen
    • , Robert Arnes-Benito
    • , Olga Sidorova
    • , Marcia P Gaspersz
    • , Nikitas Georgakopoulos
    • , Bon-Kyoung Koo
    • , Sabine Dietmann
    • , Susan E Davies
    • , Raaj K Praseedom
    • , Ruby Lieshout
    • , Jan N M IJzermans
    • , Stephen J Wigmore
    • , Kourosh Saeb-Parsy
    • , Mathew J Garnett
    • , Luc JW van der Laan
    •  & Meritxell Huch

News & Comment

  • Correspondence |

    • Ross A Cardarelli
    • , Karen Jones
    • , Lucie I Pisella
    • , Heike J Wobst
    • , Lisa J McWilliams
    • , Paul M Sharpe
    • , Matthew P Burnham
    • , David J Baker
    • , Ilona Chudotvorova
    • , Justine Guyot
    • , Liliya Silayeva
    • , Danielle H Morrow
    • , Niek Dekker
    • , Stephen Zicha
    • , Paul A Davies
    • , Jörg Holenz
    • , Mark E Duggan
    • , John Dunlop
    • , Robert J Mather
    • , Qi Wang
    • , Igor Medina
    • , Nicholas J Brandon
    • , Tarek Z Deeb
    •  & Stephen J Moss
  • News and Views |

    In an article published recently in Nature Medicine, the authors generate organoid models of liver neoplasia. In doing so, they highlight both the diversity of current organoid methodologies and their application to cancer modeling and therapeutics discovery.

    • Amber R Smith
    •  & Calvin J Kuo
  • News |

    This past year included numerous research studies that broke the mold and elucidated new biology and drug targets. Here are some of the exciting papers from 2017 that moved biomedicine forward.

    • Tanya Bondar
    • , Javier Carmona
    • , Kate Gao
    • , Brett Benedetti
    • , Michael Basson
    • , Randy Levinson
    • , Hannah Stower
    •  & Alison Farrell
  • News and Views |

    In a recent study, Maciocia et al. develop a novel T cell receptor beta (TCRB) constant C1-chain-directed cellular immunotherapy for the treatment of T cell malignancies.

    • Teresa Palomero
    •  & Adolfo Ferrando
  • News and Views |

    Signals that govern immune cells in the heart remain poorly defined. A new report in mice shows that pathways involved in sensing viruses orchestrate monocyte and macrophage activation through recognition of DNA derived from dying cardiomyocytes following myocardial infarction.

    • Kory J Lavine
    •  & Douglas L Mann

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